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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Hsa-046189
Ensembl Protein ID ENSP00000360672.2
UniProt Accession Q9BYG5; A2A2A7; Q9Y510; PAR6B_HUMAN
Genbank Protein ID BAB40756.1; BAF92013.1; AAH60847.1
Protein Name Partitioning defective 6 homolog beta
Genbank Nucleotide ID AB044555; AB178534; AL031680
Gene Name PARD6B; PAR6B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000124171.8 ENST00000371610.6 ENSP00000360672.2
ENSG00000124171.8 ENST00000396039.1 ENSP00000379354.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UFD/PB1 PB1 17726178
Classification
Family E-value Score Start End
ULD/UDP/UFD/PB1 4.80e-22 79.6 16 96
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UFD/PB1

   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelknsevalkYeDedGDlvtlksDedldkavsllaskksllrlliqkk 84
    t++vk+++++e+r+f+l+++kpgkfe+++ +++++++++n +v ++Y+D +GDl+++++D++++kavs ++++llr++iqkk
   Q: 16 TMEVKSKFGAEFRRFSLERSKPGKFEEFYGLLQHVHKIPNVDVLVGYADIHGDLLPINNDDNYHKAVS---TANPLLRIFIQKK 96
    589*****************************************************************...9**********86 PP
   

Organism Homo sapiens
Functional Description
(View)

Functional Description



     Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound ARHQ/TC10. Interacts with MPP5 (By similarity). Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with ALS2CR19. Interacts with ECT2.
Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound ARHQ/TC10. Interacts with MPP5 (By similarity). Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with ALS2CR19. Interacts with ECT2.
Protein Sequence
(Fasta)
MNRSHRHGAG SGCLGTMEVK SKFGAEFRRF SLERSKPGKF EEFYGLLQHV HKIPNVDVLV 60
GYADIHGDLL PINNDDNYHK AVSTANPLLR IFIQKKEEAD YSAFGTDTLI KKKNVLTNVL 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-046189|ULD,PB1|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGGGAGGGA GCTGCTTCCC CGCCTGCCGC GCCACCAGTC CGACCCTCGG TCCCGCCGTG 60
TGAGCAGCTG GTGGAGTGGA GCTCAGCGCG GACGCCGGAG CTGCGGCCGC CCCCTCTGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046189|ULD,PB1|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0796--Tight junction

Interpro

IPR000270--PB1_dom
IPR001478--PDZ

PROSITE

PS51745--PB1
PS50106--PDZ

Pfam

PF00564--PB1
PF00595--PDZ

SMART

SM00666--PB1
SM00228--PDZ

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005923--C:bicellular tight junction
GO:0005938--C:cell cortex
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0007409--P:axonogenesis
GO:0070830--P:bicellular tight junction assembly
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0007043--P:cell-cell junction assembly
GO:0007163--P:establishment or maintenance of cell polarity
GO:0006461--P:protein complex assembly
GO:0030334--P:regulation of cell migration

KEGG hsa:84612
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000216 Aegilops tauschii 35.90 1.10e-01 29.60
IUUC-Aml-002050 Ailuropoda melanoleuca 97.04 0.00e+00 687.00
IUUC-Apl-003829 Anas platyrhynchos 80.75 5.00e-157 546.00
IUUC-Aca-004451 Anolis carolinensis 84.78 2.00e-129 454.00
IUUC-Ame-011428 Astyanax mexicanus 80.31 8.00e-120 423.00
IUUC-Bta-013165 Bos taurus 85.25 6.00e-178 616.00
IUUC-Cja-018719 Callithrix jacchus 97.85 0.00e+00 711.00
IUUC-Cfa-020802 Canis familiaris 83.11 1.00e-158 552.00
IUUC-Cpo-021864 Cavia porcellus 96.29 0.00e+00 631.00
IUUC-Csa-023766 Chlorocebus sabaeus 98.39 0.00e+00 697.00
IUUC-Cho-024608 Choloepus hoffmanni 94.09 0.00e+00 679.00
IUUC-Cin-025213 Ciona intestinalis 53.28 1.00e-71 263.00
IUUC-Csv-025825 Ciona savignyi 55.14 2.00e-71 262.00
IUUC-Dre-028158 Danio rerio 80.31 2.00e-116 412.00
IUUC-Dno-030052 Dasypus novemcinctus 96.51 0.00e+00 679.00
IUUC-Dor-030924 Dipodomys ordii 87.63 2.00e-177 615.00
IUUC-Dme-031864 Drosophila melanogaster 62.34 5.00e-74 271.00
IUUC-Ete-032876 Echinops telfairi 79.57 1.00e-151 529.00
IUUC-Eca-033894 Equus caballus 94.86 0.00e+00 639.00
IUUC-Eeu-034442 Erinaceus europaeus 89.78 7.00e-178 616.00
IUUC-Fca-035602 Felis catus 96.29 0.00e+00 634.00
IUUC-Fal-037422 Ficedula albicollis 83.71 3.00e-144 504.00
IUUC-Fso-038312 Fusarium solani 32.61 2.10e+00 27.70
IUUC-Gga-040289 Gallus gallus 83.33 4.00e-156 544.00
IUUC-Gac-041720 Gasterosteus aculeatus 84.52 6.00e-117 414.00
IUUC-Ggo-045502 Gorilla gorilla 100.00 0.00e+00 707.00
IUUC-Itr-048930 Ictidomys tridecemlineatus 95.43 0.00e+00 640.00
IUUC-Lch-050235 Latimeria chalumnae 73.67 3.00e-142 498.00
IUUC-Loc-052534 Lepisosteus oculatus 69.47 3.00e-132 464.00
IUUC-Laf-053439 Loxodonta africana 93.55 0.00e+00 667.00
IUUC-Mcc-054945 Macaca mulatta 97.05 0.00e+00 684.00
IUUC-Meu-056703 Macropus eugenii 89.71 2.00e-172 597.00
IUUC-Mor-057134 Magnaporthe oryzae 32.93 6.70e-02 31.20
IUUC-Mga-059330 Meleagris gallopavo 82.49 1.00e-146 513.00
IUUC-Mmr-060844 Microcebus murinus 97.15 0.00e+00 648.00
IUUC-Mdo-062120 Monodelphis domestica 88.71 0.00e+00 639.00
IUUC-Mmu-064360 Mus musculus 91.40 5.00e-175 607.00
IUUC-Mpu-066914 Mustela putorius furo 96.29 0.00e+00 635.00
IUUC-Mlu-067135 Myotis lucifugus 95.71 0.00e+00 639.00
IUUC-Nle-069266 Nomascus leucogenys 99.73 0.00e+00 707.00
IUUC-Ont-071750 Oreochromis niloticus 81.47 3.00e-123 435.00
IUUC-Oan-073082 Ornithorhynchus anatinus 92.37 5.00e-180 623.00
IUUC-Ocu-074563 Oryctolagus cuniculus 91.15 0.00e+00 632.00
IUUC-Ola-086459 Oryzias latipes 59.80 1.00e-120 426.00
IUUC-Oga-089180 Otolemur garnettii 97.85 0.00e+00 697.00
IUUC-Oar-089284 Ovis aries 87.06 1.00e-161 562.00
IUUC-Ptr-090918 Pan troglodytes 99.73 0.00e+00 701.00
IUUC-Pan-092624 Papio anubis 98.39 0.00e+00 697.00
IUUC-Psi-093544 Pelodiscus sinensis 81.55 4.00e-158 550.00
IUUC-Pfo-097463 Poecilia formosa 80.71 1.00e-118 419.00
IUUC-Pab-097846 Pongo abelii 100.00 0.00e+00 707.00
IUUC-Pva-103173 Pteropus vampyrus 95.43 0.00e+00 672.00
IUUC-Rno-105169 Rattus norvegicus 91.40 0.00e+00 655.00
IUUC-Sha-106608 Sarcophilus harrisii 89.52 0.00e+00 641.00
IUUC-Ssc-115788 Sus scrofa 97.04 0.00e+00 709.00
IUUC-Tgu-117327 Taeniopygia guttata 83.06 2.00e-152 532.00
IUUC-Tru-117906 Takifugu rubripes 78.12 2.00e-115 409.00
IUUC-Tsy-119156 Tarsius syrichta 91.71 1.00e-178 619.00
IUUC-Tae-123026 Triticum aestivum 23.66 1.50e-01 32.70
IUUC-Tbe-127604 Tupaia belangeri 92.00 3.00e-174 603.00
IUUC-Ttr-128716 Tursiops truncatus 97.58 0.00e+00 691.00
IUUC-Vpa-130278 Vicugna pacos 96.24 0.00e+00 689.00
IUUC-Xtr-132550 Xenopus tropicalis 75.46 2.00e-142 499.00
IUUC-Xma-133768 Xiphophorus maculatus 81.08 1.00e-121 429.00
Created Date 25-Jun-2017

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