iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cne-027069

Ensembl Protein ID

AAW44697

UniProt Accession

P0CS48; Q55PP3; Q5KDR4; PRP46_CRYNJ

Genbank Protein ID

AAW44697.1

Protein Name

Pre-mRNA-splicing factor PRP46; Pre-mRNA-processing protein 46

Genbank Nucleotide ID

AE017347

Gene Name

PRP46; CNG03060

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CNG03060	AAW44697	AAW44697

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.50e-44	145.3	180	216
UBD/Beta-Prp	3.50e-64	215.2	181	430

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH ++v+++a  ++   +++G++D +ik+WDl +g l
   Q: 180  GHMGWVRAVAMdPGnQWFATGAGDRVIKIWDLASGEL 216
           8***********77799***************99976 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdk 108
           h+   +++v++ p+++++atg  d+ ik+wd+ +g l  sl gh ++++ +  s++ ++l +++eD+++k wdl+t+k +++++gh + v+sls++p+ d+
   Q: 181  HMG-WVRAVAMDPGNQWFATGAGDRVIKIWDLASGELKLSLTGHISTIRGLAVSDRHPYLFSCAEDKMVKCWDLETNKVIRHYHGHFSGVYSLSVHPTLDV 280
           444.667799******************************************************************************************* PP
   S: 109  lvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsld.gtvklwd 208
           lv+G++d  +rvwd++t+  +  tl+gh+++v  v++++++  ++sGs D+tvrlWdl+ gk++ tlt  h++sv+ l+++++  +++s+s   + +k w 
   Q: 281  LVTGGRDASVRVWDMRTRANIF-TLTGHTSTVGDVKTQDSDPQIISGSMDSTVRLWDLAAGKCMNTLTH-HKKSVRALAIHPTEYSFASASSGgNNIKKWK 379
           *********************9.*********************************************9.******************99876268***** PP
   S: 209  lqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktl 260
           + +g  v+ + gh++ ++ +     ++ l sg++ g++ +Wd+++g + + l
   Q: 380  CPEGIFVNNFVGHEAIINTLSIN-SENVLFSGADNGTLTLWDYKTGLPFQHL 430
           ******************99999.99*******************9877766 PP

Organism

Cryptococcus neoformans

Functional Description
(View)

Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.

Protein Sequence
(Fasta)

MSTSLETPSG ASAGPSIVAS GLPPLADLVR AGSKRTRVVY GAETSAVEDD GLARANKIKL 60
ATKLAIEYKD VQTLPPILQA QQTGPAGPKR PTQPSIAASA TAGPNVKLIG GPEAEKASSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCTCTCCA AACTGGATAA CTCCATTTCC GCCAATGTCA ACATCACTCG AAACCCCCTC 60
AGGGGCCTCC GCTGGCCCTT CAATTGTTGC CAGCGGGCTC CCCCCTCTAG CTGATTTAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0071014--C:post-mRNA release spliceosomal complex
GO:0071011--C:precatalytic spliceosome
GO:0000974--C:Prp19 complex
GO:0045292--P:mRNA cis splicing, via spliceosome
GO:0000398--P:mRNA splicing, via spliceosome

KEGG

cne:CNG03060

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000084	Aegilops tauschii	46.05	4.00e-113	399.00
IUUC-Aml-001605	Ailuropoda melanoleuca	54.61	1.00e-127	447.00
IUUC-Atr-002757	Amborella trichopoda	49.19	2.00e-117	413.00
IUUC-Apl-003198	Anas platyrhynchos	48.67	6.00e-129	452.00
IUUC-Aca-004683	Anolis carolinensis	50.10	3.00e-129	453.00
IUUC-Aly-005775	Arabidopsis lyrata	47.44	2.00e-115	407.00
IUUC-Ath-007460	Arabidopsis thaliana	46.31	4.00e-115	406.00
IUUC-Ago-007884	Ashbya gossypii	53.12	6.00e-104	369.00
IUUC-Acl-008153	Aspergillus clavatus	56.18	1.00e-135	474.00
IUUC-Afl-008384	Aspergillus flavus	56.05	5.00e-139	485.00
IUUC-Afu-009045	Aspergillus fumigatus	57.08	9.00e-136	474.00
IUUC-Ani-009229	Aspergillus nidulans	67.82	1.00e-131	460.00
IUUC-Ang-009812	Aspergillus niger	71.43	3.00e-126	442.00
IUUC-Aor-010059	Aspergillus oryzae	56.05	5.00e-139	485.00
IUUC-Ate-010351	Aspergillus terreus	68.14	2.00e-138	483.00
IUUC-Ame-011613	Astyanax mexicanus	36.21	2.00e-67	247.00
IUUC-Bgr-012042	Blumeria graminis	56.10	2.00e-142	497.00
IUUC-Bta-012406	Bos taurus	63.44	2.00e-127	447.00
IUUC-Bci-013760	Botrytis cinerea	57.95	3.00e-140	489.00
IUUC-Bdi-014776	Brachypodium distachyon	48.83	7.00e-115	405.00
IUUC-Bol-016189	Brassica oleracea	48.05	3.00e-116	410.00
IUUC-Bra-018044	Brassica rapa	48.74	3.00e-117	413.00
IUUC-Cel-018651	Caenorhabditis elegans	62.16	3.00e-125	439.00
IUUC-Cja-019974	Callithrix jacchus	63.12	7.00e-127	445.00
IUUC-Cfa-021085	Canis familiaris	61.56	2.00e-127	447.00
IUUC-Cpo-021458	Cavia porcellus	63.44	1.00e-127	447.00
IUUC-Cre-022880	Chlamydomonas reinhardtii	59.19	4.00e-117	412.00
IUUC-Csa-023883	Chlorocebus sabaeus	63.44	2.00e-127	447.00
IUUC-Cho-024623	Choloepus hoffmanni	63.12	1.00e-123	434.00
IUUC-Cin-025190	Ciona intestinalis	66.12	1.00e-127	447.00
IUUC-Csv-026367	Ciona savignyi	66.12	3.00e-128	449.00
IUUC-Cgl-026499	Colletotrichum gloeosporioides	60.33	2.00e-146	510.00
IUUC-Cme-027233	Cyanidioschyzon merolae	29.23	5.00e-32	130.00
IUUC-Dre-028260	Danio rerio	50.10	2.00e-131	460.00
IUUC-Dno-029112	Dasypus novemcinctus	63.44	2.00e-127	447.00
IUUC-Dor-031118	Dipodomys ordii	63.12	8.00e-127	444.00
IUUC-Dse-031493	Dothistroma septosporum	54.51	3.00e-138	483.00
IUUC-Dme-032138	Drosophila melanogaster	67.11	3.00e-130	456.00
IUUC-Ete-032411	Echinops telfairi	55.03	6.00e-103	365.00
IUUC-Eca-033521	Equus caballus	55.09	7.00e-128	448.00
IUUC-Eeu-035249	Erinaceus europaeus	54.69	2.00e-99	353.00
IUUC-Fca-036358	Felis catus	61.26	8.00e-127	445.00
IUUC-Fal-036933	Ficedula albicollis	50.55	3.00e-128	450.00
IUUC-Fox-037713	Fusarium oxysporum	56.72	2.00e-146	510.00
IUUC-Fso-038380	Fusarium solani	69.35	1.00e-138	484.00
IUUC-Gmo-039133	Gadus morhua	49.90	5.00e-128	449.00
IUUC-Ggr-039915	Gaeumannomyces graminis	71.99	9.00e-134	468.00
IUUC-Gga-041176	Gallus gallus	47.84	7.00e-127	445.00
IUUC-Gac-042344	Gasterosteus aculeatus	65.15	1.00e-127	448.00
IUUC-Gma-043328	Glycine max	48.71	6.00e-117	412.00
IUUC-Ggo-044478	Gorilla gorilla	63.44	2.00e-127	447.00
IUUC-Hsa-046037	Homo sapiens	63.44	2.00e-127	447.00
IUUC-Hvu-047349	Hordeum vulgare	49.06	2.00e-117	414.00
IUUC-Itr-048390	Ictidomys tridecemlineatus	63.44	3.00e-127	446.00
IUUC-Kpa-049343	Komagataella pastoris	49.55	4.00e-120	422.00
IUUC-Lch-049830	Latimeria chalumnae	51.43	3.00e-129	452.00
IUUC-Lpe-051442	Leersia perrieri	48.23	2.00e-114	404.00
IUUC-Loc-051794	Lepisosteus oculatus	50.52	1.00e-131	461.00
IUUC-Lma-053137	Leptosphaeria maculans	52.35	5.00e-136	476.00
IUUC-Laf-053471	Loxodonta africana	62.27	2.00e-127	447.00
IUUC-Mcc-055627	Macaca mulatta	63.44	2.00e-127	447.00
IUUC-Meu-056148	Macropus eugenii	62.81	2.00e-125	440.00
IUUC-Mor-056960	Magnaporthe oryzae	70.13	2.00e-140	490.00
IUUC-Mtr-057816	Medicago truncatula	48.47	1.00e-113	401.00
IUUC-Mla-059031	Melampsora laricipopulina	65.57	2.00e-166	576.00
IUUC-Mga-059337	Meleagris gallopavo	48.05	4.00e-127	446.00
IUUC-Mvi-060217	Microbotryum violaceum	76.52	5.00e-163	565.00
IUUC-Mmr-061018	Microcebus murinus	62.58	2.00e-127	446.00
IUUC-Mdo-062863	Monodelphis domestica	64.59	3.00e-124	436.00
IUUC-Mmu-063988	Mus musculus	63.44	6.00e-127	445.00
IUUC-Mac-064459	Musa acuminata	59.60	7.00e-110	388.00
IUUC-Mpu-066559	Mustela putorius furo	54.61	4.00e-128	449.00
IUUC-Mlu-067361	Myotis lucifugus	62.92	9.00e-128	448.00
IUUC-Nfi-068492	Neosartorya fischeri	56.40	7.00e-136	474.00
IUUC-Ncr-068808	Neurospora crassa	53.81	7.00e-142	495.00
IUUC-Nle-069875	Nomascus leucogenys	63.44	2.00e-127	447.00
IUUC-Opr-070462	Ochotona princeps	64.39	2.00e-104	370.00
IUUC-Ont-071365	Oreochromis niloticus	49.90	2.00e-129	453.00
IUUC-Oan-072708	Ornithorhynchus anatinus	63.75	2.00e-127	447.00
IUUC-Ocu-074594	Oryctolagus cuniculus	63.44	3.00e-127	446.00
IUUC-Oba-075570	Oryza barthii	57.63	7.00e-114	402.00
IUUC-Obr-076366	Oryza brachyantha	61.92	3.00e-90	322.00
IUUC-Ogl-077153	Oryza glaberrima	57.63	3.00e-113	399.00
IUUC-Ogu-078540	Oryza glumaepatula	57.63	8.00e-114	402.00
IUUC-Oin-079612	Oryza indica	56.75	6.00e-112	395.00
IUUC-Olo-081077	Oryza longistaminata	56.75	6.00e-112	395.00
IUUC-Ome-081236	Oryza meridionalis	56.44	7.00e-112	395.00
IUUC-Oni-082499	Oryza nivara	57.63	8.00e-114	402.00
IUUC-Opu-083499	Oryza punctata	56.75	5.00e-112	395.00
IUUC-Oru-084276	Oryza rufipogon	57.63	8.00e-114	402.00
IUUC-Osa-085849	Oryza sativa	57.63	8.00e-114	402.00
IUUC-Ola-086655	Oryzias latipes	49.18	3.00e-130	456.00
IUUC-Olu-087637	Ostreococcus lucimarinus	61.36	9.00e-119	417.00
IUUC-Oga-087934	Otolemur garnettii	54.61	1.00e-127	447.00
IUUC-Oar-090185	Ovis aries	62.92	4.00e-128	449.00
IUUC-Ptr-091198	Pan troglodytes	63.44	2.00e-127	447.00
IUUC-Pan-092622	Papio anubis	63.44	2.00e-127	447.00
IUUC-Psi-093320	Pelodiscus sinensis	61.26	3.00e-126	443.00
IUUC-Pma-094638	Petromyzon marinus	65.72	4.00e-131	459.00
IUUC-Pno-094826	Phaeosphaeria nodorum	55.00	2.00e-107	380.00
IUUC-Ppa-095576	Physcomitrella patens	61.95	7.00e-116	408.00
IUUC-Pfo-096894	Poecilia formosa	50.72	4.00e-131	459.00
IUUC-Pab-098020	Pongo abelii	63.44	2.00e-127	447.00
IUUC-Pop-099180	Populus trichocarpa	46.93	6.00e-112	395.00
IUUC-Pca-100909	Procavia capensis	64.44	1.00e-106	378.00
IUUC-Ppe-101346	Prunus persica	48.01	2.00e-115	407.00
IUUC-Pva-102167	Pteropus vampyrus	54.10	1.00e-103	368.00
IUUC-Pgr-103516	Puccinia graminis	64.16	6.00e-172	595.00
IUUC-Ptt-103738	Puccinia triticina	62.86	4.00e-170	588.00
IUUC-Pte-104352	Pyrenophora teres	51.78	5.00e-137	479.00
IUUC-Pyt-104632	Pyrenophora triticirepentis	51.88	1.00e-137	480.00
IUUC-Rno-105291	Rattus norvegicus	63.12	4.00e-127	446.00
IUUC-Sce-106204	Saccharomyces cerevisiae	45.28	5.00e-108	382.00
IUUC-Sha-106943	Sarcophilus harrisii	63.40	6.00e-121	426.00
IUUC-Sja-107659	Schizosaccharomyces japonicus	67.51	7.00e-131	458.00
IUUC-Spo-108049	Schizosaccharomyces pombe	68.54	3.00e-133	466.00
IUUC-Smo-109043	Selaginella moellendorffii	60.75	1.00e-119	421.00
IUUC-Sit-110431	Setaria italica	48.35	6.00e-115	405.00
IUUC-Sly-111391	Solanum lycopersicum	47.54	4.00e-110	389.00
IUUC-Stu-112364	Solanum tuberosum	52.61	4.00e-91	325.00
IUUC-Sar-113450	Sorex araneus	63.12	5.00e-126	442.00
IUUC-Sbi-113829	Sorghum bicolor	48.58	2.00e-115	407.00
IUUC-Sre-115153	Sporisorium reilianum	74.77	4.00e-152	529.00
IUUC-Ssc-116274	Sus scrofa	62.61	1.00e-127	447.00
IUUC-Tgu-117417	Taeniopygia guttata	50.77	2.00e-129	453.00
IUUC-Tru-117615	Takifugu rubripes	50.10	2.00e-124	437.00
IUUC-Tsy-119480	Tarsius syrichta	63.44	3.00e-127	446.00
IUUC-Tni-119847	Tetraodon nigroviridis	62.06	1.00e-128	451.00
IUUC-Tca-121287	Theobroma cacao	46.76	6.00e-116	409.00
IUUC-Tre-122010	Trichoderma reesei	72.26	1.00e-144	504.00
IUUC-Tvi-122475	Trichoderma virens	57.70	3.00e-147	513.00
IUUC-Tae-124243	Triticum aestivum	49.06	2.00e-117	413.00
IUUC-Tur-126116	Triticum urartu	40.28	1.00e-86	311.00
IUUC-Tme-126992	Tuber melanosporum	56.03	6.00e-144	502.00
IUUC-Tbe-127803	Tupaia belangeri	64.86	2.00e-104	370.00
IUUC-Ttr-128933	Tursiops truncatus	63.44	3.00e-127	446.00
IUUC-Uma-129447	Ustilago maydis	72.19	5.00e-147	512.00
IUUC-Vda-129780	Verticillium dahliae	57.47	3.00e-145	506.00
IUUC-Vpa-130557	Vicugna pacos	41.67	3.00e-37	147.00
IUUC-Vvi-130918	Vitis vinifera	45.92	1.00e-111	394.00
IUUC-Xtr-132409	Xenopus tropicalis	63.12	3.00e-126	443.00
IUUC-Xma-133420	Xiphophorus maculatus	50.52	3.00e-131	459.00
IUUC-Yli-134362	Yarrowia lipolytica	51.67	4.00e-121	426.00
IUUC-Zma-135804	Zea mays	55.25	2.00e-111	393.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence