iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003446

Ensembl Protein ID

ENSAPLP00000013059.1

UniProt Accession

U3J0N2; U3J0N2_ANAPL

Genbank Protein ID

ENSAPLP00000013059

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

ADON01076081

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000013192.1	ENSAPLT00000013807.1	ENSAPLP00000013059.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	8.80e-117	390.5	18	527

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 4    QirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnvea 92
           Q rlwG+++qe+l+sa+v++++a+++G+E+lKnLvl G+gs+t+vD+++v+ ++++++F+++++++g+s+A++a e l+eln dv++ +
   Q: 18   QYRLWGDHGQEALESAHVCVINATATGTEILKNLVLPGIGSFTIVDGNRVSGEDVGNNFFLQKSHIGQSRAQSATELLQELNNDVSGNF 106
           99*************************************************************************************** PP
   S: 93   heesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlk 177
           +ees+++l ++++ Ff++f++Vv+++ ++++ +++++l++n +vpl+ ++t+Gl+G++rviik++++ +s++d   +++++++Pf++l 
   Q: 107  VEESPEKLLDNDPsFFNRFNLVVATQLPESTLLRLAELLWNSNVPLLVCRTYGLVGYMRVIIKEHPVVESHPDnalEDLRLDKPFPELS 195
           ***************************************************************************************** PP
   S: 178  etpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakttin 251
           e+++         +++++++w+v+++k+l ++  e++ + +++++eke++++++++++ +      edeenfeeai+++++a+++t  +
   Q: 196  EHIQsydldhmdkKDHSHTPWIVIVAKYLTKWFNEKSDQLPKSYKEKEAFRQLIRQGILKnengipEDEENFEEAIKNVNSALNTTKVP 284
           **99999999999**************************************************************************** PP
   S: 252  s.ikqllksfecdivtkskspfwv................................................................. 274
             i+++++++ c ++t+++++fwv                                                                 
   Q: 285  RcIEEIFNDDCCTNLTEQSPSFWVlvralkefvanegqgslpvrgtipdmiadsnkfirlqnvyrekakkdiaavgnhaakllqslgka 373
           ***************************************************************************************** PP
   S: 275  ..........sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdl 335
                      +csn++ l+v             + +kde+++ +++p     lyl+lra++rf k++gr+pg+ +++++dd+  + ++
   Q: 374  pesiserelkLLCSNSAFLRVVrcrslseeyglNTFNKDEIISNMDNPdsevvLYLMLRAVDRFYKQHGRYPGVYNYQVEDDIgkLKSC 462
           **********99********777777777777766777777766666666777*****************************999999* PP
   S: 336  vtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           +t+++    +++g++ +++dd+++e++++++++ + ++a+ gG+aaqEviKv++g+f+ ++n++++ ++
   Q: 463  LTSFL----QEHGLSVVVKDDYVHEFCRYGAAEPHAIAAFMGGAAAQEVIKVITGQFVIFNNTYIYSGM 527
           **999....********************************************************9776 PP

Organism

Anas platyrhynchos

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MITLLWKMKH RVLLFISQYR LWGDHGQEAL ESAHVCVINA TATGTEILKN LVLPGIGSFT 60
IVDGNRVSGE DVGNNFFLQK SHIGQSRAQS ATELLQELNN DVSGNFVEES PEKLLDNDPS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATCACTT TACTATGGAA AATGAAACAC AGAGTGCTTC TGTTTATATC CCAATATAGA 60
TTGTGGGGTG ATCATGGACA AGAAGCTCTA GAATCTGCCC ATGTTTGTGT GATAAATGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	42.50	7.00e-123	433.00
IUUC-Aml-002333	Ailuropoda melanoleuca	83.49	0.00e+00	937.00
IUUC-Atr-002644	Amborella trichopoda	40.04	3.00e-108	385.00
IUUC-Aca-004450	Anolis carolinensis	81.50	0.00e+00	910.00
IUUC-Aly-006187	Arabidopsis lyrata	39.92	2.00e-121	429.00
IUUC-Ath-007600	Arabidopsis thaliana	39.62	2.00e-121	429.00
IUUC-Ago-007900	Ashbya gossypii	26.50	4.00e-35	142.00
IUUC-Acl-008333	Aspergillus clavatus	33.21	1.00e-74	273.00
IUUC-Afl-008529	Aspergillus flavus	33.94	8.00e-80	290.00
IUUC-Afu-009071	Aspergillus fumigatus	33.52	1.00e-75	276.00
IUUC-Ani-009443	Aspergillus nidulans	33.09	9.00e-73	267.00
IUUC-Ang-009669	Aspergillus niger	32.48	4.00e-77	281.00
IUUC-Aor-009914	Aspergillus oryzae	33.27	1.00e-76	280.00
IUUC-Ate-010450	Aspergillus terreus	33.21	6.00e-78	284.00
IUUC-Ame-011183	Astyanax mexicanus	72.45	0.00e+00	817.00
IUUC-Bgr-012111	Blumeria graminis	31.11	3.00e-58	219.00
IUUC-Bta-012583	Bos taurus	84.39	0.00e+00	944.00
IUUC-Bci-013892	Botrytis cinerea	31.83	2.00e-61	229.00
IUUC-Bdi-014592	Brachypodium distachyon	43.10	1.00e-123	436.00
IUUC-Bol-016399	Brassica oleracea	40.42	2.00e-121	429.00
IUUC-Bra-017506	Brassica rapa	38.58	1.00e-115	409.00
IUUC-Cel-018456	Caenorhabditis elegans	35.82	2.00e-88	319.00
IUUC-Cja-020007	Callithrix jacchus	83.52	0.00e+00	937.00
IUUC-Cfa-020324	Canis familiaris	84.59	0.00e+00	948.00
IUUC-Cpo-022248	Cavia porcellus	56.68	2.00e-154	538.00
IUUC-Csa-023149	Chlorocebus sabaeus	80.68	0.00e+00	814.00
IUUC-Cho-024537	Choloepus hoffmanni	73.54	0.00e+00	715.00
IUUC-Cin-025763	Ciona intestinalis	50.37	9.00e-156	543.00
IUUC-Csv-026113	Ciona savignyi	47.55	6.00e-143	500.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	31.11	3.00e-60	226.00
IUUC-Cne-026884	Cryptococcus neoformans	29.19	2.00e-65	243.00
IUUC-Cme-027210	Cyanidioschyzon merolae	27.35	8.00e-19	88.20
IUUC-Dre-028140	Danio rerio	73.80	0.00e+00	835.00
IUUC-Dno-030033	Dasypus novemcinctus	83.41	0.00e+00	822.00
IUUC-Dor-030513	Dipodomys ordii	60.70	1.00e-103	369.00
IUUC-Dse-031536	Dothistroma septosporum	32.67	5.00e-77	281.00
IUUC-Dme-031683	Drosophila melanogaster	44.11	3.00e-124	438.00
IUUC-Ete-032420	Echinops telfairi	72.87	0.00e+00	796.00
IUUC-Eca-033992	Equus caballus	84.46	0.00e+00	807.00
IUUC-Eeu-034713	Erinaceus europaeus	69.29	3.00e-104	372.00
IUUC-Fca-036548	Felis catus	83.04	0.00e+00	929.00
IUUC-Fal-037600	Ficedula albicollis	90.30	0.00e+00	978.00
IUUC-Fox-038037	Fusarium oxysporum	32.15	2.00e-69	256.00
IUUC-Fso-038387	Fusarium solani	33.39	5.00e-73	268.00
IUUC-Gmo-038562	Gadus morhua	70.83	0.00e+00	808.00
IUUC-Ggr-040005	Gaeumannomyces graminis	32.90	1.00e-66	247.00
IUUC-Gga-041129	Gallus gallus	96.15	0.00e+00	1028.00
IUUC-Gac-042558	Gasterosteus aculeatus	71.59	0.00e+00	815.00
IUUC-Gma-043610	Glycine max	40.04	6.00e-117	414.00
IUUC-Ggo-045611	Gorilla gorilla	83.52	0.00e+00	937.00
IUUC-Hsa-046563	Homo sapiens	83.82	0.00e+00	940.00
IUUC-Hvu-047790	Hordeum vulgare	38.68	2.00e-76	279.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	84.01	0.00e+00	937.00
IUUC-Kpa-049309	Komagataella pastoris	33.52	8.00e-77	280.00
IUUC-Lch-050038	Latimeria chalumnae	75.63	0.00e+00	835.00
IUUC-Lpe-051535	Leersia perrieri	40.77	5.00e-108	384.00
IUUC-Loc-051917	Lepisosteus oculatus	69.32	0.00e+00	771.00
IUUC-Lma-053112	Leptosphaeria maculans	35.64	6.00e-83	301.00
IUUC-Laf-053690	Loxodonta africana	84.39	0.00e+00	945.00
IUUC-Mcc-055117	Macaca mulatta	82.22	0.00e+00	922.00
IUUC-Meu-056761	Macropus eugenii	71.26	0.00e+00	758.00
IUUC-Mor-057230	Magnaporthe oryzae	33.15	5.00e-72	265.00
IUUC-Mpo-057514	Magnaporthe poae	32.04	2.00e-64	239.00
IUUC-Mtr-058551	Medicago truncatula	39.93	4.00e-115	408.00
IUUC-Mla-059183	Melampsora laricipopulina	36.20	2.00e-96	345.00
IUUC-Mga-060144	Meleagris gallopavo	95.40	0.00e+00	1025.00
IUUC-Mvi-060221	Microbotryum violaceum	34.46	4.00e-76	278.00
IUUC-Mmr-061325	Microcebus murinus	83.52	0.00e+00	934.00
IUUC-Mdo-062532	Monodelphis domestica	84.97	0.00e+00	951.00
IUUC-Mmu-063956	Mus musculus	84.78	0.00e+00	946.00
IUUC-Mac-064521	Musa acuminata	39.29	9.00e-117	413.00
IUUC-Mpu-066716	Mustela putorius furo	82.75	0.00e+00	877.00
IUUC-Mlu-067459	Myotis lucifugus	83.08	0.00e+00	932.00
IUUC-Nfi-068245	Neosartorya fischeri	33.70	2.00e-76	280.00
IUUC-Ncr-068910	Neurospora crassa	31.57	2.00e-68	253.00
IUUC-Nle-070034	Nomascus leucogenys	82.69	0.00e+00	924.00
IUUC-Opr-070552	Ochotona princeps	76.13	0.00e+00	766.00
IUUC-Ont-071426	Oreochromis niloticus	72.25	0.00e+00	826.00
IUUC-Oan-073389	Ornithorhynchus anatinus	80.63	0.00e+00	754.00
IUUC-Ocu-074911	Oryctolagus cuniculus	84.01	0.00e+00	943.00
IUUC-Oba-075437	Oryza barthii	41.73	7.00e-114	404.00
IUUC-Obr-076684	Oryza brachyantha	41.73	6.00e-109	387.00
IUUC-Ogl-077170	Oryza glaberrima	41.73	7.00e-114	404.00
IUUC-Ogu-078844	Oryza glumaepatula	42.66	1.00e-107	382.00
IUUC-Oin-079105	Oryza indica	41.73	3.00e-113	401.00
IUUC-Olo-080943	Oryza longistaminata	39.55	3.00e-102	365.00
IUUC-Oni-082891	Oryza nivara	38.65	8.00e-107	380.00
IUUC-Opu-083457	Oryza punctata	41.73	2.00e-113	402.00
IUUC-Oru-084960	Oryza rufipogon	39.55	3.00e-102	365.00
IUUC-Osa-085358	Oryza sativa	41.92	6.00e-114	404.00
IUUC-Ola-086420	Oryzias latipes	71.31	3.00e-169	587.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.47	9.00e-60	224.00
IUUC-Oga-088810	Otolemur garnettii	83.62	0.00e+00	940.00
IUUC-Oar-089196	Ovis aries	83.91	0.00e+00	938.00
IUUC-Ptr-090617	Pan troglodytes	84.01	0.00e+00	941.00
IUUC-Pan-092761	Papio anubis	84.20	0.00e+00	943.00
IUUC-Psi-093191	Pelodiscus sinensis	87.24	0.00e+00	983.00
IUUC-Pma-094380	Petromyzon marinus	62.76	0.00e+00	654.00
IUUC-Pno-095084	Phaeosphaeria nodorum	32.84	3.00e-66	246.00
IUUC-Ppa-095875	Physcomitrella patens	40.19	2.00e-118	418.00
IUUC-Pfo-096467	Poecilia formosa	71.26	0.00e+00	807.00
IUUC-Pab-098255	Pongo abelii	82.52	0.00e+00	769.00
IUUC-Pop-099871	Populus trichocarpa	40.34	4.00e-121	427.00
IUUC-Pca-100807	Procavia capensis	70.57	5.00e-107	380.00
IUUC-Ppe-101280	Prunus persica	38.89	5.00e-116	410.00
IUUC-Pva-102333	Pteropus vampyrus	81.03	0.00e+00	891.00
IUUC-Pgr-103401	Puccinia graminis	31.45	1.00e-78	286.00
IUUC-Ptt-103889	Puccinia triticina	28.40	7.00e-60	224.00
IUUC-Pte-104355	Pyrenophora teres	35.21	1.00e-83	303.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	35.45	5.00e-85	308.00
IUUC-Rno-105810	Rattus norvegicus	84.01	0.00e+00	938.00
IUUC-Sce-106397	Saccharomyces cerevisiae	24.77	3.00e-33	135.00
IUUC-Sha-106770	Sarcophilus harrisii	84.96	5.00e-139	486.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	33.33	3.00e-71	262.00
IUUC-Spo-108276	Schizosaccharomyces pombe	34.48	2.00e-78	285.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.65	1.00e-63	236.00
IUUC-Smo-109296	Selaginella moellendorffii	42.03	7.00e-119	420.00
IUUC-Sit-110157	Setaria italica	43.65	4.00e-130	457.00
IUUC-Sly-111105	Solanum lycopersicum	39.70	2.00e-120	425.00
IUUC-Stu-112469	Solanum tuberosum	39.51	8.00e-121	427.00
IUUC-Sar-113083	Sorex araneus	63.37	0.00e+00	672.00
IUUC-Sbi-113813	Sorghum bicolor	42.69	6.00e-127	447.00
IUUC-Sre-115058	Sporisorium reilianum	38.43	5.00e-80	291.00
IUUC-Tgu-116772	Taeniopygia guttata	87.69	0.00e+00	937.00
IUUC-Tru-118686	Takifugu rubripes	70.91	0.00e+00	820.00
IUUC-Tsy-119111	Tarsius syrichta	77.24	3.00e-123	435.00
IUUC-Tni-120231	Tetraodon nigroviridis	69.09	0.00e+00	746.00
IUUC-Tca-121491	Theobroma cacao	39.46	2.00e-113	402.00
IUUC-Tre-122103	Trichoderma reesei	35.19	2.00e-75	276.00
IUUC-Tvi-122672	Trichoderma virens	35.01	5.00e-71	261.00
IUUC-Tae-125679	Triticum aestivum	43.10	5.00e-125	441.00
IUUC-Tur-126487	Triticum urartu	42.37	8.00e-122	430.00
IUUC-Tme-127097	Tuber melanosporum	35.42	4.00e-86	311.00
IUUC-Ttr-128465	Tursiops truncatus	78.74	0.00e+00	871.00
IUUC-Uma-129645	Ustilago maydis	33.56	2.00e-85	309.00
IUUC-Vda-129989	Verticillium dahliae	29.18	4.00e-50	192.00
IUUC-Vpa-130529	Vicugna pacos	81.03	0.00e+00	898.00
IUUC-Vvi-131059	Vitis vinifera	40.42	3.00e-118	418.00
IUUC-Xtr-132002	Xenopus tropicalis	75.92	0.00e+00	861.00
IUUC-Xma-133930	Xiphophorus maculatus	71.87	0.00e+00	813.00
IUUC-Yli-134505	Yarrowia lipolytica	34.04	1.00e-81	296.00
IUUC-Zma-135895	Zea mays	42.31	8.00e-126	443.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence