iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118250

UUCD1 version

UUC-TaR-00717

Ensembl Protein ID

ENSTRUP00000008695.1

UniProt Accession

H2S8H0; H2S8H0_TAKRU

Protein Name

E3 ubiquitin-protein ligase

Gene Name

LOC101074163

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000003707.1	ENSTRUT00000008746.1	ENSTRUP00000008695.1
ENSTRUG00000003707.1	ENSTRUT00000008747.1	ENSTRUP00000008696.1
ENSTRUG00000003707.1	ENSTRUT00000008748.1	ENSTRUP00000008697.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	82.35	9.00e-125	442.00	IUUC-Dme-031700
E3 activity/RING/RING	92.91	4.00e-157	551.00	IUUC-Hsa-046357
E3 activity/RING/RING	93.26	2.00e-157	551.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Takifugu rubripes

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

IGRRTRSSSP EGEAVSXPSQ RVPTLSGTTA SNSDLASLFE CPVCFDYVLP PILQCQSGHL 60
VCSNCRPKLT CCPCRGPLGS IRNLAMEKVA NSVLFPCKYA SSGCEVTLPH TEKTEHEELC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCGGCCGCC GGACCCGCAG CAGCAGCCCG GAGGGAGAAG CCGTCTCGGG TGAGTCCCGC 60
CGGGCTTTGG GCGGCCGCTG CGGCGGGGAA AATAACAAGA GGCTCGCTGG AGCAGAAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	37.64	6.00e-44	171.00
IUUC-Aml-001186	Ailuropoda melanoleuca	92.91	2.00e-158	551.00
IUUC-Atr-002857	Amborella trichopoda	36.19	1.00e-43	169.00
IUUC-Apl-003813	Anas platyrhynchos	92.91	1.00e-158	551.00
IUUC-Aca-005014	Anolis carolinensis	92.91	7.00e-159	552.00
IUUC-Aly-006522	Arabidopsis lyrata	36.58	9.00e-40	157.00
IUUC-Ath-007049	Arabidopsis thaliana	35.12	1.00e-39	156.00
IUUC-Ame-011196	Astyanax mexicanus	93.97	5.00e-160	556.00
IUUC-Bta-012887	Bos taurus	92.91	1.00e-158	551.00
IUUC-Bdi-014200	Brachypodium distachyon	38.02	1.00e-44	173.00
IUUC-Bol-016263	Brassica oleracea	35.02	9.00e-41	160.00
IUUC-Bra-016910	Brassica rapa	36.05	7.00e-40	157.00
IUUC-Cel-018320	Caenorhabditis elegans	71.60	2.00e-113	402.00
IUUC-Cja-019796	Callithrix jacchus	92.91	3.00e-158	550.00
IUUC-Cfa-020642	Canis familiaris	92.91	2.00e-159	554.00
IUUC-Cpo-022348	Cavia porcellus	92.91	2.00e-158	551.00
IUUC-Csa-023974	Chlorocebus sabaeus	92.91	2.00e-158	551.00
IUUC-Cin-025674	Ciona intestinalis	84.11	4.00e-132	463.00
IUUC-Csv-026233	Ciona savignyi	84.65	8.00e-131	459.00
IUUC-Dre-028041	Danio rerio	93.97	5.00e-160	556.00
IUUC-Dno-029764	Dasypus novemcinctus	92.91	1.00e-158	551.00
IUUC-Dme-031700	Drosophila melanogaster	84.27	4.00e-118	417.00
IUUC-Ete-032423	Echinops telfairi	92.11	8.00e-148	516.00
IUUC-Eca-033536	Equus caballus	92.91	1.00e-158	551.00
IUUC-Eeu-035314	Erinaceus europaeus	92.11	8.00e-148	516.00
IUUC-Fca-035362	Felis catus	92.91	9.00e-159	552.00
IUUC-Fal-037487	Ficedula albicollis	92.91	1.00e-158	551.00
IUUC-Gga-040269	Gallus gallus	92.91	1.00e-158	551.00
IUUC-Gac-042282	Gasterosteus aculeatus	94.68	3.00e-160	556.00
IUUC-Gma-042926	Glycine max	34.53	7.00e-41	160.00
IUUC-Ggo-045444	Gorilla gorilla	92.91	2.00e-158	551.00
IUUC-Hsa-046357	Homo sapiens	92.91	2.00e-158	551.00
IUUC-Hvu-047574	Hordeum vulgare	37.08	9.00e-44	170.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	92.91	2.00e-158	551.00
IUUC-Lch-049504	Latimeria chalumnae	93.26	4.00e-159	553.00
IUUC-Lpe-050879	Leersia perrieri	39.42	4.00e-41	161.00
IUUC-Loc-052191	Lepisosteus oculatus	93.26	1.00e-158	552.00
IUUC-Laf-053668	Loxodonta africana	92.91	1.00e-158	551.00
IUUC-Mcc-054640	Macaca mulatta	92.91	2.00e-158	551.00
IUUC-Mtr-058422	Medicago truncatula	34.64	3.00e-41	161.00
IUUC-Mga-059503	Meleagris gallopavo	92.91	1.00e-158	552.00
IUUC-Mmr-060794	Microcebus murinus	92.91	2.00e-158	551.00
IUUC-Mmu-064129	Mus musculus	93.26	1.00e-158	551.00
IUUC-Mac-065014	Musa acuminata	35.88	9.00e-41	160.00
IUUC-Mpu-066488	Mustela putorius furo	92.91	2.00e-158	551.00
IUUC-Mlu-067207	Myotis lucifugus	92.91	7.00e-159	552.00
IUUC-Nle-069706	Nomascus leucogenys	92.91	3.00e-158	550.00
IUUC-Ont-071849	Oreochromis niloticus	94.68	3.00e-160	557.00
IUUC-Ocu-074876	Oryctolagus cuniculus	92.91	5.00e-158	550.00
IUUC-Oba-075454	Oryza barthii	39.83	5.00e-41	161.00
IUUC-Obr-076037	Oryza brachyantha	34.07	4.00e-39	155.00
IUUC-Ogl-077712	Oryza glaberrima	39.83	5.00e-41	161.00
IUUC-Ogu-078910	Oryza glumaepatula	40.00	9.00e-41	160.00
IUUC-Oin-079749	Oryza indica	39.83	5.00e-41	161.00
IUUC-Olo-080244	Oryza longistaminata	34.07	2.00e-39	156.00
IUUC-Ome-081318	Oryza meridionalis	39.83	5.00e-41	161.00
IUUC-Oni-083109	Oryza nivara	39.83	5.00e-41	161.00
IUUC-Opu-084065	Oryza punctata	40.25	2.00e-41	162.00
IUUC-Oru-084785	Oryza rufipogon	39.83	5.00e-41	161.00
IUUC-Osa-085610	Oryza sativa	39.83	5.00e-41	161.00
IUUC-Ola-086814	Oryzias latipes	94.68	3.00e-160	556.00
IUUC-Oga-088399	Otolemur garnettii	92.91	2.00e-158	551.00
IUUC-Oar-089323	Ovis aries	92.91	2.00e-158	551.00
IUUC-Ptr-090692	Pan troglodytes	92.91	2.00e-158	551.00
IUUC-Pan-092012	Papio anubis	92.91	2.00e-158	551.00
IUUC-Psi-093687	Pelodiscus sinensis	92.91	7.00e-159	552.00
IUUC-Pma-094387	Petromyzon marinus	90.11	6.00e-153	532.00
IUUC-Ppa-095212	Physcomitrella patens	35.07	6.00e-39	154.00
IUUC-Pfo-097134	Poecilia formosa	94.68	3.00e-160	556.00
IUUC-Pab-097555	Pongo abelii	92.91	2.00e-158	551.00
IUUC-Pop-099970	Populus trichocarpa	34.90	2.00e-43	168.00
IUUC-Ppe-101760	Prunus persica	35.53	4.00e-41	161.00
IUUC-Rno-104866	Rattus norvegicus	93.26	1.00e-158	551.00
IUUC-Sha-106547	Sarcophilus harrisii	92.91	1.00e-158	551.00
IUUC-Smo-109412	Selaginella moellendorffii	33.94	1.00e-37	149.00
IUUC-Sit-110595	Setaria italica	36.33	3.00e-40	159.00
IUUC-Sly-111259	Solanum lycopersicum	35.97	5.00e-40	157.00
IUUC-Stu-112474	Solanum tuberosum	34.19	4.00e-41	161.00
IUUC-Sbi-114090	Sorghum bicolor	36.72	4.00e-41	161.00
IUUC-Tgu-116579	Taeniopygia guttata	92.91	1.00e-158	551.00
IUUC-Tni-120488	Tetraodon nigroviridis	94.33	9.00e-157	545.00
IUUC-Tca-121228	Theobroma cacao	34.55	6.00e-41	160.00
IUUC-Tae-123647	Triticum aestivum	37.64	6.00e-44	171.00
IUUC-Tur-126049	Triticum urartu	34.65	1.00e-37	150.00
IUUC-Ttr-129166	Tursiops truncatus	96.68	8.00e-139	486.00
IUUC-Vvi-131451	Vitis vinifera	36.36	3.00e-40	158.00
IUUC-Xtr-132553	Xenopus tropicalis	93.26	1.00e-158	551.00
IUUC-Xma-133670	Xiphophorus maculatus	94.68	3.00e-160	556.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence