iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052868

Ensembl Protein ID

ENSLOCP00000012502.1

UniProt Accession

W5MVU3; W5MVU3_LEPOC

Genbank Protein ID

ENSLOCP00000012502

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Genbank Nucleotide ID

AHAT01034636

Gene Name

wdr12; WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000010208.1	ENSLOCT00000012524.1	ENSLOCP00000012502.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.10e-43	144.5	341	376
UBD/Beta-Prp	1.50e-47	162.4	247	414

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtgv 34
           H ++vt++++ ++  + lvsGs D+++k+WD+r+++
   Q: 341  HHGWVTAVKWsPTheHQLVSGSLDNVVKLWDTRSCK 376
           889*******9444577**************99876 PP

UBD/Beta-Prp

   S: 84   gkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktgk 170
           +++ +tl+gh++ + s+ +s  ++ + s+s+d ti+vwd etg   + tl+g + v n++++ p ++ l+sGs+Dr +rlWd   k g+
   Q: 247  RTPSMTLSGHNEAISSVLWSD-TEEICSASWDHTIKVWDAETGGLKS-TLTGSK-VFNSISYTPLCKRLASGSADRHIRLWDPrsKDGS 332
           66789***************9.99**********************9.***987.99*************************9666677 PP
   S: 171  llrtltgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl 251
           l++     h++ v+ ++++++   +lvsgsld+ vklwd +  +  ++ l +h+d v++v+ + ++ +l+sg++D+ ++ + +
   Q: 333  LVQLSLTSHHGWVTAVKWSPTHeHQLVSGSLDNVVKLWDTRsCKAPLYDLAAHEDKVLCVDWT-ESGLLLSGGADNKLYTYKY 414
           87755445************99788****************54566****************9.99**********9998754 PP

Organism

Lepisosteus oculatus

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MSQLQARFFT ENKKYAVDEV PFSIPASSEI LDLSNVINKL LEAKHEEHKH VEFDFLIKGQ 60
FLRMPLINHM EAENISTEDV VEIEYVEKFT APQPEECMMH DDWISAVEAD GEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCACAGC TACAAGCGAG GTTCTTCACA GAAAATAAGA AGTAAGTGTG CCTTCTAAGT 60
TACGGATGTG CGTGTCACAC TACTTGAATG CAAGGCTTCA GATGTATACC GTGATGTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	33.73	2.00e-65	243.00
IUUC-Aml-001997	Ailuropoda melanoleuca	80.98	0.00e+00	645.00
IUUC-Atr-002544	Amborella trichopoda	32.94	1.00e-58	220.00
IUUC-Apl-003981	Anas platyrhynchos	82.76	0.00e+00	626.00
IUUC-Aca-004370	Anolis carolinensis	80.47	0.00e+00	720.00
IUUC-Aly-006455	Arabidopsis lyrata	33.89	3.00e-62	232.00
IUUC-Ath-006669	Arabidopsis thaliana	33.65	1.00e-57	216.00
IUUC-Ago-007864	Ashbya gossypii	30.23	4.00e-45	175.00
IUUC-Acl-008177	Aspergillus clavatus	28.64	1.00e-38	154.00
IUUC-Afl-008617	Aspergillus flavus	28.78	2.00e-39	156.00
IUUC-Afu-008752	Aspergillus fumigatus	29.23	2.00e-37	150.00
IUUC-Ani-009136	Aspergillus nidulans	29.31	2.00e-39	156.00
IUUC-Ang-009701	Aspergillus niger	27.44	5.00e-36	145.00
IUUC-Aor-009884	Aspergillus oryzae	28.54	1.00e-38	154.00
IUUC-Ame-011432	Astyanax mexicanus	82.27	0.00e+00	723.00
IUUC-Bgr-012218	Blumeria graminis	27.88	9.00e-38	151.00
IUUC-Bta-012829	Bos taurus	82.03	0.00e+00	672.00
IUUC-Bci-013953	Botrytis cinerea	28.61	4.00e-40	159.00
IUUC-Bdi-014351	Brachypodium distachyon	36.17	3.00e-63	235.00
IUUC-Bol-016190	Brassica oleracea	35.55	7.00e-60	224.00
IUUC-Bra-017876	Brassica rapa	35.40	4.00e-62	231.00
IUUC-Cel-018569	Caenorhabditis elegans	31.12	3.00e-51	196.00
IUUC-Cja-019468	Callithrix jacchus	80.14	0.00e+00	648.00
IUUC-Cfa-020471	Canis familiaris	80.61	0.00e+00	664.00
IUUC-Cpo-022260	Cavia porcellus	81.09	0.00e+00	655.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	31.39	4.00e-44	172.00
IUUC-Csa-023989	Chlorocebus sabaeus	79.91	0.00e+00	649.00
IUUC-Cho-024426	Choloepus hoffmanni	79.68	2.00e-138	485.00
IUUC-Cin-025789	Ciona intestinalis	41.36	6.00e-100	357.00
IUUC-Cne-027063	Cryptococcus neoformans	23.32	9.00e-20	91.70
IUUC-Dre-027907	Danio rerio	83.22	0.00e+00	733.00
IUUC-Dno-029225	Dasypus novemcinctus	80.38	0.00e+00	666.00
IUUC-Dor-031082	Dipodomys ordii	66.19	2.00e-143	502.00
IUUC-Dse-031308	Dothistroma septosporum	28.31	1.00e-41	164.00
IUUC-Dme-032189	Drosophila melanogaster	40.00	4.00e-99	354.00
IUUC-Ete-032247	Echinops telfairi	75.89	1.00e-178	619.00
IUUC-Eca-034285	Equus caballus	81.09	0.00e+00	668.00
IUUC-Eeu-035322	Erinaceus europaeus	74.87	8.00e-166	576.00
IUUC-Fca-036114	Felis catus	80.85	0.00e+00	667.00
IUUC-Fal-036891	Ficedula albicollis	83.33	4.00e-168	583.00
IUUC-Fox-037965	Fusarium oxysporum	25.45	5.00e-35	142.00
IUUC-Fso-038244	Fusarium solani	25.37	2.00e-36	147.00
IUUC-Gmo-039040	Gadus morhua	81.32	0.00e+00	713.00
IUUC-Ggr-040093	Gaeumannomyces graminis	24.66	4.00e-16	79.30
IUUC-Gga-040610	Gallus gallus	80.38	0.00e+00	689.00
IUUC-Gac-042117	Gasterosteus aculeatus	81.09	0.00e+00	690.00
IUUC-Gma-043967	Glycine max	35.58	2.00e-66	246.00
IUUC-Ggo-045179	Gorilla gorilla	79.67	0.00e+00	640.00
IUUC-Hsa-046114	Homo sapiens	80.14	0.00e+00	645.00
IUUC-Hvu-047331	Hordeum vulgare	34.44	8.00e-61	227.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	80.85	0.00e+00	669.00
IUUC-Kpa-049304	Komagataella pastoris	31.17	3.00e-46	179.00
IUUC-Lch-050655	Latimeria chalumnae	76.12	1.00e-146	511.00
IUUC-Lpe-051675	Leersia perrieri	34.69	6.00e-65	241.00
IUUC-Lma-053258	Leptosphaeria maculans	27.52	2.00e-39	158.00
IUUC-Laf-053993	Loxodonta africana	80.85	0.00e+00	667.00
IUUC-Mcc-055128	Macaca mulatta	65.48	3.00e-145	508.00
IUUC-Meu-056501	Macropus eugenii	72.12	1.00e-148	519.00
IUUC-Mor-057114	Magnaporthe oryzae	26.65	3.00e-32	132.00
IUUC-Mtr-058367	Medicago truncatula	35.97	5.00e-64	238.00
IUUC-Mla-059107	Melampsora laricipopulina	26.51	2.00e-34	139.00
IUUC-Mga-059745	Meleagris gallopavo	77.99	0.00e+00	662.00
IUUC-Mvi-060362	Microbotryum violaceum	27.09	1.00e-32	134.00
IUUC-Mdo-062257	Monodelphis domestica	79.29	0.00e+00	674.00
IUUC-Mmu-063546	Mus musculus	79.91	0.00e+00	664.00
IUUC-Mac-065540	Musa acuminata	33.65	1.00e-60	227.00
IUUC-Mpu-066284	Mustela putorius furo	80.61	0.00e+00	668.00
IUUC-Mlu-067241	Myotis lucifugus	80.38	0.00e+00	665.00
IUUC-Nfi-068260	Neosartorya fischeri	28.64	3.00e-37	149.00
IUUC-Ncr-068719	Neurospora crassa	26.89	4.00e-32	132.00
IUUC-Nle-068981	Nomascus leucogenys	79.91	0.00e+00	645.00
IUUC-Opr-071218	Ochotona princeps	75.88	3.00e-178	617.00
IUUC-Ont-071646	Oreochromis niloticus	80.00	0.00e+00	684.00
IUUC-Oan-073453	Ornithorhynchus anatinus	82.98	0.00e+00	733.00
IUUC-Ocu-074008	Oryctolagus cuniculus	80.85	0.00e+00	668.00
IUUC-Oba-075712	Oryza barthii	30.60	5.00e-50	191.00
IUUC-Obr-076721	Oryza brachyantha	34.68	2.00e-64	239.00
IUUC-Ogl-077229	Oryza glaberrima	34.45	3.00e-65	242.00
IUUC-Ogu-078977	Oryza glumaepatula	30.60	2.00e-50	193.00
IUUC-Oin-079683	Oryza indica	34.69	8.00e-66	244.00
IUUC-Olo-080291	Oryza longistaminata	29.53	1.00e-33	136.00
IUUC-Ome-081834	Oryza meridionalis	34.93	2.00e-66	246.00
IUUC-Oni-082507	Oryza nivara	33.09	3.00e-61	228.00
IUUC-Opu-083396	Oryza punctata	33.97	3.00e-64	239.00
IUUC-Oru-085220	Oryza rufipogon	33.65	8.00e-61	227.00
IUUC-Osa-085767	Oryza sativa	34.69	8.00e-66	244.00
IUUC-Ola-087420	Oryzias latipes	80.61	0.00e+00	719.00
IUUC-Olu-087740	Ostreococcus lucimarinus	28.51	6.00e-41	161.00
IUUC-Oga-088264	Otolemur garnettii	80.14	0.00e+00	662.00
IUUC-Oar-089335	Ovis aries	81.56	0.00e+00	668.00
IUUC-Ptr-091320	Pan troglodytes	80.14	0.00e+00	645.00
IUUC-Pan-092833	Papio anubis	79.43	0.00e+00	644.00
IUUC-Psi-093504	Pelodiscus sinensis	81.32	0.00e+00	685.00
IUUC-Pma-094189	Petromyzon marinus	69.58	4.00e-173	600.00
IUUC-Pno-094929	Phaeosphaeria nodorum	27.59	2.00e-38	153.00
IUUC-Ppa-095429	Physcomitrella patens	35.39	3.00e-65	242.00
IUUC-Pfo-096337	Poecilia formosa	79.91	0.00e+00	712.00
IUUC-Pab-097571	Pongo abelii	79.91	0.00e+00	645.00
IUUC-Pop-099977	Populus trichocarpa	35.82	1.00e-68	253.00
IUUC-Pca-100394	Procavia capensis	76.53	1.00e-172	598.00
IUUC-Ppe-101848	Prunus persica	36.39	3.00e-67	248.00
IUUC-Pva-102921	Pteropus vampyrus	79.76	6.00e-102	363.00
IUUC-Pgr-103637	Puccinia graminis	28.69	6.00e-41	161.00
IUUC-Ptt-103781	Puccinia triticina	28.48	1.00e-39	157.00
IUUC-Pte-104135	Pyrenophora teres	27.27	2.00e-37	151.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	25.93	1.00e-37	150.00
IUUC-Rno-105114	Rattus norvegicus	79.91	0.00e+00	662.00
IUUC-Sce-106401	Saccharomyces cerevisiae	30.13	2.00e-45	176.00
IUUC-Sha-107122	Sarcophilus harrisii	80.54	0.00e+00	652.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	32.63	1.00e-56	213.00
IUUC-Spo-108134	Schizosaccharomyces pombe	29.43	3.00e-46	179.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	28.61	2.00e-41	162.00
IUUC-Smo-108720	Selaginella moellendorffii	33.49	4.00e-58	218.00
IUUC-Sit-110311	Setaria italica	36.22	3.00e-63	235.00
IUUC-Sly-111023	Solanum lycopersicum	32.52	1.00e-61	230.00
IUUC-Stu-112778	Solanum tuberosum	35.95	8.00e-67	247.00
IUUC-Sar-113596	Sorex araneus	67.85	8.00e-147	513.00
IUUC-Sbi-114193	Sorghum bicolor	36.06	9.00e-63	234.00
IUUC-Sre-115002	Sporisorium reilianum	27.63	2.00e-17	83.60
IUUC-Ssc-116066	Sus scrofa	81.09	0.00e+00	666.00
IUUC-Tgu-117048	Taeniopygia guttata	81.96	6.00e-179	619.00
IUUC-Tsy-119573	Tarsius syrichta	52.15	3.00e-114	404.00
IUUC-Tni-119820	Tetraodon nigroviridis	80.05	0.00e+00	686.00
IUUC-Tca-121605	Theobroma cacao	36.54	4.00e-67	248.00
IUUC-Tre-121947	Trichoderma reesei	26.51	4.00e-37	149.00
IUUC-Tvi-122481	Trichoderma virens	26.94	8.00e-39	154.00
IUUC-Tae-125861	Triticum aestivum	33.97	6.00e-66	244.00
IUUC-Tur-126586	Triticum urartu	34.44	9.00e-63	233.00
IUUC-Tme-126900	Tuber melanosporum	31.21	2.00e-52	199.00
IUUC-Tbe-127736	Tupaia belangeri	61.56	6.00e-124	437.00
IUUC-Ttr-129041	Tursiops truncatus	71.16	2.00e-167	581.00
IUUC-Vpa-130260	Vicugna pacos	81.80	0.00e+00	673.00
IUUC-Vvi-131009	Vitis vinifera	35.48	2.00e-65	242.00
IUUC-Xtr-132083	Xenopus tropicalis	77.78	0.00e+00	662.00
IUUC-Xma-133094	Xiphophorus maculatus	79.20	0.00e+00	706.00
IUUC-Yli-134531	Yarrowia lipolytica	24.17	3.00e-24	106.00
IUUC-Zma-135509	Zea mays	34.05	3.00e-63	235.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence