iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059500

UUCD1 version

UUC-MeG-00271

Ensembl Protein ID

ENSMGAP00000005508.2

UniProt Accession

G1N1S9; G1N1S9_MELGA

Protein Name

Uncharacterized protein

Gene Name

HECTD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000005581.2	ENSMGAT00000006243.2	ENSMGAP00000005508.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.90e-82	275.0	3619	3979

Active Site

Position(s)	Description	Evidence
3953	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++lF+f+G+llg+a++
   Q: 3619 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----AEEQLFHFFGQLLGIAIR 3701
           5667788*********************************9999999888888***********9....689*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelyks.lkeikenaesdieelgldltfs..vseei...............lget 151
            + +l+l+l +sf+k+l+g++l+   dl+e d  +y++ +k+ + n+e+++e+l+++++++  +  ++                 + 
   Q: 3702 ADVPLPLDLLPSFWKTLVGEPLDPdIDLQEADILTYNYiKKFENINDETELEALCAEIASQhlA--TEspdcpnkpcckftylTMTG 3786
           ************************88************55555566688999999999998532..334699********9655555 PP
   S: 152  keeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykg 237
           +e+eL+p+G+++pV +eNk+ Y  ++ ++r++e +  e+++a+r+G+ ++ipl+ll+ +t+ e+el +cG ++i++e lk++t+y+ 
   Q: 3787 EEVELCPRGRHVPVGWENKDVYAAAIRNLRMRElQTPECMTAVRAGLGSIIPLQLLTTLTPLEMELRTCGLPYINLEFLKAHTMYQV 3873
           6667*****************************99**************************************************** PP
   S: 238  gytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLP 311
           g++e++++i++Fw++le+f++ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP
   Q: 3874 GLMETDQHIEFFWSALEMFTQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgaaGSPDSRYIRVETCMFMIKLP 3960
           *********************************************9999999998888888888*955555**************** PP
   S: 312  eYsskeilkekLlyAieet 330
           +Yss +i+ ekL+yAi+++
   Q: 3961 QYSSLDIMLEKLRYAIHYR 3979
           ****************986 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MPVNHFPVGS TMTTVHLSSD GTYFYWIWSP ASLNEKTPKG HSVFMDVFEL IVENGVCIAN 60
PLQERIILMR KEGESAKSIN EMLLSRLSRY RASPSATLAA LTGSTISNTL KEDQAAANTS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCAGTAA ATCACTTCCC AGTTGGCAGT ACTATGACCA CCGTGCATCT TTCTTCAGAT 60
GGTACATATT TCTACTGGAT TTGGTCTCCT GCAAGCCTCA ATGAGAAAAC ACCAAAAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	92.38	0.00e+00	6867.00
IUUC-Apl-004161	Anas platyrhynchos	98.31	0.00e+00	5450.00
IUUC-Aca-005341	Anolis carolinensis	90.99	0.00e+00	6730.00
IUUC-Ame-011574	Astyanax mexicanus	80.61	0.00e+00	4469.00
IUUC-Bta-012514	Bos taurus	89.59	0.00e+00	1775.00
IUUC-Cja-019148	Callithrix jacchus	91.41	0.00e+00	5007.00
IUUC-Cfa-020499	Canis familiaris	91.29	0.00e+00	6854.00
IUUC-Cpo-021894	Cavia porcellus	94.02	0.00e+00	2692.00
IUUC-Csa-023079	Chlorocebus sabaeus	91.42	0.00e+00	6831.00
IUUC-Cho-024415	Choloepus hoffmanni	89.40	0.00e+00	4861.00
IUUC-Dre-027452	Danio rerio	78.67	0.00e+00	4481.00
IUUC-Dno-029595	Dasypus novemcinctus	91.13	0.00e+00	6852.00
IUUC-Dor-030849	Dipodomys ordii	94.21	0.00e+00	1757.00
IUUC-Ete-032563	Echinops telfairi	83.99	0.00e+00	1524.00
IUUC-Eca-034202	Equus caballus	92.69	0.00e+00	6843.00
IUUC-Eeu-035175	Erinaceus europaeus	92.77	0.00e+00	1018.00
IUUC-Fca-036295	Felis catus	91.19	0.00e+00	6659.00
IUUC-Fal-037003	Ficedula albicollis	95.97	0.00e+00	6435.00
IUUC-Gmo-038579	Gadus morhua	84.87	0.00e+00	2860.00
IUUC-Gga-040961	Gallus gallus	97.60	0.00e+00	7376.00
IUUC-Gac-041899	Gasterosteus aculeatus	85.13	0.00e+00	2914.00
IUUC-Ggo-045099	Gorilla gorilla	92.30	0.00e+00	6027.00
IUUC-Hsa-046331	Homo sapiens	91.46	0.00e+00	6893.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	89.25	0.00e+00	1973.00
IUUC-Lch-049923	Latimeria chalumnae	85.17	0.00e+00	2633.00
IUUC-Loc-052630	Lepisosteus oculatus	84.98	0.00e+00	4081.00
IUUC-Laf-053394	Loxodonta africana	91.02	0.00e+00	6905.00
IUUC-Mcc-055763	Macaca mulatta	91.39	0.00e+00	6819.00
IUUC-Meu-056039	Macropus eugenii	88.42	0.00e+00	5018.00
IUUC-Mmr-060868	Microcebus murinus	87.77	0.00e+00	6573.00
IUUC-Mdo-062772	Monodelphis domestica	91.84	0.00e+00	6950.00
IUUC-Mmu-063606	Mus musculus	90.15	0.00e+00	6831.00
IUUC-Mpu-065860	Mustela putorius furo	90.47	0.00e+00	6727.00
IUUC-Mlu-067376	Myotis lucifugus	93.04	0.00e+00	5145.00
IUUC-Nle-069693	Nomascus leucogenys	90.97	0.00e+00	6770.00
IUUC-Opr-071065	Ochotona princeps	88.24	0.00e+00	1123.00
IUUC-Ont-072470	Oreochromis niloticus	83.20	0.00e+00	4628.00
IUUC-Oan-073693	Ornithorhynchus anatinus	92.10	0.00e+00	5182.00
IUUC-Ocu-074032	Oryctolagus cuniculus	90.41	0.00e+00	6831.00
IUUC-Ola-087433	Oryzias latipes	82.85	0.00e+00	1575.00
IUUC-Oga-088546	Otolemur garnettii	92.15	0.00e+00	6556.00
IUUC-Oar-089643	Ovis aries	87.22	0.00e+00	712.00
IUUC-Ptr-090504	Pan troglodytes	92.51	0.00e+00	6911.00
IUUC-Pan-092543	Papio anubis	91.30	0.00e+00	6813.00
IUUC-Psi-093952	Pelodiscus sinensis	92.81	0.00e+00	7011.00
IUUC-Pfo-096356	Poecilia formosa	81.59	0.00e+00	4571.00
IUUC-Pab-098240	Pongo abelii	91.44	0.00e+00	6823.00
IUUC-Pca-100994	Procavia capensis	93.20	0.00e+00	2902.00
IUUC-Pva-102263	Pteropus vampyrus	91.59	0.00e+00	6788.00
IUUC-Rno-104888	Rattus norvegicus	89.96	0.00e+00	6780.00
IUUC-Sha-106944	Sarcophilus harrisii	92.42	0.00e+00	7003.00
IUUC-Sar-113556	Sorex araneus	83.00	0.00e+00	911.00
IUUC-Ssc-116187	Sus scrofa	92.54	0.00e+00	4898.00
IUUC-Tgu-116655	Taeniopygia guttata	97.48	0.00e+00	5363.00
IUUC-Tru-118093	Takifugu rubripes	83.65	0.00e+00	3015.00
IUUC-Tni-119739	Tetraodon nigroviridis	83.07	0.00e+00	1610.00
IUUC-Tbe-127962	Tupaia belangeri	83.89	0.00e+00	1080.00
IUUC-Ttr-128819	Tursiops truncatus	86.99	0.00e+00	2655.00
IUUC-Vpa-130482	Vicugna pacos	91.88	0.00e+00	4311.00
IUUC-Xtr-132222	Xenopus tropicalis	88.36	0.00e+00	6650.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence