iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cin-025780

Ensembl Protein ID

ENSCINP00000004803.3

UniProt Accession

F6RA92; F6RA92_CIOIN

Genbank Protein ID

ENSCINP00000004803

Protein Name

Presenilin

Genbank Nucleotide ID

EAAA01001313

Gene Name

LOC100180547

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000002361.3	ENSCINT00000004803.3	ENSCINP00000004803.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/CUE	48.76	5.00e-89	324.00	IUUC-Cel-018553

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ciona intestinalis

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MSNSAVSTTN ANQSNNTTDS PARRIRDEAE DAEEELRYGA STVISLFIPV TLCMLVVVAT 60
ITSVSYYTDQ SQQQFLVYTP FHTTNAAPAQ VVWESIANSL IMIGVIVVMT VFLVLLYKYR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAGAAATC GCTTAGATGA ATTCTTCGGG CGACTCAGAC GCCGAGAGAC AGCGTTTAAT 60
TGAAACACCG AGTGTTAATA TGAGTAACTC CGCAGTTTCA ACAACAAACG CTAACCAATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	31.12	1.00e-32	134.00
IUUC-Aml-001648	Ailuropoda melanoleuca	61.52	4.00e-99	353.00
IUUC-Atr-003039	Amborella trichopoda	31.75	4.00e-42	164.00
IUUC-Apl-003727	Anas platyrhynchos	62.34	3.00e-112	397.00
IUUC-Aca-004582	Anolis carolinensis	62.16	1.00e-115	408.00
IUUC-Aly-005455	Arabidopsis lyrata	50.47	2.00e-22	98.60
IUUC-Ath-006730	Arabidopsis thaliana	50.47	2.00e-22	99.00
IUUC-Ame-010686	Astyanax mexicanus	61.35	6.00e-117	412.00
IUUC-Bta-013026	Bos taurus	61.37	3.00e-115	407.00
IUUC-Bdi-014196	Brachypodium distachyon	34.72	2.00e-40	159.00
IUUC-Bol-015841	Brassica oleracea	35.14	5.00e-37	147.00
IUUC-Bra-017580	Brassica rapa	57.14	7.00e-23	100.00
IUUC-Cel-018553	Caenorhabditis elegans	48.76	5.00e-96	343.00
IUUC-Cja-019994	Callithrix jacchus	62.91	4.00e-113	400.00
IUUC-Cfa-020074	Canis familiaris	62.91	2.00e-114	404.00
IUUC-Cpo-022237	Cavia porcellus	63.41	7.00e-115	405.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	34.56	3.00e-29	122.00
IUUC-Csa-023537	Chlorocebus sabaeus	62.91	5.00e-114	402.00
IUUC-Cho-024735	Choloepus hoffmanni	55.64	5.00e-103	366.00
IUUC-Csv-025967	Ciona savignyi	82.47	2.00e-164	570.00
IUUC-Dre-028526	Danio rerio	61.90	6.00e-115	405.00
IUUC-Dno-029758	Dasypus novemcinctus	63.16	8.00e-115	405.00
IUUC-Dor-031127	Dipodomys ordii	68.10	3.00e-82	297.00
IUUC-Dme-031929	Drosophila melanogaster	53.86	1.00e-109	388.00
IUUC-Ete-033081	Echinops telfairi	47.88	9.00e-36	143.00
IUUC-Eca-034387	Equus caballus	69.40	1.00e-86	312.00
IUUC-Eeu-035134	Erinaceus europaeus	63.34	4.00e-94	336.00
IUUC-Fca-036243	Felis catus	62.41	3.00e-113	400.00
IUUC-Fal-036600	Ficedula albicollis	62.50	2.00e-114	404.00
IUUC-Gmo-039665	Gadus morhua	60.17	8.00e-98	349.00
IUUC-Gga-040993	Gallus gallus	62.66	1.00e-115	408.00
IUUC-Gac-042511	Gasterosteus aculeatus	60.29	9.00e-106	375.00
IUUC-Gma-043822	Glycine max	39.93	2.00e-29	121.00
IUUC-Ggo-045338	Gorilla gorilla	62.13	7.00e-92	329.00
IUUC-Hsa-046822	Homo sapiens	62.91	6.00e-114	402.00
IUUC-Hvu-047141	Hordeum vulgare	32.71	2.00e-34	138.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	63.02	2.00e-91	328.00
IUUC-Lch-049946	Latimeria chalumnae	55.86	4.00e-91	327.00
IUUC-Lpe-051132	Leersia perrieri	28.14	9.00e-28	116.00
IUUC-Loc-052427	Lepisosteus oculatus	62.16	5.00e-120	423.00
IUUC-Laf-053758	Loxodonta africana	57.37	1.00e-118	418.00
IUUC-Mcc-055682	Macaca mulatta	62.91	6.00e-114	402.00
IUUC-Meu-056004	Macropus eugenii	50.38	4.00e-86	310.00
IUUC-Mtr-058392	Medicago truncatula	33.49	8.00e-34	136.00
IUUC-Mga-059466	Meleagris gallopavo	62.66	2.00e-115	407.00
IUUC-Mmr-060890	Microcebus murinus	59.86	1.00e-91	328.00
IUUC-Mdo-062122	Monodelphis domestica	62.03	3.00e-115	407.00
IUUC-Mmu-063176	Mus musculus	62.91	1.00e-109	388.00
IUUC-Mac-064858	Musa acuminata	35.68	8.00e-25	106.00
IUUC-Mpu-065927	Mustela putorius furo	62.66	7.00e-114	402.00
IUUC-Mlu-067079	Myotis lucifugus	62.66	7.00e-122	429.00
IUUC-Nle-070180	Nomascus leucogenys	62.91	6.00e-114	402.00
IUUC-Opr-070847	Ochotona princeps	61.50	1.00e-107	382.00
IUUC-Ont-071846	Oreochromis niloticus	60.90	4.00e-110	390.00
IUUC-Oan-073378	Ornithorhynchus anatinus	60.06	3.00e-103	367.00
IUUC-Ocu-074527	Oryctolagus cuniculus	62.91	9.00e-116	409.00
IUUC-Oba-075256	Oryza barthii	31.52	5.00e-34	137.00
IUUC-Obr-076302	Oryza brachyantha	42.48	1.00e-22	99.80
IUUC-Ogl-077097	Oryza glaberrima	31.67	9.00e-37	146.00
IUUC-Ogu-078570	Oryza glumaepatula	32.12	1.00e-36	145.00
IUUC-Oin-079244	Oryza indica	31.94	6.00e-37	147.00
IUUC-Olo-080484	Oryza longistaminata	60.26	4.00e-21	94.00
IUUC-Ome-081814	Oryza meridionalis	59.49	9.00e-21	93.60
IUUC-Oni-082057	Oryza nivara	32.40	7.00e-37	146.00
IUUC-Opu-084176	Oryza punctata	33.15	4.00e-37	147.00
IUUC-Oru-084618	Oryza rufipogon	32.40	7.00e-37	146.00
IUUC-Osa-085602	Oryza sativa	32.40	6.00e-37	146.00
IUUC-Ola-086707	Oryzias latipes	67.10	3.00e-83	300.00
IUUC-Olu-087811	Ostreococcus lucimarinus	34.69	1.00e-46	179.00
IUUC-Oga-088560	Otolemur garnettii	69.83	3.00e-91	327.00
IUUC-Oar-090348	Ovis aries	62.16	1.00e-116	411.00
IUUC-Ptr-091060	Pan troglodytes	62.91	6.00e-114	402.00
IUUC-Pan-091742	Papio anubis	62.13	3.00e-91	327.00
IUUC-Psi-093505	Pelodiscus sinensis	61.40	1.00e-113	402.00
IUUC-Pma-094612	Petromyzon marinus	61.56	2.00e-98	351.00
IUUC-Ppa-095431	Physcomitrella patens	29.74	1.00e-23	103.00
IUUC-Pfo-097396	Poecilia formosa	63.25	1.00e-117	414.00
IUUC-Pab-098591	Pongo abelii	62.91	6.00e-114	402.00
IUUC-Pop-099661	Populus trichocarpa	32.58	9.00e-39	152.00
IUUC-Pca-101029	Procavia capensis	61.40	3.00e-103	367.00
IUUC-Ppe-101495	Prunus persica	31.50	3.00e-43	167.00
IUUC-Pva-102244	Pteropus vampyrus	60.65	9.00e-109	385.00
IUUC-Rno-105861	Rattus norvegicus	63.16	6.00e-112	395.00
IUUC-Sha-107045	Sarcophilus harrisii	62.66	3.00e-115	407.00
IUUC-Smo-109325	Selaginella moellendorffii	35.60	5.00e-37	147.00
IUUC-Sit-110624	Setaria italica	57.30	5.00e-21	94.40
IUUC-Sly-110865	Solanum lycopersicum	53.45	3.00e-12	62.00
IUUC-Stu-112433	Solanum tuberosum	32.68	8.00e-36	143.00
IUUC-Sar-113169	Sorex araneus	57.65	9.00e-89	319.00
IUUC-Sbi-114305	Sorghum bicolor	41.91	6.00e-21	94.00
IUUC-Ssc-115766	Sus scrofa	61.90	5.00e-113	399.00
IUUC-Tgu-117280	Taeniopygia guttata	62.94	3.00e-111	394.00
IUUC-Tru-117732	Takifugu rubripes	60.84	9.00e-111	392.00
IUUC-Tsy-119624	Tarsius syrichta	58.65	4.00e-103	366.00
IUUC-Tni-119852	Tetraodon nigroviridis	57.54	2.00e-104	370.00
IUUC-Tca-121865	Theobroma cacao	32.20	5.00e-40	157.00
IUUC-Tae-123984	Triticum aestivum	31.42	1.00e-33	136.00
IUUC-Tur-126237	Triticum urartu	33.24	2.00e-33	134.00
IUUC-Tbe-127632	Tupaia belangeri	69.40	1.00e-90	325.00
IUUC-Ttr-128793	Tursiops truncatus	61.65	6.00e-110	389.00
IUUC-Vpa-130625	Vicugna pacos	52.88	4.00e-90	323.00
IUUC-Vvi-131312	Vitis vinifera	53.54	3.00e-22	98.20
IUUC-Xtr-131790	Xenopus tropicalis	62.47	2.00e-110	391.00
IUUC-Xma-133377	Xiphophorus maculatus	61.35	1.00e-114	405.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence