iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.70e-34	119.4	19	144

Active Site

Position(s)	Description	Evidence
99	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk.ifhPnvyenGkvClsilkeeekWspals 97
           Rl+kel e++ +pp+g++ k++d+  l++w ++++G ++t Y++ +++l+++fpe+YP+++P+v fl +  +hP++y+nG++Cl+il   + Wspa++
   Q: 19   RLQKELVEWQMNPPTGFKHKVTDN--LQRWIIEVIGAPGTLYANDTYQLQVDFPEHYPMESPQVIFLHPaPLHPHIYSNGHICLDILY--DSWSPAMT 112
           9****************9998887..*****************************************9989****************9..******** PP
   S: 98   vesvllsiqsll.aepnpesplneeaaellkk 128
           v+s+++si s+l ++ + + p +++ + + +k
   Q: 113  VSSICISILSMLsSSTEKQRPTDNDRYVKNCK 144
           ************65588888988887754444 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.

Protein Sequence
(Fasta)

MSSSGAPSRK TLSKIATNRL QKELVEWQMN PPTGFKHKVT DNLQRWIIEV IGAPGTLYAN 60
DTYQLQVDFP EHYPMESPQV IFLHPAPLHP HIYSNGHICL DILYDSWSPA MTVSSICISI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGACACAAA TACACGAAAG TACGAAACGG TCGTGGATCT AAAAAGCACA AAACAGTACA 60
CGTGGCATGA TCTTTACCGT CCCTAGATAC CACCTTCCAA TCTGAATATC ATCTGATCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

KEGG

ath:AT1G75440

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002375	Ailuropoda melanoleuca	50.69	1.00e-35	141.00
IUUC-Apl-003950	Anas platyrhynchos	51.05	1.00e-35	141.00
IUUC-Afl-008476	Aspergillus flavus	37.97	2.00e-23	100.00
IUUC-Ame-011757	Astyanax mexicanus	51.72	2.00e-36	144.00
IUUC-Bta-013365	Bos taurus	51.72	3.00e-37	146.00
IUUC-Bci-013609	Botrytis cinerea	37.74	3.00e-24	103.00
IUUC-Bra-017578	Brassica rapa	94.41	8.00e-80	288.00
IUUC-Cja-018997	Callithrix jacchus	50.68	3.00e-36	143.00
IUUC-Cfa-020790	Canis familiaris	51.72	3.00e-37	146.00
IUUC-Cpo-021615	Cavia porcellus	51.05	1.00e-35	141.00
IUUC-Cre-022615	Chlamydomonas reinhardtii	47.10	2.00e-35	140.00
IUUC-Csa-024236	Chlorocebus sabaeus	51.72	3.00e-37	146.00
IUUC-Cho-024448	Choloepus hoffmanni	44.60	2.00e-27	113.00
IUUC-Cin-025579	Ciona intestinalis	47.30	2.00e-34	137.00
IUUC-Dre-028337	Danio rerio	51.72	1.00e-36	144.00
IUUC-Dno-029321	Dasypus novemcinctus	51.72	3.00e-37	146.00
IUUC-Dor-030985	Dipodomys ordii	55.26	2.00e-31	126.00
IUUC-Dme-032116	Drosophila melanogaster	50.34	1.00e-33	135.00
IUUC-Ete-032344	Echinops telfairi	51.72	5.00e-37	145.00
IUUC-Eca-033939	Equus caballus	51.05	1.00e-35	141.00
IUUC-Eeu-034593	Erinaceus europaeus	51.72	5.00e-37	145.00
IUUC-Fca-035457	Felis catus	50.00	8.00e-36	142.00
IUUC-Gmo-039574	Gadus morhua	51.03	2.00e-36	143.00
IUUC-Gga-040125	Gallus gallus	51.72	5.00e-37	145.00
IUUC-Gac-041300	Gasterosteus aculeatus	49.32	2.00e-35	140.00
IUUC-Gma-043703	Glycine max	90.06	7.00e-78	281.00
IUUC-Ggo-044461	Gorilla gorilla	51.72	5.00e-37	145.00
IUUC-Hsa-046710	Homo sapiens	51.72	5.00e-37	146.00
IUUC-Itr-048816	Ictidomys tridecemlineatus	51.72	5.00e-37	145.00
IUUC-Kpa-049405	Komagataella pastoris	42.66	9.00e-27	111.00
IUUC-Lch-050426	Latimeria chalumnae	50.34	5.00e-36	142.00
IUUC-Loc-052247	Lepisosteus oculatus	51.72	6.00e-37	145.00
IUUC-Laf-053849	Loxodonta africana	51.05	1.00e-35	141.00
IUUC-Mcc-055520	Macaca mulatta	51.72	6.00e-37	145.00
IUUC-Mor-057224	Magnaporthe oryzae	38.06	5.00e-26	109.00
IUUC-Mtr-058312	Medicago truncatula	90.68	7.00e-78	281.00
IUUC-Mga-059919	Meleagris gallopavo	51.72	6.00e-37	145.00
IUUC-Mvi-060408	Microbotryum violaceum	43.31	1.00e-30	124.00
IUUC-Mmr-061136	Microcebus murinus	50.00	6.00e-36	142.00
IUUC-Mdo-062768	Monodelphis domestica	51.72	5.00e-37	145.00
IUUC-Mmu-063097	Mus musculus	51.72	8.00e-37	145.00
IUUC-Mac-064913	Musa acuminata	91.89	5.00e-77	278.00
IUUC-Mpu-066887	Mustela putorius furo	50.68	6.00e-36	142.00
IUUC-Mlu-067762	Myotis lucifugus	51.72	1.00e-36	145.00
IUUC-Ncr-068788	Neurospora crassa	40.26	2.00e-27	114.00
IUUC-Nle-070082	Nomascus leucogenys	51.72	3.00e-37	146.00
IUUC-Ont-072026	Oreochromis niloticus	51.72	2.00e-37	147.00
IUUC-Oan-073013	Ornithorhynchus anatinus	53.28	9.00e-33	131.00
IUUC-Ocu-074009	Oryctolagus cuniculus	50.00	5.00e-36	142.00
IUUC-Oga-087990	Otolemur garnettii	51.72	5.00e-37	145.00
IUUC-Oar-090149	Ovis aries	50.00	8.00e-36	142.00
IUUC-Ptr-090701	Pan troglodytes	51.72	7.00e-37	145.00
IUUC-Pan-092007	Papio anubis	51.72	4.00e-37	146.00
IUUC-Psi-093380	Pelodiscus sinensis	51.01	3.00e-37	146.00
IUUC-Pma-094682	Petromyzon marinus	51.68	2.00e-38	150.00
IUUC-Ppa-095456	Physcomitrella patens	80.86	4.00e-67	246.00
IUUC-Pfo-097000	Poecilia formosa	51.72	7.00e-37	145.00
IUUC-Pab-098188	Pongo abelii	51.72	3.00e-37	146.00
IUUC-Pop-099874	Populus trichocarpa	90.68	3.00e-82	296.00
IUUC-Pca-100346	Procavia capensis	50.70	5.00e-35	139.00
IUUC-Pte-104294	Pyrenophora teres	41.91	1.00e-22	97.80
IUUC-Pyt-104534	Pyrenophora triticirepentis	41.91	2.00e-23	100.00
IUUC-Rno-105466	Rattus norvegicus	51.02	3.00e-37	146.00
IUUC-Sha-106707	Sarcophilus harrisii	51.05	2.00e-35	141.00
IUUC-Smo-108745	Selaginella moellendorffii	83.66	2.00e-67	246.00
IUUC-Sly-111213	Solanum lycopersicum	89.44	5.00e-77	278.00
IUUC-Sar-113531	Sorex araneus	49.35	5.00e-37	145.00
IUUC-Ssc-115770	Sus scrofa	51.72	4.00e-37	146.00
IUUC-Tgu-117316	Taeniopygia guttata	51.72	3.00e-37	146.00
IUUC-Tru-117640	Takifugu rubripes	52.41	2.00e-37	147.00
IUUC-Tsy-119222	Tarsius syrichta	50.69	5.00e-36	142.00
IUUC-Tni-120737	Tetraodon nigroviridis	52.41	2.00e-37	147.00
IUUC-Tca-121226	Theobroma cacao	93.75	4.00e-71	259.00
IUUC-Tre-121998	Trichoderma reesei	35.29	1.00e-13	68.20
IUUC-Tur-126577	Triticum urartu	85.29	4.00e-65	238.00
IUUC-Tme-127110	Tuber melanosporum	37.33	1.00e-22	97.80
IUUC-Tbe-127701	Tupaia belangeri	51.72	6.00e-37	145.00
IUUC-Vda-129698	Verticillium dahliae	35.95	4.00e-22	96.70
IUUC-Vvi-131254	Vitis vinifera	89.44	1.00e-76	277.00
IUUC-Xtr-132804	Xenopus tropicalis	37.24	5.00e-23	99.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence