iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	2.60e-12	48.0	207	267

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.d.vqpevfrallkFlYtgkld 66
           +Dvi+vv++  f+ahk vLaasS ++++l  +        +  +++ d v+p vfr +l+F+Ytg+l+
   Q: 207  CDVIIVVQNALFRAHKNVLAASSAYLKSLVVH-------DNLLNLDhDmVSPAVFRLVLDFIYTGRLT 267
           9*****************************77.......4566677678*****************96 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MITRMRHHPW LKSSSFEDRT FPSPPPNWRD ITYKYVLGST QHKTPRFMGL PGPISESPGG 60
HIWKRANLQD LLSSASASLL AQVCARGRSP AAHSPRVAAR WRHGRGSVCR FGPLQIRVCG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATTACAA GAATGCGCCA CCATCCCTGG CTTAAGAGTT CCTCATTTGA AGACAGAACC 60
TTCCCCTCCC CCCCCCCGAA TTGGCGCGAT ATAACATATA AATATGTACT CGGGAGCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR028424--HIC1
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0046872--F:metal ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030178--P:negative regulation of Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001347	Ailuropoda melanoleuca	91.15	9.00e-150	523.00
IUUC-Aca-004680	Anolis carolinensis	56.47	5.00e-68	252.00
IUUC-Ame-010967	Astyanax mexicanus	60.67	2.00e-93	337.00
IUUC-Bta-013567	Bos taurus	95.72	2.00e-160	559.00
IUUC-Cja-019621	Callithrix jacchus	92.75	2.00e-59	220.00
IUUC-Cfa-020731	Canis familiaris	95.15	0.00e+00	874.00
IUUC-Cpo-021326	Cavia porcellus	91.23	0.00e+00	1021.00
IUUC-Csa-023645	Chlorocebus sabaeus	95.15	0.00e+00	861.00
IUUC-Dre-028027	Danio rerio	57.93	2.00e-91	330.00
IUUC-Dno-028900	Dasypus novemcinctus	94.04	0.00e+00	900.00
IUUC-Fal-036980	Ficedula albicollis	62.29	6.00e-111	394.00
IUUC-Gga-040708	Gallus gallus	59.02	0.00e+00	634.00
IUUC-Ggo-044591	Gorilla gorilla	99.41	8.00e-139	487.00
IUUC-Hsa-046769	Homo sapiens	95.42	0.00e+00	848.00
IUUC-Itr-048627	Ictidomys tridecemlineatus	94.74	0.00e+00	1016.00
IUUC-Lch-049412	Latimeria chalumnae	53.16	0.00e+00	637.00
IUUC-Loc-051883	Lepisosteus oculatus	63.47	6.00e-93	335.00
IUUC-Laf-053358	Loxodonta africana	92.65	8.00e-168	583.00
IUUC-Mcc-054981	Macaca mulatta	95.10	0.00e+00	846.00
IUUC-Meu-056181	Macropus eugenii	73.66	3.00e-112	398.00
IUUC-Mga-059592	Meleagris gallopavo	72.16	4.00e-102	365.00
IUUC-Mmr-061560	Microcebus murinus	94.96	0.00e+00	848.00
IUUC-Mdo-062511	Monodelphis domestica	66.62	4.00e-165	575.00
IUUC-Mpu-065911	Mustela putorius furo	94.96	0.00e+00	859.00
IUUC-Mlu-067575	Myotis lucifugus	78.76	4.00e-126	444.00
IUUC-Ont-072493	Oreochromis niloticus	65.97	3.00e-80	293.00
IUUC-Ola-086584	Oryzias latipes	61.34	4.00e-88	319.00
IUUC-Oga-088774	Otolemur garnettii	94.45	0.00e+00	933.00
IUUC-Ptr-090491	Pan troglodytes	99.18	3.00e-120	425.00
IUUC-Pma-094179	Petromyzon marinus	70.51	4.00e-31	125.00
IUUC-Pfo-096282	Poecilia formosa	59.46	4.00e-87	315.00
IUUC-Pab-098488	Pongo abelii	95.44	2.00e-170	592.00
IUUC-Pca-100667	Procavia capensis	95.48	2.00e-148	520.00
IUUC-Pva-102421	Pteropus vampyrus	95.15	0.00e+00	856.00
IUUC-Rno-105528	Rattus norvegicus	95.47	0.00e+00	879.00
IUUC-Sar-113478	Sorex araneus	98.76	1.00e-118	420.00
IUUC-Ssc-115420	Sus scrofa	92.17	0.00e+00	849.00
IUUC-Tgu-116642	Taeniopygia guttata	59.13	1.00e-180	626.00
IUUC-Tru-118583	Takifugu rubripes	60.13	5.00e-84	305.00
IUUC-Xtr-132210	Xenopus tropicalis	59.01	0.00e+00	659.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence