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Tag Content
UUCD2 ID IUUC-Ola-086772
UUCD1 version UUC-OrL-00447
Ensembl Protein ID ENSORLP00000009921.1
UniProt Accession H2LUZ3; H2LUZ3_ORYLA
Genbank Protein ID ENSORLP00000009921
Protein Name Lissencephaly-1 homolog
Genbank Nucleotide ID BAAF04035093
Gene Name pafah1b1b (1 of many); pafah1b1; LIS1; PAFAH1B1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSORLG00000007910.1 ENSORLT00000009922.1 ENSORLP00000009921.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.50e-59 194.8 336 374
UBD/Beta-Prp 6.10e-94 314.8 107 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH ++v+++ f ++ +++vs++dD+t+++WD++ ++ k
   Q: 336 GHDNWVRGILFhPGgKFIVSCADDKTLRIWDYKNKRCMK 374
    8***********999****************99998876 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
    h s++t v f+p s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195
    5678889********************************************************************************** PP
   S: 98 lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
    s++++p+gd++vs+s+d+ti++w++ tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++++++ +l++ h++ v+++
   Q: 196 SSVAIMPNGDHIVSASRDKTIKMWEVATGYCVK-TFAGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVASKECKAELRE-HEHVVECI 282
    *********************************.*********************************************9.******** PP
   S: 187 sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
    s+ +++ ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ + f+p ++++vs+++D+++riWd++++
   Q: 283 SWAPESasptileatgsetkksgkpgPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGILFHPGGKFIVSCADDKTLRIWDYKNKR 371
    ***************************************************************************************** PP
   S: 256 llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
    ++ktl h++ v+s ++ + + +v+gs d++v++w+++
   Q: 372 CMKTLCAHEHFVTSLDF-HKAAPFVVTGSVDQTVKVWECR 410
    *****************.999****************985 PP
   

Organism Oryzias latipes
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Protein Sequence
(Fasta)
MVLSQRQRDE LNRAIADYLR SNGYEEAYST FKKEAELDNN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEIT LGGPVTQKRD PKEWIPRPPE RYALSGHRSP VTRVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Ola-086772|E3,WD_repeat;UBD,Beta-Prp|Oryzias latipes
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGCAGAGAC CGCACTTCAC CTCCGCATCA CAAGATCACA CTCAGGAGCG GAAAAAACTC 60
ACGCCCTTTT CGGGTCGTGT TGCCGTTGGT GACGACTGGA GATATCCTCA GACAGCCGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Ola-086772|E3,WD_repeat;UBD,Beta-Prp|Oryzias latipes
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005815--C:microtubule organizing center
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0007399--P:nervous system development
GO:0006810--P:transport

KEGG ola:101169717
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 93.98 0.00e+00 790.00
IUUC-Apl-004024 Anas platyrhynchos 94.15 0.00e+00 812.00
IUUC-Aca-004564 Anolis carolinensis 93.66 0.00e+00 805.00
IUUC-Ang-009873 Aspergillus niger 44.81 2.00e-93 336.00
IUUC-Ame-010969 Astyanax mexicanus 95.85 0.00e+00 828.00
IUUC-Bgr-011972 Blumeria graminis 47.26 5.00e-104 371.00
IUUC-Bta-013106 Bos taurus 94.15 0.00e+00 813.00
IUUC-Cel-018459 Caenorhabditis elegans 57.18 4.00e-148 517.00
IUUC-Cja-018755 Callithrix jacchus 91.71 0.00e+00 793.00
IUUC-Cfa-020749 Canis familiaris 94.15 0.00e+00 813.00
IUUC-Cpo-022371 Cavia porcellus 94.15 0.00e+00 813.00
IUUC-Csa-023524 Chlorocebus sabaeus 93.04 0.00e+00 681.00
IUUC-Cho-024764 Choloepus hoffmanni 83.56 0.00e+00 641.00
IUUC-Cin-025753 Ciona intestinalis 71.53 0.00e+00 629.00
IUUC-Csv-025817 Ciona savignyi 70.24 0.00e+00 641.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 47.03 5.00e-98 351.00
IUUC-Dre-028314 Danio rerio 94.63 0.00e+00 822.00
IUUC-Dno-029050 Dasypus novemcinctus 93.90 0.00e+00 812.00
IUUC-Dor-030222 Dipodomys ordii 85.85 0.00e+00 729.00
IUUC-Ete-032508 Echinops telfairi 78.29 0.00e+00 654.00
IUUC-Eca-034288 Equus caballus 93.48 0.00e+00 786.00
IUUC-Eeu-034984 Erinaceus europaeus 85.61 0.00e+00 726.00
IUUC-Fca-036498 Felis catus 94.15 0.00e+00 813.00
IUUC-Fal-036920 Ficedula albicollis 94.15 0.00e+00 812.00
IUUC-Gmo-038983 Gadus morhua 96.10 0.00e+00 827.00
IUUC-Gga-040623 Gallus gallus 94.15 0.00e+00 812.00
IUUC-Gac-041613 Gasterosteus aculeatus 97.07 0.00e+00 837.00
IUUC-Ggo-045410 Gorilla gorilla 83.71 0.00e+00 683.00
IUUC-Hsa-046358 Homo sapiens 94.15 0.00e+00 812.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 94.15 0.00e+00 813.00
IUUC-Lch-049936 Latimeria chalumnae 94.88 0.00e+00 817.00
IUUC-Loc-052476 Lepisosteus oculatus 95.49 0.00e+00 802.00
IUUC-Laf-053713 Loxodonta africana 92.18 0.00e+00 793.00
IUUC-Mcc-054628 Macaca mulatta 93.66 0.00e+00 810.00
IUUC-Meu-055927 Macropus eugenii 80.51 3.00e-132 464.00
IUUC-Mga-059945 Meleagris gallopavo 93.90 0.00e+00 811.00
IUUC-Mvi-060403 Microbotryum violaceum 50.45 5.00e-130 457.00
IUUC-Mmr-061289 Microcebus murinus 93.98 0.00e+00 790.00
IUUC-Mdo-061912 Monodelphis domestica 93.41 0.00e+00 805.00
IUUC-Mmu-063253 Mus musculus 94.15 0.00e+00 813.00
IUUC-Mpu-066638 Mustela putorius furo 94.15 0.00e+00 813.00
IUUC-Mlu-067267 Myotis lucifugus 92.65 0.00e+00 796.00
IUUC-Nfi-068571 Neosartorya fischeri 45.39 9.00e-100 357.00
IUUC-Nle-069087 Nomascus leucogenys 94.63 0.00e+00 663.00
IUUC-Opr-070579 Ochotona princeps 93.90 0.00e+00 812.00
IUUC-Ont-072432 Oreochromis niloticus 97.07 0.00e+00 836.00
IUUC-Oan-073072 Ornithorhynchus anatinus 94.15 0.00e+00 813.00
IUUC-Ocu-074180 Oryctolagus cuniculus 93.90 0.00e+00 812.00
IUUC-Oga-088219 Otolemur garnettii 91.93 0.00e+00 792.00
IUUC-Oar-090394 Ovis aries 94.15 0.00e+00 813.00
IUUC-Ptr-091517 Pan troglodytes 94.15 0.00e+00 813.00
IUUC-Pan-092421 Papio anubis 93.66 0.00e+00 810.00
IUUC-Psi-093370 Pelodiscus sinensis 93.90 0.00e+00 811.00
IUUC-Pma-094319 Petromyzon marinus 86.25 0.00e+00 635.00
IUUC-Pfo-097089 Poecilia formosa 97.80 0.00e+00 842.00
IUUC-Pab-098421 Pongo abelii 94.15 0.00e+00 813.00
IUUC-Pca-100120 Procavia capensis 69.06 6.00e-155 540.00
IUUC-Pva-102960 Pteropus vampyrus 93.90 0.00e+00 808.00
IUUC-Pgr-103538 Puccinia graminis 47.43 2.00e-118 419.00
IUUC-Ptt-103990 Puccinia triticina 43.50 2.00e-45 177.00
IUUC-Rno-105123 Rattus norvegicus 94.15 0.00e+00 813.00
IUUC-Sce-106208 Saccharomyces cerevisiae 28.51 1.00e-37 150.00
IUUC-Sha-107010 Sarcophilus harrisii 93.17 0.00e+00 804.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 33.26 7.00e-67 247.00
IUUC-Sar-113309 Sorex araneus 93.23 0.00e+00 780.00
IUUC-Ssc-116148 Sus scrofa 94.15 0.00e+00 813.00
IUUC-Tgu-117299 Taeniopygia guttata 93.90 0.00e+00 810.00
IUUC-Tru-117721 Takifugu rubripes 96.34 0.00e+00 833.00
IUUC-Tsy-119493 Tarsius syrichta 93.41 0.00e+00 801.00
IUUC-Tni-120355 Tetraodon nigroviridis 96.83 0.00e+00 811.00
IUUC-Tbe-127492 Tupaia belangeri 61.32 2.00e-121 429.00
IUUC-Ttr-128929 Tursiops truncatus 94.15 0.00e+00 811.00
IUUC-Vda-129837 Verticillium dahliae 46.15 9.00e-100 357.00
IUUC-Vpa-130532 Vicugna pacos 80.05 0.00e+00 627.00
IUUC-Xtr-131985 Xenopus tropicalis 93.41 0.00e+00 810.00
Created Date 25-Jun-2017

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