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Tag Content
UUCD2 ID IUUC-Oan-073275
UUCD1 version UUC-OrA-00345
Ensembl Protein ID ENSOANP00000020481.2
UniProt Accession F6ZBF4; F6ZBF4_ORNAN
Genbank Protein ID ENSOANP00000020481
Protein Name Histone deacetylase
Genbank Nucleotide ID AAPN01389737
Gene Name HDAC4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOANG00000012951.3 ENSOANT00000020484.2 ENSOANP00000020481.2
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 89.06 0.00e+00 1675.00 IUUC-Hsa-046925
Active Site
Position(s) Description Evidence
798 N/A {ECO:0000256|PIRSR:PIRSR037911-1}
Organism Ornithorhynchus anatinus
Functional Description
(View)

Functional Description



     Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Protein Sequence
(Fasta)
AASSSHPEGL FYVEIVVQSP DLAFVFAPPI TVDVTTALPL QVAPSSVPMD LRLDHQFSMP 60
GSEPTLREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQQEMLA 120
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Protein Fasta Sequence



>IUUC-Oan-073275|E3,E3 activity/Other|Ornithorhynchus anatinus
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Nucleotide Sequence
(Fasta)
GCAGCCTCAT CTTCACACCC TGAAGGACTG TTCTATGTAT GTGCACATAA ATACCCATGT 60
CTACTTTTGA AAGTCCTTGA GGCTACAAAA TATGACATTT AATAATGTTG GTATTCGTTA 120
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Nucleotide Fasta Sequence



>IUUC-Oan-073275|E3,E3 activity/Other|Ornithorhynchus anatinus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0042641--C:actomyosin
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000749 Aegilops tauschii 47.54 2.00e-60 226.00
IUUC-Aml-002279 Ailuropoda melanoleuca 88.43 0.00e+00 1652.00
IUUC-Atr-002745 Amborella trichopoda 38.99 3.00e-71 262.00
IUUC-Apl-003250 Anas platyrhynchos 90.80 0.00e+00 1666.00
IUUC-Aca-004668 Anolis carolinensis 84.15 0.00e+00 1651.00
IUUC-Aly-006432 Arabidopsis lyrata 41.84 2.00e-70 259.00
IUUC-Ath-007355 Arabidopsis thaliana 42.56 2.00e-76 279.00
IUUC-Ago-007972 Ashbya gossypii 38.23 8.00e-69 254.00
IUUC-Acl-008187 Aspergillus clavatus 39.59 2.00e-72 266.00
IUUC-Afl-008399 Aspergillus flavus 43.15 2.00e-40 159.00
IUUC-Afu-008954 Aspergillus fumigatus 35.66 7.00e-60 224.00
IUUC-Ani-009142 Aspergillus nidulans 38.80 1.00e-68 253.00
IUUC-Ang-009522 Aspergillus niger 28.61 2.00e-32 134.00
IUUC-Aor-010069 Aspergillus oryzae 37.30 4.00e-65 242.00
IUUC-Ate-010291 Aspergillus terreus 40.51 5.00e-74 271.00
IUUC-Bta-013215 Bos taurus 87.82 0.00e+00 1639.00
IUUC-Bci-013789 Botrytis cinerea 36.71 6.00e-68 251.00
IUUC-Bdi-014007 Brachypodium distachyon 41.13 1.00e-72 267.00
IUUC-Bol-015468 Brassica oleracea 43.15 6.00e-77 281.00
IUUC-Bra-016680 Brassica rapa 42.75 3.00e-77 281.00
IUUC-Cja-019816 Callithrix jacchus 88.87 0.00e+00 1689.00
IUUC-Cfa-020861 Canis familiaris 88.89 0.00e+00 1650.00
IUUC-Cpo-021562 Cavia porcellus 87.44 0.00e+00 1665.00
IUUC-Cre-022561 Chlamydomonas reinhardtii 50.45 3.00e-53 200.00
IUUC-Csa-023612 Chlorocebus sabaeus 88.55 0.00e+00 1655.00
IUUC-Csv-026359 Ciona savignyi 54.73 3.00e-93 333.00
IUUC-Cgl-026709 Colletotrichum gloeosporioides 36.10 1.00e-67 250.00
IUUC-Cne-026978 Cryptococcus neoformans 38.05 3.00e-73 269.00
IUUC-Dre-028284 Danio rerio 87.77 0.00e+00 878.00
IUUC-Dno-029951 Dasypus novemcinctus 87.78 0.00e+00 1562.00
IUUC-Dor-030362 Dipodomys ordii 78.02 0.00e+00 1375.00
IUUC-Dse-031186 Dothistroma septosporum 34.34 3.00e-61 229.00
IUUC-Dme-031766 Drosophila melanogaster 59.10 3.00e-161 562.00
IUUC-Fca-036187 Felis catus 91.22 0.00e+00 1668.00
IUUC-Fox-038067 Fusarium oxysporum 38.56 1.00e-67 250.00
IUUC-Fso-038263 Fusarium solani 38.06 1.00e-69 257.00
IUUC-Gmo-038473 Gadus morhua 77.30 0.00e+00 745.00
IUUC-Ggr-040062 Gaeumannomyces graminis 38.50 4.00e-64 238.00
IUUC-Gga-040501 Gallus gallus 91.71 0.00e+00 1701.00
IUUC-Gac-042335 Gasterosteus aculeatus 69.62 0.00e+00 1267.00
IUUC-Gma-043738 Glycine max 42.35 3.00e-67 248.00
IUUC-Ggo-045380 Gorilla gorilla 88.68 0.00e+00 1655.00
IUUC-Hsa-046925 Homo sapiens 89.06 0.00e+00 1666.00
IUUC-Hvu-047285 Hordeum vulgare 41.38 2.00e-70 258.00
IUUC-Itr-048036 Ictidomys tridecemlineatus 89.04 0.00e+00 1612.00
IUUC-Kpa-049281 Komagataella pastoris 38.01 4.00e-70 258.00
IUUC-Lch-050325 Latimeria chalumnae 84.38 0.00e+00 1523.00
IUUC-Lpe-051214 Leersia perrieri 41.98 2.00e-75 276.00
IUUC-Loc-052231 Lepisosteus oculatus 82.39 0.00e+00 1486.00
IUUC-Lma-053263 Leptosphaeria maculans 40.81 1.00e-76 281.00
IUUC-Laf-054490 Loxodonta africana 84.28 0.00e+00 1600.00
IUUC-Mcc-055265 Macaca mulatta 88.58 0.00e+00 1666.00
IUUC-Meu-056676 Macropus eugenii 86.29 0.00e+00 759.00
IUUC-Mor-057095 Magnaporthe oryzae 37.47 4.00e-69 255.00
IUUC-Mpo-057389 Magnaporthe poae 38.32 7.00e-64 238.00
IUUC-Mtr-058463 Medicago truncatula 40.41 4.00e-69 255.00
IUUC-Mla-059143 Melampsora laricipopulina 40.61 3.00e-69 255.00
IUUC-Mmr-061633 Microcebus murinus 87.43 0.00e+00 1142.00
IUUC-Mmu-063089 Mus musculus 89.78 0.00e+00 1636.00
IUUC-Mac-064630 Musa acuminata 41.67 5.00e-73 268.00
IUUC-Mpu-065887 Mustela putorius furo 88.49 0.00e+00 1651.00
IUUC-Mlu-067470 Myotis lucifugus 90.36 0.00e+00 1687.00
IUUC-Nfi-068404 Neosartorya fischeri 38.82 2.00e-71 263.00
IUUC-Ncr-068672 Neurospora crassa 38.81 3.00e-69 256.00
IUUC-Nle-069099 Nomascus leucogenys 84.81 0.00e+00 1080.00
IUUC-Ont-071613 Oreochromis niloticus 72.84 0.00e+00 1280.00
IUUC-Oba-075489 Oryza barthii 42.15 2.00e-74 272.00
IUUC-Obr-076150 Oryza brachyantha 41.86 2.00e-75 276.00
IUUC-Ogl-077437 Oryza glaberrima 42.15 8.00e-75 274.00
IUUC-Ogu-078370 Oryza glumaepatula 41.86 2.00e-74 273.00
IUUC-Oin-079210 Oryza indica 41.86 2.00e-74 273.00
IUUC-Olo-080971 Oryza longistaminata 43.43 2.00e-65 243.00
IUUC-Oni-082031 Oryza nivara 41.86 3.00e-74 272.00
IUUC-Opu-083471 Oryza punctata 41.86 4.00e-75 275.00
IUUC-Oru-084755 Oryza rufipogon 41.86 2.00e-74 273.00
IUUC-Osa-085447 Oryza sativa 41.86 2.00e-74 273.00
IUUC-Ola-087031 Oryzias latipes 68.34 0.00e+00 1196.00
IUUC-Oga-088201 Otolemur garnettii 81.30 0.00e+00 1453.00
IUUC-Oar-089997 Ovis aries 81.46 0.00e+00 1360.00
IUUC-Ptr-091116 Pan troglodytes 88.96 0.00e+00 1697.00
IUUC-Pan-092132 Papio anubis 91.13 0.00e+00 1132.00
IUUC-Psi-093734 Pelodiscus sinensis 92.52 0.00e+00 1632.00
IUUC-Pma-094347 Petromyzon marinus 70.35 0.00e+00 720.00
IUUC-Pno-095131 Phaeosphaeria nodorum 46.21 3.00e-67 248.00
IUUC-Ppa-095550 Physcomitrella patens 43.02 5.00e-73 268.00
IUUC-Pfo-096293 Poecilia formosa 70.75 0.00e+00 1219.00
IUUC-Pab-098491 Pongo abelii 85.97 0.00e+00 1598.00
IUUC-Pop-099174 Populus trichocarpa 39.95 5.00e-73 268.00
IUUC-Pca-101004 Procavia capensis 79.41 0.00e+00 863.00
IUUC-Ppe-101644 Prunus persica 40.35 3.00e-73 268.00
IUUC-Pva-102961 Pteropus vampyrus 67.38 0.00e+00 828.00
IUUC-Ptt-103841 Puccinia triticina 38.54 3.00e-68 252.00
IUUC-Pte-104383 Pyrenophora teres 37.61 5.00e-73 268.00
IUUC-Pyt-104427 Pyrenophora triticirepentis 38.30 5.00e-74 271.00
IUUC-Rno-105005 Rattus norvegicus 89.97 0.00e+00 1609.00
IUUC-Sce-106274 Saccharomyces cerevisiae 36.03 2.00e-65 243.00
IUUC-Sha-107646 Sarcophilus harrisii 67.76 0.00e+00 1002.00
IUUC-Sja-107915 Schizosaccharomyces japonicus 38.38 1.00e-72 267.00
IUUC-Spo-108300 Schizosaccharomyces pombe 39.90 6.00e-76 278.00
IUUC-Smo-109615 Selaginella moellendorffii 43.46 3.00e-79 288.00
IUUC-Sit-110160 Setaria italica 40.71 1.00e-70 260.00
IUUC-Sly-111164 Solanum lycopersicum 40.16 1.00e-76 280.00
IUUC-Stu-112685 Solanum tuberosum 37.77 2.00e-57 216.00
IUUC-Sbi-114301 Sorghum bicolor 40.99 4.00e-69 255.00
IUUC-Sre-115013 Sporisorium reilianum 39.69 2.00e-68 253.00
IUUC-Ssc-115428 Sus scrofa 89.31 0.00e+00 1608.00
IUUC-Tgu-116776 Taeniopygia guttata 92.83 0.00e+00 1673.00
IUUC-Tru-118180 Takifugu rubripes 69.92 0.00e+00 1268.00
IUUC-Tsy-119468 Tarsius syrichta 86.00 0.00e+00 739.00
IUUC-Tni-120196 Tetraodon nigroviridis 69.08 0.00e+00 1251.00
IUUC-Tca-121312 Theobroma cacao 43.24 2.00e-76 280.00
IUUC-Tre-121930 Trichoderma reesei 38.86 2.00e-72 266.00
IUUC-Tvi-122373 Trichoderma virens 38.31 8.00e-70 257.00
IUUC-Tae-123064 Triticum aestivum 39.83 1.00e-67 249.00
IUUC-Tme-127027 Tuber melanosporum 44.57 1.00e-60 226.00
IUUC-Ttr-128360 Tursiops truncatus 82.19 0.00e+00 968.00
IUUC-Uma-129408 Ustilago maydis 43.81 3.00e-69 256.00
IUUC-Vda-129994 Verticillium dahliae 41.39 1.00e-62 234.00
IUUC-Vvi-131038 Vitis vinifera 39.89 2.00e-75 275.00
IUUC-Xtr-132956 Xenopus tropicalis 81.99 0.00e+00 1459.00
IUUC-Xma-134265 Xiphophorus maculatus 70.02 0.00e+00 1229.00
IUUC-Yli-134680 Yarrowia lipolytica 40.25 3.00e-69 256.00
IUUC-Zma-135110 Zea mays 40.05 6.00e-70 257.00
Created Date 25-Jun-2017

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