iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033269

Ensembl Protein ID

ENSECAP00000013412.1

UniProt Accession

F6W5D6; F6W5D6_HORSE

Protein Name

Uncharacterized protein

Gene Name

HCLS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000015460.1	ENSECAT00000016602.1	ENSECAP00000013412.1
ENSECAG00000015460.1	ENSECAT00000016678.1	ENSECAP00000013479.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.40e-11	43.6	436	487

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
            +lydy+++ +de ++   d+++ i  e  degW++g    +g  GlfP+n+v+ l
   Q: 436  VALYDYQGEGSDEISFDPDDIITDI--EMVDEGWWRG--RCHGHFGLFPANYVKLL 487
           68**********************9..9*********..8*************977 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRAE HINIHQLRNK 60
VSEEHDILKK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAARGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTAGCTCAG AGTTTCTTGC TCTAAAGAGG CAGCAGCCAG AGAGGGAGCC GAGTATCGAC 60
GCGAGGAGCT GGGAGCTTGG AGCAAACACT CGCACTGTTA GAGGTGGGTA CTCTAAGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0009725--P:response to hormone

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001194	Ailuropoda melanoleuca	85.69	0.00e+00	726.00
IUUC-Bta-012591	Bos taurus	87.98	0.00e+00	689.00
IUUC-Cja-019982	Callithrix jacchus	80.77	0.00e+00	661.00
IUUC-Cfa-020262	Canis familiaris	87.78	0.00e+00	644.00
IUUC-Cpo-021362	Cavia porcellus	79.10	8.00e-178	616.00
IUUC-Csa-023911	Chlorocebus sabaeus	90.08	3.00e-169	588.00
IUUC-Dor-030437	Dipodomys ordii	71.57	2.00e-165	575.00
IUUC-Ete-033160	Echinops telfairi	73.65	2.00e-146	511.00
IUUC-Eeu-035032	Erinaceus europaeus	71.32	4.00e-122	431.00
IUUC-Fca-035999	Felis catus	88.58	0.00e+00	778.00
IUUC-Gga-040335	Gallus gallus	65.02	4.00e-101	361.00
IUUC-Ggo-044505	Gorilla gorilla	81.38	0.00e+00	676.00
IUUC-Hsa-046728	Homo sapiens	88.98	2.00e-167	581.00
IUUC-Itr-048592	Ictidomys tridecemlineatus	65.78	1.00e-160	559.00
IUUC-Laf-054202	Loxodonta africana	79.84	0.00e+00	639.00
IUUC-Mcc-055824	Macaca mulatta	89.83	2.00e-169	588.00
IUUC-Mmr-061281	Microcebus murinus	74.54	4.00e-164	570.00
IUUC-Mdo-062515	Monodelphis domestica	67.20	3.00e-141	494.00
IUUC-Mmu-064341	Mus musculus	82.93	0.00e+00	685.00
IUUC-Mpu-066565	Mustela putorius furo	86.35	0.00e+00	687.00
IUUC-Mlu-066942	Myotis lucifugus	84.23	0.00e+00	662.00
IUUC-Nle-069436	Nomascus leucogenys	77.80	5.00e-175	607.00
IUUC-Opr-070288	Ochotona princeps	75.10	1.00e-161	562.00
IUUC-Ocu-074686	Oryctolagus cuniculus	81.26	1.00e-176	612.00
IUUC-Ola-086894	Oryzias latipes	58.04	2.00e-90	326.00
IUUC-Oga-088585	Otolemur garnettii	75.30	0.00e+00	629.00
IUUC-Oar-089686	Ovis aries	86.49	0.00e+00	704.00
IUUC-Ptr-090461	Pan troglodytes	89.83	5.00e-169	587.00
IUUC-Pan-091887	Papio anubis	90.11	2.00e-170	591.00
IUUC-Psi-093785	Pelodiscus sinensis	59.82	9.00e-109	387.00
IUUC-Pab-098222	Pongo abelii	89.27	4.00e-168	584.00
IUUC-Pca-100668	Procavia capensis	81.11	0.00e+00	649.00
IUUC-Pva-102767	Pteropus vampyrus	75.56	8.00e-163	566.00
IUUC-Rno-106001	Rattus norvegicus	82.52	0.00e+00	679.00
IUUC-Sar-113338	Sorex araneus	77.54	3.00e-167	581.00
IUUC-Ssc-116027	Sus scrofa	87.63	0.00e+00	731.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence