iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071906

Ensembl Protein ID

ENSONIP00000017552.1

UniProt Accession

I3K8V7; I3K8V7_ORENI

Genbank Protein ID

ENSONIP00000017552

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AERX01059840

Gene Name

siah2l; LOC100695892

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000013966.1	ENSONIT00000017567.1	ENSONIP00000017552.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	90.12	4.00e-139	491.00	IUUC-Hsa-046179
E3 activity/RING/RING	90.12	2.00e-139	493.00	IUUC-Mmu-063206
E3 activity/RING/RING	90.12	1.00e-139	493.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Oreochromis niloticus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MTVPPVRQLS GTGPQLEAMS RPSSAGGGGL GAGKAGGGKH GGAGGASAAV AAAAGVSSVA 60
GSGSVPPSST VSMPATGLAG QSSELTALFE CPVCFDYVLP PILQCQAGHL VCNQCRQKLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACGGTAC CGCCTGTTCG GCAGCTCTCA GGAACGGGAC CGCAGCTGGA AGCTATGAGT 60
CGTCCGTCTT CAGCCGGAGG TGGGGGACTC GGGGCCGGAA AAGCAGGCGG GGGGAAGCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	90.12	1.00e-140	492.00
IUUC-Ame-011678	Astyanax mexicanus	96.85	1.00e-149	522.00
IUUC-Bta-012750	Bos taurus	89.72	3.00e-140	491.00
IUUC-Cja-019800	Callithrix jacchus	90.12	1.00e-140	492.00
IUUC-Cfa-020505	Canis familiaris	89.72	3.00e-140	491.00
IUUC-Cpo-021394	Cavia porcellus	88.72	1.00e-140	492.00
IUUC-Csa-023374	Chlorocebus sabaeus	90.12	1.00e-140	492.00
IUUC-Cho-024933	Choloepus hoffmanni	90.12	1.00e-140	492.00
IUUC-Dre-027711	Danio rerio	97.24	1.00e-149	522.00
IUUC-Dno-029260	Dasypus novemcinctus	86.15	1.00e-136	479.00
IUUC-Dor-030489	Dipodomys ordii	89.07	6.00e-100	355.00
IUUC-Ete-032946	Echinops telfairi	90.12	3.00e-140	491.00
IUUC-Eca-033546	Equus caballus	89.45	2.00e-141	494.00
IUUC-Eeu-034861	Erinaceus europaeus	87.35	9.00e-136	476.00
IUUC-Gmo-039091	Gadus morhua	96.17	3.00e-150	524.00
IUUC-Gga-040252	Gallus gallus	88.93	5.00e-138	483.00
IUUC-Gac-041673	Gasterosteus aculeatus	98.42	8.00e-152	529.00
IUUC-Ggo-044618	Gorilla gorilla	90.12	1.00e-140	492.00
IUUC-Hsa-046179	Homo sapiens	90.12	1.00e-140	492.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	89.33	9.00e-140	489.00
IUUC-Lch-049496	Latimeria chalumnae	85.82	1.00e-141	495.00
IUUC-Loc-052107	Lepisosteus oculatus	97.20	7.00e-148	516.00
IUUC-Laf-054257	Loxodonta africana	88.03	7.00e-139	486.00
IUUC-Mcc-055023	Macaca mulatta	90.12	1.00e-140	492.00
IUUC-Meu-055922	Macropus eugenii	88.54	3.00e-137	481.00
IUUC-Mga-060070	Meleagris gallopavo	84.85	3.00e-134	471.00
IUUC-Mmr-061494	Microcebus murinus	90.12	1.00e-140	492.00
IUUC-Mdo-061971	Monodelphis domestica	90.12	2.00e-140	491.00
IUUC-Mmu-063206	Mus musculus	90.12	8.00e-141	493.00
IUUC-Mpu-066597	Mustela putorius furo	90.12	1.00e-140	492.00
IUUC-Mlu-067199	Myotis lucifugus	89.72	5.00e-140	490.00
IUUC-Nle-069342	Nomascus leucogenys	90.12	1.00e-140	492.00
IUUC-Opr-070341	Ochotona princeps	56.86	4.00e-50	191.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	8.00e-50	190.00
IUUC-Ocu-073950	Oryctolagus cuniculus	89.72	3.00e-140	491.00
IUUC-Oga-089154	Otolemur garnettii	90.12	1.00e-140	492.00
IUUC-Oar-089446	Ovis aries	89.72	3.00e-140	490.00
IUUC-Ptr-091088	Pan troglodytes	90.12	1.00e-140	492.00
IUUC-Psi-093079	Pelodiscus sinensis	90.12	2.00e-140	491.00
IUUC-Pfo-097007	Poecilia formosa	92.89	9.00e-143	499.00
IUUC-Pab-098092	Pongo abelii	90.12	1.00e-140	492.00
IUUC-Pca-100328	Procavia capensis	87.75	2.00e-136	478.00
IUUC-Pva-102368	Pteropus vampyrus	96.36	6.00e-61	227.00
IUUC-Rno-105477	Rattus norvegicus	90.12	8.00e-141	493.00
IUUC-Sha-107630	Sarcophilus harrisii	89.72	5.00e-140	489.00
IUUC-Ssc-116441	Sus scrofa	89.72	3.00e-140	491.00
IUUC-Tru-118004	Takifugu rubripes	94.92	1.00e-146	512.00
IUUC-Tsy-119548	Tarsius syrichta	86.26	3.00e-64	237.00
IUUC-Tni-120846	Tetraodon nigroviridis	96.84	1.00e-148	518.00
IUUC-Vpa-130799	Vicugna pacos	91.81	2.00e-96	344.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence