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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Mmu-063929
Ensembl Protein ID ENSMUSP00000105383.2
UniProt Accession P54726; B7ZNQ1; RD23A_MOUSE
Genbank Protein ID CAA63145.1; AAI45373.1; EDL10960.1
Protein Name UV excision repair protein RAD23 homolog A
Genbank Nucleotide ID X92410; BC145372; CH466525
Gene Name Rad23a; Mhr23a
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000003813.15 ENSMUST00000144675.7 ENSMUSP00000114431.1
ENSMUSG00000003813.15 ENSMUST00000003911.12 ENSMUSP00000003911.6
ENSMUSG00000003813.15 ENSMUST00000109761.8 ENSMUSP00000105383.2
ENSMUSG00000003813.15 ENSMUST00000128035.1 ENSMUSP00000115664.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 15336624
ULD/UDP/UBQ/UBQ_PIM UBQ_PIM 15336624
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 1.40e-20 73.8 162 201
ULD/UDP/UBQ/UBQ_PIM 3.20e-26 92.2 3 80
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLldg 41
    e+e +l ++++MG++re+++ aLra++nn+ +AveyLl+g
   Q: 162 EYETMLTEIMSMGYERERVVAALRASYNNPHRAVEYLLTG 201
    7899**********************************97 PP
   


   ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesg...vppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
    +++t+ktl++++f++++++d+tv+ lKeki++e+g +p++ qkLIyaGkiL+Dd +++e++i+++++v+++v+k+k
   Q: 3 VTITLKTLQQQTFKIRMEPDETVKVLKEKIEAEKGrdaFPVAGQKLIYAGKILSDDVPIKEYHIDEKNFVVVMVTKAK 80
    68*************************************************************************987 PP
   

Organism Mus musculus
Functional Description
(View)

Functional Description



     Involved in nucleotide excision repair and is thought to be functional equivalent for Rad23b in global genome nucleotide excision repair (GG-NER) by association with Xpc. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize Xpc. Reported differences to Rad23b in regard to NER activity and Xpc stabilization are probably due to differences in expression levels with Rad23a being much less expressed than Rad23b.
Involved in nucleotide excision repair and is thought to be functional equivalent for Rad23b in global genome nucleotide excision repair (GG-NER) by association with Xpc. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize Xpc. Reported differences to Rad23b in regard to NER activity and Xpc stabilization are probably due to differences in expression levels with Rad23a being much less expressed than Rad23b.
Protein Sequence
(Fasta)
MAVTITLKTL QQQTFKIRME PDETVKVLKE KIEAEKGRDA FPVAGQKLIY AGKILSDDVP 60
IKEYHIDEKN FVVVMVTKAK AGQGIPAPPE ASPTAVPEPS TPFPPVLASG MSHPPPTSRE 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mmu-063929|UBD,UBA;ULD,UBQ_PIM|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAAGTGCTT GGCGCGGCGC GGCTGGGCGC TAAGATGGCG GCGGCGTGAG TTGCATGTAG 60
TACGAGGATC CCGGGGCTGC CGCATTGCTC CGGCCCCGCC ATGGCCGTCA CCATCACCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-063929|UBD,UBA;ULD,UBQ_PIM|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR004806--Rad23
IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR015360--XPC-bd

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin
PF09280--XPC-binding

PRINTS

PR01839--RAD23PROTEIN

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005815--C:microtubule organizing center
GO:0005654--C:nucleoplasm
GO:0000502--C:proteasome complex
GO:0003684--F:damaged DNA binding
GO:0031593--F:polyubiquitin binding
GO:1990381--F:ubiquitin-specific protease binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006289--P:nucleotide-excision repair
GO:0045070--P:positive regulation of viral genome replication
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process

KEGG mmu:19358
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000770 Aegilops tauschii 38.52 8.00e-33 134.00
IUUC-Aml-001515 Ailuropoda melanoleuca 89.69 1.00e-140 493.00
IUUC-Atr-003116 Amborella trichopoda 41.15 8.00e-31 127.00
IUUC-Aca-004704 Anolis carolinensis 80.40 3.00e-114 404.00
IUUC-Aly-006159 Arabidopsis lyrata 35.44 1.00e-49 189.00
IUUC-Ago-007830 Ashbya gossypii 29.06 2.00e-15 76.60
IUUC-Ani-009460 Aspergillus nidulans 39.20 3.00e-29 122.00
IUUC-Bta-012377 Bos taurus 92.84 1.00e-145 508.00
IUUC-Bci-013933 Botrytis cinerea 35.43 5.00e-22 98.60
IUUC-Bra-016970 Brassica rapa 35.14 5.00e-45 174.00
IUUC-Cja-018946 Callithrix jacchus 93.39 4.00e-142 497.00
IUUC-Cfa-020577 Canis familiaris 93.94 5.00e-151 527.00
IUUC-Cpo-021850 Cavia porcellus 91.46 1.00e-165 575.00
IUUC-Csa-023183 Chlorocebus sabaeus 94.49 1.00e-151 528.00
IUUC-Dre-027581 Danio rerio 51.58 4.00e-72 265.00
IUUC-Dno-030017 Dasypus novemcinctus 90.40 2.00e-128 451.00
IUUC-Dor-030358 Dipodomys ordii 84.89 3.00e-127 448.00
IUUC-Eca-033599 Equus caballus 90.56 1.00e-133 469.00
IUUC-Fca-036051 Felis catus 93.11 4.00e-149 520.00
IUUC-Gmo-038528 Gadus morhua 58.29 1.00e-90 326.00
IUUC-Gga-040133 Gallus gallus 87.91 3.00e-76 278.00
IUUC-Ggo-045084 Gorilla gorilla 94.77 7.00e-152 530.00
IUUC-Hsa-046614 Homo sapiens 94.77 2.00e-152 531.00
IUUC-Itr-047875 Ictidomys tridecemlineatus 95.32 5.00e-170 590.00
IUUC-Lch-050563 Latimeria chalumnae 62.91 3.00e-103 368.00
IUUC-Laf-054589 Loxodonta africana 93.66 4.00e-144 503.00
IUUC-Mcc-055860 Macaca mulatta 94.49 1.00e-151 528.00
IUUC-Meu-056459 Macropus eugenii 94.88 2.00e-106 378.00
IUUC-Mmr-060819 Microcebus murinus 94.21 8.00e-162 562.00
IUUC-Mdo-062742 Monodelphis domestica 84.42 1.00e-143 502.00
IUUC-Mac-065180 Musa acuminata 34.27 8.00e-43 167.00
IUUC-Mpu-066684 Mustela putorius furo 93.94 7.00e-154 536.00
IUUC-Mlu-067787 Myotis lucifugus 92.01 5.00e-148 517.00
IUUC-Nle-069846 Nomascus leucogenys 83.11 5.00e-131 460.00
IUUC-Oan-073572 Ornithorhynchus anatinus 79.06 4.00e-130 457.00
IUUC-Ocu-074968 Oryctolagus cuniculus 91.24 1.00e-102 367.00
IUUC-Oba-074972 Oryza barthii 34.41 1.00e-45 176.00
IUUC-Olo-080559 Oryza longistaminata 33.42 4.00e-45 175.00
IUUC-Oni-082812 Oryza nivara 34.41 2.00e-45 176.00
IUUC-Oga-089075 Otolemur garnettii 93.66 9.00e-145 506.00
IUUC-Oar-090387 Ovis aries 92.56 6.00e-143 500.00
IUUC-Ptr-090912 Pan troglodytes 91.18 1.00e-141 495.00
IUUC-Pan-092140 Papio anubis 94.49 3.00e-151 527.00
IUUC-Psi-093347 Pelodiscus sinensis 87.50 3.00e-62 231.00
IUUC-Pfo-096607 Poecilia formosa 63.97 2.00e-96 345.00
IUUC-Pab-097738 Pongo abelii 90.91 1.00e-143 502.00
IUUC-Pca-100348 Procavia capensis 90.93 8.00e-142 496.00
IUUC-Pva-102412 Pteropus vampyrus 93.66 3.00e-152 531.00
IUUC-Pgr-103618 Puccinia graminis 37.45 5.00e-25 108.00
IUUC-Ptt-103717 Puccinia triticina 50.76 2.00e-24 107.00
IUUC-Rno-105569 Rattus norvegicus 96.97 1.00e-153 535.00
IUUC-Sha-106918 Sarcophilus harrisii 85.42 5.00e-131 461.00
IUUC-Sja-107851 Schizosaccharomyces japonicus 38.87 8.00e-33 134.00
IUUC-Spo-108298 Schizosaccharomyces pombe 35.00 1.00e-46 180.00
IUUC-Smo-109518 Selaginella moellendorffii 38.00 1.00e-31 130.00
IUUC-Sit-109813 Setaria italica 35.68 1.00e-46 180.00
IUUC-Sly-111480 Solanum lycopersicum 35.86 5.00e-53 201.00
IUUC-Ssc-115460 Sus scrofa 93.11 7.00e-150 523.00
IUUC-Tsy-119385 Tarsius syrichta 76.47 6.00e-69 253.00
IUUC-Tni-120493 Tetraodon nigroviridis 71.16 1.00e-73 270.00
IUUC-Tca-121594 Theobroma cacao 35.01 3.00e-50 192.00
IUUC-Tae-125354 Triticum aestivum 38.11 3.00e-33 135.00
IUUC-Tur-126610 Triticum urartu 38.52 3.00e-33 136.00
IUUC-Tbe-127603 Tupaia belangeri 84.67 6.00e-55 207.00
IUUC-Ttr-129232 Tursiops truncatus 99.53 6.00e-105 374.00
Created Date 25-Jun-2017

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