iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	12105183

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	1.00e-88	296.4	543	891

Active Site

Position(s)	Description	Evidence
860	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq.pnpdsglknp...ehlklFeflGrllgkalqdgrlldlplsksfykll 100
            dl k+l++efv+E g+d+gG+ +e+++ll+k l+np++glf y ++++++++ ++p ++ k++    +l+l++++G+++g+a++++ +ldl+++k++yk+l
   Q: 543  GDLLKSLRIEFVNEPGIDAGGLRKEWFFLLTKSLFNPMNGLFIYIKESSRSWFaIDPPNFDKSKgknSQLELYYLFGVVMGLAIFNSTILDLQFPKALYKKL 644
           577789************************************99999777765355555433335559********************************** PP
   S: 101  lgkklsledleevdpelykslkeikenaesdieelgldltfsvseei..........lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqvea 192
           ++++ls+ed++e+ pe+ ++l +++++ e++ e+  + ltf+++ ++           +e+ ++eL+++G+n+p+t++Nk+e+v + ve+ l+++i+ q+++
   Q: 645  CSEPLSFEDYSELFPETSRNLIKMLNYTEDNFEDV-FSLTFETTYRNnnwilndsksSKEYVTVELCENGRNVPITQSNKHEFVMKWVEFYLEKSIEPQYNK 745
           ***************************99999997.9999997666668999999999999999************************************** PP
   S: 193  freGfnevipl.ellslFteeelellicGe...eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvir 290
           f +Gf++v+ + ++++lF+ eele l+cG+   +++d+++l++ tky gg+++ds+a+ wFwe++e+++   +k++LqFvT s+r+P+ G+ +++   f i+
   Q: 746  FVSGFKRVFAEcNSIKLFNSEELERLVCGDeeqTKFDFKSLRSVTKYVGGFSDDSRAVCWFWEIIESWDYPLQKKLLQFVTASDRIPATGISTIP---FKIS 844
           ********97627****************95344689**********************************************************...6666 PP
   S: 291  k..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
              +++ d+lP ++TCfn ++L++Yssk++l+ kLl+Ai+e++g+++
   Q: 845  LlgSHDSDDLPLAHTCFNEICLWNYSSKKKLELKLLWAINESEGYGF 891
           6656778***********************************99875 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Probable E3 ubiquitin-protein ligase, component of the TRAMP (TRF4) complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates.

Protein Sequence
(Fasta)

MVSLFDKLNA KKDGRDGSVS KELLSHSVAH TKNRLPKSGR RTSERSLAAS VKDGSCSNSK 60
SNKRNSSASV SGEEDKSCLI SLNCLCCGVP LRFPASITKF RCSACQVTVI VKEPEINSNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTTTCTT TATTTGATAA GCTTAATGCA AAAAAAGACG GTAGAGATGG ATCTGTGTCG 60
AAGGAGTTGC TATCACATTC TGTAGCCCAT ACTAAGAACA GGTTACCCAA ATCAGGAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0016567--P:protein ubiquitination

KEGG

sce:YJR036C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	34.65	8.00e-72	263.00
IUUC-Apl-003589	Anas platyrhynchos	34.84	2.00e-68	251.00
IUUC-Aca-004350	Anolis carolinensis	35.42	2.00e-70	258.00
IUUC-Ago-007908	Ashbya gossypii	42.61	0.00e+00	648.00
IUUC-Acl-008288	Aspergillus clavatus	32.38	4.00e-82	297.00
IUUC-Afl-008402	Aspergillus flavus	31.82	1.00e-72	266.00
IUUC-Afu-008762	Aspergillus fumigatus	32.48	1.00e-85	310.00
IUUC-Ani-009176	Aspergillus nidulans	33.85	6.00e-83	300.00
IUUC-Ang-009791	Aspergillus niger	32.58	4.00e-81	294.00
IUUC-Aor-009921	Aspergillus oryzae	31.36	3.00e-72	264.00
IUUC-Ate-010295	Aspergillus terreus	32.63	2.00e-82	298.00
IUUC-Ame-011166	Astyanax mexicanus	36.36	1.00e-65	243.00
IUUC-Bgr-011981	Blumeria graminis	33.28	8.00e-80	290.00
IUUC-Bta-012945	Bos taurus	35.36	2.00e-70	258.00
IUUC-Bci-013697	Botrytis cinerea	31.26	2.00e-71	262.00
IUUC-Cel-018150	Caenorhabditis elegans	28.74	1.00e-43	169.00
IUUC-Cja-019263	Callithrix jacchus	34.73	1.00e-68	252.00
IUUC-Cfa-020486	Canis familiaris	34.65	2.00e-71	261.00
IUUC-Cpo-021755	Cavia porcellus	34.65	5.00e-72	263.00
IUUC-Cre-022963	Chlamydomonas reinhardtii	36.73	2.00e-56	210.00
IUUC-Csa-023378	Chlorocebus sabaeus	36.60	1.00e-65	242.00
IUUC-Cho-025059	Choloepus hoffmanni	33.49	4.00e-52	197.00
IUUC-Cin-025643	Ciona intestinalis	37.68	9.00e-64	236.00
IUUC-Csv-026282	Ciona savignyi	37.59	1.00e-59	222.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	34.46	6.00e-72	264.00
IUUC-Cme-027151	Cyanidioschyzon merolae	34.13	2.00e-71	262.00
IUUC-Dre-028551	Danio rerio	35.98	9.00e-73	266.00
IUUC-Dno-029497	Dasypus novemcinctus	34.94	3.00e-69	254.00
IUUC-Dor-030158	Dipodomys ordii	31.45	8.00e-52	196.00
IUUC-Dse-031239	Dothistroma septosporum	28.12	5.00e-74	271.00
IUUC-Dme-032103	Drosophila melanogaster	33.93	2.00e-55	209.00
IUUC-Ete-032902	Echinops telfairi	32.67	8.00e-65	239.00
IUUC-Eca-033678	Equus caballus	34.65	2.00e-71	261.00
IUUC-Eeu-035109	Erinaceus europaeus	34.97	2.00e-58	218.00
IUUC-Fca-035590	Felis catus	34.84	3.00e-72	264.00
IUUC-Fal-036747	Ficedula albicollis	36.36	4.00e-66	244.00
IUUC-Fox-037941	Fusarium oxysporum	33.09	3.00e-84	305.00
IUUC-Fso-038388	Fusarium solani	32.63	5.00e-84	304.00
IUUC-Gmo-039553	Gadus morhua	32.51	6.00e-60	223.00
IUUC-Ggr-040110	Gaeumannomyces graminis	32.92	2.00e-77	282.00
IUUC-Gga-040406	Gallus gallus	34.84	5.00e-72	263.00
IUUC-Gac-042141	Gasterosteus aculeatus	32.45	7.00e-73	266.00
IUUC-Ggo-045504	Gorilla gorilla	34.73	8.00e-69	253.00
IUUC-Hsa-045786	Homo sapiens	34.73	6.00e-69	253.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	35.66	7.00e-62	229.00
IUUC-Kpa-049152	Komagataella pastoris	36.32	3.00e-126	444.00
IUUC-Lch-050197	Latimeria chalumnae	33.81	1.00e-66	245.00
IUUC-Loc-052173	Lepisosteus oculatus	35.63	9.00e-75	272.00
IUUC-Laf-054017	Loxodonta africana	34.25	6.00e-70	256.00
IUUC-Mcc-055713	Macaca mulatta	34.73	1.00e-68	252.00
IUUC-Meu-056061	Macropus eugenii	36.13	1.00e-64	239.00
IUUC-Mor-057045	Magnaporthe oryzae	32.88	1.00e-78	286.00
IUUC-Mla-059187	Melampsora laricipopulina	33.60	7.00e-62	229.00
IUUC-Mga-059884	Meleagris gallopavo	35.78	2.00e-66	245.00
IUUC-Mmr-061344	Microcebus murinus	34.84	3.00e-72	264.00
IUUC-Mdo-062653	Monodelphis domestica	35.21	1.00e-69	256.00
IUUC-Mmu-063775	Mus musculus	35.36	2.00e-71	261.00
IUUC-Mpu-066069	Mustela putorius furo	34.65	1.00e-71	262.00
IUUC-Mlu-067925	Myotis lucifugus	35.98	1.00e-71	262.00
IUUC-Nfi-068439	Neosartorya fischeri	32.33	3.00e-85	308.00
IUUC-Ncr-068903	Neurospora crassa	34.01	5.00e-73	267.00
IUUC-Nle-070046	Nomascus leucogenys	33.86	1.00e-69	256.00
IUUC-Opr-070570	Ochotona princeps	35.69	2.00e-44	172.00
IUUC-Ont-072126	Oreochromis niloticus	35.04	6.00e-77	280.00
IUUC-Oan-072933	Ornithorhynchus anatinus	35.15	2.00e-68	251.00
IUUC-Ocu-073800	Oryctolagus cuniculus	34.94	9.00e-69	252.00
IUUC-Ola-086988	Oryzias latipes	35.56	3.00e-75	274.00
IUUC-Oga-088117	Otolemur garnettii	35.56	3.00e-71	260.00
IUUC-Oar-089371	Ovis aries	35.36	3.00e-70	258.00
IUUC-Ptr-090551	Pan troglodytes	34.73	9.00e-69	253.00
IUUC-Pan-092067	Papio anubis	34.73	1.00e-68	252.00
IUUC-Psi-092963	Pelodiscus sinensis	35.36	5.00e-70	257.00
IUUC-Pma-094643	Petromyzon marinus	36.71	3.00e-64	238.00
IUUC-Ppa-095354	Physcomitrella patens	36.75	2.00e-68	252.00
IUUC-Pfo-096562	Poecilia formosa	33.86	2.00e-73	268.00
IUUC-Pab-098680	Pongo abelii	34.73	6.00e-69	253.00
IUUC-Pca-100869	Procavia capensis	36.28	5.00e-64	237.00
IUUC-Pva-103040	Pteropus vampyrus	36.72	2.00e-55	208.00
IUUC-Pgr-103315	Puccinia graminis	30.41	3.00e-77	281.00
IUUC-Ptt-103736	Puccinia triticina	36.33	7.00e-80	290.00
IUUC-Rno-105270	Rattus norvegicus	35.36	2.00e-70	258.00
IUUC-Sha-106819	Sarcophilus harrisii	35.10	2.00e-73	268.00
IUUC-Sja-107974	Schizosaccharomyces japonicus	29.24	2.00e-50	191.00
IUUC-Spo-108271	Schizosaccharomyces pombe	30.60	6.00e-94	336.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	30.78	1.00e-76	280.00
IUUC-Smo-108858	Selaginella moellendorffii	36.25	2.00e-74	271.00
IUUC-Sar-113293	Sorex araneus	36.13	3.00e-64	238.00
IUUC-Ssc-115441	Sus scrofa	35.36	6.00e-71	260.00
IUUC-Tgu-117166	Taeniopygia guttata	34.84	2.00e-68	251.00
IUUC-Tru-118368	Takifugu rubripes	36.36	2.00e-66	244.00
IUUC-Tsy-118898	Tarsius syrichta	31.54	4.00e-54	204.00
IUUC-Tni-120143	Tetraodon nigroviridis	36.60	2.00e-66	245.00
IUUC-Tre-122108	Trichoderma reesei	31.96	3.00e-70	258.00
IUUC-Tvi-122644	Trichoderma virens	33.64	1.00e-75	276.00
IUUC-Tme-127004	Tuber melanosporum	31.22	3.00e-85	308.00
IUUC-Tbe-127640	Tupaia belangeri	30.87	3.00e-46	178.00
IUUC-Ttr-129078	Tursiops truncatus	36.36	2.00e-64	238.00
IUUC-Vda-129969	Verticillium dahliae	32.93	1.00e-76	280.00
IUUC-Vpa-130448	Vicugna pacos	31.66	7.00e-53	200.00
IUUC-Xtr-132881	Xenopus tropicalis	36.60	9.00e-68	249.00
IUUC-Xma-133299	Xiphophorus maculatus	37.70	1.00e-64	239.00
IUUC-Yli-134470	Yarrowia lipolytica	38.86	5.00e-86	310.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence