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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106192
Ensembl Protein ID YNR006W
UniProt Accession P40343; D6W1I1; VPS27_YEAST
Genbank Protein ID AAA96002.1; CAA54574.1; CAA96282.1; DAA10547.1
Protein Name Vacuolar protein sorting-associated protein 27; Golgi retention defective protein 11
Genbank Nucleotide ID U24218; X77395; Z71620; BK006947
Gene Name VPS27; DID7; GRD11; SSV17; VPL23; VPT27; YNR006W; N2038
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YNR006W YNR006W YNR006W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 12750381; 16689637; 17543868
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UIM 7.30e-07 27.1 258 276
UBD/Alpha-Helix/UIM 2.6e-05 13.3 301 319
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEeee 19
           dE+e++++A++lSl+E ++
   Q: 258  DEEELIRKAIELSLKESRN 276
           7***************875 PP
   

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEeee 19
           +Ed++L  A+++Sl E+ee
   Q: 301  EEDPDLKAAIQESLREAEE 319
           7****************98 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. Controls exit from the prevacuolar compartment (PVC) in both the forward direction to the vacuole and the return to the Golgi. Allows VPS10 to return to the (trans-Golgi network) TGN from the PVC. Might also function as an alternate adapter in the COPIb clathrin-like coat.
 Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. Controls exit from the prevacuolar compartment (PVC) in both the forward direction to the vacuole and the return to the Golgi. Allows VPS10 to return to the (trans-Golgi network) TGN from the PVC. Might also function as an alternate adapter in the COPIb clathrin-like coat.
Protein Sequence
(Fasta)
MSVSTPSELD ALIEQATSES IPNGDLDLPI ALEISDVLRS RRVNPKDSMR CIKKRILNTA 60
DNPNTQLSSW KLTNICVKNG GTPFIKEICS REFMDTMEHV ILREDSNEEL SELVKTILYE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106192|UBD,UIM|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTCCGTTA GCACGCCAAG TGAGTTAGAC GCATTAATAG AACAAGCCAC TAGTGAGAGC 60
ATTCCCAACG GTGACCTTGA TCTCCCCATA GCGTTGGAAA TTTCAGATGT GTTAAGATCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106192|UBD,UIM|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0967--Endosome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR008942--ENTH_VHS
IPR017073--Ubi-bd_Hrs_VPS27
IPR003903--UIM_dom
IPR002014--VHS_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50330--UIM
PS50179--VHS
PS50178--ZF_FYVE
Pfam

PF01363--FYVE
PF02809--UIM
PF00790--VHS
SMART

SM00064--FYVE
SM00726--UIM
SM00288--VHS
Gene Ontology

GO:0005768--C:endosome
GO:0010008--C:endosome membrane
GO:0033565--C:ESCRT-0 complex
