iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pop-099550

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin activating enzyme 2 family protein

Genbank Nucleotide ID

CM000337

Gene Name

POPTRDRAFT_815464; POPTR_0001s28750g

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
POPTR_0001s28750	POPTR_0001s28750.1	POPTR_0001s28750.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	8.30e-163	543.5	483	969

Active Site

Position(s)	Description	Evidence
663	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnp 86
           YD Qi ++G++ q+kl+ a+ ++vG g+lGcE+lKnL+l+Gv     g++t++D+d +e+snl+rqFLfr++++g+ K+ vaa a++ +np
   Q: 483  YDAQISVFGSKLQKKLEDANLFVVGSGALGCEFLKNLALMGVscgeqGKLTLTDDDVIEKSNLSRQFLFRDWNIGQAKSTVAASAAALINP 573
           ******************************************************************************************* PP
   S: 87   dvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfc 174
           + ++ea +++++++ e+++   F ++++ Vv+aldn+ ar++v r    +++pl+esgtlG + +++ ii++lte y +s+dpp+k++P+c
   Q: 574  HLKIEALQNRVSPESENVFddtFWENLTAVVNALDNVNARLYVTRGA-VLQKPLLESGTLGAKCNTQMIIPHLTENYGASRDPPEKQAPMC 663
           *****************99************************9988.78***************************************** PP
   S: 175  tlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsi 253
           t+ ++p +++h+++wa              +n +l++    ++   k   +++++++++v + l++e+ e+f+++i++a+  f+ ++   +
   Q: 664  TVHSFPHNIDHCLTWArsefeglvektpTEVNAYLSNPVDYTNAMTKAGDAQSRDTLERVLECLEKEKCETFQDCITWARLRFEDYFADRV 754
           **************************9988888888888888888889999**************************************** PP
   S: 254  kqllksfecdivtkskspfwv.........................................................sfcsnae.alqvp 286
           kql+  f+ d  t+ ++pfw+                                                         +f + ++ +++++
   Q: 755  KQLIFTFPEDASTSTGAPFWSapkrfphplqfstadpshlhfvmaasilraetfgisvpewvkhpktlaeavekvivpEFQPREDvKIETD 845
           ***************************************************************9999999999999997776665155666 PP
   S: 287  ekvekdeevvkasap.lylllralerfekk..kgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiatt 372
           ek++   +v+ ++a+ +  l+r+le+ ++k  +   ++ ++fekddd   ++dl++ +an+ra +++i++ +d+ + k iag+iipaiat 
   Q: 846  EKATTISTVSVDDAAvINELIRKLEQCRHKlpPAYRMTPIQFEKDDDTnyHMDLIAGLANMRARNYSIPE-VDKLKAKFIAGRIIPAIATS 935
           7777777666666669*********99887445567889*******************************.******************** PP
   S: 373  navvgGlaaqEviKvvsg..kfeplknfflfdae 404
           +a+  Gl+++E++Kv++g  k e ++n+f ++a+
   Q: 936  TAMATGLVCLELYKVLDGghKVEDYRNTFANLAL 969
           ******************999********99875 PP

Organism

Populus trichocarpa

Protein Sequence
(Fasta)

MLPIKRPVEA VLVEGEEAPD NSISDSFSFK KNRIDCSLES NVSSNKNSCV IGNCSDTDRD 60
SNNRCKEELI MSPGDSKPME IDEDLHSRQL AVYGRETMRR LFGSNVLVSG MHGLGVEIAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTCTCCTTC ACAGACACTC TACAAGCTAC CAAAACCAAA CCCCAACCCC AACCCTCCCC 60
CCCCCCCCCA GATTCCATCC TTCCTCACTG GGCTAAACGG TACGTTTATC ACTTCCTCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

KEGG

pop:POPTR_0001s28750g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ptr-090609	Pan troglodytes	39.00	0.00e+00	675.00
IUUC-Pma-094214	Petromyzon marinus	47.62	9.00e-34	135.00
IUUC-Tsy-119436	Tarsius syrichta	35.12	1.00e-161	563.00
IUUC-Vpa-130716	Vicugna pacos	37.98	0.00e+00	655.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence