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Tag Content
UUCD2 ID IUUC-Nle-069099
UUCD1 version UUC-NoL-00675
Ensembl Protein ID ENSNLEP00000016326.2
UniProt Accession G1RSV2; G1RSV2_NOMLE
Genbank Protein ID ENSNLEP00000016326
Protein Name Histone deacetylase
Genbank Nucleotide ID ADFV01115277
Gene Name HDAC4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSNLEG00000013474.2 ENSNLET00000017164.2 ENSNLEP00000016326.2
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 95.68 0.00e+00 1259.00 IUUC-Hsa-046925
Active Site
Position(s) Description Evidence
802 N/A {ECO:0000256|PIRSR:PIRSR037911-1}
Organism Nomascus leucogenys
Functional Description
(View)

Functional Description



     Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Protein Sequence
(Fasta)
MSSQSHPDGL SGRDQPVELL NPARVNHMPS TVDVATALPL QVAPSAVPMD LRLDHQFSLP 60
VAEPALREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQQEMLA 120
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Protein Fasta Sequence



>IUUC-Nle-069099|E3,E3 activity/Other|Nomascus leucogenys
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Nucleotide Sequence
(Fasta)
CTACGCCTCC GTGCGCACGC AGCACCACGT GACCCACCAC CAGTACCCAA GATGGACGCC 60
GCGGCGAGGC CTGGCCGGCT CCCCGCCTCA GCCTGCATCC CATTGTGTGC CCTCTAAGCG 120
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Nucleotide Fasta Sequence



>IUUC-Nle-069099|E3,E3 activity/Other|Nomascus leucogenys
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

Gene Ontology

GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0017053--C:transcriptional repressor complex
GO:0001047--F:core promoter binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070933--P:histone H4 deacetylation
GO:0010832--P:negative regulation of myotube differentiation
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0070555--P:response to interleukin-1
GO:0006351--P:transcription, DNA-templated

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002279 Ailuropoda melanoleuca 89.93 0.00e+00 1163.00
IUUC-Apl-003250 Anas platyrhynchos 83.12 0.00e+00 1010.00
IUUC-Aca-004668 Anolis carolinensis 78.79 0.00e+00 1085.00
IUUC-Bta-013215 Bos taurus 89.01 0.00e+00 1177.00
IUUC-Cja-019816 Callithrix jacchus 94.44 0.00e+00 1268.00
IUUC-Cfa-020861 Canis familiaris 91.23 0.00e+00 1224.00
IUUC-Cpo-021562 Cavia porcellus 89.38 0.00e+00 1203.00
IUUC-Csa-023612 Chlorocebus sabaeus 94.85 0.00e+00 1244.00
IUUC-Dre-028284 Danio rerio 73.70 2.00e-154 540.00
IUUC-Dno-029951 Dasypus novemcinctus 88.51 0.00e+00 1069.00
IUUC-Dor-030362 Dipodomys ordii 84.58 0.00e+00 1032.00
IUUC-Fca-036187 Felis catus 90.28 0.00e+00 1142.00
IUUC-Gmo-038473 Gadus morhua 62.72 4.00e-121 429.00
IUUC-Gga-040501 Gallus gallus 86.96 0.00e+00 1098.00
IUUC-Gac-042335 Gasterosteus aculeatus 64.19 4.00e-123 436.00
IUUC-Ggo-045380 Gorilla gorilla 96.05 0.00e+00 1295.00
IUUC-Hsa-046925 Homo sapiens 95.68 0.00e+00 1246.00
IUUC-Itr-048036 Ictidomys tridecemlineatus 90.55 0.00e+00 1120.00
IUUC-Lch-050325 Latimeria chalumnae 80.10 0.00e+00 1016.00
IUUC-Loc-052231 Lepisosteus oculatus 75.66 0.00e+00 928.00
IUUC-Laf-054490 Loxodonta africana 80.33 0.00e+00 1061.00
IUUC-Mcc-055265 Macaca mulatta 94.97 0.00e+00 1249.00
IUUC-Meu-056676 Macropus eugenii 77.89 4.00e-109 389.00
IUUC-Mmr-061633 Microcebus murinus 82.59 0.00e+00 1032.00
IUUC-Mmu-063089 Mus musculus 90.25 0.00e+00 1120.00
IUUC-Mpu-065887 Mustela putorius furo 88.89 0.00e+00 1164.00
IUUC-Mlu-067470 Myotis lucifugus 90.78 0.00e+00 1171.00
IUUC-Ont-071613 Oreochromis niloticus 70.88 1.00e-131 464.00
IUUC-Oan-073275 Ornithorhynchus anatinus 84.81 0.00e+00 1089.00
IUUC-Ola-087031 Oryzias latipes 59.66 0.00e+00 679.00
IUUC-Oga-088201 Otolemur garnettii 83.45 0.00e+00 968.00
IUUC-Oar-089997 Ovis aries 78.90 0.00e+00 850.00
IUUC-Ptr-091116 Pan troglodytes 95.93 0.00e+00 1290.00
IUUC-Pan-092132 Papio anubis 91.88 1.00e-177 616.00
IUUC-Psi-093734 Pelodiscus sinensis 84.91 0.00e+00 1016.00
IUUC-Pma-094347 Petromyzon marinus 67.72 5.00e-70 259.00
IUUC-Pfo-096293 Poecilia formosa 67.01 1.00e-109 390.00
IUUC-Pab-098491 Pongo abelii 96.17 0.00e+00 1295.00
IUUC-Pca-101004 Procavia capensis 79.38 0.00e+00 852.00
IUUC-Pva-102961 Pteropus vampyrus 72.93 3.00e-172 598.00
IUUC-Rno-105005 Rattus norvegicus 90.00 0.00e+00 1092.00
IUUC-Sha-107646 Sarcophilus harrisii 70.90 6.00e-99 355.00
IUUC-Ssc-115428 Sus scrofa 89.37 0.00e+00 1070.00
IUUC-Tgu-116776 Taeniopygia guttata 86.79 0.00e+00 1091.00
IUUC-Tru-118180 Takifugu rubripes 68.09 7.00e-135 474.00
IUUC-Tsy-119468 Tarsius syrichta 89.57 1.00e-177 617.00
IUUC-Tni-120196 Tetraodon nigroviridis 61.95 3.00e-136 479.00
IUUC-Ttr-128360 Tursiops truncatus 74.85 1.00e-90 328.00
IUUC-Xtr-132956 Xenopus tropicalis 75.93 0.00e+00 914.00
Created Date 25-Jun-2017

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