iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID	PINA	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	2.30e-17	63.5	30	93

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgklden 68
           +Dv +vv+g  f+ah++vLaasSs+F++lf++    s+ +  ve+   vqp++f+++l F+Ytg+l++n
   Q: 30   CDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SR-SAVVELPAaVQPQSFQQILTFCYTGRLSMN 93
           8*****************************55....77.899****66******************987 PP

Organism

Rattus norvegicus

Functional Description
(View)

Functions as a transcriptional repressor. Isoform 1 is a stronger transcriptional repressor than isoform 2. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.

Protein Sequence
(Fasta)

MAQTLQMEIP NFGNSILECL NEQRLQGLYC DVSVVVKGHA FKAHRAVLAA SSSYFRDLFN 60
SSRSAVVELP AAVQPQSFQQ ILTFCYTGRL SMNMGDQFLL IYTAGFLQIQ EIMEKGTEFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGCGGAGG CCGCAGAGGC GGAGGCCGAG GCCGAGGCGC AGGGGGGCGC GCCCCGGGCC 60
CAGGCCCGGC CCCAGCTGCC GCTGCGGAGC CCGCCGGGAG GCCCCGGAGC GCGGCCACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation

Interpro

IPR018379--BEN_domain
IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ

PROSITE

PS51457--BEN
PS50097--BTB

Pfam

PF10523--BEN
PF00651--BTB

SMART

SM01025--BEN
SM00225--BTB

Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0008284--P:positive regulation of cell proliferation
GO:0051260--P:protein homooligomerization
GO:0006351--P:transcription, DNA-templated

KEGG

rno:171454

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001349	Ailuropoda melanoleuca	85.71	0.00e+00	838.00
IUUC-Aca-005131	Anolis carolinensis	87.41	2.00e-127	449.00
IUUC-Ame-011526	Astyanax mexicanus	67.76	0.00e+00	636.00
IUUC-Bta-012628	Bos taurus	85.82	0.00e+00	830.00
IUUC-Cfa-021135	Canis familiaris	82.90	0.00e+00	839.00
IUUC-Cpo-022362	Cavia porcellus	86.11	0.00e+00	867.00
IUUC-Csa-023358	Chlorocebus sabaeus	85.85	0.00e+00	868.00
IUUC-Dre-028574	Danio rerio	67.40	0.00e+00	641.00
IUUC-Dno-029850	Dasypus novemcinctus	80.62	0.00e+00	764.00
IUUC-Dor-030712	Dipodomys ordii	91.76	0.00e+00	751.00
IUUC-Ete-032755	Echinops telfairi	74.64	2.00e-157	548.00
IUUC-Eca-034373	Equus caballus	84.62	0.00e+00	842.00
IUUC-Fca-035796	Felis catus	87.18	0.00e+00	853.00
IUUC-Fox-037719	Fusarium oxysporum	30.30	2.00e-07	50.10
IUUC-Gmo-038551	Gadus morhua	69.96	6.00e-90	324.00
IUUC-Gac-041350	Gasterosteus aculeatus	71.98	1.00e-93	337.00
IUUC-Ggo-045146	Gorilla gorilla	85.66	0.00e+00	865.00
IUUC-Hsa-046990	Homo sapiens	85.66	0.00e+00	865.00
IUUC-Itr-048458	Ictidomys tridecemlineatus	91.46	0.00e+00	909.00
IUUC-Lch-049952	Latimeria chalumnae	74.47	0.00e+00	763.00
IUUC-Laf-054517	Loxodonta africana	89.71	0.00e+00	872.00
IUUC-Mcc-055004	Macaca mulatta	77.97	0.00e+00	750.00
IUUC-Meu-056774	Macropus eugenii	86.21	0.00e+00	826.00
IUUC-Mmr-061098	Microcebus murinus	89.63	2.00e-135	476.00
IUUC-Mdo-062959	Monodelphis domestica	84.60	0.00e+00	835.00
IUUC-Mmu-064296	Mus musculus	98.64	0.00e+00	910.00
IUUC-Mpu-066424	Mustela putorius furo	91.82	2.00e-137	482.00
IUUC-Mlu-067831	Myotis lucifugus	88.78	0.00e+00	873.00
IUUC-Nle-069864	Nomascus leucogenys	81.13	0.00e+00	804.00
IUUC-Opr-070926	Ochotona princeps	78.84	1.00e-144	506.00
IUUC-Ont-071927	Oreochromis niloticus	66.04	8.00e-174	603.00
IUUC-Oan-073318	Ornithorhynchus anatinus	82.73	1.00e-173	602.00
IUUC-Ocu-074921	Oryctolagus cuniculus	61.01	4.00e-44	172.00
IUUC-Ola-086614	Oryzias latipes	70.23	2.00e-92	333.00
IUUC-Oga-088564	Otolemur garnettii	82.70	0.00e+00	768.00
IUUC-Oar-090443	Ovis aries	87.13	1.00e-134	473.00
IUUC-Ptr-090668	Pan troglodytes	85.66	0.00e+00	865.00
IUUC-Pan-092655	Papio anubis	85.66	0.00e+00	865.00
IUUC-Pfo-096632	Poecilia formosa	72.37	5.00e-94	338.00
IUUC-Pab-098490	Pongo abelii	85.66	0.00e+00	865.00
IUUC-Pva-102597	Pteropus vampyrus	88.78	0.00e+00	884.00
IUUC-Sha-107275	Sarcophilus harrisii	85.05	0.00e+00	766.00
IUUC-Sar-113571	Sorex araneus	79.83	8.00e-148	516.00
IUUC-Ssc-115494	Sus scrofa	85.31	0.00e+00	827.00
IUUC-Tru-118779	Takifugu rubripes	83.16	2.00e-90	326.00
IUUC-Tni-120653	Tetraodon nigroviridis	71.55	4.00e-86	311.00
IUUC-Ttr-128342	Tursiops truncatus	84.79	0.00e+00	864.00
IUUC-Vpa-130746	Vicugna pacos	77.00	3.00e-82	299.00
IUUC-Xtr-132831	Xenopus tropicalis	68.92	1.00e-172	599.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence