iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053758

Ensembl Protein ID

ENSLAFP00000021788.1

UniProt Accession

G3U1T0; G3U1T0_LOXAF

Protein Name

Presenilin

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000007445.3	ENSLAFT00000028050.1	ENSLAFP00000021788.1
ENSLAFG00000007445.3	ENSLAFT00000007446.3	ENSLAFP00000006262.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.40e-07	30.5	278	316

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 278  VETAQERNEPIFPALIYSSAMVWTVGMAKPDPSSQGALQ 316
           89*************************999999888875 PP

Organism

Loxodonta africana

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MLTFMASDSE EEVCDERTSL MSAESPTPRT HQEGRQGPED AENTTQWRSQ ENEEDCEEDP 60
DRYVCSGVPG RPSGLEEELT LKYGAKHVIM LFVPVTLCMV VVVATIKSVR FYTEKNGQLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAGGAAGTGT GTGACGAGAG GACCTCCCTG 60
ATGTCGGCTG AGAGCCCCAC ACCGCGCACC CACCAGGAGG GCAGGCAGGG CCCGGAGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	82.04	9.00e-169	586.00
IUUC-Atr-003039	Amborella trichopoda	30.97	1.00e-35	144.00
IUUC-Apl-003959	Anas platyrhynchos	74.53	3.00e-162	564.00
IUUC-Aca-005160	Anolis carolinensis	74.62	3.00e-166	578.00
IUUC-Ath-006730	Arabidopsis thaliana	31.63	2.00e-18	87.00
IUUC-Ame-010686	Astyanax mexicanus	79.18	9.00e-149	519.00
IUUC-Bta-013097	Bos taurus	88.52	0.00e+00	679.00
IUUC-Bol-015841	Brassica oleracea	31.25	1.00e-29	123.00
IUUC-Cel-018553	Caenorhabditis elegans	48.16	2.00e-93	336.00
IUUC-Cja-018824	Callithrix jacchus	89.16	0.00e+00	700.00
IUUC-Cfa-020253	Canis familiaris	88.91	0.00e+00	699.00
IUUC-Cpo-021401	Cavia porcellus	88.27	0.00e+00	699.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.33	8.00e-30	125.00
IUUC-Csa-023369	Chlorocebus sabaeus	91.13	0.00e+00	718.00
IUUC-Cin-025780	Ciona intestinalis	61.15	1.00e-120	426.00
IUUC-Csv-025967	Ciona savignyi	61.67	2.00e-122	431.00
IUUC-Dre-028526	Danio rerio	69.21	1.00e-147	515.00
IUUC-Dor-031127	Dipodomys ordii	85.14	0.00e+00	670.00
IUUC-Dme-031929	Drosophila melanogaster	53.19	8.00e-110	390.00
IUUC-Ete-033081	Echinops telfairi	76.14	2.00e-86	312.00
IUUC-Eca-034387	Equus caballus	88.69	0.00e+00	658.00
IUUC-Eeu-034846	Erinaceus europaeus	78.04	2.00e-139	489.00
IUUC-Fca-035396	Felis catus	88.44	0.00e+00	695.00
IUUC-Fal-037457	Ficedula albicollis	75.33	5.00e-162	563.00
IUUC-Gmo-038550	Gadus morhua	82.83	2.00e-106	379.00
IUUC-Gga-040706	Gallus gallus	75.98	2.00e-160	558.00
IUUC-Gac-042511	Gasterosteus aculeatus	66.04	4.00e-135	474.00
IUUC-Gma-043822	Glycine max	35.64	2.00e-23	102.00
IUUC-Ggo-045338	Gorilla gorilla	91.35	0.00e+00	718.00
IUUC-Hsa-046455	Homo sapiens	91.35	0.00e+00	718.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	90.02	0.00e+00	709.00
IUUC-Lch-049638	Latimeria chalumnae	67.31	3.00e-143	501.00
IUUC-Loc-052427	Lepisosteus oculatus	73.67	2.00e-160	558.00
IUUC-Mcc-054755	Macaca mulatta	91.13	0.00e+00	716.00
IUUC-Mtr-058392	Medicago truncatula	35.62	1.00e-34	140.00
IUUC-Mmr-060890	Microcebus murinus	88.47	0.00e+00	696.00
IUUC-Mdo-062197	Monodelphis domestica	76.86	2.00e-172	598.00
IUUC-Mmu-063823	Mus musculus	89.36	0.00e+00	714.00
IUUC-Mac-064858	Musa acuminata	40.91	5.00e-21	94.70
IUUC-Mpu-066181	Mustela putorius furo	89.14	0.00e+00	701.00
IUUC-Nle-069596	Nomascus leucogenys	90.20	0.00e+00	669.00
IUUC-Opr-070344	Ochotona princeps	88.27	0.00e+00	691.00
IUUC-Ont-071867	Oreochromis niloticus	69.42	1.00e-134	473.00
IUUC-Oan-073378	Ornithorhynchus anatinus	72.64	1.00e-154	539.00
IUUC-Ocu-074652	Oryctolagus cuniculus	89.36	0.00e+00	670.00
IUUC-Obr-076302	Oryza brachyantha	36.96	1.00e-17	84.70
IUUC-Ola-086707	Oryzias latipes	67.51	9.00e-108	382.00
IUUC-Olu-087811	Ostreococcus lucimarinus	37.43	6.00e-45	174.00
IUUC-Oga-088560	Otolemur garnettii	89.16	0.00e+00	677.00
IUUC-Oar-089200	Ovis aries	88.08	0.00e+00	656.00
IUUC-Ptr-090569	Pan troglodytes	91.13	0.00e+00	716.00
IUUC-Pan-091742	Papio anubis	91.13	0.00e+00	716.00
IUUC-Pma-094612	Petromyzon marinus	75.85	1.00e-126	446.00
IUUC-Ppa-095431	Physcomitrella patens	31.52	2.00e-27	116.00
IUUC-Pab-098531	Pongo abelii	91.13	0.00e+00	718.00
IUUC-Pop-099661	Populus trichocarpa	32.51	3.00e-35	142.00
IUUC-Pca-101120	Procavia capensis	88.91	0.00e+00	702.00
IUUC-Pva-102934	Pteropus vampyrus	82.26	0.00e+00	664.00
IUUC-Rno-106052	Rattus norvegicus	89.14	0.00e+00	725.00
IUUC-Sha-106876	Sarcophilus harrisii	76.50	5.00e-171	593.00
IUUC-Smo-109325	Selaginella moellendorffii	35.03	7.00e-34	137.00
IUUC-Ssc-115380	Sus scrofa	90.24	0.00e+00	731.00
IUUC-Tgu-117280	Taeniopygia guttata	75.76	1.00e-163	569.00
IUUC-Tca-121865	Theobroma cacao	32.50	3.00e-39	155.00
IUUC-Tbe-127632	Tupaia belangeri	93.39	2.00e-171	594.00
IUUC-Ttr-129008	Tursiops truncatus	88.91	0.00e+00	691.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence