iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000001692.1	ENSONIT00000002120.1	ENSONIP00000002120.1
ENSONIG00000001692.1	ENSONIT00000002121.1	ENSONIP00000002121.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.00e-53	182.2	324	869
UBD/Alpha-Helix/UBA	1.40e-17	63.6	726	764

Active Site

Position(s)	Description	Evidence
333	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
832	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel.............w..kskkkavsprell 74
           tG+kNlgN+CY+  v+Q+L++ip++++++   + +++ + +p +p+++++++++kl + l             +  ++++k +s r+l+
   Q: 324  TGIKNLGNSCYLSTVMQVLFSIPDFQRMYVG-NLQRIFDYSPLDPTQDFATQMAKLGHGLlsgqyskppmkseLieQHQQKGISARMLK 411
           7******************************.7777778889******************777777777766515699999******** PP
   S: 75   kalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvs 163
           + +++ ++efs+++qqDa+Efl ++++ +e++                               +++  sd+F++ ++++++c + ++v 
   Q: 412  ALVSRGHPEFSSNRQQDAHEFLLHMINLVERNS-----------------------------AGSENPSDVFRFLVEERVQCCQTRRVR 471
           ******************************999.............................678899**************9999988 PP
   S: 164  sreepfldlslpvpgkeetkke.............................slqdcLesftkeeelegenkyycekckkkqeaekklkl 223
            ++   + ++lp p +  ++                                ++ cL++ft++e++ +   ++++  ++k+  +k+ ++
   Q: 472  YTQRVDYCIQLPAPFEAASNRVpeellayevkrkeaeenmrpspepvrariPFTACLQAFTEPENVPD---FWSSALQAKSAGVKTSRF 557
           7777777777777766544444679*****************************************97...****************** PP
   S: 224  kklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts............................................. 267
            ++Pe+L++++k+f+f  + ++++k++  +++p+ Ldl++  ++                                             
   Q: 558  ASFPEYLVVQIKKFTFGVD-WVPKKLDVAIDVPDFLDLNRLRATglqageeelpdlmppivlpedtrvclnilglnmpdsflslinhps 645
           ****************776.*******************98888889999999999999999999999999999999999988888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 646  tpeideaavmqlaemgfpleacrkavyytgnmgpemafnwiiahmeepdfaepltlpsmidpgpsagdsptgaallgnsppeesiailt 734
           88888888888888888888888888888888888888888888888888888888888888877777777777777777777777777 PP
   S: 268  .................................peekqke..........................................kkkYeLi 281
                                            +     e                                          + +YeL+
   Q: 735  smgfprthsihalkatnnnleraldwifthpeeE-----EsdalsdmadtepndnafsnanshsdstlspdgdasgprvkdgPGRYELF 818
           7777777777777666666666666666665440.....0445666666666666777777777888888888889999999******* PP
   S: 282  avvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           a ++H+G s+ sGHYv+++k+ +g+W+ ++D+kV  +  e+  +   + +Y++fY+r
   Q: 819  AFISHMGaSTMSGHYVCHIKK-EGRWVIYNDHKVCLS--ERPPK---DLGYIYFYHR 869
           *********************.9***********988..78888...89******97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
            e+ ++ l++MGF+r + + aL a+nnnle+A+++++++
   Q: 726  PEESIAILTSMGFPRTHSIHALKATNNNLERALDWIFTH 764
           5899*********************************98 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MAADLGELLV PYMPTIRVPR TGDRVFKSEC AFSFDSPESE GGLYVCMNTF LGFGREHVER 60
HYRKTGQSVY MHLKRHVKEK ATGAAGGGTI PRRRNGKVFL DLELNRDFNG EDYEYEDEAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGCAG ACCTAGGAGA GCTGCTGGTC CCATACATGC CCACCATCAG GGTCCCCAGA 60
ACAGGAGACA GGGTTTTCAA GAGCGAGTGC GCCTTTTCTT TCGACTCTCC CGTAAGTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	72.15	0.00e+00	1226.00
IUUC-Apl-003712	Anas platyrhynchos	71.72	0.00e+00	1200.00
IUUC-Aca-004634	Anolis carolinensis	73.07	0.00e+00	1244.00
IUUC-Ame-011470	Astyanax mexicanus	82.16	0.00e+00	1438.00
IUUC-Bta-013349	Bos taurus	72.58	0.00e+00	1241.00
IUUC-Cja-019021	Callithrix jacchus	72.10	0.00e+00	1221.00
IUUC-Cfa-020614	Canis familiaris	72.15	0.00e+00	1225.00
IUUC-Cpo-022484	Cavia porcellus	71.02	0.00e+00	1157.00
IUUC-Csa-024078	Chlorocebus sabaeus	72.21	0.00e+00	1227.00
IUUC-Dre-027651	Danio rerio	83.77	0.00e+00	1506.00
IUUC-Dno-028975	Dasypus novemcinctus	71.48	0.00e+00	1214.00
IUUC-Dor-030130	Dipodomys ordii	65.18	3.00e-167	582.00
IUUC-Ete-032251	Echinops telfairi	60.45	0.00e+00	952.00
IUUC-Eca-033568	Equus caballus	71.02	0.00e+00	1161.00
IUUC-Fca-036280	Felis catus	71.87	0.00e+00	1162.00
IUUC-Fal-036610	Ficedula albicollis	72.30	0.00e+00	1174.00
IUUC-Gmo-038906	Gadus morhua	82.20	0.00e+00	1452.00
IUUC-Gga-041215	Gallus gallus	71.98	0.00e+00	1250.00
IUUC-Gac-042441	Gasterosteus aculeatus	86.86	0.00e+00	1544.00
IUUC-Ggo-044446	Gorilla gorilla	72.21	0.00e+00	1228.00
IUUC-Hsa-046546	Homo sapiens	71.98	0.00e+00	1222.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	69.12	0.00e+00	1148.00
IUUC-Lch-050425	Latimeria chalumnae	74.04	0.00e+00	1305.00
IUUC-Loc-052072	Lepisosteus oculatus	77.27	0.00e+00	1322.00
IUUC-Laf-053909	Loxodonta africana	70.76	0.00e+00	1212.00
IUUC-Mcc-054686	Macaca mulatta	72.10	0.00e+00	1229.00
IUUC-Meu-056361	Macropus eugenii	73.98	0.00e+00	942.00
IUUC-Mga-059972	Meleagris gallopavo	68.83	0.00e+00	1166.00
IUUC-Mmr-060916	Microcebus murinus	71.75	0.00e+00	1224.00
IUUC-Mdo-062302	Monodelphis domestica	74.20	0.00e+00	1306.00
IUUC-Mmu-063639	Mus musculus	71.51	0.00e+00	1221.00
IUUC-Mpu-066533	Mustela putorius furo	72.03	0.00e+00	1225.00
IUUC-Mlu-067786	Myotis lucifugus	70.00	0.00e+00	1165.00
IUUC-Nle-069997	Nomascus leucogenys	71.79	0.00e+00	1145.00
IUUC-Oan-072959	Ornithorhynchus anatinus	79.06	1.00e-110	392.00
IUUC-Ocu-074265	Oryctolagus cuniculus	71.64	0.00e+00	1219.00
IUUC-Ola-087344	Oryzias latipes	88.44	0.00e+00	1609.00
IUUC-Oga-088734	Otolemur garnettii	71.97	0.00e+00	1208.00
IUUC-Oar-089636	Ovis aries	72.45	0.00e+00	1206.00
IUUC-Ptr-090982	Pan troglodytes	72.10	0.00e+00	1225.00
IUUC-Pan-091991	Papio anubis	72.21	0.00e+00	1229.00
IUUC-Psi-093509	Pelodiscus sinensis	73.15	0.00e+00	1273.00
IUUC-Pfo-096029	Poecilia formosa	89.92	0.00e+00	1634.00
IUUC-Pab-098672	Pongo abelii	68.76	0.00e+00	1142.00
IUUC-Pva-102545	Pteropus vampyrus	71.30	0.00e+00	1020.00
IUUC-Rno-105210	Rattus norvegicus	71.40	0.00e+00	1209.00
IUUC-Sar-113733	Sorex araneus	74.39	6.00e-173	601.00
IUUC-Tgu-116591	Taeniopygia guttata	73.27	0.00e+00	1265.00
IUUC-Tru-118627	Takifugu rubripes	89.04	0.00e+00	1627.00
IUUC-Tsy-119278	Tarsius syrichta	64.33	0.00e+00	1031.00
IUUC-Tni-120804	Tetraodon nigroviridis	89.55	0.00e+00	1624.00
IUUC-Ttr-128295	Tursiops truncatus	66.10	0.00e+00	1113.00
IUUC-Vpa-130170	Vicugna pacos	63.66	0.00e+00	991.00
IUUC-Xtr-132809	Xenopus tropicalis	67.39	0.00e+00	1194.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence