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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046247
UUCD1 version UUC-HoS-00907
Ensembl Protein ID ENSP00000235090.5
UniProt Accession Q9BQA1; B3KMW6; B4DP38; Q3LID2; Q53FU2; Q6JZZ5; Q96GK4; Q9BWY3; MEP50_HUMAN
Genbank Protein ID AAL79917.1; BAG51128.1; BAG60450.1; BAD96909.1; AAP79114.1; BAD38641.1; CAC36041.1; EAW56493.1; AAH01679.1; AAH06477.1; AAH09411.1; AAH11778.1; AAH16946.1; BAE45736.1
Protein Name Methylosome protein 50; Androgen receptor cofactor p44; WD repeat-containing protein 77; p44/Mep50
Genbank Nucleotide ID AF478464; AK022860; AK298179; AK223189; AY225316; AB073603; AL390195; CH471122; BC001679; BC006477; BC009411; BC011778; BC016946; AB074171
Gene Name WDR77; MEP50; WD45; HKMT1069; Nbla10071
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000116455.13 ENST00000235090.9 ENSP00000235090.5
ENSG00000116455.13 ENST00000449340.1 ENSP00000409300.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.50e-16 61.4 124 160
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           H d v+ ++  s+ t  vsGs D  ikvWDl ++v+l
   Q: 124  HDDIVSTVSVlSSgTQAVSGSKDICIKVWDLAQQVVL 160
           89999999977555*****************999987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
 Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
Protein Sequence
(Fasta)
MRKETPPPLV PPAAREWNLP PNAPACMERQ LEAARYRSDG ALLLGASSLS GRCWAGSLWL 60
FKDPCAAPNE GFCSAGVQTE AGVADLTWVG ERGILVASDS GAVELWELDE NETLIVSKFC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046247|E3,WD_repeat|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGTCAAGTAA CGCTGAGAGC CTATCGCATG AGGGCGACAG CCGGAAAGCA GGATGGAGCC 60
ATAGAAGCAA TTCTCGCGAG AAGTAGAGTT GCGGTTCCCT CGGGAGAGGG GCGGAGGCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046247|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0034709--C:methylosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0008327--F:methyl-CpG binding
GO:0016274--F:protein-arginine N-methyltransferase activity
GO:0060770--P:negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0008284--P:positive regulation of cell proliferation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0060528--P:secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0000387--P:spliceosomal snRNP assembly
KEGG hsa:79084
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002192 Ailuropoda melanoleuca 91.55 3.00e-179 620.00
IUUC-Apl-003921 Anas platyrhynchos 62.63 7.00e-66 243.00
IUUC-Aca-004870 Anolis carolinensis 70.25 5.00e-119 420.00
IUUC-Ame-011872 Astyanax mexicanus 47.22 4.00e-38 150.00
IUUC-Bta-013325 Bos taurus 92.11 0.00e+00 628.00
IUUC-Cja-019059 Callithrix jacchus 97.08 0.00e+00 650.00
IUUC-Cfa-021036 Canis familiaris 91.41 1.00e-157 549.00
IUUC-Cpo-022369 Cavia porcellus 90.06 1.00e-177 615.00
IUUC-Csa-023585 Chlorocebus sabaeus 98.25 0.00e+00 659.00
IUUC-Cho-024470 Choloepus hoffmanni 82.99 7.00e-115 406.00
IUUC-Dno-029867 Dasypus novemcinctus 89.18 7.00e-178 616.00
IUUC-Dor-030834 Dipodomys ordii 64.43 3.00e-114 404.00
IUUC-Ete-032245 Echinops telfairi 83.16 3.00e-140 491.00
IUUC-Eca-033360 Equus caballus 91.52 2.00e-173 602.00
IUUC-Eeu-035353 Erinaceus europaeus 89.77 5.00e-177 613.00
IUUC-Fca-036277 Felis catus 92.69 0.00e+00 629.00
IUUC-Fal-037383 Ficedula albicollis 67.05 3.00e-102 364.00
IUUC-Gmo-038575 Gadus morhua 54.65 2.00e-100 358.00
IUUC-Gga-040658 Gallus gallus 69.33 2.00e-128 452.00
IUUC-Gac-041463 Gasterosteus aculeatus 52.04 5.00e-85 307.00
IUUC-Ggo-045120 Gorilla gorilla 99.12 0.00e+00 664.00
IUUC-Itr-048292 Ictidomys tridecemlineatus 94.15 4.00e-180 624.00
IUUC-Lch-049741 Latimeria chalumnae 65.51 1.00e-112 399.00
IUUC-Loc-052695 Lepisosteus oculatus 59.28 2.00e-106 379.00
IUUC-Laf-054535 Loxodonta africana 88.79 2.00e-175 608.00
IUUC-Mcc-054699 Macaca mulatta 98.25 0.00e+00 659.00
IUUC-Meu-056053 Macropus eugenii 76.09 1.00e-138 486.00
IUUC-Mga-059672 Meleagris gallopavo 64.43 6.00e-71 259.00
IUUC-Mmr-060963 Microcebus murinus 93.27 0.00e+00 637.00
IUUC-Mdo-062694 Monodelphis domestica 73.76 1.00e-132 466.00
IUUC-Mmu-064031 Mus musculus 89.77 1.00e-176 612.00
IUUC-Mpu-066408 Mustela putorius furo 92.11 0.00e+00 627.00
IUUC-Mlu-068184 Myotis lucifugus 90.09 2.00e-175 608.00
IUUC-Nle-069251 Nomascus leucogenys 97.95 0.00e+00 658.00
IUUC-Opr-071156 Ochotona princeps 85.09 9.00e-165 572.00
IUUC-Ont-072683 Oreochromis niloticus 57.32 2.00e-97 349.00
IUUC-Oan-073042 Ornithorhynchus anatinus 75.52 3.00e-126 444.00
IUUC-Ocu-074843 Oryctolagus cuniculus 93.29 9.00e-177 612.00
IUUC-Ola-086929 Oryzias latipes 53.54 3.00e-89 322.00
IUUC-Oga-088237 Otolemur garnettii 92.11 0.00e+00 626.00
IUUC-Oar-089312 Ovis aries 91.77 2.00e-165 575.00
IUUC-Ptr-091625 Pan troglodytes 99.42 0.00e+00 667.00
IUUC-Pan-091902 Papio anubis 93.31 3.00e-179 620.00
IUUC-Psi-094035 Pelodiscus sinensis 71.53 6.00e-126 443.00
IUUC-Pma-094565 Petromyzon marinus 64.04 3.00e-57 214.00
IUUC-Pfo-097070 Poecilia formosa 54.49 1.00e-92 332.00
IUUC-Pab-098007 Pongo abelii 99.42 0.00e+00 666.00
IUUC-Pca-100513 Procavia capensis 74.06 7.00e-104 369.00
IUUC-Pva-102821 Pteropus vampyrus 86.55 2.00e-165 574.00
IUUC-Rno-105836 Rattus norvegicus 88.79 4.00e-177 613.00
IUUC-Sha-106847 Sarcophilus harrisii 69.80 2.00e-88 318.00
IUUC-Sar-113451 Sorex araneus 85.42 4.00e-168 583.00
IUUC-Ssc-115978 Sus scrofa 90.94 1.00e-173 602.00
IUUC-Tgu-116745 Taeniopygia guttata 69.30 6.00e-95 339.00
IUUC-Tru-117945 Takifugu rubripes 52.80 1.00e-81 296.00
IUUC-Tsy-119059 Tarsius syrichta 88.70 6.00e-91 326.00
IUUC-Tni-120414 Tetraodon nigroviridis 54.60 9.00e-95 340.00
IUUC-Tbe-127559 Tupaia belangeri 95.03 0.00e+00 643.00
IUUC-Ttr-128505 Tursiops truncatus 89.77 2.00e-174 605.00
IUUC-Vpa-130350 Vicugna pacos 93.96 2.00e-100 358.00
IUUC-Xtr-132939 Xenopus tropicalis 61.83 5.00e-113 400.00
Created Date 25-Jun-2017

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