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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063816
UUCD1 version UUC-MuM-00682
Ensembl Protein ID ENSMUSP00000047208.7
UniProt Accession Q8BZJ7; Q3U1U0; Q7TMX3; DCNL2_MOUSE
Genbank Protein ID BAC28695.1; BAE33403.1; ENSMUSP00000047208
Protein Name DCN1-like protein 2; DCUN1 domain-containing protein 2; Defective in cullin neddylation protein 1-like protein 2
Genbank Nucleotide ID AK034394; AK155726; AC130818
Gene Name Dcun1d2; Dcun1l2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000038506.13 ENSMUST00000110840.7 ENSMUSP00000106464.1
ENSMUSG00000038506.13 ENSMUST00000203467.2 ENSMUSP00000145399.1
ENSMUSG00000038506.13 ENSMUST00000045366.9 ENSMUSP00000047208.7
ENSMUSG00000038506.13 ENSMUST00000110838.7 ENSMUSP00000106462.1
ENSMUSG00000038506.13 ENSMUST00000203604.1 ENSMUSP00000145430.1
ENSMUSG00000038506.13 ENSMUST00000110839.9 ENSMUSP00000106463.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 26860454
Classification
Family E-value Score Start End
E3 activity/DCUN1 9.30e-90 300.9 60 247
UBD/Alpha-Helix/UBA 1.80e-05 25.8 7 45
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/DCUN1
   S: 1    vskkkleelferYkdpqed.ligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktlesel 88
           v++kkle+l++rYkdpq++ +igi+g+++fc+dl++dp++i+vLv+awk++aat+cefs++ef+dg+t+lgcds+e l++ l++le+el
   Q: 60   VDQKKLEQLYSRYKDPQDEnKIGIDGIQQFCDDLSLDPASISVLVIAWKFRAATQCEFSKKEFVDGMTELGCDSTERLKALLPRLEQEL 148
           589**************999********************************************************************* PP
   S: 89   kdeqkfkdiYrfafnfakdkgqksldldtaialwkLllaerefklldawlkfLeeekkksiskDtWnllLefskviakdlsnYdeegaW 177
           kd +kfkd+Y+f+f+fak++gqk+ldl++a+a+wkL+l++r fk+ld+w++fL e++k+si++DtWnllL+f ++ia+dlsnYdeegaW
   Q: 149  KDPAKFKDLYQFTFTFAKNPGQKGLDLEMAVAYWKLVLSGR-FKFLDLWNTFLLEHHKRSIPRDTWNLLLDFGNMIADDLSNYDEEGAW 236
           ****************************************9.*********************************************** PP
   S: 178  PvliDefveyl 188
           PvliD+fvey+
   Q: 237  PVLIDDFVEYA 247
           *********97 PP
   

   UBD/Alpha-Helix/UBA
   S: 2    ededkleqlve.MGFdreealqaLraannnleaAveyLl 39
           +++dk++q+++ +  ++ +a+ +L ++ + l++A++ ++
   Q: 7    AQKDKVRQFMAcTQASERTAIYCLTQNEWKLDEATDSFF 45
           79**********************************998 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).
 Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).
Protein Sequence
(Fasta)
MHKLKSAQKD KVRQFMACTQ ASERTAIYCL TQNEWKLDEA TDSFFQNPEA FHRESMKSSV 60
DQKKLEQLYS RYKDPQDENK IGIDGIQQFC DDLSLDPASI SVLVIAWKFR AATQCEFSKK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063816|UBD,UBA;E3,DCUN1|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACGCCGGGAA CTGGAGTCCC GGGAGCCGGC CGGCCAGCCA GCTTCCAGAG AGTGCGTAAG 60
CCTAAGAGCC TCAGAACAGC AACAGCCTCC GAGAGAGGTT ACGATGTGAC CCAAACGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063816|UBD,UBA;E3,DCUN1|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR014764--DCN-prot
IPR011992--EF-hand-dom_pair
IPR005176--PONY_dom
IPR009060--UBA-like
PROSITE

PS51229--DCUN1
Pfam

PF03556--Cullin_binding
Gene Ontology

GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation
KEGG mmu:102323
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000561 Aegilops tauschii 45.75 7.00e-63 233.00
IUUC-Atr-002662 Amborella trichopoda 41.94 1.00e-24 106.00
IUUC-Apl-003933 Anas platyrhynchos 89.02 5.00e-139 486.00
IUUC-Aca-005059 Anolis carolinensis 87.71 1.00e-126 445.00
IUUC-Aly-006285 Arabidopsis lyrata 37.65 3.00e-45 174.00
IUUC-Ath-007531 Arabidopsis thaliana 43.32 3.00e-58 218.00
IUUC-Acl-008172 Aspergillus clavatus 25.46 2.00e-23 102.00
IUUC-Afl-008569 Aspergillus flavus 28.14 2.00e-29 122.00
IUUC-Ame-011739 Astyanax mexicanus 83.82 1.00e-125 442.00
IUUC-Bta-012373 Bos taurus 81.10 6.00e-123 433.00
IUUC-Bdi-014138 Brachypodium distachyon 45.34 2.00e-62 231.00
IUUC-Bol-016110 Brassica oleracea 44.13 9.00e-59 219.00
IUUC-Bra-017111 Brassica rapa 44.53 8.00e-59 219.00
IUUC-Cja-018854 Callithrix jacchus 92.64 2.00e-146 511.00
IUUC-Cpo-021832 Cavia porcellus 91.54 5.00e-143 499.00
IUUC-Cre-022620 Chlamydomonas reinhardtii 39.22 9.00e-51 193.00
IUUC-Csa-023108 Chlorocebus sabaeus 92.64 2.00e-145 507.00
IUUC-Cgl-026386 Colletotrichum gloeosporioides 32.96 4.00e-25 107.00
IUUC-Cne-026950 Cryptococcus neoformans 32.58 1.00e-31 130.00
IUUC-Dno-029524 Dasypus novemcinctus 90.57 9.00e-134 469.00
IUUC-Dor-030143 Dipodomys ordii 91.86 4.00e-144 503.00
IUUC-Dse-031365 Dothistroma septosporum 27.34 1.00e-27 117.00
IUUC-Fal-036715 Ficedula albicollis 89.41 9.00e-140 489.00
IUUC-Fox-037884 Fusarium oxysporum 34.72 2.00e-19 88.60
IUUC-Fso-038150 Fusarium solani 28.67 6.00e-24 104.00
IUUC-Gmo-038750 Gadus morhua 84.31 2.00e-132 464.00
IUUC-Gga-040224 Gallus gallus 89.33 5.00e-138 483.00
IUUC-Gma-043545 Glycine max 43.32 1.00e-59 223.00
IUUC-Ggo-044972 Gorilla gorilla 91.89 7.00e-145 505.00
IUUC-Hsa-046994 Homo sapiens 91.12 1.00e-144 504.00
IUUC-Hvu-047636 Hordeum vulgare 40.95 2.00e-22 98.60
IUUC-Itr-047902 Ictidomys tridecemlineatus 87.89 1.00e-137 481.00
IUUC-Kpa-049127 Komagataella pastoris 30.71 9.00e-24 103.00
IUUC-Lch-049751 Latimeria chalumnae 86.33 1.00e-136 478.00
IUUC-Lpe-051540 Leersia perrieri 45.93 3.00e-62 231.00
IUUC-Loc-051976 Lepisosteus oculatus 85.16 1.00e-135 475.00
IUUC-Laf-053972 Loxodonta africana 90.31 4.00e-141 493.00
IUUC-Mcc-054700 Macaca mulatta 92.66 5.00e-146 509.00
IUUC-Meu-056791 Macropus eugenii 73.26 1.00e-108 385.00
IUUC-Mpo-057299 Magnaporthe poae 25.00 3.00e-18 85.90
IUUC-Mtr-057964 Medicago truncatula 42.51 8.00e-59 220.00
IUUC-Mga-060072 Meleagris gallopavo 89.02 9.00e-139 485.00
IUUC-Mac-065016 Musa acuminata 46.75 9.00e-44 169.00
IUUC-Nle-069475 Nomascus leucogenys 91.89 8.00e-145 505.00
IUUC-Ont-071813 Oreochromis niloticus 86.27 1.00e-134 472.00
IUUC-Ocu-074349 Oryctolagus cuniculus 92.53 2.00e-134 471.00
IUUC-Oba-074993 Oryza barthii 46.15 4.00e-63 234.00
IUUC-Obr-076341 Oryza brachyantha 46.15 1.00e-63 236.00
IUUC-Ogl-077099 Oryza glaberrima 46.15 4.00e-63 234.00
IUUC-Ogu-078285 Oryza glumaepatula 45.75 7.00e-62 230.00
IUUC-Oin-079441 Oryza indica 46.15 5.00e-63 234.00
IUUC-Olo-081037 Oryza longistaminata 46.15 5.00e-63 234.00
IUUC-Ome-081357 Oryza meridionalis 46.15 5.00e-63 234.00
IUUC-Oni-082632 Oryza nivara 46.15 4.00e-63 234.00
IUUC-Opu-083351 Oryza punctata 45.26 2.00e-57 215.00
IUUC-Oru-084306 Oryza rufipogon 46.15 5.00e-63 234.00
IUUC-Osa-085307 Oryza sativa 46.15 5.00e-63 234.00
IUUC-Ola-086371 Oryzias latipes 85.49 4.00e-134 470.00
IUUC-Oga-088621 Otolemur garnettii 93.80 4.00e-147 513.00
IUUC-Ptr-091595 Pan troglodytes 91.47 1.00e-143 501.00
IUUC-Pan-092825 Papio anubis 92.28 1.00e-145 508.00
IUUC-Psi-093029 Pelodiscus sinensis 88.38 6.00e-130 456.00
IUUC-Pno-095145 Phaeosphaeria nodorum 31.88 7.00e-25 107.00
IUUC-Pfo-096813 Poecilia formosa 84.77 1.00e-131 462.00
IUUC-Pab-098197 Pongo abelii 92.21 8.00e-137 479.00
IUUC-Pop-098821 Populus trichocarpa 42.02 3.00e-24 103.00
IUUC-Pca-100195 Procavia capensis 90.31 2.00e-139 487.00
IUUC-Ppe-102032 Prunus persica 43.78 1.00e-61 229.00
IUUC-Pva-102691 Pteropus vampyrus 90.73 2.00e-142 498.00
IUUC-Ptt-103979 Puccinia triticina 25.86 2.00e-04 40.40
IUUC-Rno-105016 Rattus norvegicus 97.30 2.00e-151 527.00
IUUC-Sha-106542 Sarcophilus harrisii 85.71 3.00e-136 477.00
IUUC-Spo-108207 Schizosaccharomyces pombe 32.29 7.00e-25 107.00
IUUC-Ssl-108410 Sclerotinia sclerotiorum 33.72 9.00e-33 133.00
IUUC-Sit-110052 Setaria italica 44.98 5.00e-63 234.00
IUUC-Sly-111489 Solanum lycopersicum 44.31 8.00e-60 223.00
IUUC-Sbi-114113 Sorghum bicolor 44.98 1.00e-63 236.00
IUUC-Tgu-117196 Taeniopygia guttata 88.63 3.00e-139 487.00
IUUC-Tru-118316 Takifugu rubripes 82.95 9.00e-131 459.00
IUUC-Tni-120315 Tetraodon nigroviridis 81.64 4.00e-131 460.00
IUUC-Tca-121033 Theobroma cacao 44.53 1.00e-59 222.00
IUUC-Tre-121986 Trichoderma reesei 26.60 3.00e-23 102.00
IUUC-Tvi-122607 Trichoderma virens 32.94 2.00e-30 126.00
IUUC-Tae-125740 Triticum aestivum 39.24 7.00e-57 214.00
IUUC-Tur-126375 Triticum urartu 35.65 3.00e-52 199.00
IUUC-Vda-129929 Verticillium dahliae 31.84 5.00e-23 102.00
IUUC-Vvi-130834 Vitis vinifera 45.75 3.00e-62 231.00
IUUC-Xma-133580 Xiphophorus maculatus 85.16 3.00e-134 470.00
IUUC-Zma-135642 Zea mays 46.15 3.00e-63 234.00
Created Date 25-Jun-2017

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