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Tag Content
iUUCD ID IUUC-Oan-073701
Ensembl Protein ID ENSOANP00000024541.2
UniProt Accession F7DZA5; F7DZA5_ORNAN
Protein Name E3 ubiquitin-protein ligase
Gene Name SIAH3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOANG00000015581.2 ENSOANT00000024545.2 ENSOANP00000024541.2
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 24.83 3.00e-10 62.40 IUUC-Ath-007192
E3 activity/RING/RING 52.12 6.00e-49 191.00 IUUC-Dme-031700
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Ornithorhynchus anatinus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
MRQTLRKLKV GMSEARKAVI MSLFHPKCSS QTHYEAKRVF SAAGQLVCVV NPTRNRKPVP 60
ARRPVAQDSP DQDGFHPHHH HHRRHHPSLR RQEPTRPGGP PLTPCPLFSC QWEGHLEVVV 120
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Protein Fasta Sequence


>IUUC-Oan-073701|E3,RING|Ornithorhynchus anatinus
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Nucleotide Sequence
(Fasta)
ATGAGGTGAG TTTGCAGTGC CATTCTGCTT ACTGGTATAG TGTACTCTCC CATGCAGTTA 60
ATACAGTGAT CTGTACACAT TGAGCATTCG ATTATGTAAT TGAAAATGTT AGTGTTATAT 120
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Nucleotide Fasta Sequence


>IUUC-Oan-073701|E3,RING|Ornithorhynchus anatinus
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
Pfam

