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Tag Content
UUCD2 ID IUUC-Cfa-020905
UUCD1 version UUC-CaF-00486
Ensembl Protein ID ENSCAFP00000015055.2
UniProt Accession F1PU58; F1PU58_CANLF
Genbank Protein ID ENSCAFP00000015055
Protein Name Uncharacterized protein
Genbank Nucleotide ID AAEX03014406
Gene Name CUL3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCAFG00000010230.2 ENSCAFT00000016275.2 ENSCAFP00000015055.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/Cullin 1.60e-230 767.3 19 647
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin
   S: 2    lreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeqlLktynreWekfreqlkvlrkifay 89
           l++a+++i+r++++  ++eely+++y+++l+k+g+klY+ l+ev++e++ ++v+++v +s ++++L+t+n++W++++++++++r+i++y
   Q: 19   LKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLiNKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMY 107
           799*********************************************99*************************************** PP
   S: 90   ldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleat 176
           +dr+yv++ ++v++v++L+l ++r+++v++  i+++l ++ll++i++eRkge+vdr  +++++++l+ L+l+ +++y+e+FEa+fle++
   Q: 108  MDRVYVQQ-NNVENVYNLGLIIFRDQVVRYgcIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMS 195
           ********.******************************************************************************** PP
   S: 177  qefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll....aelvallrdkktedlsrmykL 261
           +ef+++es++fl+en+ + Y+kkvear+nee er++++l++ste+++++vve+eli+kh+++++    ++lv++l++ ktedl++mykL
   Q: 196  AEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVemenSGLVHMLKNGKTEDLACMYKL 284
           ****************************************************************99999******************** PP
   S: 262  lsrvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaakspE 350
           +srv+ngl++++++++s+++eqgka++++e + k+p++y++ ll+lk++++++++e+Fnnd+ F ++++ +fe+f+n n     ++spE
   Q: 285  FSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLN-----SRSPE 368
           *******************************************************************************.....***** PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfq 439
           +l+ +iD++L+k++kglte+e+e++ldk++++f++++ekdvFe+yYk+hLa+RLl++ks+s+++E+++i+kLk+ecg++ftskLe+Mf+
   Q: 369  YLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFR 457
           ***************************************************************************************** PP
   S: 440  dlkvSedlnrqFkeekentees.esvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkael. 526
           d+++S++++++F+++ ++t  s  +v+l+v+vL++g+Wpt+s+t+k+++P+  ++++e+f++fYl khsgR+L++qh++g+a+l+a++ 
   Q: 458  DMSISNTTMDEFRQHLQATGVSlGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFy 546
           ********************99889**************************************************************** PP
   S: 527  .....................kkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqvlkkepeskei 592
                                +++k++lqVstfQm++L++fnn+ek+++ee++++t++pe+eL r+lqsL+++k  ++vl+kep+skei
   Q: 547  gpvkkedgsevgvggaqvtgsNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKptQRVLTKEPKSKEI 635
           *********999999998888888***************************************************************** PP
   S: 593  eeedlfsvNqef 604
           e++++f+vN++f
   Q: 636  ENGHIFTVNDQF 647
           **********99 PP
   
Organism Canis familiaris
Protein Sequence
(Fasta)
RILQMTMDEK YVNSIWDLLK NAIQEIQRKN NSGLSFEELY RNAYTMVLHK HGEKLYTGLR 60
EVVTEHLINK VREDVLNSLN NNFLQTLNQA WNDHQTAMVM IRDILMYMDR VYVQQNNVEN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cfa-020905|E3,Cullin|Canis familiaris
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGATATTAC AGATGACCAT GGATGAAAAA TATGTAAACA GCATATGGGA CCTTCTGAAA 60
AATGCAATTC AAGAAATCCA GCGTAAGAAT AACAGTGGTC TTAGTTTTGA GGAGCTCTAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cfa-020905|E3,Cullin|Canis familiaris
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2
Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8
SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0031461--C:cullin-RING ubiquitin ligase complex
GO:0070062--C:extracellular exosome
GO:0000139--C:Golgi membrane
GO:0005634--C:nucleus
GO:0005827--C:polar microtubule
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0016477--P:cell migration
GO:0048208--P:COPII vesicle coating
GO:0040016--P:embryonic cleavage
GO:0044346--P:fibroblast apoptotic process
GO:0007369--P:gastrulation
GO:0007229--P:integrin-mediated signaling pathway
GO:0072576--P:liver morphogenesis
GO:0007080--P:mitotic metaphase plate congression
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032467--P:positive regulation of cytokinesis
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0017145--P:stem cell division
GO:0043149--P:stress fiber assembly
GO:0001831--P:trophectodermal cellular morphogenesis
GO:0071630--P:ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome
GO:0016055--P:Wnt signaling pathway
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000335 Aegilops tauschii 47.07 0.00e+00 686.00
IUUC-Aml-002278 Ailuropoda melanoleuca 99.47 0.00e+00 1517.00
IUUC-Atr-002616 Amborella trichopoda 53.00 0.00e+00 771.00
IUUC-Apl-004172 Anas platyrhynchos 99.87 0.00e+00 1521.00
IUUC-Aca-004309 Anolis carolinensis 99.47 0.00e+00 1524.00
IUUC-Aly-005566 Arabidopsis lyrata 52.14 0.00e+00 767.00
IUUC-Ath-007587 Arabidopsis thaliana 52.54 0.00e+00 772.00
IUUC-Ago-007795 Ashbya gossypii 25.33 8.00e-48 185.00
IUUC-Acl-008317 Aspergillus clavatus 36.87 6.00e-145 508.00
IUUC-Afl-008727 Aspergillus flavus 36.53 9.00e-145 507.00
IUUC-Afu-008879 Aspergillus fumigatus 37.96 5.00e-133 468.00
IUUC-Ani-009393 Aspergillus nidulans 35.99 2.00e-135 476.00
IUUC-Ang-009626 Aspergillus niger 36.44 3.00e-141 495.00
IUUC-Aor-010207 Aspergillus oryzae 36.53 1.00e-144 506.00
IUUC-Ate-010305 Aspergillus terreus 37.16 2.00e-140 493.00
IUUC-Ame-011805 Astyanax mexicanus 97.07 0.00e+00 1488.00
IUUC-Bgr-012098 Blumeria graminis 36.02 6.00e-121 428.00
IUUC-Bta-013445 Bos taurus 99.60 0.00e+00 1526.00
IUUC-Bci-013612 Botrytis cinerea 36.61 3.00e-139 489.00
IUUC-Bdi-014269 Brachypodium distachyon 53.29 0.00e+00 745.00
IUUC-Bol-015350 Brassica oleracea 52.67 0.00e+00 771.00
IUUC-Bra-016763 Brassica rapa 52.81 0.00e+00 773.00
IUUC-Cel-018641 Caenorhabditis elegans 48.56 0.00e+00 717.00
IUUC-Cja-019175 Callithrix jacchus 99.47 0.00e+00 1523.00
IUUC-Cpo-021293 Cavia porcellus 99.47 0.00e+00 1521.00
IUUC-Cre-022776 Chlamydomonas reinhardtii 48.60 0.00e+00 696.00
IUUC-Csa-023800 Chlorocebus sabaeus 99.33 0.00e+00 1520.00
IUUC-Cho-024839 Choloepus hoffmanni 98.97 0.00e+00 1356.00
IUUC-Cin-025201 Ciona intestinalis 71.33 0.00e+00 1004.00
IUUC-Csv-026107 Ciona savignyi 71.33 0.00e+00 1095.00
IUUC-Cgl-026630 Colletotrichum gloeosporioides 35.43 1.00e-124 440.00
IUUC-Cne-027048 Cryptococcus neoformans 34.80 2.00e-117 417.00
IUUC-Cme-027254 Cyanidioschyzon merolae 31.09 6.00e-88 318.00
IUUC-Dre-028488 Danio rerio 97.47 0.00e+00 1498.00
IUUC-Dno-029784 Dasypus novemcinctus 99.60 0.00e+00 1526.00
IUUC-Dor-030682 Dipodomys ordii 92.63 0.00e+00 1369.00
IUUC-Dse-031326 Dothistroma septosporum 35.74 2.00e-128 453.00
IUUC-Dme-032112 Drosophila melanogaster 69.30 0.00e+00 1078.00
IUUC-Ete-032347 Echinops telfairi 82.64 0.00e+00 1196.00
IUUC-Eca-033560 Equus caballus 99.87 0.00e+00 1522.00
IUUC-Eeu-034502 Erinaceus europaeus 97.94 0.00e+00 1346.00
IUUC-Fca-035544 Felis catus 100.00 0.00e+00 1523.00
IUUC-Fal-036751 Ficedula albicollis 99.73 0.00e+00 1524.00
IUUC-Fox-037857 Fusarium oxysporum 36.92 2.00e-137 483.00
IUUC-Fso-038163 Fusarium solani 36.75 3.00e-141 496.00
IUUC-Gmo-039270 Gadus morhua 96.95 0.00e+00 1497.00
IUUC-Ggr-039999 Gaeumannomyces graminis 33.87 7.00e-128 451.00
IUUC-Gga-040329 Gallus gallus 99.47 0.00e+00 1525.00
IUUC-Gac-041510 Gasterosteus aculeatus 96.83 0.00e+00 1491.00
IUUC-Gma-043182 Glycine max 52.86 0.00e+00 747.00
IUUC-Ggo-044903 Gorilla gorilla 99.60 0.00e+00 1513.00
IUUC-Hsa-046000 Homo sapiens 99.33 0.00e+00 1520.00
IUUC-Hvu-047831 Hordeum vulgare 52.46 0.00e+00 701.00
IUUC-Itr-049067 Ictidomys tridecemlineatus 100.00 0.00e+00 943.00
IUUC-Kpa-049372 Komagataella pastoris 35.07 2.00e-115 410.00
IUUC-Lch-050458 Latimeria chalumnae 99.33 0.00e+00 1516.00
IUUC-Lpe-051396 Leersia perrieri 52.62 0.00e+00 756.00
IUUC-Loc-052186 Lepisosteus oculatus 98.80 0.00e+00 1519.00
IUUC-Lma-053030 Leptosphaeria maculans 38.55 8.00e-144 504.00
IUUC-Laf-053684 Loxodonta africana 100.00 0.00e+00 1523.00
IUUC-Mcc-055770 Macaca mulatta 99.33 0.00e+00 1520.00
IUUC-Meu-056852 Macropus eugenii 100.00 0.00e+00 763.00
IUUC-Mor-057273 Magnaporthe oryzae 34.76 5.00e-133 468.00
IUUC-Mpo-057403 Magnaporthe poae 34.00 1.00e-129 457.00
IUUC-Mtr-058317 Medicago truncatula 52.14 0.00e+00 753.00
IUUC-Mla-059055 Melampsora laricipopulina 37.40 3.00e-133 469.00
IUUC-Mga-060076 Meleagris gallopavo 98.26 0.00e+00 1489.00
IUUC-Mvi-060470 Microbotryum violaceum 33.64 9.00e-136 477.00
IUUC-Mmr-060976 Microcebus murinus 99.60 0.00e+00 1526.00
IUUC-Mdo-062741 Monodelphis domestica 99.60 0.00e+00 1526.00
IUUC-Mmu-063905 Mus musculus 99.33 0.00e+00 1522.00
IUUC-Mac-064718 Musa acuminata 51.48 0.00e+00 729.00
IUUC-Mpu-066356 Mustela putorius furo 100.00 0.00e+00 1523.00
IUUC-Mlu-067768 Myotis lucifugus 99.47 0.00e+00 1517.00
IUUC-Nfi-068285 Neosartorya fischeri 37.20 1.00e-146 513.00
IUUC-Ncr-068883 Neurospora crassa 36.54 2.00e-138 486.00
IUUC-Nle-069638 Nomascus leucogenys 99.60 0.00e+00 1522.00
IUUC-Opr-070333 Ochotona princeps 90.90 0.00e+00 1271.00
IUUC-Ont-071601 Oreochromis niloticus 98.00 0.00e+00 1540.00
IUUC-Oan-073281 Ornithorhynchus anatinus 99.84 0.00e+00 1304.00
IUUC-Ocu-074504 Oryctolagus cuniculus 99.60 0.00e+00 1523.00
IUUC-Oba-075332 Oryza barthii 53.04 0.00e+00 747.00
IUUC-Obr-076435 Oryza brachyantha 53.12 0.00e+00 715.00
IUUC-Ogl-077655 Oryza glaberrima 53.02 0.00e+00 757.00
IUUC-Ogu-078458 Oryza glumaepatula 53.04 0.00e+00 749.00
IUUC-Oin-079567 Oryza indica 52.89 0.00e+00 755.00
IUUC-Olo-080930 Oryza longistaminata 53.02 0.00e+00 758.00
IUUC-Ome-081353 Oryza meridionalis 53.02 0.00e+00 757.00
IUUC-Oni-082378 Oryza nivara 53.02 0.00e+00 757.00
IUUC-Opu-084055 Oryza punctata 53.02 0.00e+00 758.00
IUUC-Oru-084202 Oryza rufipogon 53.04 0.00e+00 748.00
IUUC-Osa-085290 Oryza sativa 53.02 0.00e+00 758.00
IUUC-Ola-087562 Oryzias latipes 97.73 0.00e+00 1504.00
IUUC-Olu-087866 Ostreococcus lucimarinus 37.79 1.00e-139 490.00
IUUC-Oga-088833 Otolemur garnettii 100.00 0.00e+00 1523.00
IUUC-Oar-089958 Ovis aries 100.00 0.00e+00 1523.00
IUUC-Ptr-091013 Pan troglodytes 99.33 0.00e+00 1520.00
IUUC-Pan-091796 Papio anubis 99.07 0.00e+00 1508.00
IUUC-Psi-093564 Pelodiscus sinensis 98.26 0.00e+00 1487.00
IUUC-Pno-094939 Phaeosphaeria nodorum 38.22 3.00e-138 486.00
IUUC-Ppa-095920 Physcomitrella patens 52.47 0.00e+00 766.00
IUUC-Pfo-097498 Poecilia formosa 93.49 0.00e+00 1486.00
IUUC-Pab-098164 Pongo abelii 99.33 0.00e+00 1520.00
IUUC-Pop-099497 Populus trichocarpa 53.74 0.00e+00 786.00
IUUC-Pca-100702 Procavia capensis 91.20 0.00e+00 1349.00
IUUC-Ppe-101271 Prunus persica 52.81 0.00e+00 743.00
IUUC-Pva-103129 Pteropus vampyrus 99.47 0.00e+00 1526.00
IUUC-Pgr-103684 Puccinia graminis 36.44 2.00e-110 393.00
IUUC-Ptt-103961 Puccinia triticina 36.62 2.00e-109 390.00
IUUC-Pte-104325 Pyrenophora teres 38.06 8.00e-136 478.00
IUUC-Pyt-104746 Pyrenophora triticirepentis 37.09 1.00e-133 470.00
IUUC-Rno-105935 Rattus norvegicus 99.87 0.00e+00 1521.00
IUUC-Sce-106354 Saccharomyces cerevisiae 26.60 6.00e-53 202.00
IUUC-Sha-106569 Sarcophilus harrisii 99.42 0.00e+00 1385.00
IUUC-Sja-107676 Schizosaccharomyces japonicus 38.75 3.00e-154 538.00
IUUC-Spo-108135 Schizosaccharomyces pombe 37.91 8.00e-138 484.00
IUUC-Smo-109555 Selaginella moellendorffii 53.49 0.00e+00 790.00
IUUC-Sit-110763 Setaria italica 53.69 0.00e+00 760.00
IUUC-Sly-111090 Solanum lycopersicum 52.27 0.00e+00 763.00
IUUC-Stu-112351 Solanum tuberosum 52.41 0.00e+00 765.00
IUUC-Sar-113144 Sorex araneus 100.00 0.00e+00 1119.00
IUUC-Sbi-114690 Sorghum bicolor 52.89 0.00e+00 761.00
IUUC-Sre-115005 Sporisorium reilianum 38.04 3.00e-135 476.00
IUUC-Ssc-116053 Sus scrofa 99.82 0.00e+00 1144.00
IUUC-Tgu-116523 Taeniopygia guttata 100.00 0.00e+00 1523.00
IUUC-Tru-118189 Takifugu rubripes 93.73 0.00e+00 1409.00
IUUC-Tsy-118962 Tarsius syrichta 93.80 0.00e+00 1390.00
IUUC-Tni-120614 Tetraodon nigroviridis 57.45 0.00e+00 877.00
IUUC-Tca-121282 Theobroma cacao 53.20 0.00e+00 768.00
IUUC-Tre-122201 Trichoderma reesei 35.88 4.00e-134 472.00
IUUC-Tvi-122321 Trichoderma virens 36.36 1.00e-134 474.00
IUUC-Tae-124292 Triticum aestivum 52.62 0.00e+00 739.00
IUUC-Tur-126800 Triticum urartu 52.48 0.00e+00 738.00
IUUC-Tme-127053 Tuber melanosporum 40.48 2.00e-156 546.00
IUUC-Tbe-127427 Tupaia belangeri 85.21 0.00e+00 1164.00
IUUC-Ttr-128662 Tursiops truncatus 98.12 0.00e+00 1483.00
IUUC-Uma-129597 Ustilago maydis 38.54 1.00e-134 473.00
IUUC-Vda-129726 Verticillium dahliae 35.26 6.00e-134 471.00
IUUC-Vpa-130809 Vicugna pacos 100.00 0.00e+00 746.00
IUUC-Vvi-131194 Vitis vinifera 52.93 0.00e+00 763.00
IUUC-Xtr-131887 Xenopus tropicalis 98.54 0.00e+00 1509.00
IUUC-Xma-133517 Xiphophorus maculatus 97.87 0.00e+00 1507.00
IUUC-Yli-134576 Yarrowia lipolytica 33.46 5.00e-111 395.00
IUUC-Zma-135030 Zea mays 53.07 0.00e+00 767.00
Created Date 25-Jun-2017

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