iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ogl-077170

UUCD1 version

UUC-OrG-02491

Ensembl Protein ID

ORGLA03G0358000.1

UniProt Accession

I1PGT4; I1PGT4_ORYGL

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ORGLA03G0358000	ORGLA03G0358000.1	ORGLA03G0358000.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.40e-110	370.2	16	522

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnvea 92
           YDRQ+r+wG+++q++l++a+++l+ +g++G+E  KnLvl+Gvgs+tvvD+++ve+s+++++FL++ae  g+s+A++++ +l+eln+ vn+++
   Q: 16   YDRQLRIWGDQGQAALEKASICLLTCGPTGTEAMKNLVLGGVGSVTVVDGSKVEQSDMGNNFLLDAECLGQSRAKSVCSFLQELNDAVNAKF 107
           ******************************************************************************************** PP
   S: 93   heesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketp 180
           +ees+ +l ++++ Ff++f+vV++++ ++ + +k++++c++a++ l+ ++++Gl G vr+++k++ +++s++d   d++++ +P+++lk++ 
   Q: 108  VEESPLALIDTNPsFFSQFTVVIATQLPERSLLKLDDICRKANIVLVAARSYGLTGLVRISVKEHNVIESKPDhflDDLRLHNPWVELKQFA 199
           *******************************************************************************************8 PP
   S: 181  n.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfec 262
                     +++++++++v++  l+e++a +++++ +++++ek e+k ++++ + + deen++ea+e + k   +  i++ i+q++++ + 
   Q: 200  KsidindkdpVVHKHTPYIVILVRLAEKWADAHDGRLPSTRQEKNEFKALIREHMLNLDEENYKEAVESSYKVSVTPGISDeIRQIIDD-SS 290
           8899999999******************************************************************************9.78 PP
   S: 263  divtkskspfwv...........................................................................sfcsn 279
           ++v++s+s+fwv                                                                           +fc+n
   Q: 291  AEVNSSSSDFWVlvaalkefianegngelplegtipdmtslteyyvslqkiyqakaesdclalehhvkdilkridrdpdsisrayikTFCKN 382
           899***************************************************************************************** PP
   S: 280  aealq...........vpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kld 354
           a++l+           + +   + +++++++++     +y+llra++r++++++r pg ++ e d+d +++l+taa +  ++++g+++ +l+
   Q: 383  ARKLRvcryrsmeeefSSPVLSEVQKYFTDEDYcfamnFYVLLRAVDRLAANYNRFPGIFESEIDED-VPRLKTAAVSV-MSEMGMNGaPLS 472
           *****666666655553355666666667777788888*******************9999999999.*****988875.6*********** PP
   S: 355  ddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           +dli+e+++++ ++i++++a++gG+a+qEviK+v+++f+pl  +f+f+++
   Q: 473  EDLITEMCRFGGAEIHPVAAFIGGVASQEVIKLVTKQFVPLLGTFIFNGI 522
           ***********************************************986 PP

Organism

Oryza glaberrima

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAAATAAAFA EPKTKYDRQL RIWGDQGQAA LEKASICLLT CGPTGTEAMK NLVLGGVGSV 60
TVVDGSKVEQ SDMGNNFLLD AECLGQSRAK SVCSFLQELN DAVNAKFVEE SPLALIDTNP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGCCG CCACCGCCGC CGCCTTCGCG GAGCCCAAGA CCAAGTACGA TCGCCAGCTC 60
AGGTAACGCA ACCGGCGCGC ATCTGCGCTC TCCCATCTCC GACGGGTAGA TTCCGGGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	88.02	0.00e+00	929.00
IUUC-Aml-002333	Ailuropoda melanoleuca	42.97	9.00e-129	452.00
IUUC-Atr-002644	Amborella trichopoda	71.98	0.00e+00	764.00
IUUC-Apl-003446	Anas platyrhynchos	41.92	3.00e-119	421.00
IUUC-Aca-004450	Anolis carolinensis	41.63	3.00e-123	434.00
IUUC-Aly-005466	Arabidopsis lyrata	67.82	0.00e+00	756.00
IUUC-Ath-006692	Arabidopsis thaliana	68.39	0.00e+00	756.00
IUUC-Ago-007900	Ashbya gossypii	27.87	7.00e-41	160.00
IUUC-Acl-008333	Aspergillus clavatus	32.24	3.00e-67	248.00
IUUC-Afl-008529	Aspergillus flavus	32.30	9.00e-72	263.00
IUUC-Afu-009071	Aspergillus fumigatus	31.88	5.00e-66	244.00
IUUC-Ani-009443	Aspergillus nidulans	31.76	3.00e-61	228.00
IUUC-Ang-009669	Aspergillus niger	31.34	4.00e-69	254.00
IUUC-Aor-009914	Aspergillus oryzae	32.01	8.00e-70	256.00
IUUC-Ate-010450	Aspergillus terreus	31.58	1.00e-67	249.00
IUUC-Ame-011183	Astyanax mexicanus	40.65	1.00e-122	432.00
IUUC-Bgr-012111	Blumeria graminis	32.34	8.00e-60	223.00
IUUC-Bta-012583	Bos taurus	43.32	2.00e-130	458.00
IUUC-Bci-013892	Botrytis cinerea	31.49	3.00e-57	215.00
IUUC-Bdi-014592	Brachypodium distachyon	88.68	0.00e+00	937.00
IUUC-Bol-016401	Brassica oleracea	67.82	0.00e+00	754.00
IUUC-Bra-017506	Brassica rapa	66.54	0.00e+00	734.00
IUUC-Cel-018456	Caenorhabditis elegans	30.61	3.00e-72	265.00
IUUC-Cja-020007	Callithrix jacchus	43.45	6.00e-129	453.00
IUUC-Cfa-020324	Canis familiaris	43.13	2.00e-130	458.00
IUUC-Cpo-022248	Cavia porcellus	40.17	3.00e-69	254.00
IUUC-Csa-023149	Chlorocebus sabaeus	40.73	6.00e-103	367.00
IUUC-Cho-024537	Choloepus hoffmanni	35.78	1.00e-87	316.00
IUUC-Cin-025763	Ciona intestinalis	41.33	3.00e-111	394.00
IUUC-Csv-026113	Ciona savignyi	39.18	2.00e-102	365.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	29.89	1.00e-56	213.00
IUUC-Cne-026884	Cryptococcus neoformans	31.07	1.00e-64	239.00
IUUC-Dre-028140	Danio rerio	41.57	6.00e-126	443.00
IUUC-Dno-030033	Dasypus novemcinctus	42.83	5.00e-112	397.00
IUUC-Dor-030513	Dipodomys ordii	36.51	5.00e-38	150.00
IUUC-Dse-031536	Dothistroma septosporum	30.20	1.00e-61	229.00
IUUC-Dme-031683	Drosophila melanogaster	38.90	3.00e-97	348.00
IUUC-Ete-032420	Echinops telfairi	38.27	5.00e-110	390.00
IUUC-Eca-033992	Equus caballus	41.22	8.00e-101	359.00
IUUC-Eeu-034713	Erinaceus europaeus	33.19	1.00e-36	146.00
IUUC-Fca-036548	Felis catus	42.75	1.00e-129	456.00
IUUC-Fal-037600	Ficedula albicollis	41.52	9.00e-117	412.00
IUUC-Fox-038037	Fusarium oxysporum	31.86	7.00e-68	250.00
IUUC-Fso-038387	Fusarium solani	32.25	1.00e-67	249.00
IUUC-Gmo-038562	Gadus morhua	40.72	9.00e-119	419.00
IUUC-Ggr-040005	Gaeumannomyces graminis	31.68	5.00e-64	237.00
IUUC-Gga-041129	Gallus gallus	41.98	3.00e-120	424.00
IUUC-Gac-042558	Gasterosteus aculeatus	41.25	5.00e-123	433.00
IUUC-Gma-043610	Glycine max	70.25	0.00e+00	754.00
IUUC-Ggo-045611	Gorilla gorilla	42.88	6.00e-128	450.00
IUUC-Hsa-046563	Homo sapiens	43.13	3.00e-129	454.00
IUUC-Hvu-047790	Hordeum vulgare	88.43	0.00e+00	685.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	43.51	4.00e-129	454.00
IUUC-Kpa-049309	Komagataella pastoris	35.32	8.00e-77	280.00
IUUC-Lch-050038	Latimeria chalumnae	42.13	6.00e-123	433.00
IUUC-Lpe-051535	Leersia perrieri	91.30	0.00e+00	883.00
IUUC-Loc-051917	Lepisosteus oculatus	38.29	8.00e-107	380.00
IUUC-Lma-053112	Leptosphaeria maculans	32.55	3.00e-69	255.00
IUUC-Laf-053690	Loxodonta africana	43.89	1.00e-131	462.00
IUUC-Mcc-055117	Macaca mulatta	42.80	6.00e-127	446.00
IUUC-Meu-056761	Macropus eugenii	35.55	2.00e-93	335.00
IUUC-Mor-057230	Magnaporthe oryzae	31.31	2.00e-67	249.00
IUUC-Mpo-057514	Magnaporthe poae	31.31	6.00e-60	224.00
IUUC-Mtr-058551	Medicago truncatula	67.04	0.00e+00	728.00
IUUC-Mla-059183	Melampsora laricipopulina	34.38	4.00e-87	314.00
IUUC-Mga-060144	Meleagris gallopavo	41.27	2.00e-116	412.00
IUUC-Mvi-060221	Microbotryum violaceum	34.01	5.00e-60	224.00
IUUC-Mmr-061325	Microcebus murinus	42.31	4.00e-126	444.00
IUUC-Mdo-062532	Monodelphis domestica	42.94	3.00e-128	451.00
IUUC-Mmu-063956	Mus musculus	42.56	2.00e-128	451.00
IUUC-Mac-064521	Musa acuminata	73.60	0.00e+00	806.00
IUUC-Mpu-066716	Mustela putorius furo	43.29	7.00e-121	426.00
IUUC-Mlu-067459	Myotis lucifugus	43.62	7.00e-131	459.00
IUUC-Nfi-068245	Neosartorya fischeri	32.24	3.00e-67	248.00
IUUC-Ncr-068910	Neurospora crassa	30.80	7.00e-63	234.00
IUUC-Nle-070034	Nomascus leucogenys	41.54	7.00e-122	429.00
IUUC-Opr-070552	Ochotona princeps	39.31	1.00e-98	352.00
IUUC-Ont-071426	Oreochromis niloticus	41.44	4.00e-125	440.00
IUUC-Oan-073389	Ornithorhynchus anatinus	39.19	3.00e-88	317.00
IUUC-Ocu-074911	Oryctolagus cuniculus	43.70	7.00e-131	459.00
IUUC-Oba-075437	Oryza barthii	100.00	0.00e+00	1008.00
IUUC-Obr-076684	Oryza brachyantha	94.03	0.00e+00	899.00
IUUC-Ogu-078844	Oryza glumaepatula	98.79	0.00e+00	946.00
IUUC-Oin-079105	Oryza indica	99.81	0.00e+00	1004.00
IUUC-Olo-080943	Oryza longistaminata	96.56	0.00e+00	919.00
IUUC-Oni-082891	Oryza nivara	96.74	0.00e+00	970.00
IUUC-Opu-083457	Oryza punctata	98.85	0.00e+00	995.00
IUUC-Oru-084960	Oryza rufipogon	96.56	0.00e+00	919.00
IUUC-Osa-085358	Oryza sativa	99.42	0.00e+00	999.00
IUUC-Ola-086420	Oryzias latipes	39.36	7.00e-78	283.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.45	9.00e-60	223.00
IUUC-Oga-088810	Otolemur garnettii	43.32	1.00e-129	455.00
IUUC-Oar-089196	Ovis aries	43.07	2.00e-128	452.00
IUUC-Ptr-090617	Pan troglodytes	43.13	1.00e-129	455.00
IUUC-Pan-092761	Papio anubis	43.32	2.00e-130	458.00
IUUC-Psi-093191	Pelodiscus sinensis	40.00	4.00e-121	427.00
IUUC-Pma-094380	Petromyzon marinus	40.64	9.00e-110	389.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.11	4.00e-61	229.00
IUUC-Ppa-095798	Physcomitrella patens	55.53	3.00e-175	607.00
IUUC-Pfo-096467	Poecilia formosa	41.40	2.00e-120	425.00
IUUC-Pab-098255	Pongo abelii	44.80	6.00e-108	383.00
IUUC-Pop-099722	Populus trichocarpa	71.02	0.00e+00	787.00
IUUC-Pca-100807	Procavia capensis	52.41	2.00e-53	202.00
IUUC-Ppe-101280	Prunus persica	70.25	0.00e+00	776.00
IUUC-Pva-102333	Pteropus vampyrus	41.75	6.00e-123	433.00
IUUC-Pgr-103401	Puccinia graminis	30.02	6.00e-69	254.00
IUUC-Ptt-103889	Puccinia triticina	27.26	1.00e-60	226.00
IUUC-Pte-104355	Pyrenophora teres	32.13	6.00e-67	247.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	32.73	4.00e-68	251.00
IUUC-Rno-105810	Rattus norvegicus	42.37	9.00e-127	446.00
IUUC-Sce-106397	Saccharomyces cerevisiae	27.24	9.00e-34	137.00
IUUC-Sha-106770	Sarcophilus harrisii	49.23	2.00e-71	261.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	33.14	3.00e-78	284.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.91	8.00e-83	300.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.36	1.00e-59	223.00
IUUC-Smo-109296	Selaginella moellendorffii	54.72	9.00e-168	582.00
IUUC-Sit-110157	Setaria italica	88.48	0.00e+00	951.00
IUUC-Sly-111105	Solanum lycopersicum	67.48	0.00e+00	748.00
IUUC-Stu-112469	Solanum tuberosum	68.41	0.00e+00	763.00
IUUC-Sar-113083	Sorex araneus	33.85	6.00e-87	313.00
IUUC-Sbi-113813	Sorghum bicolor	89.25	0.00e+00	959.00
IUUC-Sre-115058	Sporisorium reilianum	33.63	2.00e-64	239.00
IUUC-Tgu-116772	Taeniopygia guttata	42.13	1.00e-116	412.00
IUUC-Tru-118686	Takifugu rubripes	40.49	4.00e-123	434.00
IUUC-Tsy-119111	Tarsius syrichta	45.25	8.00e-63	233.00
IUUC-Tni-120231	Tetraodon nigroviridis	39.43	2.00e-109	388.00
IUUC-Tca-121491	Theobroma cacao	70.44	0.00e+00	745.00
IUUC-Tre-122103	Trichoderma reesei	32.65	1.00e-71	263.00
IUUC-Tvi-122672	Trichoderma virens	31.58	6.00e-67	247.00
IUUC-Tae-125316	Triticum aestivum	88.87	0.00e+00	935.00
IUUC-Tur-126487	Triticum urartu	87.43	0.00e+00	907.00
IUUC-Tme-127097	Tuber melanosporum	34.24	2.00e-78	285.00
IUUC-Ttr-128465	Tursiops truncatus	40.04	1.00e-113	402.00
IUUC-Uma-129645	Ustilago maydis	29.01	8.00e-66	243.00
IUUC-Vda-129989	Verticillium dahliae	29.26	2.00e-49	188.00
IUUC-Vpa-130529	Vicugna pacos	40.99	6.00e-119	420.00
IUUC-Vvi-131059	Vitis vinifera	71.59	0.00e+00	786.00
IUUC-Xtr-132002	Xenopus tropicalis	43.16	1.00e-126	445.00
IUUC-Xma-133930	Xiphophorus maculatus	41.71	4.00e-124	437.00
IUUC-Yli-134505	Yarrowia lipolytica	34.17	7.00e-80	290.00
IUUC-Zma-135895	Zea mays	87.14	0.00e+00	941.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence