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Tag Content
UUCD2 ID IUUC-Pab-098514
UUCD1 version UUC-PoA-01059
Ensembl Protein ID ENSPPYP00000005527.2
UniProt Accession H2NIA9; H2NIA9_PONAB
Genbank Protein ID ENSPPYP00000005527
Protein Name Ubiquitinyl hydrolase 1
Genbank Nucleotide ID ABGA01028525
Gene Name USP44
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPPYG00000004845.2 ENSPPYT00000005741.2 ENSPPYP00000005527.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.10e-97 326.4 273 678
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.........kkkeklneenp...................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+                   +                                      
   Q: 273  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnqwlamTA--------Sektrssckhplvtdtvvyhmnecqekdtgfvrsrqssl 353
           7******************************87776655522........122344455778889999999999988999999999999 PP
   S: 43   ......................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk 109
                                 +++  +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el  
   Q: 354  ssglsggasksrkmeliqpkepTSQYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQREL-- 440
           999999999888888888777666677************************************************************.. PP
   S: 110  eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcL 191
                  e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +        ++++L
   Q: 441  -------ETTGTSLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCSGKdiasqpcLVTEML 522
           .......7889999999999************************************************9998877788888889***** PP
   S: 192  esftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspe 269
           ++ft++e leg+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++
   Q: 523  AKFTETEALEGKI-YVCDQCNSKRRrfsskpvvlteAQKQLMICHLPQVLRLHLKRFRWSGH-NNREKIGVHVGFEEILNMEPYCCRET 609
           **********965.*******999999999999999***********************998.7778********************99 PP
   S: 270  ekqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
            k+ +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev++   ++aY+lfY++
   Q: 610  LKSLRpeCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSMCTMDEVCK---AQAYILFYTQ 678
           88876779***************************9999********************...********98 PP
   
Organism Pongo abelii
Protein Sequence
(Fasta)
MLAMDKCKHV GQLRLAQDHS SLNPQKWHCV DCNTTESIWA CLSCSHVACG RYIEEHALKH 60
FQESSHPVAL EVNEMYVFCY LCDDYVLNDN ATGDLKLLRS TLSAIKSQNY HCTTRSGRFL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Pab-098514|DUB,USP|Pongo abelii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGGGGGGGC CGGGGTGAGC GCTAAGATGG CCGCCCCGGC TCGGGCTGGT GAGTGTGCTG 60
GAGGGCGCGC GGCCGCGGCG ATGGGCGGAG TGAGGACCCC TGCGGGAGCG GACGTGCGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Pab-098514|DUB,USP|Pongo abelii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG pon:100443916
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001220 Ailuropoda melanoleuca 91.44 0.00e+00 1311.00
IUUC-Apl-003673 Anas platyrhynchos 76.47 0.00e+00 1050.00
IUUC-Aca-004434 Anolis carolinensis 74.34 0.00e+00 1016.00
IUUC-Ame-010986 Astyanax mexicanus 65.06 0.00e+00 880.00
IUUC-Bta-012774 Bos taurus 88.64 0.00e+00 1264.00
IUUC-Cja-019619 Callithrix jacchus 92.85 0.00e+00 1311.00
IUUC-Cfa-020957 Canis familiaris 90.18 0.00e+00 1310.00
IUUC-Csa-023177 Chlorocebus sabaeus 95.23 0.00e+00 1342.00
IUUC-Cho-024877 Choloepus hoffmanni 88.47 0.00e+00 837.00
IUUC-Cin-025587 Ciona intestinalis 47.02 9.00e-103 368.00
IUUC-Csv-025814 Ciona savignyi 44.43 3.00e-151 528.00
IUUC-Dre-027878 Danio rerio 65.03 0.00e+00 852.00
IUUC-Dno-029832 Dasypus novemcinctus 91.16 0.00e+00 1316.00
IUUC-Ete-032627 Echinops telfairi 86.27 0.00e+00 1238.00
IUUC-Eca-033863 Equus caballus 86.48 0.00e+00 1208.00
IUUC-Eeu-035225 Erinaceus europaeus 86.40 0.00e+00 1197.00
IUUC-Fca-036288 Felis catus 91.58 0.00e+00 1312.00
IUUC-Fal-037207 Ficedula albicollis 75.53 0.00e+00 1013.00
IUUC-Gmo-039249 Gadus morhua 70.25 4.00e-132 465.00
IUUC-Gga-040457 Gallus gallus 74.89 0.00e+00 1016.00
IUUC-Gac-042595 Gasterosteus aculeatus 53.86 0.00e+00 698.00
IUUC-Ggo-044926 Gorilla gorilla 97.62 0.00e+00 1369.00
IUUC-Hsa-046079 Homo sapiens 97.34 0.00e+00 1368.00
IUUC-Itr-048737 Ictidomys tridecemlineatus 90.46 0.00e+00 1281.00
IUUC-Lch-050260 Latimeria chalumnae 67.32 0.00e+00 919.00
IUUC-Laf-054491 Loxodonta africana 88.70 0.00e+00 1215.00
IUUC-Mcc-055694 Macaca mulatta 95.65 0.00e+00 1345.00
IUUC-Mga-059523 Meleagris gallopavo 74.57 0.00e+00 1027.00
IUUC-Mmr-060885 Microcebus murinus 93.55 0.00e+00 1339.00
IUUC-Mdo-063018 Monodelphis domestica 79.92 0.00e+00 1120.00
IUUC-Mmu-064012 Mus musculus 79.66 0.00e+00 1092.00
IUUC-Mpu-066207 Mustela putorius furo 89.76 0.00e+00 1314.00
IUUC-Mlu-066929 Myotis lucifugus 86.94 0.00e+00 1181.00
IUUC-Nle-069313 Nomascus leucogenys 87.79 0.00e+00 1194.00
IUUC-Opr-070375 Ochotona princeps 81.65 0.00e+00 1110.00
IUUC-Ont-071637 Oreochromis niloticus 64.23 0.00e+00 868.00
IUUC-Oan-073030 Ornithorhynchus anatinus 78.87 0.00e+00 857.00
IUUC-Ocu-074836 Oryctolagus cuniculus 88.03 0.00e+00 1251.00
IUUC-Oga-088367 Otolemur garnettii 92.57 0.00e+00 1304.00
IUUC-Oar-089953 Ovis aries 89.92 0.00e+00 1300.00
IUUC-Ptr-090980 Pan troglodytes 97.62 0.00e+00 1371.00
IUUC-Pan-092748 Papio anubis 95.93 0.00e+00 1345.00
IUUC-Pfo-096860 Poecilia formosa 65.50 7.00e-169 587.00
IUUC-Pva-102984 Pteropus vampyrus 89.05 0.00e+00 1236.00
IUUC-Rno-106019 Rattus norvegicus 79.75 0.00e+00 1123.00
IUUC-Sha-106965 Sarcophilus harrisii 78.59 0.00e+00 1109.00
IUUC-Ssc-115299 Sus scrofa 91.02 0.00e+00 1321.00
IUUC-Tgu-117160 Taeniopygia guttata 74.74 0.00e+00 1018.00
IUUC-Tru-118156 Takifugu rubripes 61.58 0.00e+00 838.00
IUUC-Tni-119733 Tetraodon nigroviridis 62.12 0.00e+00 853.00
IUUC-Tbe-128084 Tupaia belangeri 85.67 0.00e+00 1209.00
IUUC-Ttr-128928 Tursiops truncatus 92.29 0.00e+00 1334.00
IUUC-Vpa-130706 Vicugna pacos 91.16 0.00e+00 1308.00
IUUC-Xtr-132061 Xenopus tropicalis 71.69 0.00e+00 923.00
Created Date 25-Jun-2017

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