iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-004255

Ensembl Protein ID

ENSACAP00000008523.3

UniProt Accession

G1KI30; G1KI30_ANOCA

Protein Name

Tyrosine-protein kinase

Gene Name

YES1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000008639.3	ENSACAT00000008706.3	ENSACAP00000008523.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.20e-15	57.2	106	161

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++d+L++kkG+  ++i  ++++++W+++ + ++gk+G +P+n+v+ ++
   Q: 106  FVALYDYEARTTDDLSFKKGERFQII--NNTEGDWWEARSIATGKSGYIPSNYVAPAD 161
           789***********************..8999**********************9875 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MKSLLLQSLS ERTMGCIKSK EDKSPTMKYG TENPDPITSH ASHYGSDSAQ TNQTPTTKGS 60
SVNFNSHSIT PFGGPSGVTP FGGASSSFPS VPCPYPSGLT GGVTIFVALY DYEARTTDDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTAAAAATA ACCTCTTTTC TCATTAAAGA GAAACAACCT CTCTCCTGAT ATTTATTTGT 60
TTCCAATTGA AGGATTACAC TGAGAAGCGG AAATTGAAAG CAATGCATTT TCTTTCCTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0015758--P:glucose transport
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002374	Ailuropoda melanoleuca	91.70	0.00e+00	1015.00
IUUC-Apl-004032	Anas platyrhynchos	94.64	0.00e+00	1055.00
IUUC-Ame-010954	Astyanax mexicanus	87.57	0.00e+00	1000.00
IUUC-Bta-013503	Bos taurus	90.94	0.00e+00	983.00
IUUC-Bdi-014324	Brachypodium distachyon	35.89	8.00e-23	102.00
IUUC-Cja-019694	Callithrix jacchus	90.61	0.00e+00	996.00
IUUC-Cfa-020402	Canis familiaris	91.50	0.00e+00	1014.00
IUUC-Cpo-022506	Cavia porcellus	91.31	0.00e+00	1006.00
IUUC-Csa-023713	Chlorocebus sabaeus	90.79	0.00e+00	1001.00
IUUC-Cin-025390	Ciona intestinalis	72.23	0.00e+00	667.00
IUUC-Csv-026029	Ciona savignyi	64.80	0.00e+00	644.00
IUUC-Dre-027978	Danio rerio	85.97	0.00e+00	964.00
IUUC-Dno-029897	Dasypus novemcinctus	89.63	0.00e+00	903.00
IUUC-Dor-030202	Dipodomys ordii	95.80	0.00e+00	917.00
IUUC-Eca-034157	Equus caballus	90.57	0.00e+00	1003.00
IUUC-Eeu-034950	Erinaceus europaeus	86.08	9.00e-170	588.00
IUUC-Fca-036233	Felis catus	91.68	0.00e+00	1047.00
IUUC-Fal-037461	Ficedula albicollis	94.45	0.00e+00	1077.00
IUUC-Gmo-038929	Gadus morhua	82.88	0.00e+00	909.00
IUUC-Gga-041107	Gallus gallus	94.64	0.00e+00	1056.00
IUUC-Gac-042321	Gasterosteus aculeatus	84.67	0.00e+00	947.00
IUUC-Hsa-047010	Homo sapiens	90.98	0.00e+00	1006.00
IUUC-Lch-050239	Latimeria chalumnae	91.13	0.00e+00	1033.00
IUUC-Lpe-051166	Leersia perrieri	34.98	1.00e-22	101.00
IUUC-Loc-052314	Lepisosteus oculatus	88.99	0.00e+00	956.00
IUUC-Laf-053517	Loxodonta africana	91.13	0.00e+00	986.00
IUUC-Mcc-055626	Macaca mulatta	90.79	0.00e+00	1000.00
IUUC-Mga-059310	Meleagris gallopavo	94.64	0.00e+00	1056.00
IUUC-Mmr-061652	Microcebus murinus	91.31	0.00e+00	1010.00
IUUC-Mdo-062963	Monodelphis domestica	90.39	0.00e+00	1016.00
IUUC-Mmu-064128	Mus musculus	91.50	0.00e+00	1028.00
IUUC-Mac-064539	Musa acuminata	28.57	6.00e-18	86.30
IUUC-Mpu-065906	Mustela putorius furo	91.87	0.00e+00	1017.00
IUUC-Mlu-067035	Myotis lucifugus	90.99	0.00e+00	1007.00
IUUC-Nle-069041	Nomascus leucogenys	86.56	0.00e+00	944.00
IUUC-Opr-070299	Ochotona princeps	82.81	0.00e+00	887.00
IUUC-Ont-072337	Oreochromis niloticus	85.74	0.00e+00	965.00
IUUC-Oan-072997	Ornithorhynchus anatinus	97.59	0.00e+00	938.00
IUUC-Ocu-074171	Oryctolagus cuniculus	91.50	0.00e+00	1016.00
IUUC-Oba-075994	Oryza barthii	34.98	6.00e-21	96.30
IUUC-Ola-086619	Oryzias latipes	83.67	0.00e+00	961.00
IUUC-Oga-087957	Otolemur garnettii	90.94	0.00e+00	998.00
IUUC-Oar-089670	Ovis aries	90.02	0.00e+00	1000.00
IUUC-Ptr-091352	Pan troglodytes	90.98	0.00e+00	1006.00
IUUC-Pan-092202	Papio anubis	90.79	0.00e+00	1000.00
IUUC-Psi-093310	Pelodiscus sinensis	93.26	0.00e+00	1079.00
IUUC-Pma-094232	Petromyzon marinus	85.81	0.00e+00	862.00
IUUC-Pfo-096137	Poecilia formosa	83.73	0.00e+00	946.00
IUUC-Pab-098301	Pongo abelii	95.67	0.00e+00	947.00
IUUC-Pva-102592	Pteropus vampyrus	87.06	0.00e+00	949.00
IUUC-Rno-105544	Rattus norvegicus	91.31	0.00e+00	996.00
IUUC-Sar-113364	Sorex araneus	87.25	0.00e+00	937.00
IUUC-Tgu-117380	Taeniopygia guttata	94.45	0.00e+00	1077.00
IUUC-Tru-117594	Takifugu rubripes	85.14	0.00e+00	959.00
IUUC-Tni-120433	Tetraodon nigroviridis	84.63	0.00e+00	949.00
IUUC-Ttr-128893	Tursiops truncatus	90.76	0.00e+00	1004.00
IUUC-Vpa-130060	Vicugna pacos	91.13	0.00e+00	1003.00
IUUC-Xtr-132322	Xenopus tropicalis	90.74	0.00e+00	1031.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence