iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001630

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01155434

Gene Name

RFFL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000014564.1	ENSAMET00000015990.1	ENSAMEP00000015351.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	90.63	0.00e+00	637.00	IUUC-Hsa-045798

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

FSPSSLAADF IMWATCCNWF CLDGQPEEGP PAQGARTQAY SNPGYSSFPS PTGSEPSCKA 60
CGTHFANTAR KQTCLDCKKN FCMTCSSQVG SGLRLCLLCQ RVRATGFQRD ELMKVKVKDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCTCCCCTT CCTCCCTTGC AGCAGATTTT ATCATGTGGG CAACCTGTTG CAACTGGTTC 60
TGCTTGGATG GACAGCCTGA GGAGGGCCCA CCGGCCCAGG GAGCCAGGAC GCAGGCCTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR003034--SAP_dom
IPR011011--Znf_FYVE_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0010008--C:endosome membrane
GO:0005886--C:plasma membrane
GO:0002947--C:tumor necrosis factor receptor superfamily complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:2001271--P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004124	Anas platyrhynchos	64.93	1.00e-119	422.00
IUUC-Ame-011616	Astyanax mexicanus	57.53	9.00e-105	373.00
IUUC-Bta-012374	Bos taurus	87.50	0.00e+00	642.00
IUUC-Cja-019780	Callithrix jacchus	89.56	0.00e+00	655.00
IUUC-Cfa-021252	Canis familiaris	92.90	0.00e+00	653.00
IUUC-Cpo-022047	Cavia porcellus	88.25	0.00e+00	646.00
IUUC-Csa-023161	Chlorocebus sabaeus	90.08	0.00e+00	684.00
IUUC-Cho-024316	Choloepus hoffmanni	89.44	7.00e-155	539.00
IUUC-Dre-028596	Danio rerio	55.22	1.00e-105	375.00
IUUC-Dno-029333	Dasypus novemcinctus	91.18	0.00e+00	665.00
IUUC-Ete-033163	Echinops telfairi	82.09	4.00e-163	566.00
IUUC-Eca-033994	Equus caballus	91.80	0.00e+00	672.00
IUUC-Eeu-035162	Erinaceus europaeus	84.00	6.00e-127	446.00
IUUC-Fca-036418	Felis catus	90.91	0.00e+00	702.00
IUUC-Fal-037427	Ficedula albicollis	65.40	2.00e-131	462.00
IUUC-Gga-041053	Gallus gallus	66.67	3.00e-129	454.00
IUUC-Ggo-045436	Gorilla gorilla	90.63	0.00e+00	686.00
IUUC-Hsa-045798	Homo sapiens	90.63	0.00e+00	686.00
IUUC-Itr-048077	Ictidomys tridecemlineatus	89.04	0.00e+00	642.00
IUUC-Lch-050639	Latimeria chalumnae	60.88	3.00e-122	431.00
IUUC-Laf-053355	Loxodonta africana	85.91	6.00e-176	609.00
IUUC-Mcc-055222	Macaca mulatta	90.08	0.00e+00	645.00
IUUC-Meu-056692	Macropus eugenii	75.21	2.00e-154	538.00
IUUC-Mga-059298	Meleagris gallopavo	66.85	9.00e-131	459.00
IUUC-Mmr-061792	Microcebus murinus	88.98	0.00e+00	642.00
IUUC-Mdo-062986	Monodelphis domestica	77.81	1.00e-162	565.00
IUUC-Mmu-063356	Mus musculus	86.38	0.00e+00	638.00
IUUC-Mpu-066273	Mustela putorius furo	94.65	0.00e+00	734.00
IUUC-Mlu-066953	Myotis lucifugus	90.98	0.00e+00	682.00
IUUC-Nle-070075	Nomascus leucogenys	89.16	0.00e+00	691.00
IUUC-Opr-070838	Ochotona princeps	88.71	0.00e+00	632.00
IUUC-Ont-071967	Oreochromis niloticus	73.43	5.00e-55	207.00
IUUC-Ocu-074807	Oryctolagus cuniculus	89.07	0.00e+00	674.00
IUUC-Obr-076159	Oryza brachyantha	39.29	9.00e-08	49.30
IUUC-Ola-086903	Oryzias latipes	49.34	2.00e-87	315.00
IUUC-Oga-088536	Otolemur garnettii	87.88	6.00e-177	613.00
IUUC-Oar-089838	Ovis aries	86.65	2.00e-180	625.00
IUUC-Ptr-090962	Pan troglodytes	90.36	0.00e+00	686.00
IUUC-Pan-092853	Papio anubis	89.53	0.00e+00	679.00
IUUC-Psi-093164	Pelodiscus sinensis	68.49	4.00e-123	434.00
IUUC-Pma-094104	Petromyzon marinus	44.14	3.00e-56	212.00
IUUC-Pno-094968	Phaeosphaeria nodorum	38.78	6.00e-09	57.40
IUUC-Pab-098304	Pongo abelii	89.70	0.00e+00	691.00
IUUC-Pca-100316	Procavia capensis	88.15	1.00e-176	612.00
IUUC-Pva-102612	Pteropus vampyrus	76.31	1.00e-154	538.00
IUUC-Rno-105449	Rattus norvegicus	87.05	0.00e+00	631.00
IUUC-Sha-107578	Sarcophilus harrisii	77.81	2.00e-153	535.00
IUUC-Sit-110649	Setaria italica	37.14	1.00e-08	52.40
IUUC-Sar-113638	Sorex araneus	86.78	2.00e-177	615.00
IUUC-Ssc-116401	Sus scrofa	89.34	0.00e+00	684.00
IUUC-Tru-118765	Takifugu rubripes	49.59	8.00e-81	293.00
IUUC-Tsy-118850	Tarsius syrichta	87.13	2.00e-151	527.00
IUUC-Tbe-128086	Tupaia belangeri	81.82	6.00e-175	606.00
IUUC-Ttr-128249	Tursiops truncatus	68.32	2.00e-138	485.00
IUUC-Vpa-130816	Vicugna pacos	86.05	3.00e-40	158.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence