iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sly-111525

Ensembl Protein ID

Solyc03g120270.2.1

UniProt Accession

K4BMH6; K4BMH6_SOLLC

Protein Name

Coatomer subunit beta'

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Solyc03g120270.2	Solyc03g120270.2.1	Solyc03g120270.2.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.10e-37	124.4	184	224
UBD/Beta-Prp	5.00e-69	233.5	14	290

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sd.tllvsGsdDgtikvWDlrtgvllks 38
           H  +v+c+++    d ++l+sGsdD+t kvWD+ t  ++++
   Q: 184  HLKGVNCVDYftgGDkPYLISGSDDHTAKVWDYQTKSCVQT 224
           8889****966*9778*******************999986 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvls 99
           ++++++cv+ +p +++++t+ ++gt+ +w+++t+++++s++  e +v++ kf+ ++++ v g++D+ i+v++++t + v ++++h+d++++
   Q: 14   RSERVKCVDLHPTEPWILTSLYSGTVCIWNYQTQTMVKSFEVTELPVRSAKFIARKQWVVAGADDMYIRVYNYNTMDKVKVFEAHTDYIRC 104
           67789************************************************************************************** PP
   S: 100  lsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvysls.. 187
           ++++ps  +++s s+d  i++wd+e+g+   ++++gh++ v+ v+++p++ n ++s+slDrt+++W+l + +   tl   h + v++++  
   Q: 105  VAVHPSLPYVLSSSDDMLIKLWDWEKGWLCTQIFEGHSHYVMQVTFNPKDtNTFASASLDRTIKIWNLGSPDPNFTLDA-HLKGVNCVDyf 194
           ****************************9999*********************************************98.*********64 PP
   S: 188  fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdn 278
              ++++l+sgs+d t k+wd+qt++cv+tl+ght nv+ v f+p+  ++++gs+Dg++riW  ++  l +tl++  ++v++v +++ +++
   Q: 195  TGGDKPYLISGSDDHTAKVWDYQTKSCVQTLEGHTHNVSAVCFHPELPIIITGSEDGTVRIWHATTYRLENTLNYGLERVWAVGCMRSSRR 285
           44555********************************************************************************888777 PP
   S: 279  vlvlg 283
           v++  
   Q: 286  VVIGY 290
           77544 PP

Organism

Solanum lycopersicum

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

Protein Sequence
(Fasta)

MPLRLEIKRK LAQRSERVKC VDLHPTEPWI LTSLYSGTVC IWNYQTQTMV KSFEVTELPV 60
RSAKFIARKQ WVVAGADDMY IRVYNYNTMD KVKVFEAHTD YIRCVAVHPS LPYVLSSSDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGAGTC TGTTAGTTTC AATCTGTTCA ACATTACGTT ACGGCTTAGA TCTGATTCAA 60
ATCGGACTCA GTTTGGTTTC GGTAACTGAT CACCGTCTCC AGGATAACAC AATTCTGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR006692--Coatomer_WD-assoc_reg
IPR016453--COPB2
IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER

KEGG

sly:101247999

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-010922	Astyanax mexicanus	55.86	0.00e+00	975.00
IUUC-Bta-013579	Bos taurus	62.38	0.00e+00	970.00
IUUC-Cel-018387	Caenorhabditis elegans	54.64	0.00e+00	981.00
IUUC-Csa-023383	Chlorocebus sabaeus	66.49	0.00e+00	841.00
IUUC-Cme-027219	Cyanidioschyzon merolae	49.66	0.00e+00	893.00
IUUC-Dor-030462	Dipodomys ordii	60.12	0.00e+00	862.00
IUUC-Dme-031791	Drosophila melanogaster	57.28	0.00e+00	1018.00
IUUC-Ete-033166	Echinops telfairi	59.29	0.00e+00	710.00
IUUC-Gac-041733	Gasterosteus aculeatus	61.43	0.00e+00	1076.00
IUUC-Gma-044086	Glycine max	85.88	0.00e+00	1635.00
IUUC-Lch-050473	Latimeria chalumnae	62.15	0.00e+00	1118.00
IUUC-Loc-052675	Lepisosteus oculatus	62.27	0.00e+00	1122.00
IUUC-Mlu-067059	Myotis lucifugus	61.55	0.00e+00	1095.00
IUUC-Opr-070334	Ochotona princeps	63.36	0.00e+00	1006.00
IUUC-Ont-071563	Oreochromis niloticus	61.31	0.00e+00	1115.00
IUUC-Oan-073416	Ornithorhynchus anatinus	62.78	0.00e+00	1056.00
IUUC-Oba-075760	Oryza barthii	80.98	0.00e+00	1513.00
IUUC-Ogl-077450	Oryza glaberrima	81.61	0.00e+00	1538.00
IUUC-Ogu-078994	Oryza glumaepatula	80.98	0.00e+00	1511.00
IUUC-Olo-080731	Oryza longistaminata	79.87	0.00e+00	1492.00
IUUC-Oni-082324	Oryza nivara	80.98	0.00e+00	1512.00
IUUC-Oru-084829	Oryza rufipogon	80.85	0.00e+00	1515.00
IUUC-Ola-087245	Oryzias latipes	61.26	0.00e+00	1115.00
IUUC-Pma-094695	Petromyzon marinus	58.62	0.00e+00	997.00
IUUC-Pno-094785	Phaeosphaeria nodorum	58.42	5.00e-104	370.00
IUUC-Pfo-096587	Poecilia formosa	61.07	0.00e+00	1115.00
IUUC-Pab-097926	Pongo abelii	60.40	0.00e+00	1046.00
IUUC-Pva-102451	Pteropus vampyrus	59.22	0.00e+00	855.00
IUUC-Sit-110239	Setaria italica	81.50	0.00e+00	1560.00
IUUC-Sar-113472	Sorex araneus	58.06	0.00e+00	770.00
IUUC-Tru-118025	Takifugu rubripes	61.84	0.00e+00	1113.00
IUUC-Tsy-118824	Tarsius syrichta	59.05	0.00e+00	796.00
IUUC-Tni-120142	Tetraodon nigroviridis	61.86	0.00e+00	1107.00
IUUC-Tbe-127770	Tupaia belangeri	60.90	0.00e+00	892.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence