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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Cel-018579
UUCD1 version UUC-CaE-00696
Ensembl Protein ID R09B3.4
UniProt Accession Q9XVK5; UBC12_CAEEL
Genbank Protein ID CAB03238.1
Protein Name NEDD8-conjugating enzyme ubc-12; NEDD8 carrier protein; NEDD8 protein ligase; Ubiquitin-conjugating enzyme E2 12
Genbank Nucleotide ID Z81108
Gene Name ubc-12; R09B3.4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00006707 R09B3.4 R09B3.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E2/UBC 3.10e-32 111.5 31 174
Active Site
Position(s) Description Evidence
112 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00388,
ECO:0000255|PROSITE-ProRule:PRU10133}
Domain Profile

   E2/UBC
   S: 4    kelkel....ekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk....eeekWspals 97
           +el++l    ++++++  ++++ + s l+e+e++++ p++ +Y+gg+F+++i++p++Y+  PP vk+ltk++hPn++e+G++Clsil+    ++  W+p+ +
   Q: 31   QELQQLetalRDQKQKLWHLEVPSTSCLHELELTVT-PQEGIYRGGKFRFKITVPPEYNNVPPVVKCLTKVWHPNINEDGSICLSILRqnslDQYGWRPTRN 131
           555555111144455666777777777*********.**************************************************87888999******* PP
   S: 98   vesvllsiqsllae.pnpesplneeaaellkknreeykkkvre 139
           +++v+ +++sl+++   ++++ln +aa+++++nre+++++vre
   Q: 132  LTDVVHGLVSLFNDlMDFNDALNIQAAQMWSQNRESFNHRVRE 174
           ************99789***********************985 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Accepts the ubiquitin-like protein NEDD8 from the uba-3-ula-1 E1 complex and catalyzes its covalent attachment to other proteins.
 Accepts the ubiquitin-like protein NEDD8 from the uba-3-ula-1 E1 complex and catalyzes its covalent attachment to other proteins.
Protein Sequence
(Fasta)
MFNLQKRING NNEDGRYLET RIAVRDKLLA QELQQLETAL RDQKQKLWHL EVPSTSCLHE 60
LELTVTPQEG IYRGGKFRFK ITVPPEYNNV PPVVKCLTKV WHPNINEDGS ICLSILRQNS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018579|E2,E2/UBC|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAATGTTCA ATCTTCAAAA ACGAATCAAC GGCAACAACG AGGACGGTCG GTATCTTGAA 60
ACCCGCATCG CCGTCCGTGA CAAGCTCCTA GCTCAGGGTA TGTGGCTGCT TTATAAAAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018579|E2,E2/UBC|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0016874--F:ligase activity
GO:0019788--F:NEDD8 transferase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0007275--P:multicellular organism development
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045116--P:protein neddylation
KEGG cel:CELE_R09B3.4
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001473 Ailuropoda melanoleuca 56.15 1.00e-41 161.00
IUUC-Apl-003569 Anas platyrhynchos 58.24 3.00e-28 115.00
IUUC-Aca-005152 Anolis carolinensis 51.88 3.00e-44 169.00
IUUC-Ath-006846 Arabidopsis thaliana 39.66 2.00e-20 90.50
IUUC-Ago-007910 Ashbya gossypii 37.68 4.00e-20 89.70
IUUC-Ang-009728 Aspergillus niger 39.52 3.00e-22 95.90
IUUC-Ame-011839 Astyanax mexicanus 45.98 1.00e-42 164.00
IUUC-Bta-013524 Bos taurus 56.15 1.00e-41 161.00
IUUC-Bdi-014079 Brachypodium distachyon 33.91 3.00e-23 99.80
IUUC-Bol-015929 Brassica oleracea 40.52 2.00e-20 90.90
IUUC-Bra-016702 Brassica rapa 38.28 6.00e-21 92.40
IUUC-Cja-019211 Callithrix jacchus 52.94 4.00e-43 166.00
IUUC-Cfa-020014 Canis familiaris 56.15 1.00e-41 161.00
IUUC-Cpo-022479 Cavia porcellus 52.94 4.00e-43 166.00
IUUC-Cre-022865 Chlamydomonas reinhardtii 39.72 3.00e-24 103.00
IUUC-Cho-024583 Choloepus hoffmanni 41.28 1.00e-20 90.90
IUUC-Cin-025378 Ciona intestinalis 38.17 1.00e-36 144.00
IUUC-Csv-026195 Ciona savignyi 44.24 2.00e-37 146.00
IUUC-Cme-027287 Cyanidioschyzon merolae 45.57 3.00e-16 77.00
IUUC-Dre-028671 Danio rerio 48.12 2.00e-42 164.00
IUUC-Dno-029004 Dasypus novemcinctus 52.83 6.00e-46 175.00
IUUC-Dor-030940 Dipodomys ordii 52.94 6.00e-43 165.00
IUUC-Eca-034345 Equus caballus 56.15 1.00e-41 161.00
IUUC-Fca-036125 Felis catus 56.15 1.00e-41 161.00
IUUC-Fal-036808 Ficedula albicollis 51.88 2.00e-45 173.00
IUUC-Fox-037877 Fusarium oxysporum 38.21 1.00e-20 91.30
IUUC-Fso-038428 Fusarium solani 39.02 3.00e-21 93.20
IUUC-Gmo-039394 Gadus morhua 56.25 7.00e-36 140.00
IUUC-Gga-041269 Gallus gallus 51.25 2.00e-43 167.00
IUUC-Gac-041480 Gasterosteus aculeatus 48.12 9.00e-44 167.00
IUUC-Gma-043805 Glycine max 38.33 8.00e-21 92.00
IUUC-Ggo-045010 Gorilla gorilla 53.46 4.00e-46 176.00
IUUC-Hsa-046664 Homo sapiens 53.46 4.00e-46 176.00
IUUC-Itr-048522 Ictidomys tridecemlineatus 51.63 6.00e-42 162.00
IUUC-Lpe-050743 Leersia perrieri 40.83 3.00e-21 93.20
IUUC-Loc-052137 Lepisosteus oculatus 51.25 5.00e-44 168.00
IUUC-Laf-053694 Loxodonta africana 53.85 6.00e-45 172.00
IUUC-Mcc-055638 Macaca mulatta 53.46 4.00e-46 176.00
IUUC-Meu-056568 Macropus eugenii 46.88 1.00e-37 147.00
IUUC-Mga-059437 Meleagris gallopavo 52.50 7.00e-46 175.00
IUUC-Mmr-060651 Microcebus murinus 51.95 1.00e-40 158.00
IUUC-Mdo-061993 Monodelphis domestica 53.46 7.00e-46 175.00
IUUC-Mmu-064372 Mus musculus 52.94 5.00e-43 165.00
IUUC-Mac-064435 Musa acuminata 40.83 7.00e-23 98.60
IUUC-Mpu-066423 Mustela putorius furo 55.38 2.00e-41 160.00
IUUC-Mlu-067910 Myotis lucifugus 54.62 6.00e-41 158.00
IUUC-Ncr-068944 Neurospora crassa 38.58 4.00e-22 96.30
IUUC-Nle-069032 Nomascus leucogenys 52.94 4.00e-43 166.00
IUUC-Opr-070798 Ochotona princeps 53.46 4.00e-46 175.00
IUUC-Ont-071232 Oreochromis niloticus 48.12 6.00e-44 168.00
IUUC-Oan-072779 Ornithorhynchus anatinus 56.41 2.00e-37 146.00
IUUC-Ocu-074366 Oryctolagus cuniculus 51.57 2.00e-44 169.00
IUUC-Oba-075203 Oryza barthii 42.50 1.00e-22 97.40
IUUC-Obr-076431 Oryza brachyantha 43.33 1.00e-23 101.00
IUUC-Ogl-077404 Oryza glaberrima 43.33 2.00e-23 100.00
IUUC-Ogu-078347 Oryza glumaepatula 42.50 1.00e-22 97.40
IUUC-Oin-080060 Oryza indica 43.33 2.00e-23 101.00
IUUC-Olo-080602 Oryza longistaminata 43.33 3.00e-23 101.00
IUUC-Ome-081870 Oryza meridionalis 43.33 2.00e-23 101.00
IUUC-Oni-082192 Oryza nivara 43.33 2.00e-23 100.00
IUUC-Opu-083937 Oryza punctata 42.50 9.00e-23 98.20
IUUC-Oru-084750 Oryza rufipogon 43.33 2.00e-23 100.00
IUUC-Osa-085857 Oryza sativa 43.33 2.00e-23 100.00
IUUC-Ola-087548 Oryzias latipes 54.70 9.00e-37 143.00
IUUC-Oga-089149 Otolemur garnettii 53.85 8.00e-45 171.00
IUUC-Oar-089662 Ovis aries 56.15 1.00e-41 161.00
IUUC-Ptr-090895 Pan troglodytes 53.46 4.00e-46 176.00
IUUC-Pan-092771 Papio anubis 53.12 9.00e-45 171.00
IUUC-Psi-093582 Pelodiscus sinensis 51.25 2.00e-45 173.00
IUUC-Pma-094321 Petromyzon marinus 61.68 4.00e-37 145.00
IUUC-Pno-094972 Phaeosphaeria nodorum 37.12 9.00e-22 95.10
IUUC-Pfo-096040 Poecilia formosa 48.12 6.00e-44 168.00
IUUC-Pab-097931 Pongo abelii 53.46 4.00e-46 176.00
IUUC-Pca-100697 Procavia capensis 56.15 2.00e-41 160.00
IUUC-Pva-102609 Pteropus vampyrus 51.32 2.00e-41 160.00
IUUC-Pyt-104616 Pyrenophora triticirepentis 39.20 2.00e-22 96.70
IUUC-Rno-105622 Rattus norvegicus 52.94 5.00e-43 165.00
IUUC-Sha-107614 Sarcophilus harrisii 52.80 1.00e-44 171.00
IUUC-Spo-108143 Schizosaccharomyces pombe 40.91 3.00e-22 96.30
IUUC-Sbi-114410 Sorghum bicolor 43.33 1.00e-23 100.00
IUUC-Ssc-115597 Sus scrofa 55.38 3.00e-41 159.00
IUUC-Tgu-117397 Taeniopygia guttata 51.88 1.00e-45 174.00
IUUC-Tru-118496 Takifugu rubripes 49.38 4.00e-44 169.00
IUUC-Tsy-119592 Tarsius syrichta 53.21 2.00e-44 170.00
IUUC-Tni-119759 Tetraodon nigroviridis 48.75 7.00e-44 168.00
IUUC-Tca-121640 Theobroma cacao 38.52 4.00e-21 92.80
IUUC-Tre-122115 Trichoderma reesei 37.01 3.00e-20 90.10
IUUC-Tbe-128085 Tupaia belangeri 41.98 9.00e-26 107.00
IUUC-Ttr-129228 Tursiops truncatus 56.69 3.00e-41 159.00
IUUC-Vvi-131182 Vitis vinifera 35.95 1.00e-21 95.10
IUUC-Xtr-131773 Xenopus tropicalis 50.48 1.00e-26 110.00
IUUC-Xma-133013 Xiphophorus maculatus 48.12 7.00e-44 168.00
IUUC-Yli-134467 Yarrowia lipolytica 41.78 3.00e-24 103.00
Created Date 25-Jun-2017

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