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Tag Content
UUCD2 ID IUUC-Bta-013345
UUCD1 version UUC-BoT-00971
Ensembl Protein ID ENSBTAP00000038956.2
UniProt Accession Q4U5R4; A5D9G2; Q3T0F8; RN114_BOVIN
Genbank Protein ID AAY33866.1; AAI02413.1; ABQ13021.1
Protein Name E3 ubiquitin-protein ligase RNF114; RING finger protein 114; RING-type E3 ubiquitin transferase RNF114; Zinc finger protein 313
Genbank Nucleotide ID DQ010409; BC102412; BT030581
Gene Name RNF114; ZNF313
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000027317.2 ENSBTAT00000039156.2 ENSBTAP00000038956.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 1.10e-07 32.0 28 74
E3 activity/RING/RING 2.00e-06 28.3 31 70
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box

   S: 5    eflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplt 51
    f Cp+ le+ + Pv +p+G+++ ++++++l+ ++ c v+r+ l+
   Q: 28 RFTCPVCLEVYEKPVQVPCGHVFCSACLQECLKPKKPVCGVCRSALA 74
    69*****************************************9986 PP
   


   E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
    C++Cle +++ p+ +pCgHvf+ Clq ++ k+ C +Cr
   Q: 31 CPVCLEVYEK-PVQVPCGHVFCSACLQEC-----LKPKKPVCGVCR 70
    **********.999************555.....499999*****8 PP
   

Organism Bos taurus
Functional Description
(View)

Functional Description



     E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.
E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.
Protein Sequence
(Fasta)
MAAQAQAPAR DGGAQLAGPA AEADPLGRFT CPVCLEVYEK PVQVPCGHVF CSACLQECLK 60
PKKPVCGVCR SALAPGVRAV ELERQIESTE TSCHGCRKNF FLSKIRAHVA TCSKYQNYIM 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Bta-013345|E3,U-box;E3,RING|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTGAGGCGC GGCGGTCCGC GGCAGCAAGA TGGCGGCGCA GGCGCAGGCC CCGGCCCGTG 60
ATGGTGGTGC GCAGCTGGCA GGACCTGCGG CGGAGGCCGA CCCCCTGGGC CGCTTCACGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Bta-013345|E3,U-box;E3,RING|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0744--Spermatogenesis
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19
PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0030154--P:cell differentiation
GO:0007275--P:multicellular organism development
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0007283--P:spermatogenesis

KEGG bta:513479
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002315 Ailuropoda melanoleuca 95.65 1.00e-130 458.00
IUUC-Apl-004036 Anas platyrhynchos 75.69 3.00e-82 296.00
IUUC-Aca-004569 Anolis carolinensis 70.74 2.00e-98 351.00
IUUC-Cja-019919 Callithrix jacchus 93.48 2.00e-127 447.00
IUUC-Cfa-021164 Canis familiaris 93.91 9.00e-128 448.00
IUUC-Cpo-022051 Cavia porcellus 84.35 6.00e-116 409.00
IUUC-Csa-023956 Chlorocebus sabaeus 95.17 2.00e-118 418.00
IUUC-Dre-027499 Danio rerio 54.23 4.00e-68 250.00
IUUC-Dno-029437 Dasypus novemcinctus 93.97 2.00e-124 437.00
IUUC-Dor-030428 Dipodomys ordii 79.57 8.00e-105 372.00
IUUC-Ete-032855 Echinops telfairi 76.29 5.00e-91 326.00
IUUC-Eca-034236 Equus caballus 96.69 5.00e-104 369.00
IUUC-Eeu-034875 Erinaceus europaeus 97.34 3.00e-109 387.00
IUUC-Fca-036017 Felis catus 97.64 2.00e-124 437.00
IUUC-Fal-037133 Ficedula albicollis 75.69 3.00e-84 304.00
IUUC-Gga-040752 Gallus gallus 70.22 3.00e-95 340.00
IUUC-Ggo-044654 Gorilla gorilla 93.13 2.00e-72 264.00
IUUC-Hsa-046280 Homo sapiens 95.65 8.00e-119 419.00
IUUC-Itr-048594 Ictidomys tridecemlineatus 95.16 3.00e-104 370.00
IUUC-Lch-050028 Latimeria chalumnae 63.33 2.00e-80 291.00
IUUC-Loc-051797 Lepisosteus oculatus 59.90 6.00e-71 259.00
IUUC-Laf-054248 Loxodonta africana 94.48 4.00e-103 366.00
IUUC-Mcc-054724 Macaca mulatta 95.17 2.00e-118 418.00
IUUC-Meu-056464 Macropus eugenii 59.12 2.00e-52 197.00
IUUC-Mga-059403 Meleagris gallopavo 72.14 5.00e-61 226.00
IUUC-Mmr-061582 Microcebus murinus 97.24 1.00e-105 374.00
IUUC-Mdo-062106 Monodelphis domestica 78.83 2.00e-101 361.00
IUUC-Mmu-064176 Mus musculus 89.47 1.00e-114 405.00
IUUC-Mpu-066083 Mustela putorius furo 95.22 3.00e-130 457.00
IUUC-Mlu-067060 Myotis lucifugus 94.69 2.00e-117 414.00
IUUC-Nle-069353 Nomascus leucogenys 95.17 6.00e-109 386.00
IUUC-Opr-070916 Ochotona princeps 87.39 7.00e-120 422.00
IUUC-Ont-072284 Oreochromis niloticus 57.69 3.00e-73 267.00
IUUC-Oan-072858 Ornithorhynchus anatinus 75.14 6.00e-82 296.00
IUUC-Ocu-074471 Oryctolagus cuniculus 97.03 3.00e-118 417.00
IUUC-Ola-087569 Oryzias latipes 54.13 6.00e-73 266.00
IUUC-Olu-087618 Ostreococcus lucimarinus 40.91 2.00e-08 52.80
IUUC-Oga-089164 Otolemur garnettii 97.16 4.00e-123 433.00
IUUC-Oar-089436 Ovis aries 98.26 4.00e-135 473.00
IUUC-Ptr-090945 Pan troglodytes 95.65 8.00e-119 419.00
IUUC-Pan-092765 Papio anubis 95.17 2.00e-118 418.00
IUUC-Psi-093593 Pelodiscus sinensis 76.06 3.00e-65 239.00
IUUC-Pfo-096157 Poecilia formosa 55.19 1.00e-70 259.00
IUUC-Pab-098509 Pongo abelii 94.74 3.00e-119 420.00
IUUC-Pca-100293 Procavia capensis 90.10 8.00e-107 379.00
IUUC-Pva-102556 Pteropus vampyrus 92.17 4.00e-125 439.00
IUUC-Rno-105634 Rattus norvegicus 88.60 2.00e-112 398.00
IUUC-Sha-107052 Sarcophilus harrisii 77.88 1.00e-91 328.00
IUUC-Sar-113680 Sorex araneus 92.82 2.00e-92 330.00
IUUC-Ssc-115451 Sus scrofa 95.58 4.00e-104 369.00
IUUC-Tgu-116515 Taeniopygia guttata 74.32 8.00e-83 298.00
IUUC-Tru-117712 Takifugu rubripes 53.95 3.00e-73 267.00
IUUC-Tsy-119419 Tarsius syrichta 96.69 1.00e-104 371.00
IUUC-Tni-119774 Tetraodon nigroviridis 54.82 2.00e-72 264.00
IUUC-Tbe-127924 Tupaia belangeri 91.56 8.00e-119 419.00
IUUC-Ttr-128721 Tursiops truncatus 94.35 2.00e-129 454.00
IUUC-Vpa-130175 Vicugna pacos 71.18 2.00e-87 314.00
IUUC-Xtr-131851 Xenopus tropicalis 56.31 3.00e-72 264.00
Created Date 25-Jun-2017

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