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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046636
Ensembl Protein ID ENSP00000427562.1
UniProt Accession P42684; A0M8X0; B7UEF2; B7UEF3; B7UEF4; B7UEF5; Q5T0X6; Q5W0C5; Q6NZY6; Q7Z301; ABL2_HUMAN
Genbank Protein ID AAA35553.1; ACK76601.1; ACK76602.1; ACK76603.1; ACK76604.1; CAD98092.1; AAY16984.1; CAH70921.1; CAH70921.1; CAH70921.1; CAH70925.1; CAH70925.1; CAH70925.1; CAI15584.1; CAI15584.1; CAI15584.1; CAI15585.1; CAI15585.1; CAI15585.1; CAI13566.1; CAI13566.1; CAI13566.1; CAI13570.1; CAI13570.1; CAI13570.1; EAW91040.1; AAH65912.1
Protein Name Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG
Genbank Nucleotide ID M35296; FJ542283; FJ542284; FJ542285; FJ542286; AK311045; DQ009672; AL139132; AL359179; AL512326; AL139132; AL359179; AL512326; AL359179; AL139132; AL512326; AL359179; AL139132; AL512326; AL512326; AL359179; AL139132; AL512326; AL359179; AL139132; CH471067; BC065912
Gene Name ABL2; ABLL; ARG
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000143322.19 ENST00000502732.5 ENSP00000427562.1
ENSG00000143322.19 ENST00000344730.7 ENSP00000339209.3
ENSG00000143322.19 ENST00000512653.5 ENSP00000423578.1
ENSG00000143322.19 ENST00000504405.5 ENSP00000426831.1
ENSG00000143322.19 ENST00000367623.8 ENSP00000356595.4
ENSG00000143322.19 ENST00000507173.5 ENSP00000423413.1
ENSG00000143322.19 ENST00000511413.5 ENSP00000424697.1
ENSG00000143322.19 ENST00000392043.3 ENSP00000375897.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbGWAS CentralOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
dbPAFPhosSNPPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 6.70e-12 46.8 109 166
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++q+++W +     ++ +G +P+n+++ ++
   Q: 109  PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNQNGEWSEV--RSKNGQGWVPSNYITPVN 166
           67899************************.*********98..788899*********997 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
 Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
Protein Sequence
(Fasta)
MGQQVGRVGE APGLQQPQPR GIRGSSAARP SGRRRDPAGR TTETGFNIFT QHDHFASCVE 60
DGFEGDKTGG SSPEALHRPY GCDVEPQALN EAIRWSSKEN LLGATESDPN LFVALYDFVA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046636|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTCGGTGGT TTAAAGATGG CGGCGGCGGT GGCGGCGGCG GCGGCGGCGG CGTTGGGGGC 60
GCGGAGCCGC GACAGGAGGA GGGAAAAGCA GAATCTGTGA GTCGCCTGGA GGCAGCGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046636|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0130--Cell adhesion
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0460--Magnesium
KW-0464--Manganese
KW-0479--Metal-binding
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation
Interpro

IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE
SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0051015--F:actin filament binding
GO:0003785--F:actin monomer binding
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004672--F:protein kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0007155--P:cell adhesion
GO:0006464--P:cellular protein modification process
GO:0071300--P:cellular response to retinoic acid
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0010976--P:positive regulation of neuron projection development
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0010863--P:positive regulation of phospholipase C activity
GO:2000249--P:regulation of actin cytoskeleton reorganization
GO:0010506--P:regulation of autophagy
GO:0030155--P:regulation of cell adhesion
GO:2000145--P:regulation of cell motility
GO:0042127--P:regulation of cell proliferation
GO:0030100--P:regulation of endocytosis
GO:0007165--P:signal transduction
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG hsa:27
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002263 Ailuropoda melanoleuca 96.93 0.00e+00 1994.00
IUUC-Apl-003389 Anas platyrhynchos 85.21 0.00e+00 1742.00
IUUC-Ame-010629 Astyanax mexicanus 58.40 0.00e+00 1078.00
IUUC-Bta-013370 Bos taurus 96.11 0.00e+00 2072.00
IUUC-Cja-018894 Callithrix jacchus 96.58 0.00e+00 2029.00
IUUC-Cfa-020398 Canis familiaris 99.21 0.00e+00 1298.00
IUUC-Cpo-022367 Cavia porcellus 94.87 0.00e+00 1531.00
IUUC-Csa-023386 Chlorocebus sabaeus 99.28 0.00e+00 2050.00
IUUC-Cho-024714 Choloepus hoffmanni 91.97 0.00e+00 1880.00
IUUC-Dre-027741 Danio rerio 66.36 0.00e+00 1382.00
IUUC-Dno-029246 Dasypus novemcinctus 94.67 0.00e+00 2019.00
IUUC-Dor-030416 Dipodomys ordii 89.09 0.00e+00 1878.00
IUUC-Ete-032899 Echinops telfairi 76.93 0.00e+00 839.00
IUUC-Eca-033387 Equus caballus 96.76 0.00e+00 2007.00
IUUC-Eeu-035058 Erinaceus europaeus 85.04 0.00e+00 1857.00
IUUC-Fca-036578 Felis catus 89.78 0.00e+00 1801.00
IUUC-Fal-037491 Ficedula albicollis 88.13 0.00e+00 1875.00
IUUC-Gmo-038509 Gadus morhua 70.98 0.00e+00 1174.00
IUUC-Gga-040638 Gallus gallus 85.60 0.00e+00 1820.00
IUUC-Gac-042550 Gasterosteus aculeatus 78.16 0.00e+00 1182.00
IUUC-Ggo-044487 Gorilla gorilla 99.75 0.00e+00 2166.00
IUUC-Itr-048685 Ictidomys tridecemlineatus 96.73 0.00e+00 2033.00
IUUC-Lch-049530 Latimeria chalumnae 75.19 0.00e+00 1587.00
IUUC-Loc-051933 Lepisosteus oculatus 69.89 0.00e+00 1432.00
IUUC-Laf-053802 Loxodonta africana 95.86 0.00e+00 2142.00
IUUC-Mcc-054836 Macaca mulatta 99.24 0.00e+00 2150.00
IUUC-Mga-059277 Meleagris gallopavo 87.85 0.00e+00 1837.00
IUUC-Mmr-061206 Microcebus murinus 96.11 0.00e+00 2048.00
IUUC-Mdo-062281 Monodelphis domestica 93.60 0.00e+00 1249.00
IUUC-Mmu-063847 Mus musculus 94.26 0.00e+00 1963.00
IUUC-Mpu-066309 Mustela putorius furo 98.54 0.00e+00 1397.00
IUUC-Mlu-068070 Myotis lucifugus 96.30 0.00e+00 1977.00
IUUC-Nle-070062 Nomascus leucogenys 99.85 0.00e+00 1366.00
IUUC-Opr-070534 Ochotona princeps 91.08 0.00e+00 1057.00
IUUC-Ont-072440 Oreochromis niloticus 64.20 0.00e+00 1350.00
IUUC-Oan-073526 Ornithorhynchus anatinus 88.67 0.00e+00 1765.00
IUUC-Ocu-074051 Oryctolagus cuniculus 95.32 0.00e+00 1887.00
IUUC-Opu-083538 Oryza punctata 34.39 8.00e-23 102.00
IUUC-Oga-088767 Otolemur garnettii 91.28 0.00e+00 1806.00
IUUC-Oar-089800 Ovis aries 96.49 0.00e+00 1976.00
IUUC-Ptr-090857 Pan troglodytes 99.85 0.00e+00 1366.00
IUUC-Pan-092279 Papio anubis 97.46 0.00e+00 2089.00
IUUC-Psi-093573 Pelodiscus sinensis 88.60 0.00e+00 1811.00
IUUC-Pfo-096543 Poecilia formosa 71.69 0.00e+00 1156.00
IUUC-Pab-097949 Pongo abelii 97.88 0.00e+00 2061.00
IUUC-Pca-100370 Procavia capensis 94.66 0.00e+00 1467.00
IUUC-Pva-103220 Pteropus vampyrus 88.00 0.00e+00 1789.00
IUUC-Rno-105924 Rattus norvegicus 91.29 0.00e+00 1929.00
IUUC-Sha-107114 Sarcophilus harrisii 87.34 0.00e+00 1390.00
IUUC-Sit-110219 Setaria italica 30.30 7.00e-20 92.80
IUUC-Ssc-115968 Sus scrofa 96.02 0.00e+00 2130.00
IUUC-Tgu-117301 Taeniopygia guttata 87.69 0.00e+00 1793.00
IUUC-Tru-118410 Takifugu rubripes 66.03 0.00e+00 1405.00
IUUC-Tni-119991 Tetraodon nigroviridis 66.56 0.00e+00 1415.00
IUUC-Tca-121389 Theobroma cacao 33.85 2.00e-23 105.00
IUUC-Tbe-127362 Tupaia belangeri 91.79 0.00e+00 1894.00
IUUC-Ttr-129291 Tursiops truncatus 96.39 0.00e+00 1981.00
IUUC-Vpa-130800 Vicugna pacos 96.00 0.00e+00 1552.00
IUUC-Xtr-132965 Xenopus tropicalis 68.07 0.00e+00 1446.00
Created Date 25-Jun-2017

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