iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-034310

Ensembl Protein ID

ENSECAP00000015042.1

UniProt Accession

F6PKU4; F6PKU4_HORSE

Protein Name

Uncharacterized protein

Gene Name

NOD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000017005.1	ENSECAT00000018435.1	ENSECAP00000015042.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	4.20e-14	53.0	148	206

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 3    eeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLktL 62
           +e+rl+++t ++r+r+lLd+++v++++l++fll++++el++  a +  +++++ ++++ L
   Q: 148  DEIRLPIFTSSQRARRLLDLATVKANGLAAFLLQHVQELPVLLALPFQDAACK-KFMSKL 206
           8***************************************************9.888877 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

LSSPGCEMCT QEAFQAQRSQ LVGLLVSGSL EGFESVLDWL LSWDVLSWED YESLSLVGQP 60
LSHLARHLLD TVWKKGAWGC EQLVAAVREA QADSQSPELP GHWDPHSPQP AQDLQSHRPA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTCCTCCC CAGGTTGTGA AATGTGCACG CAGGAGGCTT TCCAGGCGCA GAGGAGCCAG 60
CTGGTGGGGC TGCTGGTCTC GGGGTCCCTG GAGGGCTTCG AGAGTGTCCT GGATTGGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS50209--CARD
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0008180--C:COP9 signalosome
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0071225--P:cellular response to muramyl dipeptide
GO:0002374--P:cytokine secretion involved in immune response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response
GO:0042981--P:regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001822	Ailuropoda melanoleuca	84.71	0.00e+00	1528.00
IUUC-Ame-011021	Astyanax mexicanus	46.88	0.00e+00	899.00
IUUC-Bta-013241	Bos taurus	83.71	0.00e+00	1653.00
IUUC-Cja-019633	Callithrix jacchus	81.00	0.00e+00	1226.00
IUUC-Cfa-020039	Canis familiaris	85.29	0.00e+00	1644.00
IUUC-Cpo-022337	Cavia porcellus	79.59	0.00e+00	1518.00
IUUC-Csa-023906	Chlorocebus sabaeus	84.15	0.00e+00	1653.00
IUUC-Dre-027568	Danio rerio	47.65	0.00e+00	829.00
IUUC-Dno-029098	Dasypus novemcinctus	81.22	0.00e+00	1478.00
IUUC-Dor-031102	Dipodomys ordii	75.48	0.00e+00	704.00
IUUC-Ete-032943	Echinops telfairi	78.16	0.00e+00	1119.00
IUUC-Eeu-034589	Erinaceus europaeus	79.84	3.00e-170	592.00
IUUC-Fca-036252	Felis catus	85.89	0.00e+00	857.00
IUUC-Gac-041442	Gasterosteus aculeatus	46.60	0.00e+00	826.00
IUUC-Ggo-044861	Gorilla gorilla	84.77	0.00e+00	1614.00
IUUC-Hsa-046093	Homo sapiens	84.48	0.00e+00	1610.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	82.07	0.00e+00	1480.00
IUUC-Lch-049454	Latimeria chalumnae	53.77	0.00e+00	922.00
IUUC-Laf-053553	Loxodonta africana	85.20	0.00e+00	1538.00
IUUC-Mcc-055772	Macaca mulatta	84.18	0.00e+00	1631.00
IUUC-Meu-056785	Macropus eugenii	70.21	6.00e-117	415.00
IUUC-Mmr-060596	Microcebus murinus	83.61	0.00e+00	1586.00
IUUC-Mdo-062983	Monodelphis domestica	68.49	0.00e+00	1120.00
IUUC-Mmu-063951	Mus musculus	77.49	0.00e+00	1499.00
IUUC-Mpu-066412	Mustela putorius furo	85.29	0.00e+00	1654.00
IUUC-Mlu-067601	Myotis lucifugus	83.60	0.00e+00	1482.00
IUUC-Nle-069913	Nomascus leucogenys	85.17	0.00e+00	1364.00
IUUC-Opr-070999	Ochotona princeps	83.02	0.00e+00	969.00
IUUC-Ont-072512	Oreochromis niloticus	46.70	0.00e+00	881.00
IUUC-Oan-073564	Ornithorhynchus anatinus	62.50	0.00e+00	1108.00
IUUC-Ocu-074837	Oryctolagus cuniculus	85.46	0.00e+00	1614.00
IUUC-Ola-086555	Oryzias latipes	45.51	0.00e+00	822.00
IUUC-Oga-088909	Otolemur garnettii	82.84	0.00e+00	1585.00
IUUC-Oar-089315	Ovis aries	83.04	0.00e+00	1591.00
IUUC-Ptr-090542	Pan troglodytes	84.87	0.00e+00	1616.00
IUUC-Pan-092545	Papio anubis	84.15	0.00e+00	1621.00
IUUC-Pma-094167	Petromyzon marinus	33.49	3.00e-63	236.00
IUUC-Ppa-095344	Physcomitrella patens	33.64	2.00e-08	54.30
IUUC-Pfo-096976	Poecilia formosa	44.67	0.00e+00	835.00
IUUC-Pab-098481	Pongo abelii	84.18	0.00e+00	1596.00
IUUC-Pca-100135	Procavia capensis	78.17	0.00e+00	1314.00
IUUC-Pva-102127	Pteropus vampyrus	83.42	0.00e+00	1486.00
IUUC-Rno-105783	Rattus norvegicus	79.27	0.00e+00	1494.00
IUUC-Sar-113448	Sorex araneus	79.23	0.00e+00	983.00
IUUC-Tru-118708	Takifugu rubripes	45.53	0.00e+00	797.00
IUUC-Tni-120172	Tetraodon nigroviridis	36.42	5.00e-33	134.00
IUUC-Tbe-127661	Tupaia belangeri	83.55	0.00e+00	812.00
IUUC-Ttr-128318	Tursiops truncatus	79.43	0.00e+00	1439.00
IUUC-Vpa-130502	Vicugna pacos	77.63	2.00e-165	576.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence