iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-010954

Ensembl Protein ID

ENSAMXP00000013688.1

UniProt Accession

W5L1H6; W5L1H6_ASTMX

Genbank Protein ID

ENSAMXP00000013688

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

APWO01027596

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000013306.1	ENSAMXT00000013688.1	ENSAMXP00000013688.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.50e-15	57.1	100	155

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++d+L++kkGd  ++i  ++++++W+++ +  +gk+G +P+n+v+ ++
   Q: 100  FVALYDYEARTSDDLSFKKGDRFQII--NNTEGDWWEARSINTGKKGYIPSNYVAPAD 155
           679***********************..8999**********************9875 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MGCVKSKEDK GPTLKYRPEA SNPTPVPSHM GHYGPDPTQM GQSPALKGPN NSYNSHPSAL 60
TPFGGSSSTI TPFGGASSSF STVAVSNTFP GAVSGGVTFF VALYDYEART SDDLSFKKGD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAGTCGGT GCAGGCGGCC ATGTTGTGGG ATGCAAGTTA GCTTAGCTAC ACCAAGTAGA 60
GAAGAGAGAG ACAGAGAGAG AGAGAGAGAG AGAGAGAGAG GGAGTGAAAG AAAGAGGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00220--S_TKc
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0034334--P:adherens junction maintenance
GO:0060027--P:convergent extension involved in gastrulation
GO:0046777--P:protein autophosphorylation
GO:0045859--P:regulation of protein kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002374	Ailuropoda melanoleuca	86.31	0.00e+00	957.00
IUUC-Apl-004032	Anas platyrhynchos	88.48	0.00e+00	986.00
IUUC-Aca-004255	Anolis carolinensis	87.57	0.00e+00	1000.00
IUUC-Bta-013503	Bos taurus	86.11	0.00e+00	948.00
IUUC-Cja-019694	Callithrix jacchus	85.74	0.00e+00	944.00
IUUC-Cfa-020402	Canis familiaris	86.11	0.00e+00	956.00
IUUC-Cpo-022506	Cavia porcellus	85.56	0.00e+00	949.00
IUUC-Csa-023713	Chlorocebus sabaeus	86.11	0.00e+00	951.00
IUUC-Cin-025390	Ciona intestinalis	72.23	0.00e+00	661.00
IUUC-Csv-026029	Ciona savignyi	63.45	0.00e+00	635.00
IUUC-Dre-027978	Danio rerio	95.61	0.00e+00	1057.00
IUUC-Dno-029897	Dasypus novemcinctus	85.27	0.00e+00	844.00
IUUC-Dor-030202	Dipodomys ordii	93.14	0.00e+00	892.00
IUUC-Eca-034157	Equus caballus	86.11	0.00e+00	954.00
IUUC-Eeu-034950	Erinaceus europaeus	78.21	9.00e-158	549.00
IUUC-Fca-036233	Felis catus	86.65	0.00e+00	989.00
IUUC-Fal-037461	Ficedula albicollis	88.48	0.00e+00	1007.00
IUUC-Gmo-038929	Gadus morhua	90.89	0.00e+00	981.00
IUUC-Gga-041107	Gallus gallus	88.12	0.00e+00	986.00
IUUC-Gac-042321	Gasterosteus aculeatus	90.91	0.00e+00	1024.00
IUUC-Gma-043938	Glycine max	33.84	1.00e-22	101.00
IUUC-Hsa-047010	Homo sapiens	86.11	0.00e+00	961.00
IUUC-Lch-050239	Latimeria chalumnae	87.59	0.00e+00	1003.00
IUUC-Lpe-051166	Leersia perrieri	35.35	5.00e-23	103.00
IUUC-Loc-052314	Lepisosteus oculatus	92.17	0.00e+00	996.00
IUUC-Laf-053517	Loxodonta africana	84.46	0.00e+00	937.00
IUUC-Mcc-055626	Macaca mulatta	86.11	0.00e+00	951.00
IUUC-Mga-059310	Meleagris gallopavo	88.12	0.00e+00	986.00
IUUC-Mmr-061652	Microcebus murinus	83.91	0.00e+00	951.00
IUUC-Mdo-062963	Monodelphis domestica	85.19	0.00e+00	961.00
IUUC-Mmu-064128	Mus musculus	85.19	0.00e+00	961.00
IUUC-Mpu-065906	Mustela putorius furo	86.47	0.00e+00	960.00
IUUC-Mlu-067035	Myotis lucifugus	85.82	0.00e+00	950.00
IUUC-Nle-069041	Nomascus leucogenys	82.08	0.00e+00	902.00
IUUC-Opr-070299	Ochotona princeps	78.06	0.00e+00	838.00
IUUC-Ont-072337	Oreochromis niloticus	91.77	0.00e+00	1041.00
IUUC-Oan-072997	Ornithorhynchus anatinus	93.91	0.00e+00	910.00
IUUC-Ocu-074171	Oryctolagus cuniculus	84.46	0.00e+00	954.00
IUUC-Ola-086619	Oryzias latipes	88.41	0.00e+00	1011.00
IUUC-Oga-087957	Otolemur garnettii	83.73	0.00e+00	945.00
IUUC-Oar-089670	Ovis aries	85.01	0.00e+00	959.00
IUUC-Ptr-091352	Pan troglodytes	86.11	0.00e+00	961.00
IUUC-Pan-092202	Papio anubis	86.11	0.00e+00	951.00
IUUC-Psi-093310	Pelodiscus sinensis	88.12	0.00e+00	1004.00
IUUC-Pma-094232	Petromyzon marinus	85.41	0.00e+00	859.00
IUUC-Pfo-097076	Poecilia formosa	87.96	0.00e+00	1023.00
IUUC-Pab-098301	Pongo abelii	91.60	0.00e+00	910.00
IUUC-Pop-099554	Populus trichocarpa	31.51	9.00e-23	102.00
IUUC-Ppe-102072	Prunus persica	38.00	1.00e-25	112.00
IUUC-Pva-102592	Pteropus vampyrus	80.26	0.00e+00	894.00
IUUC-Rno-105544	Rattus norvegicus	84.49	0.00e+00	946.00
IUUC-Sar-113364	Sorex araneus	81.35	0.00e+00	895.00
IUUC-Tgu-117380	Taeniopygia guttata	88.48	0.00e+00	1007.00
IUUC-Tru-117784	Takifugu rubripes	90.13	0.00e+00	1021.00
IUUC-Tni-120433	Tetraodon nigroviridis	87.00	0.00e+00	985.00
IUUC-Ttr-128893	Tursiops truncatus	85.92	0.00e+00	952.00
IUUC-Vpa-130060	Vicugna pacos	84.46	0.00e+00	950.00
IUUC-Vvi-131181	Vitis vinifera	35.29	1.00e-21	99.00
IUUC-Xtr-132322	Xenopus tropicalis	88.12	0.00e+00	999.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence