iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108076

UUCD1 version

UUC-ScP-00206

Ensembl Protein ID

SPAC20H4.10.1:pep

UniProt Accession

Q9HE05; O60009; Q9P7A3; Q9UTT4; Q9UU63; UFD2_SCHPO

Genbank Protein ID

AAC80427.1; CAC19740.1; BAA87095.1; BAA84654.1

Protein Name

Ubiquitin conjugation factor E4; Ubiquitin fusion degradation protein 2

Genbank Nucleotide ID

AF059906; CU329670; AB027791; AB032715

Gene Name

ufd2; SPAC145.04; SPAC20H4.10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC20H4.10	SPAC20H4.10.1	SPAC20H4.10.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	3.50e-23	79.6	930	1003

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 1    evpeeflCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceenss 74
           ++p++fl+p+++++M+dPvvlp sGi++drs+I+ +l s+ + +P++r+plt +d++Pn tlr+ i+ +++++++
   Q: 930  DIPDYFLDPLMFTIMKDPVVLPrSGISIDRSTIKAHLLSDAT-DPFNRTPLTLDDVTPNDTLREEINTFLKSKRN 1003
           69**************************************98.***************************99875 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

E4 ubiquitin chain-elongation enzyme specifically involved in polyubiquitin chain assembly. Binds to cdc48 and elongates mono- and diubiquitinated ERAD substrates presented by the ufd1-npl4-cdc48 (UNC) AAA ATPase complex to a chain length of 4 to 6 ubiquitin moieties. Delivers these polyubiquitinated substrates to downstream ERAD components, which target them to the proteasome. Enhances ubiquitination at 'Lys-48', but not at 'Lys-29' of the Ub moiety.

Protein Sequence
(Fasta)

MSDLEKIRLK RLAKLQQTNS EANSSKEPKE SNIAPEPKKP DLKKRFIGSK ATTSNSEQKE 60
ISPPVTSGAP KHRLFSKDEW MHFITCQALN ITLSETDSSK YYLEGFKKDL EEEGSPLLFN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCCACCAA CTTGCTCAAT CCACCCCATT ATGAGTGATT TGGAAAAGGT AAGAGAAAAA 60
TTTCAGCTAA TTGCTAATAT TGGCCCATAG ATTCGTCTTA AAAGGCTTGC TAAATTGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0436--Ligase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR019474--Ub_conjug_fac_E4_core
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51698--U_BOX

Pfam

PF04564--U-box
PF10408--Ufd2P_core

SMART

SM00504--Ubox

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0016874--F:ligase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0000209--P:protein polyubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

spo:SPAC20H4.10

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000585	Aegilops tauschii	30.46	4.00e-98	350.00
IUUC-Aml-002396	Ailuropoda melanoleuca	33.33	8.00e-108	383.00
IUUC-Atr-002479	Amborella trichopoda	31.00	2.00e-95	342.00
IUUC-Apl-003747	Anas platyrhynchos	32.65	5.00e-110	390.00
IUUC-Aca-004866	Anolis carolinensis	32.48	3.00e-108	385.00
IUUC-Aly-006300	Arabidopsis lyrata	28.07	2.00e-89	322.00
IUUC-Ath-006962	Arabidopsis thaliana	28.71	3.00e-83	301.00
IUUC-Ago-007880	Ashbya gossypii	36.11	5.00e-137	480.00
IUUC-Acl-008289	Aspergillus clavatus	38.64	8.00e-171	592.00
IUUC-Afl-008711	Aspergillus flavus	38.45	5.00e-171	593.00
IUUC-Afu-008766	Aspergillus fumigatus	38.60	2.00e-175	607.00
IUUC-Ani-009126	Aspergillus nidulans	36.52	1.00e-171	595.00
IUUC-Ang-009837	Aspergillus niger	38.02	9.00e-169	585.00
IUUC-Aor-009919	Aspergillus oryzae	37.87	8.00e-167	578.00
IUUC-Ate-010300	Aspergillus terreus	37.57	4.00e-168	583.00
IUUC-Ame-011355	Astyanax mexicanus	33.62	2.00e-116	412.00
IUUC-Bgr-011995	Blumeria graminis	36.01	2.00e-161	561.00
IUUC-Bta-013056	Bos taurus	33.21	5.00e-108	384.00
IUUC-Bci-013605	Botrytis cinerea	38.14	5.00e-155	540.00
IUUC-Bdi-015032	Brachypodium distachyon	28.49	5.00e-96	343.00
IUUC-Bol-016124	Brassica oleracea	27.39	5.00e-85	307.00
IUUC-Bra-017426	Brassica rapa	28.95	3.00e-85	308.00
IUUC-Cel-018606	Caenorhabditis elegans	27.77	3.00e-64	238.00
IUUC-Cja-018872	Callithrix jacchus	33.33	4.00e-108	384.00
IUUC-Cfa-020045	Canis familiaris	33.33	3.00e-108	384.00
IUUC-Cpo-022309	Cavia porcellus	33.17	8.00e-108	383.00
IUUC-Cre-022726	Chlamydomonas reinhardtii	30.59	1.00e-35	142.00
IUUC-Csa-023765	Chlorocebus sabaeus	29.83	3.00e-70	258.00
IUUC-Cho-024614	Choloepus hoffmanni	35.62	8.00e-61	227.00
IUUC-Cin-025533	Ciona intestinalis	35.41	3.00e-120	424.00
IUUC-Csv-026081	Ciona savignyi	50.54	7.00e-44	167.00
IUUC-Cgl-026710	Colletotrichum gloeosporioides	37.82	7.00e-172	595.00
IUUC-Cne-027098	Cryptococcus neoformans	31.38	2.00e-136	478.00
IUUC-Cme-027352	Cyanidioschyzon merolae	30.50	4.00e-87	314.00
IUUC-Dre-027979	Danio rerio	33.41	4.00e-110	391.00
IUUC-Dno-029282	Dasypus novemcinctus	33.01	7.00e-108	383.00
IUUC-Dor-030421	Dipodomys ordii	29.06	2.00e-65	242.00
IUUC-Dse-031393	Dothistroma septosporum	34.25	4.00e-160	556.00
IUUC-Dme-031666	Drosophila melanogaster	31.97	3.00e-104	371.00
IUUC-Ete-032519	Echinops telfairi	43.56	6.00e-69	254.00
IUUC-Eca-033778	Equus caballus	33.09	4.00e-107	380.00
IUUC-Eeu-035315	Erinaceus europaeus	49.21	1.00e-43	170.00
IUUC-Fca-035658	Felis catus	33.29	1.00e-106	379.00
IUUC-Fal-037638	Ficedula albicollis	32.97	3.00e-113	401.00
IUUC-Fox-037909	Fusarium oxysporum	35.07	1.00e-144	505.00
IUUC-Fso-038406	Fusarium solani	34.46	9.00e-146	509.00
IUUC-Gmo-039379	Gadus morhua	33.01	2.00e-112	398.00
IUUC-Ggr-039851	Gaeumannomyces graminis	37.49	5.00e-159	553.00
IUUC-Gga-041136	Gallus gallus	32.73	2.00e-111	395.00
IUUC-Gac-041910	Gasterosteus aculeatus	32.73	6.00e-111	393.00
IUUC-Gma-043587	Glycine max	29.24	5.00e-95	340.00
IUUC-Ggo-045354	Gorilla gorilla	32.49	6.00e-93	333.00
IUUC-Hsa-046880	Homo sapiens	33.33	4.00e-111	394.00
IUUC-Hvu-047157	Hordeum vulgare	30.54	9.00e-97	345.00
IUUC-Itr-048213	Ictidomys tridecemlineatus	41.79	4.00e-68	249.00
IUUC-Kpa-049211	Komagataella pastoris	32.96	6.00e-111	393.00
IUUC-Lch-050534	Latimeria chalumnae	30.92	3.00e-107	381.00
IUUC-Lpe-051022	Leersia perrieri	29.38	4.00e-92	330.00
IUUC-Loc-052622	Lepisosteus oculatus	32.81	6.00e-110	390.00
IUUC-Lma-053241	Leptosphaeria maculans	36.41	2.00e-159	555.00
IUUC-Laf-053646	Loxodonta africana	33.45	7.00e-109	387.00
IUUC-Mcc-055588	Macaca mulatta	33.33	7.00e-108	383.00
IUUC-Meu-055991	Macropus eugenii	29.70	1.00e-71	263.00
IUUC-Mor-057064	Magnaporthe oryzae	37.50	8.00e-176	608.00
IUUC-Mpo-057452	Magnaporthe poae	38.06	5.00e-161	560.00
IUUC-Mtr-058016	Medicago truncatula	29.71	3.00e-101	361.00
IUUC-Mla-058887	Melampsora laricipopulina	38.61	5.00e-133	466.00
IUUC-Mga-059497	Meleagris gallopavo	32.48	1.00e-110	392.00
IUUC-Mvi-060343	Microbotryum violaceum	35.75	2.00e-132	464.00
IUUC-Mmr-061173	Microcebus murinus	31.33	4.00e-91	328.00
IUUC-Mdo-062102	Monodelphis domestica	32.81	2.00e-107	381.00
IUUC-Mmu-063223	Mus musculus	32.45	5.00e-107	380.00
IUUC-Mac-065531	Musa acuminata	28.04	3.00e-98	351.00
IUUC-Mpu-066624	Mustela putorius furo	36.26	5.00e-79	288.00
IUUC-Mlu-068018	Myotis lucifugus	33.50	2.00e-106	379.00
IUUC-Nfi-068590	Neosartorya fischeri	38.53	7.00e-174	602.00
IUUC-Ncr-068901	Neurospora crassa	38.94	5.00e-161	560.00
IUUC-Nle-069605	Nomascus leucogenys	33.37	2.00e-107	381.00
IUUC-Opr-071011	Ochotona princeps	42.02	6.00e-63	234.00
IUUC-Ont-072304	Oreochromis niloticus	33.13	3.00e-104	371.00
IUUC-Oan-073410	Ornithorhynchus anatinus	36.10	5.00e-93	332.00
IUUC-Ocu-074910	Oryctolagus cuniculus	33.45	2.00e-109	389.00
IUUC-Oba-075073	Oryza barthii	29.79	2.00e-97	348.00
IUUC-Obr-076452	Oryza brachyantha	29.07	4.00e-98	350.00
IUUC-Ogl-077141	Oryza glaberrima	29.79	2.00e-97	348.00
IUUC-Ogu-078116	Oryza glumaepatula	29.79	2.00e-97	348.00
IUUC-Oin-079066	Oryza indica	29.91	6.00e-98	350.00
IUUC-Olo-080253	Oryza longistaminata	28.12	2.00e-85	308.00
IUUC-Ome-081263	Oryza meridionalis	29.79	1.00e-96	345.00
IUUC-Oni-082019	Oryza nivara	29.91	9.00e-98	349.00
IUUC-Opu-083558	Oryza punctata	30.44	9.00e-100	356.00
IUUC-Oru-085002	Oryza rufipogon	29.91	2.00e-97	348.00
IUUC-Osa-085980	Oryza sativa	29.91	8.00e-98	350.00
IUUC-Ola-086323	Oryzias latipes	33.55	1.00e-105	376.00
IUUC-Olu-087901	Ostreococcus lucimarinus	29.59	2.00e-98	351.00
IUUC-Oga-087969	Otolemur garnettii	34.42	6.00e-101	360.00
IUUC-Oar-090020	Ovis aries	33.25	7.00e-108	383.00
IUUC-Ptr-091589	Pan troglodytes	33.33	5.00e-111	394.00
IUUC-Pan-091718	Papio anubis	39.64	2.00e-88	318.00
IUUC-Psi-093013	Pelodiscus sinensis	33.13	2.00e-110	391.00
IUUC-Pma-094627	Petromyzon marinus	40.35	1.00e-86	311.00
IUUC-Pno-094840	Phaeosphaeria nodorum	39.15	0.00e+00	638.00
IUUC-Ppa-095989	Physcomitrella patens	29.50	2.00e-88	318.00
IUUC-Pfo-096436	Poecilia formosa	32.76	2.00e-110	392.00
IUUC-Pab-098275	Pongo abelii	35.59	4.00e-94	337.00
IUUC-Pop-098797	Populus trichocarpa	28.28	4.00e-99	354.00
IUUC-Pca-100762	Procavia capensis	28.59	1.00e-65	243.00
IUUC-Ppe-101230	Prunus persica	30.24	4.00e-101	360.00
IUUC-Pva-102459	Pteropus vampyrus	34.33	1.00e-106	379.00
IUUC-Pgr-103485	Puccinia graminis	36.56	3.00e-161	560.00
IUUC-Ptt-104001	Puccinia triticina	45.04	2.00e-50	192.00
IUUC-Pte-104084	Pyrenophora teres	38.31	3.00e-180	624.00
IUUC-Pyt-104484	Pyrenophora triticirepentis	37.50	3.00e-180	624.00
IUUC-Rno-105719	Rattus norvegicus	33.83	8.00e-107	379.00
IUUC-Sce-106135	Saccharomyces cerevisiae	35.23	2.00e-130	458.00
IUUC-Sha-106760	Sarcophilus harrisii	33.13	5.00e-107	380.00
IUUC-Sja-107698	Schizosaccharomyces japonicus	55.72	0.00e+00	1076.00
IUUC-Ssl-108624	Sclerotinia sclerotiorum	38.30	1.00e-161	561.00
IUUC-Smo-109042	Selaginella moellendorffii	28.77	6.00e-88	317.00
IUUC-Sit-109949	Setaria italica	28.55	1.00e-92	332.00
IUUC-Sly-110973	Solanum lycopersicum	27.86	9.00e-66	243.00
IUUC-Stu-112372	Solanum tuberosum	29.44	2.00e-98	352.00
IUUC-Sar-113131	Sorex araneus	34.84	8.00e-53	200.00
IUUC-Sbi-113828	Sorghum bicolor	28.60	8.00e-93	333.00
IUUC-Sre-114967	Sporisorium reilianum	37.30	2.00e-145	508.00
IUUC-Ssc-115841	Sus scrofa	27.47	5.00e-72	264.00
IUUC-Tgu-117290	Taeniopygia guttata	32.69	1.00e-104	373.00
IUUC-Tru-118193	Takifugu rubripes	33.13	3.00e-109	388.00
IUUC-Tsy-118926	Tarsius syrichta	33.45	4.00e-108	384.00
IUUC-Tni-120862	Tetraodon nigroviridis	33.13	9.00e-109	386.00
IUUC-Tca-121096	Theobroma cacao	30.50	3.00e-98	351.00
IUUC-Tre-122104	Trichoderma reesei	35.94	8.00e-147	513.00
IUUC-Tvi-122345	Trichoderma virens	35.58	1.00e-149	523.00
IUUC-Tae-124839	Triticum aestivum	29.67	9.00e-99	352.00
IUUC-Tur-126056	Triticum urartu	30.46	5.00e-98	350.00
IUUC-Tme-127074	Tuber melanosporum	35.85	7.00e-170	589.00
IUUC-Tbe-127533	Tupaia belangeri	34.20	4.00e-106	377.00
IUUC-Ttr-128757	Tursiops truncatus	32.53	1.00e-103	369.00
IUUC-Uma-129550	Ustilago maydis	37.81	2.00e-148	517.00
IUUC-Vda-129901	Verticillium dahliae	35.23	3.00e-170	590.00
IUUC-Vpa-130636	Vicugna pacos	36.38	4.00e-91	328.00
IUUC-Vvi-130891	Vitis vinifera	28.01	8.00e-97	346.00
IUUC-Xtr-132364	Xenopus tropicalis	32.49	7.00e-105	374.00
IUUC-Xma-133772	Xiphophorus maculatus	32.76	1.00e-110	392.00
IUUC-Yli-134506	Yarrowia lipolytica	33.51	5.00e-131	460.00
IUUC-Zma-135557	Zea mays	29.35	1.00e-88	319.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence