iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066082

Ensembl Protein ID

ENSMPUP00000016673.1

UniProt Accession

M3YZB3; M3YZB3_MUSPF

Genbank Protein ID

ENSMPUP00000016673

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AEYP01066496

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000016778.1	ENSMPUT00000016922.1	ENSMPUP00000016673.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.80e-64	217.0	361	867
UBD/Alpha-Helix/UBA	6.00e-23	80.3	737	774

Active Site

Position(s)	Description	Evidence
370	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
830	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                    +k+ +  ++
   Q: 361  TGIQNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPTDPTQDFSTQVAKLGHGLlsgeyskpapesgdgeqvpdQKEVQDGIA 448
           7******************************.99999999********************66666666666666555443366666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ +l++ +e+++                             ++++  +++F++ ++++ikcl+
   Q: 449  PRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNC-----------------------------RSSENPNEVFRFLVEEKIKCLA 508
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekk 220
            ++v+ ++   + ++lpvp+++  +ke                            +++cLe++ ++e++++   ++++  ++k+ a+k+
   Q: 509  TEKVKYTQRVDYIMQLPVPMDTALNKEelleyeekkrqaeeeklplpelvraqvPFSSCLEAYGAPEQVDD---FWSTALQAKSVAVKT 594
           **********************99999******************************************97...*************** PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.......................................... 267
           +++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+                                              
   Q: 595  TRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQLRGAglqpgeeelpdiapplvtpdepkapmldesviiqlvemgfpm 682
           *******************997.*******************98888788888888888888888888888777777777777777777 PP
   S: 268  ..........................................................peekqke........................ 274
                                                                     +     +                        
   Q: 683  dacrkavyytgnsgaeaamnwvmshmddpdfanplilpgssgpgstsaaadpppedcvS-----Tivsmgfsrdqalkalratnnsler 766
           77777777777777777777777666666666666666666666666665555555550.....0555555555555555566666666 PP
   S: 275  ...........................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevke 319
                                                      + kY+L+a ++H+G s+ +GHYv+++k+ +g+W+ ++D+kV ++  
   Q: 767  avdwifshiddldaeaamdisegrsaadsisesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHYVCHIKK-EGRWVIYNDQKVCAS-- 852
           6677777777777777777777777777888888888888888****************************.9***********999.. PP
   S: 320  eevleetgstaYvlfYkr 337
           e+  +   + +Y++fY+r
   Q: 853  EKPPK---DLGYIYFYQR 867
           78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ed +  +v+MGF+r++al+aLra+nn+le+Av++++++
   Q: 737  EDCVSTIVSMGFSRDQALKALRATNNSLERAVDWIFSH 774
           8999********************************97 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MHLTSSAHWT ASLGGGGLGT VGALGAVCGG AAAGVMAELS EEALLSVLPT IRVPKAGDRV 60
HKDECAFSFD TPESEGGLYI CMNTFLGFGK QYVERHFNKT GQRVYLHLRR TRRLKEEDTT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCACCTAA CGAGTAGTGC TCATTGGACG GCAAGCCTAG GGGGTGGGGG ACTGGGAACG 60
GTGGGAGCCT TGGGAGCTGT GTGTGGAGGA GCTGCTGCCG GTGTCATGGC GGAGCTGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	45.21	0.00e+00	651.00
IUUC-Aml-002104	Ailuropoda melanoleuca	95.64	0.00e+00	1583.00
IUUC-Atr-002580	Amborella trichopoda	46.84	0.00e+00	740.00
IUUC-Apl-003774	Anas platyrhynchos	88.37	0.00e+00	1463.00
IUUC-Aca-005368	Anolis carolinensis	88.50	0.00e+00	1523.00
IUUC-Aly-005727	Arabidopsis lyrata	48.33	0.00e+00	739.00
IUUC-Ath-006974	Arabidopsis thaliana	48.56	0.00e+00	738.00
IUUC-Ago-007890	Ashbya gossypii	29.35	2.00e-82	300.00
IUUC-Acl-008057	Aspergillus clavatus	35.08	4.00e-127	449.00
IUUC-Afl-008547	Aspergillus flavus	37.36	2.00e-120	426.00
IUUC-Afu-008805	Aspergillus fumigatus	34.73	8.00e-117	414.00
IUUC-Ani-009441	Aspergillus nidulans	33.08	3.00e-102	365.00
IUUC-Ang-009720	Aspergillus niger	34.56	2.00e-121	429.00
IUUC-Aor-010111	Aspergillus oryzae	34.92	1.00e-130	460.00
IUUC-Ate-010531	Aspergillus terreus	32.31	2.00e-105	376.00
IUUC-Ame-011893	Astyanax mexicanus	67.62	0.00e+00	1013.00
IUUC-Bgr-012183	Blumeria graminis	34.73	3.00e-125	442.00
IUUC-Bta-013179	Bos taurus	95.04	0.00e+00	1581.00
IUUC-Bci-013858	Botrytis cinerea	35.83	5.00e-134	471.00
IUUC-Bdi-014904	Brachypodium distachyon	48.26	0.00e+00	716.00
IUUC-Bol-015296	Brassica oleracea	48.62	0.00e+00	751.00
IUUC-Bra-017939	Brassica rapa	48.86	0.00e+00	754.00
IUUC-Cel-018625	Caenorhabditis elegans	36.01	1.00e-139	490.00
IUUC-Cja-019063	Callithrix jacchus	93.65	0.00e+00	1550.00
IUUC-Cfa-020976	Canis familiaris	96.44	0.00e+00	1618.00
IUUC-Cpo-022265	Cavia porcellus	98.06	0.00e+00	1598.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	41.01	3.00e-115	409.00
IUUC-Csa-024177	Chlorocebus sabaeus	98.04	0.00e+00	1471.00
IUUC-Cho-024702	Choloepus hoffmanni	85.24	0.00e+00	934.00
IUUC-Cin-025411	Ciona intestinalis	51.15	0.00e+00	840.00
IUUC-Csv-026347	Ciona savignyi	47.09	0.00e+00	799.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	35.69	4.00e-117	415.00
IUUC-Cne-026831	Cryptococcus neoformans	36.30	8.00e-132	464.00
IUUC-Dre-027982	Danio rerio	65.24	0.00e+00	1079.00
IUUC-Dno-029034	Dasypus novemcinctus	95.28	0.00e+00	1598.00
IUUC-Dor-030479	Dipodomys ordii	91.98	0.00e+00	661.00
IUUC-Dse-031467	Dothistroma septosporum	37.43	4.00e-135	475.00
IUUC-Dme-032075	Drosophila melanogaster	50.47	0.00e+00	811.00
IUUC-Ete-032865	Echinops telfairi	84.50	0.00e+00	1404.00
IUUC-Eca-034059	Equus caballus	95.33	0.00e+00	1595.00
IUUC-Eeu-035304	Erinaceus europaeus	89.73	0.00e+00	1438.00
IUUC-Fca-035515	Felis catus	95.75	0.00e+00	1590.00
IUUC-Fal-037271	Ficedula albicollis	90.49	0.00e+00	1444.00
IUUC-Fox-037745	Fusarium oxysporum	36.16	6.00e-132	464.00
IUUC-Fso-038158	Fusarium solani	37.05	3.00e-132	465.00
IUUC-Gmo-039071	Gadus morhua	64.52	0.00e+00	1080.00
IUUC-Ggr-040098	Gaeumannomyces graminis	35.01	6.00e-123	435.00
IUUC-Gga-040635	Gallus gallus	88.23	0.00e+00	1533.00
IUUC-Gac-042528	Gasterosteus aculeatus	64.70	0.00e+00	1094.00
IUUC-Gma-043614	Glycine max	48.02	0.00e+00	712.00
IUUC-Ggo-044602	Gorilla gorilla	94.92	0.00e+00	1577.00
IUUC-Hsa-045959	Homo sapiens	94.92	0.00e+00	1577.00
IUUC-Hvu-047563	Hordeum vulgare	48.87	1.00e-171	596.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	94.81	0.00e+00	1580.00
IUUC-Kpa-049156	Komagataella pastoris	33.96	1.00e-116	414.00
IUUC-Lch-049648	Latimeria chalumnae	83.82	0.00e+00	1379.00
IUUC-Lpe-051523	Leersia perrieri	47.46	0.00e+00	718.00
IUUC-Lma-053216	Leptosphaeria maculans	35.04	1.00e-114	408.00
IUUC-Laf-054327	Loxodonta africana	94.69	0.00e+00	1574.00
IUUC-Mcc-055443	Macaca mulatta	95.28	0.00e+00	1584.00
IUUC-Meu-056298	Macropus eugenii	93.06	0.00e+00	1061.00
IUUC-Mor-057106	Magnaporthe oryzae	36.71	1.00e-133	470.00
IUUC-Mpo-057589	Magnaporthe poae	35.85	1.00e-127	450.00
IUUC-Mtr-058680	Medicago truncatula	49.28	0.00e+00	741.00
IUUC-Mla-058903	Melampsora laricipopulina	33.18	6.00e-122	431.00
IUUC-Mga-059669	Meleagris gallopavo	87.39	0.00e+00	1452.00
IUUC-Mvi-060476	Microbotryum violaceum	35.39	1.00e-122	434.00
IUUC-Mmr-060575	Microcebus murinus	95.40	0.00e+00	1587.00
IUUC-Mdo-062183	Monodelphis domestica	92.34	0.00e+00	1534.00
IUUC-Mmu-063592	Mus musculus	95.04	0.00e+00	1580.00
IUUC-Mac-065634	Musa acuminata	43.67	0.00e+00	690.00
IUUC-Mlu-067345	Myotis lucifugus	93.53	0.00e+00	1556.00
IUUC-Nfi-068558	Neosartorya fischeri	35.41	4.00e-125	442.00
IUUC-Ncr-068960	Neurospora crassa	35.58	9.00e-120	424.00
IUUC-Nle-070173	Nomascus leucogenys	97.82	0.00e+00	1593.00
IUUC-Opr-070556	Ochotona princeps	94.57	0.00e+00	1578.00
IUUC-Ont-071502	Oreochromis niloticus	66.67	0.00e+00	1098.00
IUUC-Ocu-074861	Oryctolagus cuniculus	94.71	0.00e+00	1602.00
IUUC-Oba-075109	Oryza barthii	47.65	0.00e+00	719.00
IUUC-Obr-076292	Oryza brachyantha	48.98	0.00e+00	718.00
IUUC-Ogl-077065	Oryza glaberrima	48.98	0.00e+00	749.00
IUUC-Ogu-078776	Oryza glumaepatula	47.65	0.00e+00	732.00
IUUC-Oin-080048	Oryza indica	48.50	0.00e+00	743.00
IUUC-Olo-080711	Oryza longistaminata	45.80	0.00e+00	662.00
IUUC-Ome-081506	Oryza meridionalis	46.91	0.00e+00	674.00
IUUC-Oni-082320	Oryza nivara	47.06	0.00e+00	718.00
IUUC-Opu-083801	Oryza punctata	47.84	0.00e+00	712.00
IUUC-Oru-085139	Oryza rufipogon	47.06	0.00e+00	719.00
IUUC-Osa-085713	Oryza sativa	49.10	0.00e+00	753.00
IUUC-Ola-086951	Oryzias latipes	64.14	0.00e+00	1055.00
IUUC-Olu-087822	Ostreococcus lucimarinus	42.17	0.00e+00	628.00
IUUC-Oga-088625	Otolemur garnettii	94.58	0.00e+00	1574.00
IUUC-Oar-089995	Ovis aries	93.41	0.00e+00	1546.00
IUUC-Ptr-090640	Pan troglodytes	92.33	0.00e+00	1555.00
IUUC-Pan-091974	Papio anubis	94.35	0.00e+00	1568.00
IUUC-Psi-093957	Pelodiscus sinensis	86.98	0.00e+00	1536.00
IUUC-Pma-094242	Petromyzon marinus	71.65	3.00e-165	574.00
IUUC-Pno-094835	Phaeosphaeria nodorum	35.41	7.00e-108	384.00
IUUC-Ppa-095901	Physcomitrella patens	50.18	0.00e+00	789.00
IUUC-Pfo-097148	Poecilia formosa	68.07	0.00e+00	1109.00
IUUC-Pab-098068	Pongo abelii	87.25	0.00e+00	1397.00
IUUC-Pop-098943	Populus trichocarpa	48.02	0.00e+00	728.00
IUUC-Pca-100738	Procavia capensis	93.68	0.00e+00	1070.00
IUUC-Ppe-101315	Prunus persica	48.39	0.00e+00	732.00
IUUC-Pva-102154	Pteropus vampyrus	93.86	0.00e+00	1556.00
IUUC-Pgr-103343	Puccinia graminis	34.91	3.00e-111	395.00
IUUC-Ptt-103928	Puccinia triticina	31.26	2.00e-109	390.00
IUUC-Pte-104306	Pyrenophora teres	32.33	2.00e-104	373.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.57	6.00e-108	385.00
IUUC-Rno-105801	Rattus norvegicus	94.81	0.00e+00	1577.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.62	3.00e-74	273.00
IUUC-Sha-107635	Sarcophilus harrisii	94.54	0.00e+00	1558.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	33.13	9.00e-112	397.00
IUUC-Spo-108144	Schizosaccharomyces pombe	33.14	6.00e-116	411.00
IUUC-Smo-108848	Selaginella moellendorffii	49.64	0.00e+00	744.00
IUUC-Sit-110728	Setaria italica	49.34	0.00e+00	773.00
IUUC-Sly-111523	Solanum lycopersicum	48.69	0.00e+00	768.00
IUUC-Sbi-114419	Sorghum bicolor	48.68	0.00e+00	755.00
IUUC-Sre-115225	Sporisorium reilianum	35.29	1.00e-129	457.00
IUUC-Ssc-115686	Sus scrofa	94.46	0.00e+00	1575.00
IUUC-Tgu-117346	Taeniopygia guttata	87.89	0.00e+00	1504.00
IUUC-Tru-118350	Takifugu rubripes	62.95	0.00e+00	1089.00
IUUC-Tni-120658	Tetraodon nigroviridis	63.93	0.00e+00	1072.00
IUUC-Tca-121585	Theobroma cacao	48.39	0.00e+00	733.00
IUUC-Tre-122043	Trichoderma reesei	35.31	3.00e-122	432.00
IUUC-Tvi-122303	Trichoderma virens	35.56	3.00e-128	452.00
IUUC-Tae-125686	Triticum aestivum	48.13	0.00e+00	734.00
IUUC-Tur-126732	Triticum urartu	45.60	0.00e+00	689.00
IUUC-Tme-126909	Tuber melanosporum	34.98	1.00e-118	421.00
IUUC-Tbe-127261	Tupaia belangeri	86.69	0.00e+00	969.00
IUUC-Uma-129599	Ustilago maydis	34.59	2.00e-131	462.00
IUUC-Vda-129688	Verticillium dahliae	34.77	2.00e-124	439.00
IUUC-Vvi-131116	Vitis vinifera	48.34	0.00e+00	712.00
IUUC-Xtr-131953	Xenopus tropicalis	77.05	0.00e+00	1302.00
IUUC-Xma-133837	Xiphophorus maculatus	68.31	0.00e+00	1112.00
IUUC-Yli-134510	Yarrowia lipolytica	36.07	7.00e-132	464.00
IUUC-Zma-135786	Zea mays	48.44	0.00e+00	721.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence