iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108209

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-conjugating enzyme E2 1; E2 ubiquitin-conjugating enzyme 1; Ubiquitin carrier protein 1; Ubiquitin-protein ligase 1

Genbank Nucleotide ID

CU329671

Gene Name

ubc1; SPBC2D10.20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC2D10.20	SPBC2D10.20.1	SPBC2D10.20.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	6.00e-45	150.5	8	143

Active Site

Position(s)	Description	Evidence
89	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeek 91
           R++kel+++++d+++gi++ + ++ d+ +++ ++ Gpe+tpYegg+F ++ie+p dYPf+PPk++f tki+hPnv+++ G++Cl+ilk  ++
   Q: 8    RIAKELADVQQDKQAGIQVWTIND-DISHLKGMFRGPEGTPYEGGYFVVDIEIPIDYPFRPPKMNFDTKIYHPNVSSQtGAICLDILK--DQ 96
           89**********************.9***************************************************99********9..** PP
   S: 92   Wspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           Wsp+++++s l+s+qsll++p+p++p+++++a+ + +n +++ +++r
   Q: 97   WSPVYTMKSALISLQSLLCTPEPSNPQDAQVAQVYLQNYQQFVRTAR 143
           ******************************************99987 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M).

Protein Sequence
(Fasta)

MSDNRSRRIA KELADVQQDK QAGIQVWTIN DDISHLKGMF RGPEGTPYEG GYFVVDIEIP 60
IDYPFRPPKM NFDTKIYHPN VSSQTGAICL DILKDQWSPV YTMKSALISL QSLLCTPEPS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCAATAAG TTACAGCATG ATCATATTAA AAGCACGAAA GTGATGTCCT TTATCTATCG 60
TCATTTAGTG CTGCTTAATA ACAAAGCTAT ATCAAATTTG AAAATGCACT ACTAATGTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR015368--UBA_C_fun
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF09288--UBA_3
PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination

KEGG

spo:SPBC2D10.20

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-003063	Amborella trichopoda	50.00	2.00e-38	149.00
IUUC-Aly-006390	Arabidopsis lyrata	48.37	6.00e-49	184.00
IUUC-Ath-006637	Arabidopsis thaliana	46.15	5.00e-47	178.00
IUUC-Ago-007714	Ashbya gossypii	50.47	6.00e-59	218.00
IUUC-Acl-008189	Aspergillus clavatus	60.65	2.00e-39	153.00
IUUC-Afl-008489	Aspergillus flavus	60.90	8.00e-41	158.00
IUUC-Afu-008850	Aspergillus fumigatus	61.04	2.00e-40	156.00
IUUC-Ani-009361	Aspergillus nidulans	60.54	8.00e-39	151.00
IUUC-Ang-009548	Aspergillus niger	61.29	8.00e-39	151.00
IUUC-Aor-010105	Aspergillus oryzae	60.90	8.00e-41	158.00
IUUC-Ate-010389	Aspergillus terreus	60.00	9.00e-40	154.00
IUUC-Bgr-012255	Blumeria graminis	56.10	1.00e-44	171.00
IUUC-Bci-013806	Botrytis cinerea	58.97	2.00e-43	166.00
IUUC-Bdi-015024	Brachypodium distachyon	55.03	3.00e-34	135.00
IUUC-Bol-015985	Brassica oleracea	51.15	3.00e-50	189.00
IUUC-Bra-016805	Brassica rapa	51.15	3.00e-50	189.00
IUUC-Cel-018527	Caenorhabditis elegans	49.68	3.00e-45	172.00
IUUC-Cin-025598	Ciona intestinalis	44.27	1.00e-37	147.00
IUUC-Csv-025831	Ciona savignyi	49.69	4.00e-36	142.00
IUUC-Cgl-026449	Colletotrichum gloeosporioides	51.92	9.00e-43	164.00
IUUC-Cne-027068	Cryptococcus neoformans	51.74	8.00e-57	211.00
IUUC-Dse-031335	Dothistroma septosporum	55.48	2.00e-47	180.00
IUUC-Fox-037969	Fusarium oxysporum	43.78	1.00e-48	183.00
IUUC-Fso-038296	Fusarium solani	46.56	5.00e-43	165.00
IUUC-Ggr-039768	Gaeumannomyces graminis	54.19	2.00e-38	149.00
IUUC-Gma-042779	Glycine max	58.90	5.00e-49	185.00
IUUC-Kpa-049297	Komagataella pastoris	48.86	7.00e-48	181.00
IUUC-Lpe-051070	Leersia perrieri	47.06	4.00e-32	128.00
IUUC-Lma-052949	Leptosphaeria maculans	61.94	3.00e-54	202.00
IUUC-Mor-056946	Magnaporthe oryzae	43.63	3.00e-36	142.00
IUUC-Mpo-057441	Magnaporthe poae	52.90	2.00e-37	146.00
IUUC-Mtr-058002	Medicago truncatula	59.03	4.00e-49	185.00
IUUC-Mla-059007	Melampsora laricipopulina	50.53	4.00e-55	205.00
IUUC-Mvi-060346	Microbotryum violaceum	44.39	3.00e-48	182.00
IUUC-Mac-065447	Musa acuminata	56.46	5.00e-39	151.00
IUUC-Nfi-068517	Neosartorya fischeri	61.04	2.00e-40	157.00
IUUC-Ncr-068749	Neurospora crassa	43.00	1.00e-45	174.00
IUUC-Opr-070651	Ochotona princeps	43.68	4.00e-36	142.00
IUUC-Oba-075530	Oryza barthii	48.13	6.00e-33	131.00
IUUC-Obr-076838	Oryza brachyantha	47.31	6.00e-32	128.00
IUUC-Ogl-077606	Oryza glaberrima	48.13	6.00e-33	131.00
IUUC-Ogu-078238	Oryza glumaepatula	48.13	6.00e-33	131.00
IUUC-Oin-079643	Oryza indica	48.39	9.00e-33	130.00
IUUC-Ome-081274	Oryza meridionalis	48.13	6.00e-33	131.00
IUUC-Oni-082651	Oryza nivara	48.13	6.00e-33	131.00
IUUC-Opu-083933	Oryza punctata	56.00	3.00e-32	129.00
IUUC-Oru-085054	Oryza rufipogon	48.92	3.00e-33	132.00
IUUC-Osa-085716	Oryza sativa	48.39	9.00e-33	130.00
IUUC-Olu-087846	Ostreococcus lucimarinus	47.59	4.00e-48	181.00
IUUC-Pma-094115	Petromyzon marinus	49.33	3.00e-37	145.00
IUUC-Pno-095102	Phaeosphaeria nodorum	62.99	1.00e-54	203.00
IUUC-Ppa-095326	Physcomitrella patens	57.43	6.00e-41	157.00
IUUC-Pop-099543	Populus trichocarpa	56.94	6.00e-47	177.00
IUUC-Ppe-101789	Prunus persica	57.24	3.00e-41	159.00
IUUC-Pgr-103643	Puccinia graminis	57.33	3.00e-50	189.00
IUUC-Ptt-103772	Puccinia triticina	57.82	5.00e-49	185.00
IUUC-Pte-104370	Pyrenophora teres	61.29	4.00e-54	202.00
IUUC-Pyt-104592	Pyrenophora triticirepentis	61.29	6.00e-54	201.00
IUUC-Sce-106394	Saccharomyces cerevisiae	52.56	3.00e-53	199.00
IUUC-Sha-106721	Sarcophilus harrisii	50.33	2.00e-37	146.00
IUUC-Sja-107866	Schizosaccharomyces japonicus	61.86	8.00e-77	277.00
IUUC-Ssl-108609	Sclerotinia sclerotiorum	56.41	7.00e-43	165.00
IUUC-Smo-109233	Selaginella moellendorffii	48.65	7.00e-42	161.00
IUUC-Sit-110639	Setaria italica	47.06	5.00e-36	141.00
IUUC-Sly-110978	Solanum lycopersicum	48.92	9.00e-48	180.00
IUUC-Stu-112088	Solanum tuberosum	58.33	7.00e-48	181.00
IUUC-Sbi-113986	Sorghum bicolor	47.06	6.00e-36	141.00
IUUC-Sre-115046	Sporisorium reilianum	48.29	2.00e-52	196.00
IUUC-Tca-121446	Theobroma cacao	48.72	2.00e-49	186.00
IUUC-Tre-122053	Trichoderma reesei	42.16	1.00e-45	173.00
IUUC-Tvi-122533	Trichoderma virens	41.92	6.00e-46	174.00
IUUC-Tae-125119	Triticum aestivum	53.69	4.00e-29	118.00
IUUC-Tme-127024	Tuber melanosporum	41.43	2.00e-50	189.00
IUUC-Uma-129512	Ustilago maydis	50.24	1.00e-52	197.00
IUUC-Vda-129947	Verticillium dahliae	43.64	2.00e-46	176.00
IUUC-Vpa-130481	Vicugna pacos	43.68	4.00e-36	142.00
IUUC-Vvi-131429	Vitis vinifera	47.83	1.00e-47	180.00
IUUC-Yli-134523	Yarrowia lipolytica	57.71	1.00e-58	217.00
IUUC-Zma-135733	Zea mays	50.31	5.00e-33	131.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence