iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000012908.2	ENSCJAT00000025091.2	ENSCJAP00000023719.2
ENSCJAG00000012908.2	ENSCJAT00000025084.1	ENSCJAP00000023712.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	6.90e-08	33.3	311	349

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 311  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 349
           89********************************99986 PP

Organism

Callithrix jacchus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

LLAGTVRFDR GCLKLFLAPK PACIDFGASR GRAMLTFMAS DSEEEVCDER TSLMSAESPT 60
PRSCQEGRQD QEDGENTAQW RSQENEEDGE EDPDRYVCSG VPGRPSGLEE ELTLKYGAKH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGTTGGCAG GGACAGTGAG ATTTGACAGG GGTTGTCTGA AGCTCTTCCT AGCCCCCAAA 60
CCTGCATGTA TAGATTTTGG ACTGCACTGG GTCCCGGATG TGGTACTACT ATGTAGAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	87.53	0.00e+00	639.00
IUUC-Apl-003959	Anas platyrhynchos	76.17	4.00e-159	554.00
IUUC-Aca-005160	Anolis carolinensis	73.04	1.00e-155	542.00
IUUC-Ang-009768	Aspergillus niger	48.15	3.90e-01	30.00
IUUC-Ame-010686	Astyanax mexicanus	77.86	7.00e-143	499.00
IUUC-Bta-013097	Bos taurus	94.88	0.00e+00	706.00
IUUC-Cfa-020253	Canis familiaris	94.42	0.00e+00	724.00
IUUC-Cpo-021401	Cavia porcellus	93.56	0.00e+00	723.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.47	6.00e-30	125.00
IUUC-Csa-023369	Chlorocebus sabaeus	97.54	0.00e+00	749.00
IUUC-Dre-028526	Danio rerio	69.27	4.00e-141	494.00
IUUC-Dor-031127	Dipodomys ordii	90.20	0.00e+00	675.00
IUUC-Ete-033081	Echinops telfairi	83.69	2.00e-93	335.00
IUUC-Eca-034387	Equus caballus	93.63	0.00e+00	687.00
IUUC-Eeu-034846	Erinaceus europaeus	80.87	3.00e-149	521.00
IUUC-Fca-035396	Felis catus	93.38	0.00e+00	746.00
IUUC-Fal-037457	Ficedula albicollis	75.65	1.00e-156	546.00
IUUC-Gga-040706	Gallus gallus	76.59	4.00e-153	534.00
IUUC-Ggo-045338	Gorilla gorilla	96.26	0.00e+00	802.00
IUUC-Hsa-046455	Homo sapiens	96.47	0.00e+00	804.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	95.31	0.00e+00	732.00
IUUC-Lch-049638	Latimeria chalumnae	68.03	1.00e-142	499.00
IUUC-Loc-052427	Lepisosteus oculatus	74.06	2.00e-153	535.00
IUUC-Laf-053758	Loxodonta africana	87.69	0.00e+00	720.00
IUUC-Mcc-054755	Macaca mulatta	95.22	0.00e+00	790.00
IUUC-Mmr-060890	Microcebus murinus	94.20	0.00e+00	723.00
IUUC-Mdo-062197	Monodelphis domestica	79.44	4.00e-173	600.00
IUUC-Mmu-063823	Mus musculus	94.20	0.00e+00	729.00
IUUC-Mac-064858	Musa acuminata	43.27	7.00e-22	97.80
IUUC-Mpu-066181	Mustela putorius furo	93.97	0.00e+00	722.00
IUUC-Nle-069596	Nomascus leucogenys	97.47	0.00e+00	699.00
IUUC-Opr-070344	Ochotona princeps	92.95	0.00e+00	736.00
IUUC-Ont-071867	Oreochromis niloticus	69.21	4.00e-128	451.00
IUUC-Oan-073378	Ornithorhynchus anatinus	73.66	2.00e-150	525.00
IUUC-Ocu-074652	Oryctolagus cuniculus	92.75	0.00e+00	697.00
IUUC-Oba-075256	Oryza barthii	60.49	3.00e-16	79.30
IUUC-Obr-076302	Oryza brachyantha	37.68	2.00e-17	83.60
IUUC-Ogl-077097	Oryza glaberrima	37.68	5.00e-17	82.40
IUUC-Ogu-078570	Oryza glumaepatula	37.68	4.00e-17	82.40
IUUC-Oin-079244	Oryza indica	38.41	3.00e-17	82.80
IUUC-Oni-082057	Oryza nivara	38.41	3.00e-17	82.80
IUUC-Oru-084618	Oryza rufipogon	38.41	3.00e-17	82.80
IUUC-Osa-085602	Oryza sativa	38.41	3.00e-17	82.80
IUUC-Ola-086707	Oryzias latipes	69.18	1.00e-102	365.00
IUUC-Oga-088560	Otolemur garnettii	94.68	0.00e+00	692.00
IUUC-Oar-089200	Ovis aries	94.65	0.00e+00	686.00
IUUC-Ptr-090569	Pan troglodytes	97.54	0.00e+00	747.00
IUUC-Pan-091742	Papio anubis	97.54	0.00e+00	747.00
IUUC-Psi-093297	Pelodiscus sinensis	75.29	2.00e-127	448.00
IUUC-Pma-094612	Petromyzon marinus	76.18	4.00e-124	437.00
IUUC-Ppa-095431	Physcomitrella patens	31.25	4.00e-27	115.00
IUUC-Pab-098531	Pongo abelii	97.54	0.00e+00	749.00
IUUC-Pca-101120	Procavia capensis	88.36	0.00e+00	717.00
IUUC-Pva-102934	Pteropus vampyrus	83.05	0.00e+00	699.00
IUUC-Rno-106052	Rattus norvegicus	93.53	0.00e+00	740.00
IUUC-Sha-106876	Sarcophilus harrisii	78.45	2.00e-169	588.00
IUUC-Ssc-115380	Sus scrofa	95.98	0.00e+00	758.00
IUUC-Tgu-117280	Taeniopygia guttata	76.09	9.00e-158	549.00
IUUC-Tbe-127632	Tupaia belangeri	95.09	3.00e-180	624.00
IUUC-Ttr-129008	Tursiops truncatus	93.57	0.00e+00	718.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence