iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-090569

Ensembl Protein ID

ENSPTRP00000051089.3

UniProt Accession

H2R821; H2R821_PANTR

Genbank Protein ID

JAA06190.1; JAA20708.1; JAA25952.1

Protein Name

Presenilin

Genbank Nucleotide ID

AACZ03006499; GABF01001437; GABD01007148

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000002052.6	ENSPTRT00000058137.3	ENSPTRP00000051089.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.20e-08	33.4	278	316

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 278  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 316
           89********************************99986 PP

Organism

Pan troglodytes

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MLTFMASDSE EEVCDERTSL MSAESPTPRS CQEGRQGPED GENTAQWRSQ ENEEDGEEDP 60
DRYVCSGVPG RPPGLEEELT LKYGAKHVIM LFVPVTLCMI VVVATIKSVR FYTEKNGQLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACCAAGTGT CCGGGATTCA GACCTTTCTG CGGCCCCAAG TGTTCGTGGT AAGTGCAGTG 60
ACTCCCAACC TGCTTTTGAA CCGGCTTTTT CCATTAGGAT TTTCTCCGTG GAGGCAGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0043025--C:neuronal cell body
GO:0005637--C:nuclear inner membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

KEGG

ptr:457790

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	89.06	0.00e+00	632.00
IUUC-Apl-003959	Anas platyrhynchos	76.81	1.00e-162	565.00
IUUC-Aca-005160	Anolis carolinensis	75.62	2.00e-159	555.00
IUUC-Ang-009768	Aspergillus niger	51.85	9.80e-02	32.00
IUUC-Ame-010686	Astyanax mexicanus	79.43	2.00e-147	515.00
IUUC-Bta-013097	Bos taurus	96.44	0.00e+00	726.00
IUUC-Cja-018824	Callithrix jacchus	97.54	0.00e+00	748.00
IUUC-Cfa-020253	Canis familiaris	95.76	0.00e+00	740.00
IUUC-Cpo-021401	Cavia porcellus	95.31	0.00e+00	737.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	34.31	2.00e-30	127.00
IUUC-Csa-023369	Chlorocebus sabaeus	99.55	0.00e+00	774.00
IUUC-Dre-028526	Danio rerio	70.29	2.00e-144	505.00
IUUC-Dor-031127	Dipodomys ordii	91.96	0.00e+00	691.00
IUUC-Ete-033081	Echinops telfairi	84.04	4.00e-94	338.00
IUUC-Eca-034387	Equus caballus	95.98	0.00e+00	703.00
IUUC-Eeu-034846	Erinaceus europaeus	81.76	4.00e-151	527.00
IUUC-Fca-035396	Felis catus	94.63	0.00e+00	749.00
IUUC-Fal-037457	Ficedula albicollis	76.30	2.00e-160	558.00
IUUC-Gga-040706	Gallus gallus	77.24	1.00e-156	545.00
IUUC-Gac-042511	Gasterosteus aculeatus	66.25	1.00e-130	459.00
IUUC-Ggo-045338	Gorilla gorilla	99.78	0.00e+00	774.00
IUUC-Hsa-046455	Homo sapiens	99.78	0.00e+00	774.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	97.10	0.00e+00	753.00
IUUC-Lch-049638	Latimeria chalumnae	69.11	1.00e-147	516.00
IUUC-Loc-052427	Lepisosteus oculatus	75.28	2.00e-158	551.00
IUUC-Laf-053758	Loxodonta africana	88.98	0.00e+00	736.00
IUUC-Mcc-054755	Macaca mulatta	99.55	0.00e+00	771.00
IUUC-Mmr-060890	Microcebus murinus	96.21	0.00e+00	748.00
IUUC-Mdo-062197	Monodelphis domestica	80.79	4.00e-177	613.00
IUUC-Mmu-063823	Mus musculus	95.76	0.00e+00	748.00
IUUC-Mac-064858	Musa acuminata	43.27	7.00e-22	97.80
IUUC-Mpu-066181	Mustela putorius furo	95.31	0.00e+00	738.00
IUUC-Nle-069596	Nomascus leucogenys	99.75	0.00e+00	724.00
IUUC-Opr-070344	Ochotona princeps	95.31	0.00e+00	751.00
IUUC-Ont-071867	Oreochromis niloticus	70.79	8.00e-134	469.00
IUUC-Oan-073378	Ornithorhynchus anatinus	75.37	7.00e-156	543.00
IUUC-Ocu-074652	Oryctolagus cuniculus	94.87	0.00e+00	707.00
IUUC-Obr-076302	Oryza brachyantha	37.68	2.00e-17	84.00
IUUC-Osa-085602	Oryza sativa	38.41	2.00e-17	83.20
IUUC-Ola-086707	Oryzias latipes	70.82	5.00e-106	377.00
IUUC-Oga-088560	Otolemur garnettii	96.67	0.00e+00	716.00
IUUC-Oar-089200	Ovis aries	95.99	0.00e+00	703.00
IUUC-Pan-091742	Papio anubis	99.55	0.00e+00	773.00
IUUC-Psi-093297	Pelodiscus sinensis	76.81	1.00e-132	465.00
IUUC-Pma-094612	Petromyzon marinus	77.75	2.00e-128	452.00
IUUC-Ppa-095431	Physcomitrella patens	31.78	6.00e-28	118.00
IUUC-Pab-098531	Pongo abelii	99.55	0.00e+00	774.00
IUUC-Pca-101120	Procavia capensis	93.75	0.00e+00	726.00
IUUC-Pva-102934	Pteropus vampyrus	86.38	0.00e+00	693.00
IUUC-Rno-106052	Rattus norvegicus	95.09	0.00e+00	759.00
IUUC-Sha-106876	Sarcophilus harrisii	79.74	1.00e-173	602.00
IUUC-Ssc-115380	Sus scrofa	97.77	0.00e+00	779.00
IUUC-Tgu-117280	Taeniopygia guttata	76.96	4.00e-161	560.00
IUUC-Tbe-127632	Tupaia belangeri	97.94	0.00e+00	638.00
IUUC-Ttr-129008	Tursiops truncatus	95.76	0.00e+00	739.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence