iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000003566.5	ENSGALT00000005647.5	ENSGALP00000005637.5
ENSGALG00000003566.5	ENSGALT00000060268.1	ENSGALP00000052166.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.60e-131	437.5	402	734

Active Site

Position(s)	Description	Evidence
703	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 402  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 489
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e vdp+l++sl +i+en   di+   ld tf+v+++ +ge+ ++eLkp+G++ipVt+eNk+eYv+l+v+
   Q: 490  GFTLPFYKQLLGKPITLDDMELVDPDLHNSLVWILEN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVN 574
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll+ F+e+elel+icG  +idv+d+k++t+ k+ +t+ds+ ++wFw+++e f++e r+++LqFv
   Q: 575  WRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKANTRLKH-CTPDSNIVKWFWKAVEFFDEERRARLLQFV 662
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ das+++lP+++TCfn++++P+Y+s+++l+ekLl+Aieet gF +
   Q: 663  TGSSRVPLQGFKALQgaagPRLFTIHQiDASTNNLPKAHTCFNRIDIPPYESYDKLYEKLLTAIEETCGFAV 734
           **********************************************************************76 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MSNQGARRNG PVKLRLTVLC AKNLVKKDFF RLPDPFAKVV VDGSGQCHST DTVKNTLDPK 60
WNQHYDLYIG KSDSITISVW NHKKIHKKQG AGFLGCVRLL SNAINRLKDT GYQRLDLCKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCAACC AAGGGGCTCG GAGGAACGGG CCCGTCAAGC TGCGGCTGAC AGGTGAGGCT 60
GAGCGCGGCG GCGGGGAGCC CCGGCCGGGC CTGCCGCTGC CTCCCGCCGC CGGGCGGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1901165--P:positive regulation of trophoblast cell migration
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	94.05	0.00e+00	1406.00
IUUC-Apl-003513	Anas platyrhynchos	95.25	0.00e+00	1441.00
IUUC-Aca-005358	Anolis carolinensis	95.23	0.00e+00	1449.00
IUUC-Ame-011320	Astyanax mexicanus	85.01	0.00e+00	1348.00
IUUC-Bta-013399	Bos taurus	94.16	0.00e+00	1402.00
IUUC-Cja-019355	Callithrix jacchus	94.06	0.00e+00	1405.00
IUUC-Cpo-022200	Cavia porcellus	94.44	0.00e+00	1409.00
IUUC-Cho-024804	Choloepus hoffmanni	98.38	0.00e+00	639.00
IUUC-Dre-027650	Danio rerio	87.78	0.00e+00	1384.00
IUUC-Dno-029534	Dasypus novemcinctus	94.02	0.00e+00	1431.00
IUUC-Ete-032715	Echinops telfairi	89.39	0.00e+00	1315.00
IUUC-Eca-033580	Equus caballus	94.44	0.00e+00	1408.00
IUUC-Eeu-034945	Erinaceus europaeus	92.17	0.00e+00	1299.00
IUUC-Fal-037275	Ficedula albicollis	94.74	0.00e+00	1433.00
IUUC-Gac-041295	Gasterosteus aculeatus	88.49	0.00e+00	1353.00
IUUC-Hsa-046726	Homo sapiens	94.29	0.00e+00	1432.00
IUUC-Lch-050026	Latimeria chalumnae	92.84	0.00e+00	1407.00
IUUC-Loc-051760	Lepisosteus oculatus	85.77	0.00e+00	1331.00
IUUC-Laf-053753	Loxodonta africana	94.30	0.00e+00	1406.00
IUUC-Mcc-054815	Macaca mulatta	94.02	0.00e+00	1428.00
IUUC-Meu-056436	Macropus eugenii	75.83	0.00e+00	1101.00
IUUC-Mga-059481	Meleagris gallopavo	77.04	0.00e+00	1091.00
IUUC-Mmr-060806	Microcebus murinus	94.17	0.00e+00	1407.00
IUUC-Mdo-062805	Monodelphis domestica	93.23	0.00e+00	1415.00
IUUC-Mmu-064034	Mus musculus	94.02	0.00e+00	1428.00
IUUC-Mpu-066762	Mustela putorius furo	94.05	0.00e+00	1406.00
IUUC-Mlu-066981	Myotis lucifugus	94.30	0.00e+00	1405.00
IUUC-Nle-069804	Nomascus leucogenys	94.39	0.00e+00	1425.00
IUUC-Opr-070591	Ochotona princeps	88.84	0.00e+00	1305.00
IUUC-Ont-072243	Oreochromis niloticus	87.37	0.00e+00	1364.00
IUUC-Oan-072699	Ornithorhynchus anatinus	91.32	0.00e+00	1423.00
IUUC-Ocu-074913	Oryctolagus cuniculus	94.29	0.00e+00	1432.00
IUUC-Ola-086597	Oryzias latipes	82.94	0.00e+00	1245.00
IUUC-Oga-089116	Otolemur garnettii	90.91	0.00e+00	1345.00
IUUC-Oar-089366	Ovis aries	93.90	0.00e+00	1404.00
IUUC-Ptr-091382	Pan troglodytes	94.29	0.00e+00	1432.00
IUUC-Psi-093298	Pelodiscus sinensis	94.57	0.00e+00	1400.00
IUUC-Pma-094354	Petromyzon marinus	70.25	0.00e+00	1063.00
IUUC-Pfo-096071	Poecilia formosa	87.60	0.00e+00	1377.00
IUUC-Pab-098682	Pongo abelii	94.29	0.00e+00	1431.00
IUUC-Pca-100516	Procavia capensis	88.95	0.00e+00	630.00
IUUC-Pva-102754	Pteropus vampyrus	93.20	0.00e+00	1370.00
IUUC-Rno-105600	Rattus norvegicus	93.76	0.00e+00	1207.00
IUUC-Sha-107144	Sarcophilus harrisii	93.00	0.00e+00	1278.00
IUUC-Sar-113122	Sorex araneus	83.13	0.00e+00	1189.00
IUUC-Tgu-117112	Taeniopygia guttata	95.09	0.00e+00	1444.00
IUUC-Tru-118497	Takifugu rubripes	87.16	0.00e+00	1317.00
IUUC-Tni-120781	Tetraodon nigroviridis	86.36	0.00e+00	1119.00
IUUC-Tbe-127371	Tupaia belangeri	84.17	0.00e+00	1131.00
IUUC-Ttr-129305	Tursiops truncatus	87.04	0.00e+00	1198.00
IUUC-Vpa-130591	Vicugna pacos	84.35	0.00e+00	1214.00
IUUC-Xtr-132979	Xenopus tropicalis	74.74	0.00e+00	1043.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence