iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064409

UUCD1 version

UUC-MuM-00950

Ensembl Protein ID

ENSMUSP00000059715.2

UniProt Accession

Q9DAH2; Q9WTN2; ZNRF4_MOUSE

Genbank Protein ID

BAA77407.1; BAB24269.1; AAI40987.1

Protein Name

E3 ubiquitin-protein ligase ZNRF4; RING-type E3 ubiquitin transferase ZNRF4; Sperizin; Zinc/RING finger protein 4

Genbank Nucleotide ID

AB016984; AK005843; CT485788

Gene Name

Znrf4; Spzn

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000044526.2	ENSMUST00000052211.2	ENSMUSP00000059715.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.50e-08	36.2	209	252

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiCl+d+++g  +++lpC H++h  C+  w     s   + +CPlC+
   Q: 209  CAICLDDYEEGerLKILPCAHAYHCRCIDPW----FSRAAQRSCPLCK 252
           ********55544999***************....999*********7 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase which specifically induces ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (By similarity). Could have a role in spermatogenesis (Probable).

Protein Sequence
(Fasta)

MARFAWTRVA PVALVTFWLV LSLSPTDAQV NLSSVDFLDL PALLGVPVDP KRARGYLLVA 60
RPADACHAIE GPWPDNHSLD PLVLVRPLGC SWEQTGRRAQ RAGATAASVG PEAPGQLREF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGGGCTG AACTGTCGCC GGGAGCCTCT TCCGCTTGAG GCCCCCGAGT TCGGCCACAG 60
TAGGCGCCGC TCCCACCCGG CCACGGGATC CCCGCGTGGC TCCGGAGATG CCCGAGGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

mmu:20834

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001654	Ailuropoda melanoleuca	50.29	1.00e-70	260.00
IUUC-Bta-012572	Bos taurus	45.93	1.00e-55	210.00
IUUC-Cja-019445	Callithrix jacchus	55.31	8.00e-62	231.00
IUUC-Cfa-020828	Canis familiaris	58.12	6.00e-73	268.00
IUUC-Csa-023281	Chlorocebus sabaeus	50.53	9.00e-60	224.00
IUUC-Ete-032610	Echinops telfairi	49.30	1.00e-60	227.00
IUUC-Ggo-045531	Gorilla gorilla	50.31	3.00e-61	229.00
IUUC-Hsa-045802	Homo sapiens	52.46	1.00e-62	233.00
IUUC-Itr-048891	Ictidomys tridecemlineatus	55.86	5.00e-57	214.00
IUUC-Laf-053469	Loxodonta africana	54.09	8.00e-73	266.00
IUUC-Mcc-054662	Macaca mulatta	52.13	1.00e-60	227.00
IUUC-Mpu-066553	Mustela putorius furo	53.94	6.00e-69	254.00
IUUC-Ptr-090842	Pan troglodytes	49.47	3.00e-60	225.00
IUUC-Pan-092278	Papio anubis	52.02	1.00e-60	226.00
IUUC-Pab-097537	Pongo abelii	51.48	5.00e-60	224.00
IUUC-Rno-104830	Rattus norvegicus	91.08	6.00e-125	440.00
IUUC-Sce-106307	Saccharomyces cerevisiae	42.31	6.00e-06	44.70
IUUC-Stu-111987	Solanum tuberosum	41.43	8.00e-12	64.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence