iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091676

UUCD1 version

UUC-PaT-00453

Ensembl Protein ID

ENSPTRP00000022319.4

UniProt Accession

H2QJM7; H2QJM7_PANTR

Genbank Protein ID

JAA02364.1; JAA20227.1; JAA27471.1; JAA34687.1

Protein Name

ATG16 autophagy related 16-like 1

Genbank Nucleotide ID

AACZ03020698; GABF01001918; GABD01005629; GABE01010052

Gene Name

ATG16L1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000013051.6	ENSPTRT00000024197.4	ENSPTRP00000022319.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.00e-31	107.6	406	445
UBD/Beta-Prp	7.80e-65	219.0	315	606

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllks 38
           gH+++v + +f  ++ ++vsGs+D t+k+WDlr+ v++k+
   Q: 406  GHSGKVLSAKFllDNARIVSGSHDRTLKLWDLRSKVCIKT 445
           8***********64489********************985 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvht 89
            +++++h++ +++v+fsp+++llatg++d+++k+w+v+ +k+    slsg +a++t+++f++ g++l+ +s+D + ++w ++++   ht
   Q: 315  LCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCefKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHT 403
           57899************************************9999******************************************** PP
   S: 90   lkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgg 178
           l+gh+ +vls +f  ++ ++vsGshdrt+++wdl+++ c++++++g +    c  + +++++++sG+ D+++r+Wd+++++++r+++  
   Q: 404  LTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS----CNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREME-- 486
           *****************************************9999988....888888889*************************6.. PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght....dnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlh 263
             ++++ l+++++++el+s+s+d  +k+ dl+t+ + +t+ +      +  ++v fsp++ +++ gs++gs++iW + +g++ k+l+++
   Q: 487  LLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGfkcgSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQ 575
           69**********************************99999988888877777************************************ PP
   S: 264  nssvisvavlsfgdnvlvlgsedskvniwkl 294
           +ss+i   ++s++++++v++++ +k+ +w++
   Q: 576  HSSSINAVAWSPSGSHVVSVDKGCKAVLWAQ 606
           *****************************85 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLAQKLQAEK 60
HDVPNRHEIS PGHDGTWNDN QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTAGCGAGC GCCCTGCGTA GGCACCGGCC CCTGAGCCCG TGCTTCGGGT GAGGGGGAGG 60
GTCTTCCGGC CCTCTCGAAA ATCATTTCCG GCATGAGCCG GAAGACCGTC CCGGATGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR013923--Autophagy-rel_prot_16
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08614--ATG16
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0000421--C:autophagosome membrane
GO:0005930--C:axoneme
GO:0000045--P:autophagosome assembly
GO:0039689--P:negative stranded viral RNA replication

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000090	Aegilops tauschii	26.22	3.00e-33	136.00
IUUC-Aml-002242	Ailuropoda melanoleuca	86.74	0.00e+00	1042.00
IUUC-Apl-003384	Anas platyrhynchos	87.52	0.00e+00	1054.00
IUUC-Aca-004962	Anolis carolinensis	83.95	0.00e+00	1023.00
IUUC-Aly-005435	Arabidopsis lyrata	29.56	1.00e-46	181.00
IUUC-Ath-006948	Arabidopsis thaliana	35.10	3.00e-46	179.00
IUUC-Ame-010915	Astyanax mexicanus	78.70	1.00e-151	528.00
IUUC-Bta-012388	Bos taurus	91.81	0.00e+00	1140.00
IUUC-Bdi-014231	Brachypodium distachyon	25.43	2.00e-37	150.00
IUUC-Bol-016174	Brassica oleracea	30.02	2.00e-46	179.00
IUUC-Bra-017165	Brassica rapa	28.52	1.00e-46	180.00
IUUC-Cel-018131	Caenorhabditis elegans	30.65	1.00e-62	234.00
IUUC-Cja-018898	Callithrix jacchus	87.44	0.00e+00	1014.00
IUUC-Cfa-020484	Canis familiaris	95.55	0.00e+00	1156.00
IUUC-Cpo-022156	Cavia porcellus	94.38	0.00e+00	1132.00
IUUC-Csa-024019	Chlorocebus sabaeus	95.72	0.00e+00	1141.00
IUUC-Cho-024311	Choloepus hoffmanni	79.49	0.00e+00	956.00
IUUC-Cin-025260	Ciona intestinalis	37.84	2.00e-101	362.00
IUUC-Csv-025836	Ciona savignyi	43.96	6.00e-47	179.00
IUUC-Dre-027702	Danio rerio	73.00	0.00e+00	875.00
IUUC-Dno-029728	Dasypus novemcinctus	91.03	0.00e+00	1142.00
IUUC-Dor-030587	Dipodomys ordii	81.69	5.00e-113	401.00
IUUC-Dme-031595	Drosophila melanogaster	38.15	2.00e-105	376.00
IUUC-Ete-032969	Echinops telfairi	75.70	0.00e+00	774.00
IUUC-Eca-034214	Equus caballus	95.33	0.00e+00	945.00
IUUC-Eeu-034537	Erinaceus europaeus	88.53	0.00e+00	900.00
IUUC-Fca-036005	Felis catus	91.88	0.00e+00	1071.00
IUUC-Fal-037593	Ficedula albicollis	84.64	0.00e+00	986.00
IUUC-Gmo-039042	Gadus morhua	64.71	0.00e+00	671.00
IUUC-Gga-040986	Gallus gallus	84.27	0.00e+00	1055.00
IUUC-Gac-041351	Gasterosteus aculeatus	71.83	0.00e+00	886.00
IUUC-Gma-043452	Glycine max	33.77	6.00e-46	178.00
IUUC-Ggo-045427	Gorilla gorilla	97.28	0.00e+00	1181.00
IUUC-Hsa-046632	Homo sapiens	99.84	0.00e+00	1203.00
IUUC-Itr-048504	Ictidomys tridecemlineatus	92.93	0.00e+00	1107.00
IUUC-Lch-049439	Latimeria chalumnae	51.06	2.00e-143	502.00
IUUC-Lpe-051254	Leersia perrieri	25.35	6.00e-40	158.00
IUUC-Loc-052610	Lepisosteus oculatus	73.71	0.00e+00	889.00
IUUC-Laf-053936	Loxodonta africana	89.31	0.00e+00	1109.00
IUUC-Mcc-055504	Macaca mulatta	92.60	0.00e+00	1179.00
IUUC-Meu-056516	Macropus eugenii	82.37	0.00e+00	987.00
IUUC-Mtr-058062	Medicago truncatula	31.68	2.00e-42	166.00
IUUC-Mga-059777	Meleagris gallopavo	84.33	0.00e+00	1042.00
IUUC-Mmr-061298	Microcebus murinus	95.18	0.00e+00	1156.00
IUUC-Mdo-062969	Monodelphis domestica	86.70	0.00e+00	1067.00
IUUC-Mmu-064076	Mus musculus	91.96	0.00e+00	1110.00
IUUC-Mac-065161	Musa acuminata	27.52	6.00e-41	161.00
IUUC-Mpu-066196	Mustela putorius furo	92.94	0.00e+00	1131.00
IUUC-Mlu-067651	Myotis lucifugus	93.42	0.00e+00	1134.00
IUUC-Nle-069853	Nomascus leucogenys	97.69	0.00e+00	1177.00
IUUC-Opr-070350	Ochotona princeps	93.19	3.00e-119	422.00
IUUC-Ont-072489	Oreochromis niloticus	71.88	0.00e+00	873.00
IUUC-Oan-072703	Ornithorhynchus anatinus	80.99	0.00e+00	967.00
IUUC-Ocu-074205	Oryctolagus cuniculus	91.49	0.00e+00	1136.00
IUUC-Oba-075619	Oryza barthii	26.56	7.00e-38	151.00
IUUC-Obr-076632	Oryza brachyantha	29.47	5.00e-37	149.00
IUUC-Ogl-077671	Oryza glaberrima	26.76	7.00e-38	151.00
IUUC-Ogu-078052	Oryza glumaepatula	26.76	7.00e-38	151.00
IUUC-Oin-079611	Oryza indica	26.56	7.00e-36	145.00
IUUC-Olo-080408	Oryza longistaminata	26.74	3.00e-36	146.00
IUUC-Ome-081560	Oryza meridionalis	26.76	6.00e-38	151.00
IUUC-Oni-082145	Oryza nivara	26.56	7.00e-38	151.00
IUUC-Opu-083918	Oryza punctata	26.34	6.00e-36	145.00
IUUC-Oru-084858	Oryza rufipogon	26.37	1.00e-35	144.00
IUUC-Osa-086277	Oryza sativa	26.56	8.00e-36	144.00
IUUC-Ola-086816	Oryzias latipes	68.98	4.00e-98	350.00
IUUC-Olu-087622	Ostreococcus lucimarinus	33.44	7.00e-44	171.00
IUUC-Oga-088765	Otolemur garnettii	93.42	0.00e+00	1066.00
IUUC-Oar-090196	Ovis aries	88.50	0.00e+00	990.00
IUUC-Pan-092068	Papio anubis	96.31	0.00e+00	1170.00
IUUC-Psi-093367	Pelodiscus sinensis	86.66	0.00e+00	1038.00
IUUC-Ppa-095699	Physcomitrella patens	28.88	5.00e-42	165.00
IUUC-Pfo-096067	Poecilia formosa	72.94	0.00e+00	861.00
IUUC-Pab-098111	Pongo abelii	96.96	0.00e+00	1176.00
IUUC-Pop-099116	Populus trichocarpa	31.79	5.00e-42	165.00
IUUC-Pca-100680	Procavia capensis	81.38	0.00e+00	927.00
IUUC-Ppe-101790	Prunus persica	26.20	9.00e-45	174.00
IUUC-Pva-102871	Pteropus vampyrus	89.76	0.00e+00	1043.00
IUUC-Rno-106088	Rattus norvegicus	91.80	0.00e+00	1108.00
IUUC-Sha-106984	Sarcophilus harrisii	89.95	0.00e+00	1069.00
IUUC-Smo-108983	Selaginella moellendorffii	26.99	1.00e-42	167.00
IUUC-Sit-110828	Setaria italica	27.42	9.00e-45	174.00
IUUC-Sly-111009	Solanum lycopersicum	26.94	4.00e-48	185.00
IUUC-Stu-112370	Solanum tuberosum	27.33	9.00e-49	187.00
IUUC-Sar-113659	Sorex araneus	63.85	7.00e-93	333.00
IUUC-Sbi-114819	Sorghum bicolor	28.48	7.00e-42	164.00
IUUC-Ssc-116241	Sus scrofa	91.95	0.00e+00	1108.00
IUUC-Tgu-116576	Taeniopygia guttata	87.31	0.00e+00	1083.00
IUUC-Tru-118336	Takifugu rubripes	64.37	0.00e+00	726.00
IUUC-Tsy-119006	Tarsius syrichta	90.69	0.00e+00	1095.00
IUUC-Tni-120300	Tetraodon nigroviridis	74.12	0.00e+00	862.00
IUUC-Tca-121002	Theobroma cacao	28.52	2.00e-49	189.00
IUUC-Tae-124868	Triticum aestivum	30.10	7.00e-34	138.00
IUUC-Tur-126463	Triticum urartu	29.41	3.00e-33	136.00
IUUC-Tbe-127631	Tupaia belangeri	96.86	0.00e+00	928.00
IUUC-Ttr-129005	Tursiops truncatus	84.83	3.00e-164	571.00
IUUC-Vpa-130246	Vicugna pacos	83.58	0.00e+00	838.00
IUUC-Vvi-130878	Vitis vinifera	34.08	1.00e-43	171.00
IUUC-Xtr-132798	Xenopus tropicalis	74.23	0.00e+00	867.00
IUUC-Xma-133264	Xiphophorus maculatus	72.90	0.00e+00	867.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence