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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046294
Ensembl Protein ID ENSP00000241436.4
UniProt Accession Q9UBT6; B2RBD2; Q5Q9G5; Q5Q9G6; Q5Q9G7; Q5Q9G8; Q86VJ8; Q8IZY0; Q8IZY1; Q8NB30; Q96L01; Q96Q86; Q96Q87; Q9UHC5; POLK_HUMAN
Genbank Protein ID BAA86943.1; AAF02540.1; AAV80827.1; AAV80829.1; AAV80828.1; AAV80830.1; AAF23270.1; AAN15780.1; AAN15781.1; BAC03714.1; BAG37179.1; AAP12648.1; EAW95763.1; AAH14955.1; AAH50718.1; BAB58975.1; BAB58976.1
Protein Name DNA polymerase kappa; DINB protein
Genbank Nucleotide ID AB027564; AF163570; AY769929; AY769931; AY769930; AY769932; AF194973; AF315602; AF318313; AK091659; AK314610; AY273797; AC010245; BC014955; BC050718; AB036934; AB036935
Gene Name POLK; DINB1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000122008.15 ENST00000241436.8 ENSP00000241436.4
ENSG00000122008.15 ENST00000503479.6 ENSP00000421997.2
ENSG00000122008.15 ENST00000505774.5 ENSP00000421879.1
ENSG00000122008.15 ENST00000515295.5 ENSP00000424174.1
ENSG00000122008.15 ENST00000514141.5 ENSP00000423526.1
ENSG00000122008.15 ENST00000504026.5 ENSP00000425075.1
ENSG00000122008.15 ENST00000508526.5 ENSP00000426853.1
ENSG00000122008.15 ENST00000509126.2 ENSP00000423532.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/UBZ UBZ 24848457
Classification
Family E-value Score Start End
UBD/ZnF/UBZ 7.50e-14 53.2 777 802
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/UBZ
   S: 2    lvCPvC...qkmvdqtdfeeHlDeCl 24
           lvCPvC   qk+ d+t+f+ H+D Cl
   Q: 777  LVCPVCnveQKTSDLTLFNVHVDVCL 802
           89****999999*************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.
 DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.
Protein Sequence
(Fasta)
MDSTKEKCDS YKDDLLLRMG LNDNKAGMEG LDKEKINKII MEATKGSRFY GNELKKEKQV 60
NQRIENMMQQ KAQITSQQLR KAQLQVDRFA MELEQSRNLS NTIVHIDMDA FYAAVEMRDN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046294|UBD,UBZ|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TACCTCCGGC TCTCCCGGGT GACGACGGGT AGAAAAGCAG GAGGAGCGGA GAAAGGAGAG 60
GGCGGGGTAG GGATGCAGCT GTGCTGCATT CTGGGAAGGG CGTTGGTCCG TCGCTCGCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046294|UBD,UBZ|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0235--DNA replication
KW-0237--DNA synthesis
KW-0238--DNA-binding
KW-0239--DNA-directed DNA polymerase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0515--Mutator protein
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0704--Schiff base
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR017961--DNA_pol_Y-fam_little_finger
IPR022880--DNApol_IV
IPR024728--PolY_HhH_motif
IPR001126--UmuC
IPR006642--Znf_Rad18_put
PROSITE

PS50173--UMUC
Pfam

PF00817--IMS
PF11799--IMS_C
PF11798--IMS_HHH
SMART

SM00734--ZnF_Rad18
Gene Ontology

GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0003684--F:damaged DNA binding
GO:0003887--F:DNA-directed DNA polymerase activity
GO:0046872--F:metal ion binding
GO:0006281--P:DNA repair
GO:0006260--P:DNA replication
GO:0042276--P:error-prone translesion synthesis
GO:0006297--P:nucleotide-excision repair, DNA gap filling
GO:0033683--P:nucleotide-excision repair, DNA incision
GO:0006296--P:nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006283--P:transcription-coupled nucleotide-excision repair
GO:0019985--P:translesion synthesis
KEGG hsa:51426
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001908 Ailuropoda melanoleuca 84.32 0.00e+00 1459.00
IUUC-Apl-003228 Anas platyrhynchos 57.38 0.00e+00 852.00
IUUC-Aca-005080 Anolis carolinensis 57.18 0.00e+00 870.00
IUUC-Afl-008688 Aspergillus flavus 30.05 1.00e-36 148.00
IUUC-Afu-008792 Aspergillus fumigatus 33.15 7.00e-51 195.00
IUUC-Aor-010225 Aspergillus oryzae 43.72 1.00e-43 171.00
IUUC-Ame-011889 Astyanax mexicanus 59.29 0.00e+00 697.00
IUUC-Bta-013127 Bos taurus 83.60 0.00e+00 1452.00
IUUC-Bra-017144 Brassica rapa 55.61 1.00e-59 224.00
IUUC-Cel-018629 Caenorhabditis elegans 43.05 5.00e-101 361.00
IUUC-Cja-019598 Callithrix jacchus 90.61 0.00e+00 1528.00
IUUC-Cfa-020661 Canis familiaris 83.52 0.00e+00 1438.00
IUUC-Cpo-022040 Cavia porcellus 74.86 0.00e+00 1226.00
IUUC-Csa-023669 Chlorocebus sabaeus 94.54 0.00e+00 1608.00
IUUC-Cho-024910 Choloepus hoffmanni 69.00 0.00e+00 705.00
IUUC-Csv-026293 Ciona savignyi 51.09 7.00e-136 477.00
IUUC-Dre-028317 Danio rerio 57.89 0.00e+00 719.00
IUUC-Dno-029973 Dasypus novemcinctus 82.84 0.00e+00 1395.00
IUUC-Dor-030667 Dipodomys ordii 80.71 0.00e+00 1405.00
IUUC-Dse-031339 Dothistroma septosporum 47.78 7.00e-50 192.00
IUUC-Ete-033030 Echinops telfairi 77.73 0.00e+00 1323.00
IUUC-Eca-033959 Equus caballus 84.39 0.00e+00 1483.00
IUUC-Fca-036160 Felis catus 80.99 0.00e+00 1401.00
IUUC-Fal-037116 Ficedula albicollis 58.79 0.00e+00 863.00
IUUC-Gmo-039003 Gadus morhua 50.00 0.00e+00 712.00
IUUC-Gga-040431 Gallus gallus 66.31 0.00e+00 830.00
IUUC-Gac-042455 Gasterosteus aculeatus 57.70 0.00e+00 703.00
IUUC-Gma-043303 Glycine max 54.35 1.00e-56 214.00
IUUC-Ggo-045024 Gorilla gorilla 97.59 0.00e+00 1709.00
IUUC-Itr-048670 Ictidomys tridecemlineatus 80.85 0.00e+00 1354.00
IUUC-Lch-050251 Latimeria chalumnae 51.51 0.00e+00 794.00
IUUC-Loc-051939 Lepisosteus oculatus 58.81 0.00e+00 720.00
IUUC-Laf-054562 Loxodonta africana 77.19 0.00e+00 1315.00
IUUC-Mcc-055653 Macaca mulatta 94.83 0.00e+00 1665.00
IUUC-Meu-055994 Macropus eugenii 76.54 1.00e-147 517.00
IUUC-Mga-059228 Meleagris gallopavo 45.81 0.00e+00 635.00
IUUC-Mvi-060383 Microbotryum violaceum 34.34 1.00e-39 158.00
IUUC-Mmr-061202 Microcebus murinus 87.50 0.00e+00 1521.00
IUUC-Mdo-062829 Monodelphis domestica 67.84 0.00e+00 1081.00
IUUC-Mmu-063675 Mus musculus 75.57 0.00e+00 1315.00
IUUC-Mpu-066825 Mustela putorius furo 83.26 0.00e+00 1417.00
IUUC-Mlu-067316 Myotis lucifugus 85.78 0.00e+00 1476.00
IUUC-Nle-069272 Nomascus leucogenys 96.79 0.00e+00 1679.00
IUUC-Opr-070616 Ochotona princeps 71.33 0.00e+00 1219.00
IUUC-Ont-072011 Oreochromis niloticus 63.70 0.00e+00 679.00
IUUC-Oan-073343 Ornithorhynchus anatinus 65.65 0.00e+00 1058.00
IUUC-Ocu-073766 Oryctolagus cuniculus 73.00 0.00e+00 1137.00
IUUC-Ogl-077190 Oryza glaberrima 36.90 7.00e-72 265.00
IUUC-Ogu-078415 Oryza glumaepatula 39.48 4.00e-86 312.00
IUUC-Ome-081300 Oryza meridionalis 62.96 2.00e-24 105.00
IUUC-Osa-085963 Oryza sativa 36.90 6.00e-72 265.00
IUUC-Ola-087034 Oryzias latipes 49.51 0.00e+00 704.00
IUUC-Oga-088157 Otolemur garnettii 81.49 0.00e+00 1406.00
IUUC-Oar-089218 Ovis aries 83.07 0.00e+00 1476.00
IUUC-Ptr-091552 Pan troglodytes 99.08 0.00e+00 1746.00
IUUC-Pan-092646 Papio anubis 93.93 0.00e+00 1644.00
IUUC-Psi-093608 Pelodiscus sinensis 59.23 0.00e+00 930.00
IUUC-Pma-094381 Petromyzon marinus 48.94 0.00e+00 702.00
IUUC-Pno-095081 Phaeosphaeria nodorum 39.04 1.00e-44 174.00
IUUC-Pfo-096545 Poecilia formosa 59.17 0.00e+00 738.00
IUUC-Pab-097613 Pongo abelii 91.07 0.00e+00 1640.00
IUUC-Pca-101071 Procavia capensis 61.99 2.00e-144 505.00
IUUC-Pva-102252 Pteropus vampyrus 85.29 0.00e+00 1489.00
IUUC-Pgr-103567 Puccinia graminis 36.61 3.00e-43 169.00
IUUC-Ptt-103934 Puccinia triticina 31.54 1.00e-28 121.00
IUUC-Rno-105793 Rattus norvegicus 72.48 0.00e+00 1200.00
IUUC-Sha-107230 Sarcophilus harrisii 69.29 0.00e+00 1145.00
IUUC-Spo-108028 Schizosaccharomyces pombe 31.41 4.00e-53 202.00
IUUC-Sly-111390 Solanum lycopersicum 55.68 8.00e-60 225.00
IUUC-Stu-112284 Solanum tuberosum 54.97 2.00e-60 227.00
IUUC-Sar-113594 Sorex araneus 71.56 0.00e+00 1202.00
IUUC-Sre-115078 Sporisorium reilianum 30.10 3.00e-45 176.00
IUUC-Ssc-116013 Sus scrofa 83.24 0.00e+00 1484.00
IUUC-Tgu-117442 Taeniopygia guttata 56.93 0.00e+00 849.00
IUUC-Tru-117935 Takifugu rubripes 56.32 0.00e+00 674.00
IUUC-Tsy-119489 Tarsius syrichta 73.36 0.00e+00 776.00
IUUC-Tni-120543 Tetraodon nigroviridis 64.37 0.00e+00 651.00
IUUC-Tbe-128112 Tupaia belangeri 82.47 0.00e+00 874.00
IUUC-Ttr-128371 Tursiops truncatus 79.13 0.00e+00 1350.00
IUUC-Uma-129377 Ustilago maydis 31.98 2.00e-45 177.00
IUUC-Vpa-130243 Vicugna pacos 85.89 0.00e+00 1513.00
IUUC-Xtr-132453 Xenopus tropicalis 54.73 0.00e+00 801.00
IUUC-Xma-133255 Xiphophorus maculatus 57.55 0.00e+00 730.00
Created Date 25-Jun-2017

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