PF03145--Sina
Gene Ontology

GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0007275--P:multicellular organism development
GO:1903215--P:negative regulation of protein targeting to mitochondrion
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000061 Aegilops tauschii 24.83 6.00e-11 60.80
IUUC-Aml-001409 Ailuropoda melanoleuca 53.85 6.00e-50 190.00
IUUC-Atr-003118 Amborella trichopoda 23.49 1.00e-11 62.80
IUUC-Apl-003813 Anas platyrhynchos 52.56 3.00e-49 187.00
IUUC-Aca-005014 Anolis carolinensis 52.56 4.00e-49 187.00
IUUC-Aly-006522 Arabidopsis lyrata 24.83 2.00e-11 62.40
IUUC-Ath-007192 Arabidopsis thaliana 24.83 2.00e-11 62.40
IUUC-Ame-011678 Astyanax mexicanus 55.13 5.00e-51 194.00
IUUC-Bta-012750 Bos taurus 53.85 3.00e-50 191.00
IUUC-Bdi-014200 Brachypodium distachyon 24.83 4.00e-11 61.20
IUUC-Bol-015884 Brassica oleracea 25.15 7.00e-12 63.90
IUUC-Bra-016775 Brassica rapa 25.15 7.00e-12 63.90
IUUC-Cel-018320 Caenorhabditis elegans 47.85 3.00e-41 161.00
IUUC-Cja-019800 Callithrix jacchus 53.85 5.00e-50 190.00
IUUC-Cfa-020505 Canis familiaris 53.85 8.00e-50 189.00
IUUC-Cpo-021394 Cavia porcellus 53.85 6.00e-50 190.00
IUUC-Csa-023374 Chlorocebus sabaeus 53.85 5.00e-50 190.00
IUUC-Cho-024933 Choloepus hoffmanni 53.85 5.00e-50 190.00
IUUC-Cin-025674 Ciona intestinalis 53.85 9.00e-49 186.00
IUUC-Csv-026233 Ciona savignyi 53.85 3.00e-48 184.00
IUUC-Dre-027711 Danio rerio 55.13 8.00e-51 193.00
IUUC-Dno-029260 Dasypus novemcinctus 53.85 7.00e-50 190.00
IUUC-Dor-030489 Dipodomys ordii 53.85 3.00e-50 190.00
IUUC-Dme-031700 Drosophila melanogaster 53.85 7.00e-50 190.00
IUUC-Ete-032946 Echinops telfairi 54.49 3.00e-50 191.00
IUUC-Eca-033546 Equus caballus 53.85 3.00e-50 191.00
IUUC-Eeu-034861 Erinaceus europaeus 53.85 2.00e-49 188.00
IUUC-Fca-035362 Felis catus 52.56 4.00e-49 187.00
IUUC-Fal-037487 Ficedula albicollis 52.56 3.00e-49 187.00
IUUC-Gmo-039091 Gadus morhua 53.85 6.00e-50 190.00
IUUC-Gga-040252 Gallus gallus 53.21 6.00e-50 190.00
IUUC-Gac-041673 Gasterosteus aculeatus 53.85 6.00e-50 190.00
IUUC-Gma-042926 Glycine max 22.82 4.00e-11 61.20
IUUC-Ggo-044618 Gorilla gorilla 53.85 5.00e-50 190.00
IUUC-Hsa-046179 Homo sapiens 53.85 5.00e-50 190.00
IUUC-Hvu-047574 Hordeum vulgare 24.83 6.00e-11 60.80
IUUC-Itr-048976 Ictidomys tridecemlineatus 53.21 2.00e-49 188.00
IUUC-Lch-049496 Latimeria chalumnae 53.21 8.00e-50 189.00
IUUC-Lpe-050879 Leersia perrieri 24.16 9.00e-11 60.50
IUUC-Loc-052107 Lepisosteus oculatus 55.13 3.00e-51 194.00
IUUC-Laf-054257 Loxodonta africana 53.85 5.00e-50 190.00
IUUC-Mcc-055023 Macaca mulatta 53.85 5.00e-50 190.00
IUUC-Meu-055922 Macropus eugenii 54.49 4.00e-50 190.00
IUUC-Mtr-058422 Medicago truncatula 24.83 4.00e-12 64.70
IUUC-Mga-060070 Meleagris gallopavo 53.85 1.00e-50 192.00
IUUC-Mmr-061494 Microcebus murinus 53.85 5.00e-50 190.00
IUUC-Mdo-061971 Monodelphis domestica 53.85 1.00e-49 189.00
IUUC-Mmu-063206 Mus musculus 53.85 4.00e-50 191.00
IUUC-Mac-065014 Musa acuminata 26.17 6.00e-12 63.90
IUUC-Mpu-066597 Mustela putorius furo 53.85 5.00e-50 190.00
IUUC-Mlu-067199 Myotis lucifugus 53.85 6.00e-50 190.00
IUUC-Nle-069342 Nomascus leucogenys 53.85 5.00e-50 190.00
IUUC-Opr-070341 Ochotona princeps 73.68 2.00e-98 351.00
IUUC-Ont-071906 Oreochromis niloticus 53.85 6.00e-50 190.00
IUUC-Ocu-073950 Oryctolagus cuniculus 53.85 4.00e-50 190.00
IUUC-Oba-075789 Oryza barthii 22.64 6.00e-12 64.30
IUUC-Obr-076037 Oryza brachyantha 22.64 9.00e-12 63.90
IUUC-Ogl-077148 Oryza glaberrima 22.64 6.00e-12 64.30
IUUC-Ogu-078042 Oryza glumaepatula 22.64 7.00e-12 63.90
IUUC-Oin-079325 Oryza indica 22.64 5.00e-12 64.30
IUUC-Olo-080244 Oryza longistaminata 22.64 1.00e-11 63.90
IUUC-Ome-081318 Oryza meridionalis 24.16 9.00e-11 60.10
IUUC-Oni-082163 Oryza nivara 22.64 6.00e-12 64.30
IUUC-Opu-084065 Oryza punctata 24.16 9.00e-11 60.10
IUUC-Oru-084833 Oryza rufipogon 22.64 5.00e-12 64.30
IUUC-Osa-085316 Oryza sativa 22.64 5.00e-12 64.30
IUUC-Ola-086814 Oryzias latipes 52.56 4.00e-49 187.00
IUUC-Oga-089154 Otolemur garnettii 53.85 5.00e-50 190.00
IUUC-Oar-089446 Ovis aries 53.85 4.00e-50 190.00
IUUC-Ptr-091088 Pan troglodytes 53.85 5.00e-50 190.00
IUUC-Pan-092012 Papio anubis 52.56 4.00e-49 187.00
IUUC-Psi-093079 Pelodiscus sinensis 53.85 5.00e-50 190.00
IUUC-Pma-094387 Petromyzon marinus 52.23 3.00e-48 184.00
IUUC-Ppa-095212 Physcomitrella patens 25.50 2.00e-12 65.90
IUUC-Pfo-097134 Poecilia formosa 52.56 4.00e-49 187.00
IUUC-Pab-098092 Pongo abelii 53.85 5.00e-50 190.00
IUUC-Pop-099563 Populus trichocarpa 26.67 1.00e-12 66.20
IUUC-Pca-100328 Procavia capensis 53.85 3.00e-50 191.00
IUUC-Ppe-101960 Prunus persica 24.83 3.00e-11 61.60
IUUC-Pva-103132 Pteropus vampyrus 68.88 8.00e-92 328.00
IUUC-Rno-105477 Rattus norvegicus 53.85 4.00e-50 191.00
IUUC-Sha-107630 Sarcophilus harrisii 53.85 8.00e-50 189.00
IUUC-Smo-109412 Selaginella moellendorffii 25.50 2.00e-12 65.90
IUUC-Sit-110245 Setaria italica 22.64 3.00e-11 62.40
IUUC-Sly-111117 Solanum lycopersicum 25.68 2.00e-11 62.80
IUUC-Stu-112474 Solanum tuberosum 24.83 1.00e-11 63.50
IUUC-Sbi-114035 Sorghum bicolor 23.27 6.00e-12 63.90
IUUC-Ssc-116441 Sus scrofa 53.85 3.00e-50 191.00
IUUC-Tgu-116579 Taeniopygia guttata 52.56 3.00e-49 187.00
IUUC-Tru-118004 Takifugu rubripes 53.85 2.00e-49 188.00
IUUC-Tsy-119548 Tarsius syrichta 51.16 6.00e-39 152.00
IUUC-Tni-120846 Tetraodon nigroviridis 53.21 6.00e-49 186.00
IUUC-Tca-121228 Theobroma cacao 23.49 7.00e-12 63.90
IUUC-Tae-123647 Triticum aestivum 24.83 6.00e-11 60.80
IUUC-Tur-126049 Triticum urartu 23.49 1.00e-10 60.10
IUUC-Ttr-129166 Tursiops truncatus 53.52 1.00e-43 169.00
IUUC-Vpa-130799 Vicugna pacos 53.85 7.00e-51 192.00
IUUC-Vvi-131233 Vitis vinifera 25.00 4.00e-12 64.70
IUUC-Xtr-132553 Xenopus tropicalis 52.56 4.00e-49 187.00
IUUC-Xma-133670 Xiphophorus maculatus 52.56 4.00e-49 187.00
Created Date 25-Jun-2017

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