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Tag Content
UUCD2 ID IUUC-Gac-041363
UUCD1 version UUC-GaA-01093
Ensembl Protein ID ENSGACP00000027091.1
UniProt Accession G3QB25; G3QB25_GASAC
Protein Name Lissencephaly-1 homolog
Gene Name pafah1b1b (1 of many); PAFAH1B1; LIS1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGACG00000020486.1 ENSGACT00000027143.1 ENSGACP00000027091.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.10e-54 178.0 190 228
UBD/Beta-Prp 2.10e-89 300.1 107 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH v+++a ++ +++vs+s+D+t+k+W++ tg ++k
   Q: 190 GHDHNVSSVAImPNgDHIVSASRDKTMKMWEVATGYCVK 228
    899*******99777********************9987 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
    h +++t v f+p s+++t+s+d+ti vwd++ g++ r+l+gh++ v++++f+++gk+l+++s D+ ik+wd++ ++c++t++gh+++v
   Q: 107 HRAPVTRVIFHPVFSVMVTASEDATISVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMSIKLWDFQGFECIRTMHGHDHNV 195
    6678999********************************************************************************** PP
   S: 98 lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
    s++++p+gd++vs+s+d+t ++w++ tg+c++ t++gh+++v++v+ ++dg+ll+s+s+D+tvr+W ++++++ +l++ h++ v+++
   Q: 196 SSVAIMPNGDHIVSASRDKTMKMWEVATGYCVK-TFTGHREWVRMVRPNQDGSLLASCSNDQTVRVWVVASKECKAELRE-HEHVVECI 282
    *********************************.*********************************************9.******** PP
   S: 187 sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
    ++ +++ ++l+sgs+d+t+k+wd++ g c++tl gh+++v+ v ++p + ++vs+++D+++riWd++++
   Q: 283 AWAPDSahptileatgsetkksgkpgPFLLSGSRDKTIKMWDVSIGICLMTLVGHDNWVRGVLVHPGGRFIVSCADDKTLRIWDYKNKR 371
    ***************************************************************************************** PP
   S: 256 llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
    ++ktl h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 372 CMKTLCAHEHFVTSLDF-HKTAPYVVTGSVDQTVKVWECR 410
    *****************.99*****************985 PP
   

Organism Gasterosteus aculeatus
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Protein Sequence
(Fasta)
MVLSQRQRDE LNRAIADYLR SNGYEEAYST FKKEAELDMN EEVDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEMT HGGPVGQKRD PKEWIPRPPE RYALSGHRAP VTRVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Gac-041363|E3,WD_repeat;UBD,Beta-Prp|Gasterosteus aculeatus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGTGCACTCT CTTCACCGCC TCCGAAGGAA GAGCATCACC GAGGGATCCG ACCGCCGCGC 60
GCTTCCCCAG CCAGACCCCC CCCCCCCAGA ACATCACCTC ACCCTCACCT CCCCCAAGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Gac-041363|E3,WD_repeat;UBD,Beta-Prp|Gasterosteus aculeatus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR003143--Cyt_cd1_C
IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005815--C:microtubule organizing center
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0007399--P:nervous system development
GO:0006810--P:transport

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ago-007862 Ashbya gossypii 27.49 3.00e-39 155.00
IUUC-Gmo-039166 Gadus morhua 97.56 0.00e+00 842.00
IUUC-Kpa-049351 Komagataella pastoris 28.81 2.00e-45 177.00
IUUC-Lch-049936 Latimeria chalumnae 92.68 0.00e+00 810.00
IUUC-Loc-052476 Lepisosteus oculatus 93.73 0.00e+00 794.00
IUUC-Ont-071905 Oreochromis niloticus 97.80 0.00e+00 841.00
IUUC-Ola-086815 Oryzias latipes 97.07 0.00e+00 839.00
IUUC-Pma-094319 Petromyzon marinus 85.67 0.00e+00 631.00
IUUC-Pfo-096228 Poecilia formosa 96.59 0.00e+00 836.00
IUUC-Sce-106208 Saccharomyces cerevisiae 27.68 7.00e-37 148.00
IUUC-Tru-118179 Takifugu rubripes 97.56 0.00e+00 841.00
IUUC-Tni-120288 Tetraodon nigroviridis 97.32 0.00e+00 835.00
Created Date 25-Jun-2017

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