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Tag Content
UUCD2 ID IUUC-Tgu-116591
UUCD1 version UUC-TaG-01006
Ensembl Protein ID ENSTGUP00000010966.1
UniProt Accession H0ZK46; H0ZK46_TAEGU
Genbank Protein ID ENSTGUP00000010966
Protein Name Ubiquitinyl hydrolase 1
Genbank Nucleotide ID ABQF01023275
Gene Name USP13
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSTGUG00000010622.1 ENSTGUT00000011081.1 ENSTGUP00000010966.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 3.30e-55 187.4 331 858
UBD/Alpha-Helix/UBA 1.20e-18 66.4 725 762
Active Site
Position(s) Description Evidence
340 Nucleophile {ECO:0000256|PIRSR:PIRSR016308-1}
821 Proton acceptor {ECO:0000256|PIRSR:PIRSR016308-1}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tG+kNlgN+CY+N+v+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 331  TGMKNLGNSCYLNAVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMAKLGHGLlsgqyskppmkselieqvmkeeHKPQHNG 418
           7******************************788777765.79*****************8888888888877777665443377777* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++++c
   Q: 419  ISPRMFKAFISKGHPEFSSNRQQDAQEFFLHLINLVERNP-----------------------------VGSENPSDVFRFLVEERTQC 478
           ************************************9998.............................788899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f+++ ++e+   ++++  ++k+  +
   Q: 479  CQSRKVRYTERVDYIMQLPVAMEAATNKDeliayelkrreaeaarrplpelvrakiPFSACLQAFSEPSNVED---FWSSALQAKSAGV 564
           *******99999999*****99998888799*****************************************7...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + + ++k++ ++++p+ Ld+s+  ++                                        
   Q: 565  KTSRFASFPEYLVVQIKKFTFGLD-WIPKKLDVSIDMPDFLDISHLRARglqpgeeelpdiappivipddpkallfsslldnpnidess 652
           *********************997.*******************999889999999999999999999999999999999998888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 653  vmqlaemgfpleacrkavyytgnlgaevafnwiiahmeepdfaeplvipafgevassgaaalgavgldnqppeemvaiiismgfqrnla 741
           88888888888888888888888888888888888888888888888888877777777777777777777777777777777777777 PP
   S: 268  .......................peekqke..................................kkkYeLiavvvHsG.slssGHYvay 298
                                  p     e                                  + +YeL++ ++H+G s+ sGHYv++
   Q: 742  iqalkatnnnleralewifshpdP-----EeesdpaldtmdmennananilsetgsegprikdgPGRYELFGFISHMGtSTMSGHYVCH 825
           766666666666666666655551.....04555566666666667777888888888999999************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            ++ +g+W+ ++D +V ++  e+  +   + +Y++fY+r
   Q: 826  LRK-EGRWVIYNDLRVCAS--ERPPK---DLGYIYFYHR 858
           ***.9***********999..78888...89******97 PP
   

   UBD/Alpha-Helix/UBA
   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaL a+nnnle+A+e+++++
   Q: 725  EEMVAIIISMGFQRNLAIQALKATNNNLERALEWIFSH 762
           89**********************************97 PP
   
Organism Taeniopygia guttata
Protein Sequence
(Fasta)
MQRAALFRAG DAQMAAGDLG ELLVPYMPTI RVPKSGDRVY KTECAFSYDS PDSEGGLYVC 60
MNTFLGFGRE HMERHYRKTG QCVYLHLKRH VRQKVPGASG GALPKRRNAK LFLDLEISSD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Tgu-116591|DUB,USP;UBD,UBA|Taeniopygia guttata
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCAGCGGG CCGCGCTCTT CCGCGCCGGC GATGCGCAGA TGGCCGCCGG GGACCTGGGC 60
GAGCTGCTCG TCCCCTACAT GCCCACGATC CGCGTGCCCA AGTCAGGGGA CCGGGTCTAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Tgu-116591|DUB,USP;UBD,UBA|Taeniopygia guttata
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP
SMART

SM00165--UBA
SM00290--ZnF_UBP
Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001356 Ailuropoda melanoleuca 84.69 0.00e+00 1429.00
IUUC-Apl-003712 Anas platyrhynchos 94.08 0.00e+00 1513.00
IUUC-Aca-004634 Anolis carolinensis 85.20 0.00e+00 1459.00
IUUC-Ame-011470 Astyanax mexicanus 75.03 0.00e+00 1322.00
IUUC-Bta-013349 Bos taurus 84.14 0.00e+00 1454.00
IUUC-Cja-019021 Callithrix jacchus 84.36 0.00e+00 1421.00
IUUC-Cfa-020614 Canis familiaris 84.70 0.00e+00 1429.00
IUUC-Cpo-022484 Cavia porcellus 84.58 0.00e+00 1350.00
IUUC-Csa-024078 Chlorocebus sabaeus 84.61 0.00e+00 1431.00
IUUC-Cho-024522 Choloepus hoffmanni 69.38 0.00e+00 1054.00
IUUC-Cme-027335 Cyanidioschyzon merolae 27.05 6.00e-53 202.00
IUUC-Dre-027651 Danio rerio 75.87 0.00e+00 1397.00
IUUC-Dno-028975 Dasypus novemcinctus 84.41 0.00e+00 1422.00
IUUC-Dor-030130 Dipodomys ordii 62.76 0.00e+00 936.00
IUUC-Ete-032251 Echinops telfairi 71.85 0.00e+00 1139.00
IUUC-Eca-033568 Equus caballus 85.31 0.00e+00 1350.00
IUUC-Eeu-034612 Erinaceus europaeus 69.47 0.00e+00 1041.00
IUUC-Fca-036280 Felis catus 85.66 0.00e+00 1355.00
IUUC-Fal-036610 Ficedula albicollis 96.25 0.00e+00 1501.00
IUUC-Gmo-038906 Gadus morhua 72.44 0.00e+00 1286.00
IUUC-Gga-041215 Gallus gallus 92.69 0.00e+00 1579.00
IUUC-Gac-042441 Gasterosteus aculeatus 73.02 0.00e+00 1313.00
IUUC-Ggo-044446 Gorilla gorilla 84.61 0.00e+00 1432.00
IUUC-Hsa-046546 Homo sapiens 84.49 0.00e+00 1428.00
IUUC-Itr-048147 Ictidomys tridecemlineatus 78.71 0.00e+00 1297.00
IUUC-Lch-050425 Latimeria chalumnae 78.73 0.00e+00 1405.00
IUUC-Loc-052072 Lepisosteus oculatus 77.23 0.00e+00 1342.00
IUUC-Laf-053909 Loxodonta africana 83.04 0.00e+00 1412.00
IUUC-Mcc-054686 Macaca mulatta 84.72 0.00e+00 1433.00
IUUC-Meu-056361 Macropus eugenii 76.68 0.00e+00 1276.00
IUUC-Mga-059972 Meleagris gallopavo 86.90 0.00e+00 1422.00
IUUC-Mmr-060916 Microcebus murinus 84.03 0.00e+00 1425.00
IUUC-Mdo-062302 Monodelphis domestica 84.02 0.00e+00 1487.00
IUUC-Mmu-063639 Mus musculus 84.90 0.00e+00 1437.00
IUUC-Mpu-066533 Mustela putorius furo 84.70 0.00e+00 1430.00
IUUC-Mlu-067786 Myotis lucifugus 80.82 0.00e+00 1333.00
IUUC-Nle-069997 Nomascus leucogenys 85.27 0.00e+00 1337.00
IUUC-Ont-071859 Oreochromis niloticus 72.92 0.00e+00 1308.00
IUUC-Oan-072959 Ornithorhynchus anatinus 87.03 4.00e-128 449.00
IUUC-Ocu-074265 Oryctolagus cuniculus 84.88 0.00e+00 1420.00
IUUC-Ola-087344 Oryzias latipes 72.68 0.00e+00 1318.00
IUUC-Oga-088734 Otolemur garnettii 85.39 0.00e+00 1400.00
IUUC-Oar-089636 Ovis aries 84.81 0.00e+00 1405.00
IUUC-Ptr-090982 Pan troglodytes 84.61 0.00e+00 1431.00
IUUC-Pan-091991 Papio anubis 84.72 0.00e+00 1432.00
IUUC-Psi-093509 Pelodiscus sinensis 89.91 0.00e+00 1546.00
IUUC-Pfo-096029 Poecilia formosa 75.20 0.00e+00 1352.00
IUUC-Pab-098672 Pongo abelii 80.56 0.00e+00 1332.00
IUUC-Pca-100860 Procavia capensis 65.85 0.00e+00 935.00
IUUC-Ppe-101315 Prunus persica 44.20 0.00e+00 681.00
IUUC-Pva-102545 Pteropus vampyrus 78.66 0.00e+00 1303.00
IUUC-Rno-105210 Rattus norvegicus 84.66 0.00e+00 1422.00
IUUC-Sar-113733 Sorex araneus 85.40 0.00e+00 710.00
IUUC-Tru-118627 Takifugu rubripes 71.90 0.00e+00 1320.00
IUUC-Tsy-119278 Tarsius syrichta 77.38 0.00e+00 1214.00
IUUC-Tni-120804 Tetraodon nigroviridis 74.19 0.00e+00 1345.00
IUUC-Tbe-127699 Tupaia belangeri 70.12 0.00e+00 790.00
IUUC-Ttr-128295 Tursiops truncatus 77.34 0.00e+00 1288.00
IUUC-Vpa-130170 Vicugna pacos 75.56 0.00e+00 1179.00
IUUC-Xtr-132809 Xenopus tropicalis 75.18 0.00e+00 1293.00
Created Date 25-Jun-2017

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