iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-116223

Ensembl Protein ID

ENSSSCP00000028053.1

UniProt Accession

I3LVA1; I3LVA1_PIG

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000021712.1	ENSSSCT00000026224.1	ENSSSCP00000028053.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.00e-87	292.7	43	363

Active Site

Position(s)	Description	Evidence
333	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
            dl+k+l vef +E +   +Gv++ef++++++e+ ++++glf y e+++++++p + +        k++ ++G+l+g++l++ ++++lp
   Q: 43   TDLRKVLVVEFIKEICSVGEGVKSEFFHCIFEEMIKKEYGLFIYPEDGSCMWFPVNXTR-----GKKMYFLFGILCGLSLYNLNVVNLP 126
           699*************9999*********************************999885.....45666688***************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           ++ +++k+ll++k sledl+e+ p l ksl+e+++ + +di+e+ l l fs    i+ + ++++L+p+G++++V + Nk++Y++++v+y
   Q: 127  FPLALFKKLLDQKPSLEDLKELSPLLGKSLQEVLNDEADDIKEE-LGLCFS----IYWDKEAVDLIPNGSSVSVDQINKKDYISKYVNY 210
           **********************************9988888876.888886....89999***************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           +++ ++   +e+f++Gf++v+++e+l+lF++eel + i G +++d+++++k+  y++gy+ ++p+i +Fw+++++++ +e+k+fL F+T
   Q: 211  IFNASVMGVYEEFQRGFHKVCDKEILKLFHPEELMTAIVGHTDYDWQQFEKNSAYDQGYHVSHPTIVMFWKAFHKLTLDEKKKFLFFLT 299
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           g++rl ++G++++   lf +++  s+++ P+  TC n L+LP+Ys++e ++e L++Ai++ kgF 
   Q: 300  GNDRLHVRGVQKMG-ILFRCPETLSERDNPRPLTCHNILDLPKYSTMERMEEALQVAINNHKGFT 363
           **************.889999999***************************************96 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MDFNQVILQR KDEFPPSPIF TLKVRRSHLV EDTLRQLSQA DATDLRKVLV VEFIKEICSV 60
GEGVKSEFFH CIFEEMIKKE YGLFIYPEDG SCMWFPVNXT RGKKMYFLFG ILCGLSLYNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAGGCCTGT GGTGCCAACA CTGCTAAGTG GATAACACTG GACCAATGTC TCAGCGTGGC 60
CAGTATCACT CCAGTAGTGC CTTGAAGAAT TATGGTGCTA TAACACATGA TCTGAGAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ete-032531	Echinops telfairi	60.44	4.00e-116	412.00
IUUC-Eeu-035028	Erinaceus europaeus	70.08	1.00e-95	344.00
IUUC-Opr-070190	Ochotona princeps	65.58	2.00e-111	396.00
IUUC-Ocu-074640	Oryctolagus cuniculus	70.72	3.00e-145	508.00
IUUC-Pan-091802	Papio anubis	75.14	5.00e-166	578.00
IUUC-Pab-098024	Pongo abelii	74.25	1.00e-165	577.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence