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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Ath-006656
Ensembl Protein ID AT3G14980.2
UniProt Accession F4IXE7; Q9LKA7; IDM1_ARATH
Genbank Protein ID BAA97061.1; AEE75596.1; ANM64196.1; ANM64199.1
Protein Name Increased DNA methylation 1; Histone H3 acetyltransferase IDM1; Protein ROS4; Repressor of silencing 4
Genbank Nucleotide ID AP000370; CP002686; CP002686; CP002686
Gene Name IDM1; ROS4; At3g14980; K15M2.12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT3G14980 AT3G14980.2 AT3G14980.2
AT3G14980 AT3G14980.5 AT3G14980.5
AT3G14980 AT3G14980.4 AT3G14980.4
AT3G14980 AT3G14980.3 AT3G14980.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
HINTMentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 8.40e-09 36.4 727 768
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkC 51
           ++C vCg+gge    l++C++C + fH+aCl+++    lp+ + w+C++C
   Q: 727  DSCGVCGDGGE----LICCDNCPSTFHQACLSMQ---VLPEGS-WYCSSC 768
           68*********....*******************...999**8.****** PP
   
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description


     Histone H3 acetyltransferase that binds methylated DNA at chromatin sites lacking histone H3K4 di- or trimethylation and catalyzes H3K18 and H3K23 acetylation (PubMed:22733760, PubMed:22700931). Prevents the transcriptional silencing of transgenes and of some endogenous genes (PubMed:22733760, PubMed:22700931). Requires the presence of IDM2 for efficient H3K18 acetylation, but not for H3K23 acetylation (PubMed:25002145).
 Histone H3 acetyltransferase that binds methylated DNA at chromatin sites lacking histone H3K4 di- or trimethylation and catalyzes H3K18 and H3K23 acetylation (PubMed:22733760, PubMed:22700931). Prevents the transcriptional silencing of transgenes and of some endogenous genes (PubMed:22733760, PubMed:22700931). Requires the presence of IDM2 for efficient H3K18 acetylation, but not for H3K23 acetylation (PubMed:25002145).
Protein Sequence
(Fasta)
MLPGAEIEML GGDCFEGSYE DHQIFREVFF GSDPGNTTKR CLVTGAINFE CDSSKNVNSS 60
LSSNSVVTSG YACPQGFEAS ASRDGSDFNT KAKRVKLSGN KHLDARDEKG SALHGFPTSD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ath-006656|E3,PHD|Arabidopsis thaliana
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAAAGAAAAA AAGAAAAAAA ACGAGAAGAG AAAGAAATAG CCAATAATAA GTATACACAC 60
ACTGTGCACA ACAAAGTGAT AGAGGCAGAT TCAGAGAGGT GAAAAAAAGT TCGTCAGAAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ath-006656|E3,PHD|Arabidopsis thaliana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0012--Acyltransferase
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR000182--GNAT_dom
IPR032308--Jas
IPR001739--Methyl_CpG_DNA-bd
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51186--GNAT
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF16135--Jas
PF00628--PHD
SMART

SM00249--PHD
Gene Ontology

GO:0005634--C:nucleus
GO:0009506--C:plasmodesma
GO:0010385--F:double-stranded methylated DNA binding
GO:0004402--F:histone acetyltransferase activity
GO:0042393--F:histone binding
GO:0008270--F:zinc ion binding
GO:0044154--P:histone H3-K14 acetylation
GO:0043971--P:histone H3-K18 acetylation
GO:0043972--P:histone H3-K23 acetylation
GO:0044030--P:regulation of DNA methylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0080188--P:RNA-directed DNA methylation
GO:0006351--P:transcription, DNA-templated
KEGG ath:AT3G14980
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000229 Aegilops tauschii 38.24 1.00e-84 308.00
IUUC-Atr-002835 Amborella trichopoda 55.74 4.00e-147 515.00
IUUC-Aly-006442 Arabidopsis lyrata 35.98 8.00e-81 294.00
IUUC-Bgr-012025 Blumeria graminis 37.10 1.00e-07 52.00
IUUC-Bta-013341 Bos taurus 35.96 2.00e-12 67.80
IUUC-Bdi-014663 Brachypodium distachyon 45.94 1.00e-109 391.00
IUUC-Bol-015215 Brassica oleracea 68.68 0.00e+00 1511.00
IUUC-Bra-017954 Brassica rapa 67.38 0.00e+00 1435.00
IUUC-Cja-019486 Callithrix jacchus 60.87 6.00e-14 70.90
IUUC-Cho-024934 Choloepus hoffmanni 35.96 9.00e-13 68.60
IUUC-Cin-025200 Ciona intestinalis 52.08 2.00e-11 64.70
IUUC-Dre-028253 Danio rerio 50.98 5.00e-13 69.30
IUUC-Gmo-039068 Gadus morhua 45.90 5.00e-13 69.30
IUUC-Gma-042984 Glycine max 43.22 0.00e+00 719.00
IUUC-Hvu-047073 Hordeum vulgare 39.14 1.00e-70 261.00
IUUC-Itr-048377 Ictidomys tridecemlineatus 35.96 6.00e-13 67.80
IUUC-Meu-056195 Macropus eugenii 46.30 1.00e-11 65.10
IUUC-Mtr-058487 Medicago truncatula 57.23 2.00e-159 556.00
IUUC-Mga-059318 Meleagris gallopavo 56.52 3.00e-10 58.50
IUUC-Mac-065614 Musa acuminata 48.48 2.00e-138 486.00
IUUC-Mpu-066679 Mustela putorius furo 35.96 2.00e-12 67.80
IUUC-Mlu-068239 Myotis lucifugus 65.22 9.00e-15 73.60
IUUC-Opr-070836 Ochotona princeps 48.15 1.00e-12 68.20
IUUC-Ont-071917 Oreochromis niloticus 42.31 5.00e-13 69.70
IUUC-Oan-073205 Ornithorhynchus anatinus 35.63 1.00e-12 67.80
IUUC-Oba-075185 Oryza barthii 32.02 3.00e-60 226.00
IUUC-Obr-076753 Oryza brachyantha 40.00 2.00e-87 317.00
IUUC-Ogl-077865 Oryza glaberrima 40.44 8.00e-100 358.00
IUUC-Ogu-078109 Oryza glumaepatula 38.57 8.00e-85 308.00
IUUC-Oin-080086 Oryza indica 30.52 3.00e-52 199.00
IUUC-Olo-080499 Oryza longistaminata 37.65 2.00e-95 343.00
IUUC-Ome-081461 Oryza meridionalis 35.81 2.00e-84 307.00
IUUC-Oni-082451 Oryza nivara 38.37 7.00e-84 305.00
IUUC-Opu-083209 Oryza punctata 40.17 1.00e-100 361.00
IUUC-Oru-084558 Oryza rufipogon 38.57 2.00e-84 307.00
IUUC-Oga-089101 Otolemur garnettii 35.96 2.00e-12 68.20
IUUC-Oar-090167 Ovis aries 35.96 2.00e-12 68.20
IUUC-Psi-093657 Pelodiscus sinensis 35.63 1.00e-12 68.60
IUUC-Pab-097704 Pongo abelii 36.78 2.00e-12 67.80
IUUC-Pop-099041 Populus trichocarpa 34.84 3.00e-75 276.00
IUUC-Ppe-101427 Prunus persica 58.92 0.00e+00 648.00
IUUC-Sha-106740 Sarcophilus harrisii 48.15 2.00e-12 67.80
IUUC-Spo-108017 Schizosaccharomyces pombe 37.50 3.00e-08 52.80
IUUC-Smo-109527 Selaginella moellendorffii 45.15 3.00e-101 361.00
IUUC-Sit-110344 Setaria italica 48.51 4.00e-134 472.00
IUUC-Sly-111539 Solanum lycopersicum 41.78 5.00e-88 319.00
IUUC-Stu-112309 Solanum tuberosum 37.83 2.00e-77 283.00
IUUC-Sbi-113930 Sorghum bicolor 43.12 2.00e-124 440.00
IUUC-Tgu-116922 Taeniopygia guttata 55.10 3.00e-13 68.60
IUUC-Tru-118426 Takifugu rubripes 45.45 2.00e-12 67.80
IUUC-Tca-121757 Theobroma cacao 62.65 0.00e+00 655.00
IUUC-Tae-123603 Triticum aestivum 44.67 5.00e-131 462.00
IUUC-Tur-126422 Triticum urartu 47.84 1.00e-135 477.00
IUUC-Tbe-127354 Tupaia belangeri 48.00 2.00e-11 64.30
IUUC-Ttr-128594 Tursiops truncatus 35.96 2.00e-12 68.20
IUUC-Vda-129988 Verticillium dahliae 43.14 4.00e-08 53.90
IUUC-Vpa-130420 Vicugna pacos 46.30 7.00e-12 65.90
IUUC-Vvi-130865 Vitis vinifera 60.81 5.00e-172 598.00
Created Date 25-Jun-2017

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