GO:0046872--F:metal ion binding
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0043130--F:ubiquitin binding
GO:1904669--P:ATP export
GO:0045324--P:late endosome to vacuole transport
GO:0045053--P:protein retention in Golgi apparatus
GO:0006623--P:protein targeting to vacuole
KEGG sce:YNR006W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001175 Aegilops tauschii 45.59 3.00e-14 70.10
IUUC-Aml-001518 Ailuropoda melanoleuca 28.44 5.00e-26 110.00
IUUC-Atr-002790 Amborella trichopoda 45.76 4.00e-13 68.90
IUUC-Apl-003662 Anas platyrhynchos 29.95 2.00e-24 105.00
IUUC-Aca-004940 Anolis carolinensis 29.07 2.00e-27 115.00
IUUC-Aly-006019 Arabidopsis lyrata 37.66 3.00e-12 65.90
IUUC-Ath-006781 Arabidopsis thaliana 38.96 6.00e-13 68.20
IUUC-Ago-007931 Ashbya gossypii 50.32 2.00e-135 474.00
IUUC-Acl-008274 Aspergillus clavatus 34.48 1.00e-73 268.00
IUUC-Afl-008521 Aspergillus flavus 35.89 8.00e-75 273.00
IUUC-Afu-008774 Aspergillus fumigatus 35.48 9.00e-74 269.00
IUUC-Ani-009445 Aspergillus nidulans 33.11 4.00e-75 273.00
IUUC-Ang-009863 Aspergillus niger 36.78 2.00e-73 268.00
IUUC-Ate-010444 Aspergillus terreus 36.08 4.00e-67 246.00
IUUC-Ame-011111 Astyanax mexicanus 29.96 5.00e-28 117.00
IUUC-Bgr-012087 Blumeria graminis 33.77 2.00e-65 241.00
IUUC-Bta-012506 Bos taurus 28.63 1.00e-27 116.00
IUUC-Bci-013782 Botrytis cinerea 33.73 7.00e-68 249.00
IUUC-Bdi-014421 Brachypodium distachyon 49.18 2.00e-14 70.90
IUUC-Bol-015456 Brassica oleracea 40.26 7.00e-14 71.20
IUUC-Bra-016882 Brassica rapa 40.26 2.00e-13 65.10
IUUC-Cel-018493 Caenorhabditis elegans 30.94 5.00e-28 117.00
IUUC-Cja-019998 Callithrix jacchus 28.12 3.00e-24 105.00
IUUC-Cfa-020615 Canis familiaris 28.19 7.00e-27 114.00
IUUC-Cpo-022019 Cavia porcellus 28.19 3.00e-27 115.00
IUUC-Csa-023596 Chlorocebus sabaeus 28.19 4.00e-27 114.00
IUUC-Cin-025488 Ciona intestinalis 30.84 9.00e-31 126.00
IUUC-Csv-025802 Ciona savignyi 27.91 8.00e-24 102.00
IUUC-Cgl-026560 Colletotrichum gloeosporioides 33.67 3.00e-71 260.00
IUUC-Cne-026847 Cryptococcus neoformans 32.20 8.00e-56 209.00
IUUC-Dre-028353 Danio rerio 29.22 4.00e-28 117.00
IUUC-Dno-029005 Dasypus novemcinctus 28.44 5.00e-27 114.00
IUUC-Dor-030280 Dipodomys ordii 28.57 4.00e-27 114.00
IUUC-Dse-031238 Dothistroma septosporum 34.70 3.00e-65 241.00
IUUC-Dme-031952 Drosophila melanogaster 33.04 5.00e-30 124.00
IUUC-Ete-032235 Echinops telfairi 28.77 2.00e-26 112.00
IUUC-Eca-033873 Equus caballus 28.25 9.00e-27 113.00
IUUC-Eeu-034820 Erinaceus europaeus 32.62 2.00e-15 75.50
IUUC-Fca-036563 Felis catus 28.63 1.00e-27 116.00
IUUC-Fal-036649 Ficedula albicollis 29.08 2.00e-25 108.00
IUUC-Fox-037962 Fusarium oxysporum 34.76 7.00e-63 233.00
IUUC-Fso-038396 Fusarium solani 35.02 2.00e-69 255.00
IUUC-Gmo-039510 Gadus morhua 29.46 5.00e-29 120.00
IUUC-Ggr-039938 Gaeumannomyces graminis 32.27 7.00e-60 223.00
IUUC-Gga-040201 Gallus gallus 29.22 4.00e-28 117.00
IUUC-Gac-041459 Gasterosteus aculeatus 29.22 1.00e-28 119.00
IUUC-Gma-042952 Glycine max 42.65 2.00e-16 77.00
IUUC-Ggo-044573 Gorilla gorilla 28.19 6.00e-27 114.00
IUUC-Hsa-046009 Homo sapiens 28.19 3.00e-27 115.00
IUUC-Hvu-047612 Hordeum vulgare 45.59 1.00e-14 71.20
IUUC-Itr-049065 Ictidomys tridecemlineatus 28.57 3.00e-27 114.00
IUUC-Kpa-049327 Komagataella pastoris 33.77 4.00e-72 263.00
IUUC-Lch-050236 Latimeria chalumnae 26.91 7.00e-17 78.60
IUUC-Lpe-051694 Leersia perrieri 45.76 1.00e-12 66.60
IUUC-Loc-051850 Lepisosteus oculatus 28.77 8.00e-26 110.00
IUUC-Lma-053252 Leptosphaeria maculans 35.94 5.00e-69 253.00
IUUC-Laf-053346 Loxodonta africana 28.57 4.00e-27 114.00
IUUC-Mcc-055789 Macaca mulatta 28.19 6.00e-27 114.00
IUUC-Meu-056329 Macropus eugenii 24.77 2.00e-16 79.00
IUUC-Mor-057205 Magnaporthe oryzae 33.27 1.00e-68 252.00
IUUC-Mpo-057295 Magnaporthe poae 32.32 2.00e-63 235.00
IUUC-Mtr-058217 Medicago truncatula 42.65 7.00e-08 48.90
IUUC-Mla-058849 Melampsora laricipopulina 38.57 3.00e-40 158.00
IUUC-Mga-059361 Meleagris gallopavo 30.10 3.00e-27 115.00
IUUC-Mvi-060561 Microbotryum violaceum 29.16 1.00e-48 186.00
IUUC-Mmr-061122 Microcebus murinus 28.57 5.00e-27 114.00
IUUC-Mdo-062171 Monodelphis domestica 28.38 4.00e-27 114.00
IUUC-Mmu-063952 Mus musculus 28.19 4.00e-27 114.00
IUUC-Mac-065112 Musa acuminata 33.07 6.00e-06 42.40
IUUC-Mpu-065852 Mustela putorius furo 28.57 5.00e-27 114.00
IUUC-Nfi-068539 Neosartorya fischeri 35.18 1.00e-74 272.00
IUUC-Ncr-068726 Neurospora crassa 34.81 1.00e-68 251.00
IUUC-Nle-070148 Nomascus leucogenys 25.45 4.00e-19 88.20
IUUC-Opr-070833 Ochotona princeps 36.36 9.00e-19 86.70
IUUC-Ont-071261 Oreochromis niloticus 28.77 7.00e-26 110.00
IUUC-Ocu-074133 Oryctolagus cuniculus 44.44 6.00e-16 77.40
IUUC-Oba-075700 Oryza barthii 45.76 2.00e-12 66.60
IUUC-Obr-076725 Oryza brachyantha 49.18 9.00e-08 48.50
IUUC-Ogl-077741 Oryza glaberrima 54.55 3.00e-06 43.50
IUUC-Ogu-078974 Oryza glumaepatula 54.55 4.00e-06 43.50
IUUC-Oin-079245 Oryza indica 54.55 3.00e-06 43.90
IUUC-Olo-080646 Oryza longistaminata 45.76 1.00e-12 67.00
IUUC-Ome-081286 Oryza meridionalis 54.55 8.00e-07 45.10
IUUC-Oni-082038 Oryza nivara 54.55 4.00e-06 43.50
IUUC-Opu-083654 Oryza punctata 54.55 3.00e-06 43.90
IUUC-Oru-084701 Oryza rufipogon 56.25 3.00e-06 43.50
IUUC-Osa-086159 Oryza sativa 54.55 3.00e-06 43.50
IUUC-Ola-087570 Oryzias latipes 28.63 1.00e-22 99.40
IUUC-Oga-089087 Otolemur garnettii 29.19 2.00e-23 102.00
IUUC-Oar-089534 Ovis aries 28.19 2.00e-27 115.00
IUUC-Ptr-091654 Pan troglodytes 27.23 1.00e-21 96.30
IUUC-Pan-092652 Papio anubis 28.19 5.00e-27 114.00
IUUC-Pma-094728 Petromyzon marinus 51.85 7.00e-15 74.70
IUUC-Pno-095125 Phaeosphaeria nodorum 35.55 1.00e-64 238.00
IUUC-Ppa-095369 Physcomitrella patens 49.18 7.00e-17 79.00
IUUC-Pfo-096757 Poecilia formosa 29.02 6.00e-25 107.00
IUUC-Pab-097788 Pongo abelii 28.19 6.00e-27 113.00
IUUC-Pop-099314 Populus trichocarpa 44.83 5.00e-13 68.60
IUUC-Pca-100145 Procavia capensis 27.68 2.00e-19 89.00
IUUC-Ppe-101769 Prunus persica 54.72 2.00e-16 77.40
IUUC-Pva-102965 Pteropus vampyrus 29.07 2.00e-27 115.00
IUUC-Pgr-103609 Puccinia graminis 39.59 5.00e-37 146.00
IUUC-Ptt-103940 Puccinia triticina 38.10 5.00e-32 130.00
IUUC-Pte-104095 Pyrenophora teres 33.26 7.00e-64 236.00
IUUC-Pyt-104668 Pyrenophora triticirepentis 34.76 2.00e-64 238.00
IUUC-Rno-105125 Rattus norvegicus 28.57 1.00e-26 112.00
IUUC-Sha-107066 Sarcophilus harrisii 28.38 5.00e-27 114.00
IUUC-Sja-107931 Schizosaccharomyces japonicus 34.03 6.00e-57 213.00
IUUC-Spo-108220 Schizosaccharomyces pombe 36.82 3.00e-68 250.00
IUUC-Ssl-108413 Sclerotinia sclerotiorum 39.05 4.00e-25 105.00
IUUC-Smo-109642 Selaginella moellendorffii 48.28 8.00e-16 75.50
IUUC-Sit-109755 Setaria italica 50.82 3.00e-15 73.60
IUUC-Sly-111265 Solanum lycopersicum 40.00 6.00e-07 44.70
IUUC-Stu-112464 Solanum tuberosum 37.66 3.00e-13 69.30
IUUC-Sar-113393 Sorex araneus 28.65 2.00e-16 78.60
IUUC-Sbi-114775 Sorghum bicolor 49.18 2.00e-14 70.90
IUUC-Sre-114986 Sporisorium reilianum 37.61 2.00e-42 166.00
IUUC-Ssc-115258 Sus scrofa 46.03 8.00e-15 73.90
IUUC-Tgu-117505 Taeniopygia guttata 29.85 3.00e-27 114.00
IUUC-Tru-118494 Takifugu rubripes 29.22 3.00e-28 118.00
IUUC-Tni-120174 Tetraodon nigroviridis 29.68 7.00e-29 120.00
IUUC-Tca-121349 Theobroma cacao 62.96 5.00e-06 43.10
IUUC-Tre-122191 Trichoderma reesei 34.36 8.00e-69 253.00
IUUC-Tvi-122318 Trichoderma virens 34.97 4.00e-71 260.00
IUUC-Tae-122898 Triticum aestivum 45.59 3.00e-14 70.50
IUUC-Tur-126023 Triticum urartu 44.78 1.00e-13 68.20
IUUC-Tme-126914 Tuber melanosporum 35.28 2.00e-70 258.00
IUUC-Tbe-127875 Tupaia belangeri 44.44 2.00e-14 73.20
IUUC-Ttr-129095 Tursiops truncatus 28.19 2.00e-27 115.00
IUUC-Uma-129475 Ustilago maydis 36.07 5.00e-39 154.00
IUUC-Vda-129908 Verticillium dahliae 29.67 1.00e-52 199.00
IUUC-Vpa-130696 Vicugna pacos 50.00 2.00e-14 73.60
IUUC-Vvi-131456 Vitis vinifera 55.56 4.00e-05 39.70
IUUC-Xtr-131900 Xenopus tropicalis 29.02 3.00e-26 111.00
IUUC-Xma-133124 Xiphophorus maculatus 29.46 3.00e-25 108.00
IUUC-Yli-134682 Yarrowia lipolytica 37.58 7.00e-74 269.00
IUUC-Zma-135288 Zea mays 45.07 2.00e-15 73.90
Created Date 25-Jun-2017

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