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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045692
Ensembl Protein ID ENSP00000298125.4
UniProt Accession Q96P53; B1AL86; Q96CS1; WDFY2_HUMAN
Genbank Protein ID AAL04162.1; CAH70585.1; CAH70585.1; CAH73431.1; CAH73431.1; EAX08883.1; AAH14004.1
Protein Name WD repeat and FYVE domain-containing protein 2; Propeller-FYVE protein; WD40- and FYVE domain-containing protein 2; Zinc finger FYVE domain-containing protein 22
Genbank Nucleotide ID AF411978; AL136525; AL139183; AL139183; AL136525; CH471075; BC014004
Gene Name WDFY2; WDF2; ZFYVE22
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000139668.8 ENST00000612477.1 ENSP00000482942.1
ENSG00000139668.8 ENST00000298125.6 ENSP00000298125.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.00e-17 63.3 197 227
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gHt++vt+l++ +  + l sGs D+++ +WD
   Q: 197  GHTGGVTALCWdPVqRVLFSGSSDHSVIMWD 227
           8**********855689************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).
 Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).
Protein Sequence
(Fasta)
MAAEIQPKPL TRKPILLQRM EGSQEVVNMA VIVPKEEGVI SVSEDRTVRV WLKRDSGQYW 60
PSVYHAMPSP CSCMSFNPET RRLSIGLDNG TISEFILSED YNKMTPVKNY QAHQSRVTMI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045692|E3,WD_repeat|Homo sapiens
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Nucleotide Sequence
(Fasta)
TCCTCTTGTA GTGGCGCCGG CTTGCATCCC AGGTCGTGGC GGTTTTGGTG CCTGAAGCAG 60
GGAGCGCGGA GTCGTTCCCG AGAGAGGCGG CCAGGCTATG CTCGCCGGTT TCCGGCGTTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045692|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS50178--ZF_FYVE
Pfam

PF01363--FYVE
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00064--FYVE
SM00320--WD40
Gene Ontology

GO:0005769--C:early endosome
GO:0031982--C:vesicle
GO:0046872--F:metal ion binding
GO:0045600--P:positive regulation of fat cell differentiation
GO:0001934--P:positive regulation of protein phosphorylation
KEGG hsa:115825
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002074 Ailuropoda melanoleuca 98.00 0.00e+00 823.00
IUUC-Apl-003892 Anas platyrhynchos 86.72 0.00e+00 652.00
IUUC-Aca-004902 Anolis carolinensis 87.03 0.00e+00 748.00
IUUC-Ame-010837 Astyanax mexicanus 83.50 0.00e+00 728.00
IUUC-Cel-018382 Caenorhabditis elegans 41.58 2.00e-99 356.00
IUUC-Cja-019949 Callithrix jacchus 98.25 0.00e+00 825.00
IUUC-Cfa-020057 Canis familiaris 96.62 0.00e+00 724.00
IUUC-Cpo-022446 Cavia porcellus 98.50 0.00e+00 829.00
IUUC-Csa-023138 Chlorocebus sabaeus 99.25 0.00e+00 831.00
IUUC-Cho-024545 Choloepus hoffmanni 83.38 0.00e+00 671.00
IUUC-Cin-025573 Ciona intestinalis 53.37 3.00e-137 481.00
IUUC-Csv-026091 Ciona savignyi 53.25 4.00e-138 484.00
IUUC-Dre-027501 Danio rerio 84.25 0.00e+00 736.00
IUUC-Dno-029611 Dasypus novemcinctus 96.00 0.00e+00 809.00
IUUC-Dor-030240 Dipodomys ordii 84.40 0.00e+00 664.00
IUUC-Dme-031869 Drosophila melanogaster 50.00 3.00e-132 464.00
IUUC-Ete-032680 Echinops telfairi 72.25 7.00e-162 563.00
IUUC-Eca-033811 Equus caballus 98.75 0.00e+00 828.00
IUUC-Eeu-034637 Erinaceus europaeus 85.50 0.00e+00 705.00
IUUC-Fca-036536 Felis catus 99.10 0.00e+00 696.00
IUUC-Fal-037221 Ficedula albicollis 94.08 0.00e+00 714.00
IUUC-Gmo-039257 Gadus morhua 80.75 0.00e+00 705.00
IUUC-Gga-040902 Gallus gallus 93.00 0.00e+00 789.00
IUUC-Gac-042268 Gasterosteus aculeatus 78.75 0.00e+00 688.00
IUUC-Ggo-044590 Gorilla gorilla 99.25 0.00e+00 832.00
IUUC-Itr-049053 Ictidomys tridecemlineatus 98.75 0.00e+00 830.00
IUUC-Loc-052370 Lepisosteus oculatus 84.46 0.00e+00 744.00
IUUC-Laf-054594 Loxodonta africana 98.00 0.00e+00 822.00
IUUC-Mcc-055882 Macaca mulatta 99.06 0.00e+00 664.00
IUUC-Meu-056323 Macropus eugenii 92.33 0.00e+00 768.00
IUUC-Mga-060043 Meleagris gallopavo 93.52 0.00e+00 706.00
IUUC-Mmr-060574 Microcebus murinus 99.37 0.00e+00 664.00
IUUC-Mdo-062455 Monodelphis domestica 92.75 0.00e+00 789.00
IUUC-Mmu-064270 Mus musculus 98.25 0.00e+00 828.00
IUUC-Mpu-066482 Mustela putorius furo 98.17 0.00e+00 672.00
IUUC-Mlu-067061 Myotis lucifugus 93.20 4.00e-165 573.00
IUUC-Nle-069796 Nomascus leucogenys 99.25 0.00e+00 833.00
IUUC-Opr-071092 Ochotona princeps 98.00 0.00e+00 822.00
IUUC-Ont-072372 Oreochromis niloticus 82.00 0.00e+00 715.00
IUUC-Oan-073463 Ornithorhynchus anatinus 91.32 0.00e+00 654.00
IUUC-Ocu-074804 Oryctolagus cuniculus 99.25 0.00e+00 832.00
IUUC-Oga-088615 Otolemur garnettii 90.33 5.00e-177 613.00
IUUC-Oar-089827 Ovis aries 97.48 0.00e+00 811.00
IUUC-Ptr-091426 Pan troglodytes 99.50 0.00e+00 834.00
IUUC-Pan-092239 Papio anubis 99.33 1.00e-178 619.00
IUUC-Psi-093305 Pelodiscus sinensis 92.91 0.00e+00 753.00
IUUC-Pfo-096834 Poecilia formosa 81.25 0.00e+00 710.00
IUUC-Pab-098398 Pongo abelii 99.50 0.00e+00 834.00
IUUC-Pca-100650 Procavia capensis 72.25 9.00e-164 569.00
IUUC-Pva-102773 Pteropus vampyrus 98.50 0.00e+00 827.00
IUUC-Rno-104983 Rattus norvegicus 97.75 0.00e+00 826.00
IUUC-Sha-107407 Sarcophilus harrisii 93.75 0.00e+00 795.00
IUUC-Sar-113400 Sorex araneus 75.47 4.00e-114 404.00
IUUC-Tgu-116478 Taeniopygia guttata 92.75 0.00e+00 789.00
IUUC-Tru-118438 Takifugu rubripes 81.50 0.00e+00 712.00
IUUC-Tsy-119319 Tarsius syrichta 97.75 0.00e+00 816.00
IUUC-Tni-120051 Tetraodon nigroviridis 80.00 0.00e+00 699.00
IUUC-Ttr-129137 Tursiops truncatus 93.25 0.00e+00 769.00
IUUC-Vpa-130398 Vicugna pacos 86.38 2.00e-176 611.00
IUUC-Xtr-132445 Xenopus tropicalis 85.50 0.00e+00 751.00
Created Date 25-Jun-2017

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