iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	5.70e-06	27.4	9	76
E3 activity/RING/RING	7.00e-10	40.4	15	59

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk.....tcPvtrqplteedlvPnltlrrl 64
           + ee  CpI lel ++Pv + +++++ r++I    +s+++      cPv+r p    +l Pnl + ++
   Q: 9    IKEEVTCPICLELLKEPVSADCNHSFCRACITLNYESNRNtdgkgNCPVCRVPYPFGNLRPNLHVANI 76
           67899**************************877766666688899****************977665 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCle +k+ p++ +C+H f++ C+  ++  +++++ ++ +CP+Cr
   Q: 15   CPICLELLKE-PVSADCNHSFCRACItLNY-ESNRNTDGKGNCPVCR 59
           ********99.***************9999.99999**********8 PP

Organism

Mus musculus

Functional Description
(View)

Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses.

Protein Sequence
(Fasta)

MASSVLEMIK EEVTCPICLE LLKEPVSADC NHSFCRACIT LNYESNRNTD GKGNCPVCRV 60
PYPFGNLRPN LHVANIVERL KGFKSIPEEE QKVNICAQHG EKLRLFCRKD MMVICWLCER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCATTTCT CTACTGGCTC TTCAGAGGAG CAGCACAGTT GGCTGAATCA TCAAGACTTA 60
GACTATGGCC TGTGTTTGCT CCTCTCCACA GATCCTGAGT CTCTTGGTTG GTATCTGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0008270--F:zinc ion binding
GO:0032715--P:negative regulation of interleukin-6 production
GO:1900226--P:negative regulation of NLRP3 inflammasome complex assembly
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0034122--P:negative regulation of toll-like receptor signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:0045732--P:positive regulation of protein catabolic process
GO:0046598--P:positive regulation of viral entry into host cell
GO:0051865--P:protein autoubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:20128

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cel-018370	Caenorhabditis elegans	29.47	7.00e-09	54.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence